Presentation
A total of 21 holstein calves (12 female, 9 male, weighted 28-52 kg), at the age of 0-30 days, were enrolled in the present study. The calves were randomly divided into 3 groups. [dialnet.unirioja.es]
Comprised of more than 90% amylopectin and etherified to the extent that an average of 7 to 8 of the OH groups present in every ten D-glucopyranose units of the polymer have been converted to OCH2CH2OH groups. [drugfuture.com]
Either hetastarch, when present at concentrations comparable to the manufacturer's maximum recommended dose of 20 mL/kg (equivalent to the high dilution used in these experiments), decreases clot tensile strength to levels associated with an increased [ncbi.nlm.nih.gov]
Presentations will also address emergency preparedness from the processing facilities perspective and response to critical reagent shortages. [celltherapysociety.org]
Entire Body System
- Intravenous Administration
HESPAN ® (6% Hetastarch in 0.9% Sodium Chloride Injection), 500 mL EXCEL ® IV container HESPAN ® (6% hetastarch in 0.9% sodium chloride injection) is a sterile, nonpyrogenic solution for intravenous administration. [bbraunusa.com]
➤ License Authorization Form (LAF) Required HESPAN® (6% hetastarch in 0.9% sodium chloride injection) is a sterile, nonpyrogenic solution for intravenous administration. [boundtree.com]
Upon intravenous administration, hydroxyethyl starch colloid increases blood volume and thus improves circulation. This agent is almost exclusively excreted by the kidneys and is potentially nephrotoxic. [cancer.gov]
Intended for intravenous administration using sterile equipment. It is recommended that intravenous administration apparatus be replaced at least once every 24 hours. [rxlist.com]
Treatment
In this study, it was aimed to compare the effectiveness of Hydroxyethyl Starch (HTS), HTS +7.2% NaCl combination and Ringer Lactate solutions in the treatment of hypovolemic calves with diarrhea. Materials and methods. [dialnet.unirioja.es]
Sepsis / Shock, Septic 1 4 Completed Treatment Subarachnoid Hemorrhage 1 4 Recruiting Treatment Hypovolaemia 1 4 Recruiting Treatment Hypovolaemia Due to Acute Blood Loss 1 4 Terminated Treatment Anaesthesia therapy 1 4 Terminated Treatment Intraoperative [drugbank.ca]
Damon L., Intracranial Bleeding During Treatment with Hydroxyethyl Starch. New England Journal of Medicine, 1987;317(15):964-965. [rxlist.com]
/ Surgery, Cardiac 1 4 Completed Treatment Coagulation Disorder 1 4 Completed Treatment Coronary Artery Bypass Grafting (CABG) / Valve Surgery 1 4 Completed Treatment Coronary Artery Disease (CAD) / Valvular Heart Disease 1 4 Completed Treatment Coronary [go.drugbank.com]
This study shows an increase in coagulopathy with the use of hetastarch as compared with the use of PPF for the treatment of postaneurysmal vasospasm. [ncbi.nlm.nih.gov]
Prognosis
Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.de]
Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities. Rehak J, Rehak M. Rehak J, et al. Curr Eye Res. 2008 Feb;33(2):111-31. doi: 10.1080/02713680701851902. Curr Eye Res. 2008. PMID: 18293182 Free PMC article. [pubmed.ncbi.nlm.nih.gov]
Etiology
Liskaser FJ, Bellomo R, Hayhoe M, Story D, Poustie S, Smith B, Letis A, Bennett M: Role of pump prime in the etiology and pathogenesis of cardiopulmonary bypass-associated acidosis. Anesthesiology 2000, 93:1170-1173. [ccforum.biomedcentral.com]
Epidemiology
Two studies in cardiac surgery patients and an epidemiological study from the current literature prompted the FDA to ask if hetastarch mediates increased bleeding in patients on cardiopulmonary bypass. [anesthesiology.pubs.asahq.org]
[…] the Department of Anesthesiology and Intensive Care Medicine (F.M.B., F.B., C.H., K.R.) and the Institute of Clinical Chemistry and Laboratory Medicine (M.K.), Friedrich Schiller University, Jena; the Institute of Medical Informatics, Statistics and Epidemiology [doi.org]
Pathophysiology
Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.de]
The pathophysiological basis for pruritus is the widespread tissue deposition of HES, prominently in macrophages. HES tissue deposits are long lasting and sometimes massive. [ncbi.nlm.nih.gov]
The increase in creatinine confirmed the pathophysiological rationale. Furthermore, the patients needed more blood products, had significant more liver failure and itching. [en.wikipedia.org]
One potential mechanism for adverse outcomes that could be modified by the administration of colloids is the unique pathophysiology associated with hip and knee arthroplasties. [bmj.com]
Prevention
IMPLICATIONS: This prospective, randomized, blinded trial showed that, in elderly surgical patients, the use of balanced IV solutions can prevent the development of hyperchloremic metabolic acidosis and provide better gastric mucosal perfusion compared [ncbi.nlm.nih.gov]
Summary Hydroxyethyl Starch is a plasma volume substitute used to treat and prevent hypovolemia. [go.drugbank.com]
Complications Associated With Artificial Fertilization / Disorder of Endocrine Ovary 1 0 Not Yet Recruiting Prevention Hypotension Drug-Induced 1 2 Completed Prevention Coagulation Defect; Bleeding 1 2 Completed Treatment Angina Pectoris / Myocardial [drugbank.ca]