Either hetastarch, when present at concentrations comparable to the manufacturer's maximum recommended dose of 20 mL/kg (equivalent to the high dilution used in these experiments), decreases clot tensile strength to levels associated with an increased [ncbi.nlm.nih.gov]

Presentations will also address emergency preparedness from the processing facilities perspective and response to critical reagent shortages. [celltherapysociety.org]

The material is presented in a brief and quick-access format which allows for topic and exam review. It provides enough detailed and specific information to address most all questions and problems that arise in the ICU. [books.google.de]

• Intravenous Administration

  License Authorization Form (LAF) Required HESPAN (6% hetastarch in 0.9% sodium chloride injection) is a sterile, nonpyrogenic solution for intravenous administration. [boundtree.com]

  Upon intravenous administration, hydroxyethyl starch colloid increases blood volume and thus improves circulation. This agent is almost exclusively excreted by the kidneys and is potentially nephrotoxic. [cancer.gov]

  HESPAN (6% Hetastarch in 0.9% Sodium Chloride Injection), 500 mL EXCEL IV container HESPAN (6% hetastarch in 0.9% sodium chloride injection) is a sterile, nonpyrogenic solution for intravenous administration. [bbraunusa.com]

  Intended for intravenous administration using sterile equipment. It is recommended that intravenous administration apparatus be replaced at least once every 24 hours. [rxlist.com]

• Base Deficit

  However, in patients receiving HEX, initial heart rate was higher, base deficit was lower, and hematocrit was lower (consistent with relative hypovolemia), even though blood product requirements were reduced, and urine output was greater (all p 0.05). [ncbi.nlm.nih.gov]

This study shows an increase in coagulopathy with the use of hetastarch as compared with the use of PPF for the treatment of postaneurysmal vasospasm. [ncbi.nlm.nih.gov]

The Sydney Resection Quotient will be compared between treatment groups using a Wilcoxon Rank-Sum test. [clinicaltrials.gov]

Two studies in cardiac surgery patients and an epidemiological study from the current literature prompted the FDA to ask if hetastarch mediates increased bleeding in patients on cardiopulmonary bypass. [anesthesiology.pubs.asahq.org]

Elke Weisshaar and Florence Dalgard, Epidemiology, Pruritus, 10.1007/978-3-319-33142-3_9, (73-79), (2016). Jialie Luo, Jing Feng, Shenbin Liu, Edgar T. [doi.org]

The pathophysiological basis for pruritus is the widespread tissue deposition of HES, prominently in macrophages. HES tissue deposits are long lasting and sometimes massive. [ncbi.nlm.nih.gov]

The increase in creatinine confirmed the pathophysiological rationale. Furthermore, the patients needed more blood products, had significant more liver failure and itching. The study was published in the NEJM in October 2012.. [en.wikipedia.org]

One potential mechanism for adverse outcomes that could be modified by the administration of colloids is the unique pathophysiology associated with hip and knee arthroplasties. [bmj.com]

IMPLICATIONS: This prospective, randomized, blinded trial showed that, in elderly surgical patients, the use of balanced IV solutions can prevent the development of hyperchloremic metabolic acidosis and provide better gastric mucosal perfusion compared [ncbi.nlm.nih.gov]

Complications Associated With Artificial Fertilization / Disorder of Endocrine Ovary 1 0 Not Yet Recruiting Prevention Hypotension Drug-Induced 1 2 Completed Prevention Coagulation Defect; Bleeding 1 2 Completed Treatment Angina Pectoris / Myocardial [drugbank.ca]

HETASTARCH (Hespan ) treats or prevents shock, following serious injury, bleeding, surgery, or burns, by increasing the volume of blood plasma. [altonmemorialhospital.org]