A total of 21 holstein calves (12 female, 9 male, weighted 28-52 kg), at the age of 0-30 days, were enrolled in the present study. The calves were randomly divided into 3 groups. [dialnet.unirioja.es]

Presentations will also address emergency preparedness from the processing facilities perspective and response to critical reagent shortages. [celltherapysociety.org]

Either hetastarch, when present at concentrations comparable to the manufacturer's maximum recommended dose of 20 mL/kg (equivalent to the high dilution used in these experiments), decreases clot tensile strength to levels associated with an increased [ncbi.nlm.nih.gov]

Comprised of more than 90% amylopectin and etherified to the extent that an average of 7 to 8 of the OH groups present in every ten D-glucopyranose units of the polymer have been converted to OCH2CH2OH groups. [drugfuture.com]

• Sepsis

  The drug 'hydroxyethyl starch' is used for treating severe sepsis (blood poisoning). But it can, according to a Danish professor, cause kidney failure and bleeding. [sciencenordic.com]

  Hydroxyethyl starch 130/0.42 versus ringer's acetate in severe sepsis. N Engl J Med 2012;367(2):124-34 Brunkhorst FM, Engel C, Bloos F et al. Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis. [ema.europa.eu]

  Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 2008 ;34: 17 - 60 3. Schortgen F, Lacherade JC, Bruneel F, et al. [doi.org]

• Pain

  Tell your caregivers right away if you have: wheezing or gasping for breath, rapid breathing, sweating, and anxiety; a light-headed feeling, like you might pass out; weak pulse, slow breathing; chest pain, fever, chills, cough; or easy bruising, unusual [everydayhealth.com]

  […] and pains runny nose shivering sore throat tingling of the feet trouble sleeping unusual weight gain or loss vomiting Other side effects not listed may also occur in some patients. [mayoclinic.org]

  Cough Fast Heartbeat Fluid Accumulation Around The Eye Fluid Retention In The Legs, Feet, Arms Or Hands Head Pain Hives Muscle Pain Nervous Puffy Face From Water Retention Rapid Breathing Slow Heartbeat Temporary Redness Of Face And Neck Wheezing Selected [webmd.com]

  Call your doctor at once if you have any of these symptoms of kidney damage: swelling, rapid weight gain, unusual tiredness, nausea, vomiting, feeling short of breath, red or pink urine, painful or difficult urination, or little or no urinating. [drugs.com]

  […] fever, chills blood disorder or anemia headache joint or muscle pains nausea, vomiting pain and burning at the injection site restlessness skin rash or redness, itching (hives) stuffy nose unusual swelling of the body, not passing urine or difficulty [altonmemorialhospital.org]

• Fever

  Tell your caregivers right away if you have: wheezing or gasping for breath, rapid breathing, sweating, and anxiety; a light-headed feeling, like you might pass out; weak pulse, slow breathing; chest pain, fever, chills, cough; or easy bruising, unusual [everydayhealth.com]

  Rare but serious side effects may include unusual headache, vision or speech problems, mental changes, drooping eyelids, loss of feeling in your face, tremors, or trouble swallowing, or fever, sore throat, and headache with a severe blistering, peeling [cardiosmart.org]

  Rare but serious side effects may include: severe headache, vision or speech problems, mental changes; drooping eyelids, loss of feeling in your face, tremors, trouble swallowing; or severe skin reaction -- fever, sore throat, swelling in your face or [drugs.com]

  Lact Electrolyte Solution Hetastarch In Lact Electrolyte Solution Side Effects by Likelihood and Severity COMMON side effects Imbalance Of Body Fluids High Blood Levels Of The Amylase Enzyme Itching Swollen Lymph Nodes INFREQUENT side effects Chills Fever [webmd.com]

• Swelling

  […] restlessness sneezing stomach cramps stopping of the heart sudden increase or decrease in the amount of urine sweating swelling around the eyes swelling in the legs and ankles swelling of the face, fingers, feet, or lower legs unconsciousness unusual [mayoclinic.org]

  Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. [everydayhealth.com]

  Hetastarch side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives ; difficulty breathing; swelling of your face, lips, tongue, or throat. [drugs.com]

• Weakness

  Tell your caregivers at once if you have a serious side effect such as chest pain, fast or slow heart rate, wheezing or gasping for breath, feeling like you might pass out, weak pulse, slow breathing (breathing may stop), pale skin, easy bruising, blood [cardiosmart.org]

  Tell your caregivers right away if you have: wheezing or gasping for breath, rapid breathing, sweating, and anxiety; a light-headed feeling, like you might pass out; weak pulse, slow breathing; chest pain, fever, chills, cough; or easy bruising, unusual [everydayhealth.com]

  […] any of these side effects: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing Change in how much or how often you urinate Unusual bleeding, bruising, or weakness [trihealth.adam.com]

  […] stopping of the heart sudden increase or decrease in the amount of urine sweating swelling around the eyes swelling in the legs and ankles swelling of the face, fingers, feet, or lower legs unconsciousness unusual bleeding or bruising unusual tiredness or weakness [mayoclinic.org]

  […] follow the principles of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to guide assessment of quality of evidence from high (A) to very low (D) and to determine the strength of recommendations as strong (1) or weak [doi.org]

• Heart Failure

  Contraindications to its use include heart failure and oliguric renal failure, because of its excellent ability to increase plasma volume, and the presence of von Willebrand's disease, because of its ability to significantly lower all components of Factor [ncbi.nlm.nih.gov]

  Before you receive hetastarch, tell your doctor if you have kidney or liver disease, heart disease, congestive heart failure, diabetes, or an electrolyte imbalance. [cardiosmart.org]

  Immediate Immediate Unknown Contraindications and precautions Contraindicated in patients with severe bleeding disorders, severe heart failure, or renal failure with oliguria and anuria. Interactions None reported. [glowm.com]

  […] surgery in association with cardiopulmonary bypass due to excess bleeding Discontinue at the first sign of coagulopathy Contraindications Hypersensitivity to hetastarch Severe bleeding disorders, severe congestive heart failure, severe renal failure [rxlist.com]

  Important Information You should not receive this medication if you have a bleeding or blood clotting disorder, congestive heart failure, kidney disease, or urination problems not caused by hypovolemia (decreased blood plasma volume). [drugs.com]

• Heart Disease

  PARTICIPANTS: Forty-seven children age 1 year or greater (mean 72.8 months; range 12 months to 15.5 years) scheduled for repair of congenital heart disease with moderate hypothermia were randomized to receive hetastarch or albumin as a postoperative volume [ncbi.nlm.nih.gov]

  / Valvular Heart Disease 1 4 Completed Treatment Coronary Heart Disease (CHD) 1 4 Completed Treatment Disorders of Coagulation 1 4 Completed Treatment Fluid Volume Disorder 1 4 Completed Treatment General Surgery / Major Abdominal Surgery by Laparotomy [drugbank.ca]

  Before you receive hetastarch, tell your doctor if you have kidney or liver disease, heart disease, congestive heart failure, diabetes, or an electrolyte imbalance. [cardiosmart.org]

  What is the ideal intraop fluid rate with heart disease? Again, looking at each patient as an individual is important. Heart disease is not necessarily heart failure. [veterinarypracticenews.com]

• Tachycardia

  A young man is admitted to the intensive care unit with severe pancreatitis, high fevers and tachycardia. [blogs.nejm.org]

  […] life-threatening anaphylactic/anaphylactoid reactions, cardiac arrest, ventricular fibrillation, severe hypotension, non-cardiac pulmonary edema, laryngeal edema, bronchospasm, angioedema, wheezing, restlessness, tachypnea, stridor, fever, chest pain, bradycardia, tachycardia [dailymed.nlm.nih.gov]

  […] intravascular coagulation (DIC) / Delayed / Incidence not known coagulopathy / Delayed / Incidence not known intracranial bleeding / Delayed / Incidence not known Moderate dyspnea / Early / Incidence not known hypotension / Rapid / Incidence not known sinus tachycardia [pdr.net]

• Pruritus

  Usually several weeks elapse between HES exposure and the onset of pruritus. Consequently, it is important to inquire about prior HES exposure in the diagnostic evaluation of pruritus sine materia. [ncbi.nlm.nih.gov]

  Florence Dalgard and Elke Weisshaar, The Epidemiology of Pruritus, Pruritus, 10.1007/978-1-84882-322-8_11, (69-75), (2009). Jacek C. Szepietowski and Adam Reich, Drugs, Pruritus, 10.1007/978-1-84882-322-8_31, (195-204), (2009). F. [doi.org]

  Body as a Whole: Pruritus, anaphylactoid reactions (periorbital edema, urticaria, wheezing), vomiting, mild fever, chills, influenza-like symptoms, headache, muscle pains, submaxillary and parotid glandular swelling. [robholland.com]

  – Pruritus, sometimes severe, can occur with skin deposition and this is one of the most common side-effects reported with HES.[5, 6] - Anaphylactoid reactions – HES can activate the alternative complement pathway resulting in the generation of C3a and [apheresis.org]

• Skin Rash

  […] tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. [everydayhealth.com]

• Blister

  Rare but serious side effects may include unusual headache, vision or speech problems, mental changes, drooping eyelids, loss of feeling in your face, tremors, or trouble swallowing, or fever, sore throat, and headache with a severe blistering, peeling [cardiosmart.org]

  […] face, tremors, trouble swallowing; or severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering [everydayhealth.com]

• Eruptions

  Berger and Martin Steinhoff, Pruritus in Elderly Patients—Eruptions of Senescence, Seminars in Cutaneous Medicine and Surgery, 30, 2, (113), (2011). A.B. Johan Groeneveld, Roberta J. Navickis and Mahlon M. [doi.org]

• Headache

  Rare but serious side effects may include unusual headache, vision or speech problems, mental changes, drooping eyelids, loss of feeling in your face, tremors, or trouble swallowing, or fever, sore throat, and headache with a severe blistering, peeling [cardiosmart.org]

  Rare but serious side effects may include: severe headache, vision or speech problems, mental changes; drooping eyelids, loss of feeling in your face, tremors, trouble swallowing; or severe skin reaction -- fever, sore throat, swelling in your face or [everydayhealth.com]

  Patient & Family Education Notify physician for any of the following: Difficulty breathing, nausea, chills, headache, itching. [robholland.com]

  Common side effects may include: mild itching or skin rash; mild headache; muscle pain; or swollen glands, mild flu symptoms. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. [drugs.com]

• Tremor

  Rare but serious side effects may include unusual headache, vision or speech problems, mental changes, drooping eyelids, loss of feeling in your face, tremors, or trouble swallowing, or fever, sore throat, and headache with a severe blistering, peeling [cardiosmart.org]

  Rare but serious side effects may include: severe headache, vision or speech problems, mental changes; drooping eyelids, loss of feeling in your face, tremors, trouble swallowing; or severe skin reaction -- fever, sore throat, swelling in your face or [everydayhealth.com]

  […] a lying or sitting position drowsiness fainting fast, slow, or irregular heartbeat or pulse fever hives, itching, skin rash increased sweating large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs muscle tremors [mayoclinic.org]

• Confusion

  Check with your doctor or nurse immediately if any of the following side effects occur: Incidence not known Bloody or cloudy urine blue lips and fingernails blurred vision chest pain, discomfort, or tightness confusion cough coughing that sometime produces [mayoclinic.org]

  […] hoarseness, or tightening of the throat swelling of your face, lips, tongue, hands, or feet tightness in the chest, cough, wheezing, or difficulty breathing unusual rash, bleeding or bruising, or pinpoint red spots on the skin unusual bleeding Other: confusion [altonmemorialhospital.org]

  Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue bleeding or bruising breathing problems confusion, dizziness [my.clevelandclinic.org]

  Signs of too much acid in the blood (acidosis) like confusion; fast breathing; fast heartbeat ; a heartbeat that does not feel normal; very bad stomach pain, upset stomach, or throwing up; feeling very sleepy; shortness of breath; or feeling very tired [drugs.com]

• Dizziness

  […] cloudy urine blue lips and fingernails blurred vision chest pain, discomfort, or tightness confusion cough coughing that sometime produces a pink frothy sputum decreased urine output difficult or painful urination difficulty swallowing dilated neck veins dizziness [mayoclinic.org]

  […] or tightening of the throat swelling of your face, lips, tongue, hands, or feet tightness in the chest, cough, wheezing, or difficulty breathing unusual rash, bleeding or bruising, or pinpoint red spots on the skin unusual bleeding Other: confusion, dizziness [altonmemorialhospital.org]

  Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue bleeding or bruising breathing problems confusion, dizziness [my.clevelandclinic.org]

• Anuria

  500-1000ml (do not usually exceed 1500ml/day) IV at a rate not to exeed 20ml/kg/hr;); - Precautions: - Not a substitute for blood or plasma; - Contraindicated in patients with severe bleeding disorders, severe CHF, or renal failure with oliguria or anuria [wheelessonline.com]

  […] əstärch] a plasma volume expander. indications It is prescribed to treat hypovolemia in shock and is used in leukapheresis to help increase the yield of granulocytes. contraindications Severe bleeding, severe heart or kidney dysfunction with oliguria or anuria [medical-dictionary.thefreedictionary.com]

  Severe bleeding disorders, CHF, renal failure with oliguria and anuria, treatment of shock not accompanied by hypovolemia, pregnancy (category C). Safe use in children is not established. [robholland.com]

  Immediate Immediate Unknown Contraindications and precautions Contraindicated in patients with severe bleeding disorders, severe heart failure, or renal failure with oliguria and anuria. Interactions None reported. [glowm.com]

  Hetastarch is contraindicated in clinical conditions where volume overload is a potential problem, including congestive heart failure and renal failure with anuria or oliguria not related to hypovolemia. [pdr.net]

• Kidney Failure

  But it can, according to a Danish professor, cause kidney failure and bleeding. (Photo: Colourbox) A large German pharmaceutical company is bringing out the heavy artillery against a Danish professor, reports Danish newspaper Berlingske. [sciencenordic.com]

  The composite endpoint of 90-day mortality or end-stage kidney failure is the primary outcome measure. [doi.org]

  Failure of kidney function, Loss of kidney function and End‐stage kidney disease) classification scheme. [cochranelibrary.com]

  Erythema Multiforme Excess Body Acid Giant Hives Hemorrhage Within The Skull High Amount Of Bilirubin In The Blood Hypersensitivity Drug Reaction Increased Risk Of Bleeding Due To Clotting Disorder Kidney Failure Life Threatening Allergic Reaction Liver [webmd.com]

• Renal Insufficiency

  Potential granulocyte donors should be questioned and/or screened for evidence of renal insufficiency and underlying renal disease. [apheresis.org]

  Hepatic or renal insufficiency, pulmonary edema in the very young or older adults, patients on sodium restriction. [robholland.com]

  Disadvantages Magnesium administration can promote hypermagnesemia in renal insufficiency and can counteract compensatory vasoconstriction and promote hypotension in low flow states. [intensivecareunit.wordpress.com]

  Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure and severe renal insufficiency and in clinical states in which edema with sodium retention occurs. [rxlist.com]

  Surg Gynecol Obstet 1970; 131:255–67Metcalf, W Papadopoulos, A Tufaro, R Barth, A Köhler H, Kirch W, Klein H, Distler A: The effect of 6% hydroxyethyl starch 450/0.7, 10% dextran and 3.5% gelatine on plasma volume in patients with terminal renal insufficiency [doi.org]

Sepsis / Shock, Septic 1 4 Completed Treatment Subarachnoid Hemorrhage 1 4 Recruiting Treatment Hypovolaemia 1 4 Recruiting Treatment Hypovolaemia Due to Acute Blood Loss 1 4 Terminated Treatment Anaesthesia therapy 1 4 Terminated Treatment Intraoperative [drugbank.ca]

This study shows an increase in coagulopathy with the use of hetastarch as compared with the use of PPF for the treatment of postaneurysmal vasospasm. [ncbi.nlm.nih.gov]

The expected benefit of treatment should be carefully weighed against the uncertainties with regard to long-term safety, and other available treatment options should be considered. [ema.europa.eu]

Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.de]

Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities. Rehak J, Rehak M. Rehak J, et al. Curr Eye Res. 2008 Feb;33(2):111-31. doi: 10.1080/02713680701851902. Curr Eye Res. 2008. PMID: 18293182 Free PMC article. [pubmed.ncbi.nlm.nih.gov]

Liskaser FJ, Bellomo R, Hayhoe M, Story D, Poustie S, Smith B, Letis A, Bennett M: Role of pump prime in the etiology and pathogenesis of cardiopulmonary bypass-associated acidosis. Anesthesiology 2000, 93:1170-1173. [ccforum.biomedcentral.com]

Elke Weisshaar and Florence Dalgard, Epidemiology, Pruritus, 10.1007/978-3-319-33142-3_9, (73-79), (2016). Jialie Luo, Jing Feng, Shenbin Liu, Edgar T. [doi.org]

Two studies in cardiac surgery patients and an epidemiological study from the current literature prompted the FDA to ask if hetastarch mediates increased bleeding in patients on cardiopulmonary bypass. [anesthesiology.pubs.asahq.org]

Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.de]

The pathophysiological basis for pruritus is the widespread tissue deposition of HES, prominently in macrophages. HES tissue deposits are long lasting and sometimes massive. [ncbi.nlm.nih.gov]

The increase in creatinine confirmed the pathophysiological rationale. Furthermore, the patients needed more blood products, had significant more liver failure and itching. [en.wikipedia.org]

One potential mechanism for adverse outcomes that could be modified by the administration of colloids is the unique pathophysiology associated with hip and knee arthroplasties. [bmj.com]

IMPLICATIONS: This prospective, randomized, blinded trial showed that, in elderly surgical patients, the use of balanced IV solutions can prevent the development of hyperchloremic metabolic acidosis and provide better gastric mucosal perfusion compared [ncbi.nlm.nih.gov]

Complications Associated With Artificial Fertilization / Disorder of Endocrine Ovary 1 0 Not Yet Recruiting Prevention Hypotension Drug-Induced 1 2 Completed Prevention Coagulation Defect; Bleeding 1 2 Completed Treatment Angina Pectoris / Myocardial [drugbank.ca]