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High-Altitude Pulmonary Edema
Mountaineer's Susceptibility to Pulmonary Edema

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WIKIDATA, CC BY-SA 4.0
WIKIDATA, CC BY-SA 4.0

Presentation

Unilateral pulmonary edema:a rare initial presentation of cardiogenic shock due to acutemyocardial infarction. J Korean Med Sci. 2012;27(2):211-214. doi:10.3346/jkms.2012.27.2.211 Maggiorini M. [revistas.asoneumocito.org]

[…] after each presentation. [sinogermanscience.org.cn]

Treatment effects for continuous variables were presented as weighted mean differences with 95% confidence intervals. RESULTS: Ten clinical trials were identified and included for the meta-analysis. [ncbi.nlm.nih.gov]

We therefore designed the present study, which aimed at direct measurements of both pressure and permeability of the pulmonary capillaries in the early stages of HAPE. [circ.ahajournals.org]

Treatment

Treatment options for this condition are unsatisfactory. Recent interest in use of selective phosphodiesterase type 5 (PDE5) inhibitors for pulmonary hypertension has suggested a possible role for these agents in the treatment of HAPH. [ncbi.nlm.nih.gov]

This review considers these issues in greater detail, examining the current state of research and clinical practice in HAPE treatment, addressing important questions raised by documented treatment practices, such as the utility of beta agonists, acetazolamide [doi.org]

However, as outlined in the 2014 WMS Practice Guidelines, its use is recommended for the treatment of people with concomitant HAPE and HACE at the treatment doses recommended for HACE alone. [en.wikipedia.org]

Etiology

Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor [published correction appears in JAMA 2002 Sep4;288(9):1064]. JAMA. 2002;287(17):2228-2235.doi:10.1001/jama.287.17.2228 Bärtsch P, Swenson ER. [revistas.asoneumocito.org]

Adapted to etiology ! Unknown borderline ! Is it harmful to use CCB in nonresponders ? Yes, at least for high doses ACCP Gd.: Level of evidence: expert opinion; benefit: substantial; grade of recommendation: E/A. [dokumen.tips]

Adapted to etiology ! Unknown borderline ! Is it harmful to use CCB in nonresponders ?Yes, at least for high doses ACCP Gd.: Level of evidence: expert opinion; benefit: substantial;grade of recommendation: E/A. [myslide.es]

Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor [published correction appears in JAMA. 2002;288(9):1064]. JAMA. 2002;287(17):2228–2235. 33. Voelkel NF. High-altitude pulmonary edema. [aafp.org]

Epidemiology

This paper reviews the epidemiological evidence for a genetic trait of the altitude-related illnesses, mainly HAPH, as well as the molecular evidence for the contribution of the specific candidate genes or pathways involved. [link.springer.com]

Discussing controversies and concepts in PH diagnosis and management, this guide explores: classification and epidemiology, pathology, pathogenesis, genetics, and diagnosis of PH causes of the condition, such as idiopathic pulmonary arterial hypertension [books.google.com]

Zhonghua Yi Xue Za Zhi 1983;63:90-92 Wu T: An epidemiological study on high altitude disease at Qinghai-Xizang (Tibet) plateau (in Chinese).. [karger.com]

Ward R (1995) Familial aggregation and genetic epidemiology of blood pressure. In:JH Laragh, BM Brenner (eds.). Hypertension: pathology, diagnosis, and management. Raven Press, New York. pp: 67-88. [clinical-and-molecular-endocrinology.imedpub.com]

Everest or bust: a cross sectional, epidemiological study of acute mountain sickness at 4243 meters in the Himalayas. Aviat Space Environ Med. 1999;70(9):867–873. 12. Sutton JR, Coates G, Houston CS. Hypoxia and Mountain Medicine. [aafp.org]

Pathophysiology

A recent finding in early HAPE suggests that transmission of excessively elevated pulmonary artery pressure to the pulmonary capillaries leading to alveolar hemorrhage as the pathophysiologic mechanism of HAPE. [ncbi.nlm.nih.gov]

All invited speakers have presented their major research findings in the field of basic aspects of the pulmonary hypertension pathophysiology and the fundamental scientific issues concerning high altitude adaptation, followed by the lively discussion [sinogermanscience.org.cn]

Pathophysiology and treatment of high-altitude pulmonary vascular disease. Circulation. [revistas.udh.edu.pe]

A lower SaO 2 level and higher MAP are predictive of HAPE pathophysiology ( 30, 31 ). [pnas.org]

Prevention

Rapid remodeling of the small precapillary arteries may prevent HAPE but increase pulmonary vascular resistance leading to pulmonary hypertension in long-term high altitude residents. [ncbi.nlm.nih.gov]

Prevention and treatment of high-altitude pulmonary edema. Prog Cardiovasc Dis. 2010;52(6):500-506.doi:10.1016/j.pcad.2010.03.001 Bates MG, Thompson AA, Baillie JK, et al. [revistas.asoneumocito.org]

The suggested rate of ascent is the same that applies to the prevention of acute mountain sickness and high-altitude cerebral edema. [en.wikipedia.org]

Prevent AD by gradual ascent and use of acetazolamide. [merckmanuals.com]

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