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High Fat Diet

Increased Fat Diet (Regime/Therapy)


Presentation

  • The present study is aimed to evaluate the effect of FM-AX supplementation, a key bioactive from finger millet, on HFD-induced metabolic and gut bacterial derangements.[ncbi.nlm.nih.gov]
  • The aim of the present study was to observe the effect of diosgenin on NAFLD and investigate the underlying mechanisms.[ncbi.nlm.nih.gov]
  • Therefore, the present study aimed to determine whether black rice anthocyanin (BRA), black soybean anthocyanin (BSA), and purple corn anthocyanin (PCA) could mitigate oxidative stress and inflammation associated obesity in C57BL/6 mice fed with a high-fat[ncbi.nlm.nih.gov]
  • Therefore, the present study investigated the in vivo and in vitro effects of an SNE on nonalcoholic fatty liver (NAFL)-induced hepatitis.[ncbi.nlm.nih.gov]
  • Presently, no approved treatment is available. Actein is isolated from the rthizomes of Cimicifuga foetida, a triterpene glycoside, exhibiting important biological properties, such as anti-inflammatory, anti-cancer, and anti-oxidant activity.[ncbi.nlm.nih.gov]
Liver Fibrosis
  • BACKGROUND: Several of the drugs in development for treatment of nonalcoholic steatohepatitis (NASH) target liver fibrosis or have side effects that prohibit their long-term use in patients with mild to moderate disease.[ncbi.nlm.nih.gov]
Diastolic Hypertension
  • The TRF reversed systolic and diastolic hypertension, hypercholesterolemia, hepatic steatosis, impaired antioxidant defense, and myeloperoxidase hyperactivity triggered by the high-fat diet.[ncbi.nlm.nih.gov]
Hyperactivity
  • The TRF reversed systolic and diastolic hypertension, hypercholesterolemia, hepatic steatosis, impaired antioxidant defense, and myeloperoxidase hyperactivity triggered by the high-fat diet.[ncbi.nlm.nih.gov]

Workup

HDL Increased
  • IF other lipid and inflammatory markers dramatically improve, generally your small particle LDL decreases, serum triglycerides reduce and HDL increases. All potent factors which reduce your overall CVD risk.[ditchthecarbs.com]
Liver Biopsy
  • Histology of liver biopsies indicated marked accumulation of lipid droplets in hepatocytes of MetS animals. Withdrawal of GCs treatment led to recovery from above-mentioned metabolic disorders.[ncbi.nlm.nih.gov]

Treatment

  • Male C57BL/6J mice were fed a standard diet (Con) or a high-fat diet (HFD) (denoted as diet) with or without 40 mg kg -1 NI (defined as treatment) for 12 weeks.[ncbi.nlm.nih.gov]
  • Our results show that treatment with IF significantly inhibited the high-fat diet-induced elevation in body weight, liver weight, lipid metabolism (TG, TC and HDL-C) and hepatic injury in mice.[ncbi.nlm.nih.gov]
  • This study aims to discern whether oil treatment change the structure of the gut microbiota during the obesity alleviation.[ncbi.nlm.nih.gov]
  • The western blot analysis further confirmed these altered expressions after RBP treatment.[ncbi.nlm.nih.gov]
  • Male, post-weaning Sprague Dawley rats were provided high-fat (60% kcal) diet for eight weeks followed by a TRF (60 mg/kg) treatment for another four weeks.[ncbi.nlm.nih.gov]

Prognosis

  • We show here that RBP4 and STRA6 expression is associated with poor oncologic prognosis. Downregulating STRA6 or RBP4 in colon cancer cells decreased the fraction of cancer stem cells and their sphere and tumor initiation frequency.[ncbi.nlm.nih.gov]

Etiology

  • Register High-Fat, Low-Carbohydrate Diet and the Etiology of Non-Insulin-dependent Diabetes Mellitus: The San Luis Valley Diabetes Study - 24 Hours access EUR 36.00 GBP 28.00 USD 45.00 Rental This article is also available for rental through DeepDyve.[academic.oup.com]
  • ., Extramural MeSH terms Animals Cell Line, Tumor Cell Self Renewal/genetics Cell Transformation, Neoplastic/metabolism* Colonic Neoplasms/etiology* Colonic Neoplasms/metabolism* Colonic Neoplasms/mortality Colonic Neoplasms/pathology Diet, High-Fat Disease[ncbi.nlm.nih.gov]
  • An overview of the role of cardiovascular reactivity to stressful challenges in the etiology of hypertension . J Cardiovasc Nurs. 1994 ; 8 : 27 – 38 . 11.[academic.oup.com]

Epidemiology

  • Abstract Epidemiological evidence indicates that anthocyanin consumption reduces the incidence of chronic and degenerative diseases.[ncbi.nlm.nih.gov]
  • “However, the emerging picture of nutritional epidemiology is difficult to reconcile with good scientific principles. The field needs radical reform .”[chriskresser.com]
  • Thus, a plausible conclusion from case-control studies is that there is indeed some association between fats and breast cancer risk, which is, however, limited and, hence, extremely difficult to prove in epidemiological terms.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Abstract An increasing amount of evidence suggests that the gut microbiota composition and structure contribute to the pathophysiology of metabolic syndrome (MS), which has been put forward as a new target in the treatment of diet-induced MS.[ncbi.nlm.nih.gov]
  • Author information 1 Department of Paediatrics, Xijing Hospital, Fourth Military Medical University, Xi'an, China. 2 Department of Physiology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.[ncbi.nlm.nih.gov]
  • Skeletal muscle, hepatic insulin resistance, and beta cell dysfunction are the characteristic pathophysiological features of type 2 diabetes mellitus. GABA has an important role in pancreatic islet cells.[ncbi.nlm.nih.gov]
  • Specifically, the reactivity hypothesis states that exaggerated responses to stress cause a cascade of pathophysiologic events that can eventually lead to sustained increases in blood pressure ( 1 , 3 , 10 – 12 ).[academic.oup.com]

Prevention

  • Further, AX supplementation prevented metagenomic alterations in cecum; improved ileal and colonic health and overall prevented metabolic endotoxemia.[ncbi.nlm.nih.gov]
  • We suggested that U. prolifera extracts may be regarded as potential candidate for the prevention of nonalcoholic fatty liver disease.[ncbi.nlm.nih.gov]
  • Results suggested that EALT might be available as functional crop and bioactive diet supplement for the prevention and/or treatment of obesity.[ncbi.nlm.nih.gov]
  • CONCLUSION: Oroxin A prevents the progression from prediabetes to diabetes through a multi-pathway intervention mechanism. Copyright 2017 Elsevier GmbH. All rights reserved.[ncbi.nlm.nih.gov]
  • Thus, EC prevented HFD-induced ileum NOX1/NOX4 upregulation, protein oxidation, and the activation of the redox-sensitive NF-κB and ERK1/2 pathways.[ncbi.nlm.nih.gov]

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