Case Presentation We present the case of a 22-year old lactating woman who presented with four months of amenorrhea associated with signs of virilization. [jmedicalcasereports.biomedcentral.com]

Top Abstract Introduction Case Presentation Discussion References [turkjpath.org]

The cut surfaces are typically yellow or orange if large amounts of lipid are present, red to brown if the cells are lipid-poor or dark brown to black if large quantities of cytoplasmic lipochrome pigment are present. [ijpmonline.org]

Although surgery has been the mainstay, a recent report showed that gonadotropin releasing hormone agonist was effective in treating steroid cell tumors. 5-6 Here, we present a case of a 51year old lady who presented with hirsutism, virilisation of 14 [jemds.com]

Growth Slow Rapid Patient’s age Younger Older Nodular Pouch od Douglas Absent Present Laparatomy Ascites Absent Present – often hemorrhagic Exophytic growth on surface Absent Present Adhesions Absent Present Cut-section Cystic Solid and hemorrhagic Peritoneal [epomedicine.com]

• Virilization

  Synopsis virilization (virilizing ovarian Leydig cell tumor) hyperandrogenism Cushing syndrome ( 18463044 ) Variants bilateral ovarian Leydig cell tumor See also Leydig cell tumor References Virilizing ovarian Leydig cell tumor in a woman with subclinical [humpath.com]

  Pre-operative retrograde venous catheterization and sampling were used to localize this virilizing tumor. [ncbi.nlm.nih.gov]

  It is usually benign and unilateral and causes hyperandrogenism and virilization. [omicsonline.org]

  Discussion In a case of rapid-onset hirsutism, virilization, and menstrual irregularity, neoplastic etiology should always be kept in mind. Therefore, comprehensive workup is required. [edmcasereports.com]

  Virilization secondary to an ovarian Leydig cell tumor. Management. The patient underwent a left salpingo-oophorectomy that confirmed the diagnosis of a unilateral Leydig cell tumor. [nature.com]

• Pathologist

  It is an essential reference for all pathologists, and an important review aid for GYN residents preparing for their Boards. [books.google.de]

  Clement, Chapter 40 in Histology for Pathologists, 2nd edition, edited by S. S. Sternberg, Lippincott-Raven Publishers © 1997 The Ovary by R. H. Young, P. B. Clement & R. E. [path.upmc.edu]

  When pathologists encounter a rare tumor of this type, they should use all the clinical, biochemical, topographic, and cytologic evidence available to determine the cell of origin. [glowm.com]

  Ferry JA, Young RH, Engel G, Scully RE International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 1994 ; 13 (3) : 259-266. [atlasgeneticsoncology.org]

  When unusual components, such as JGCT and SLCT of intermediate differentiation coexist, the pathologist’s report is more meaningful if the specific designation of each component is included as diagnostic terms. [basicmedicalkey.com]

• Swelling

  Swelling, one of the cardinal signs of inflammations, morbid enlargement. Origin: L. Tumere = to swell (12 May 1997) tumor marker A substance in the body that usually indicates the presence of cancer. [kmle.co.kr]

  If there are symptoms, they may include Pressure Bloating Swelling Pain in the lower abdomen, on the side where the cyst is If your health care provider finds a cyst, you may be able to wait to see if it gets bigger. [icdlist.com]

  When JGCT occurs after puberty, patients usually present with abdominal pain, swelling, menstrual irregularities, or amenorrhea. [emedicine.medscape.com]

  Electron microscopic examination has shown that the vacuoles may result from generalized edema of the cytoplasm, from swelling of mitochondria, or as a result of formation of cytoplasmic pseudoinclusions composed of edematous extracellular matrix ( 78 [basicmedicalkey.com]

  […] as frequent in postmenopausal as in premenopausal women with these neoplasms, and is of low grade and amenable to curative therapy in the majority of cases. 5 Granulosa cell tumors may be associated with additional estrogenic manifestations, such as swelling [glowm.com]

• Inflammation

  Swelling, one of the cardinal signs of inflammations, morbid enlargement. Origin: L. Tumere = to swell (12 May 1997) tumor marker A substance in the body that usually indicates the presence of cancer. [kmle.co.kr]

• Vomiting

  Method and Result : Case 1 was a 6-month-old boy with history of bilious vomiting. L... [researchmap.jp]

• Hirsutism

  To describe provocative testing and alternative imaging strategies used to localize an androgen-producing tumor in a 58-year-old woman with severe hirsutism. Case report. Clinical Research Center. [ncbi.nlm.nih.gov]

  Discussion In a case of rapid-onset hirsutism, virilization, and menstrual irregularity, neoplastic etiology should always be kept in mind. Therefore, comprehensive workup is required. [edmcasereports.com]

  Following total abdominal hysterectomy and bilateral salpingo-oophorectomy, the patient had regression of the hirsutism, and the plasma testosterone dropped to normal level. © 1997 S. [karger.com]

  Hirsutism and virilisation. In Harrison’s Principles pf Internal Medicine. 17th edition. [ijrcog.org]

  The noticeable presentation of a patient with a Virilizing ovarian tumour is hirsutism and virilisation because of hyperandrogenism, as seen in this case. Other symptoms include abdominal pain, abdominal distention, and bloating. [jemds.com]

• Adnexal Mass

  Página 406 - Goldstein SR, Subramanyam B, Snyder JR et al: The postmenopausal cystic adnexal mass, the potential role of ultrasound in conservative management. Obstet Gynaecol 73:8, 1989. ‎ Página 46 - Kelly, SJ (1977). [books.google.es]

  Management of ovarian masses. AAGL 1990 survey. J. Reprod. Med. 37, 599–602 (1992). 27. Fanfani, F. et al. A prospective randomized study of laparoscopy and minilaparotomy in the management of benign adnexal masses. Hum. [nature.com]

  Pelvic examination was notable for an enlarged clitoris and a 5 cm right adnexal mass. Abdominal ultrasound identified a 64 × 52 × 51 mm, solid, left ovarian mass. Doppler evaluation of intratumoral blood vessels confirmed a low resistance to flow. [ovarianresearch.biomedcentral.com]

• Ovarian Disorder

  Young and Scully´s 1979 classification of ovarian tumors with endocrine manifestations ( Figure 1 ) includes sex-cord stromal tumors, steroid-cell tumors and other ovarian disorders with endocrine function. [omicsonline.org]

Therefore, comprehensive workup is required. Serum testosterone and DHEA-S assays are the first tests used for the evaluation of either an adrenal or ovarian source of pathology for the hyperandrogenism. [edmcasereports.com]

• Ovarian Mass

  Frozen section of the both ovary masses demonstrated a malignant ovarian stromal tumor. [ovarianresearch.biomedcentral.com]

  Management of ovarian masses. AAGL 1990 survey. J. Reprod. Med. 37, 599–602 (1992). 27. Fanfani, F. et al. A prospective randomized study of laparoscopy and minilaparotomy in the management of benign adnexal masses. Hum. [nature.com]

  Uterus was bulky showing an anterior myometrial mass of 4.3 cm size. Overall picture of USG was suggestive of ovarian malignancy with peritoneal spread, with the mass in uterus possibly due to uterine involvement. [jemds.com]

  According to Outwater et al. the ovarian masses are isoechogenic (82%) or hypoechogenic (18%) and ascites is an infrequent finding (23%). Only a minority of SCT (14%) are calcified on image studies. [omicsonline.org]

  Most patients are first seen for nonspecific symptoms related to an ovarian mass; estrogenic manifestations have been present only occasionally, whereas virilization during pregnancy has been noted ( 74 ). All reported tumors were benign. [basicmedicalkey.com]

• Hepatocellular Carcinoma

  Embryonal carcinoma with syncytiotrophoblast cells (magnification, ×34). AFIP Neg. 75-14208. (Kurman RJ, Norris HJ: Embryonal carcinoma of the ovary. [glowm.com]

Salvage therapy Patients with failed primary treatment are offered salvage treatment protocols (e.g. TIP, GPT) and in some cases high dose intensity multi drug treatment. Salvage treatment is with curative intent. [bccancer.bc.ca]

The primary treatment is surgical extirpation of the primary lesion, and there are no reports of effective treatment with radiation or chemotherapy [ 10 ]. [jmedicalcasereports.biomedcentral.com]

Treatment [ edit ] The usual treatment is surgery. The surgery usually is a fertility-sparing unilateral salpingo-oophorectomy. [en.wikipedia.org]

Removal is usually the treatment of choice by laparotomy (surgery) or laparoscopy (with a scope). [kmle.co.kr]

The primary treatment is surgical extirpation of the primary lesion and there are no reports of effective treatment with radiation or chemotherapy. [ijpmonline.org]

The prognosis is generally good as the tumour tends to grow slowly and usually is benign : 25% are malignant. [ citation needed ] For malignant tumours with undifferentiated histology, prognosis is poor. [7] See also [ edit ] Androgen-dependent syndromes [en.wikipedia.org]

Prognosis The prognosis of sex-cord-stromal tumours is good, as these tumours usually present when confined to a single ovary, and are responsive to chemotherapy. [atlasgeneticsoncology.org]

The prognosis is similar to that of the latter tumor. [glowm.com]

The prognosis is variable, but cure is possible in up to 1/3 of cases treated with salvage therapy. [bccancer.bc.ca]

Prognosis and predictive factors About 30% of cases are clinically malignant and have an extraovarian spread of tumor at the time of operation. [emedicine.medscape.com]

Discussion In a case of rapid-onset hirsutism, virilization, and menstrual irregularity, neoplastic etiology should always be kept in mind. Therefore, comprehensive workup is required. [edmcasereports.com]

The neoplasm occurs mainly during the first 3 decades of life. [1] Etiology The etiology of JGCT is unknown. [emedicine.medscape.com]

Etiology There appear to be several established clinical syndromes associated with several subtypes of sex cord-stromal tumours. 30% of patients with sex cord tumours with annular tubules have Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder [atlasgeneticsoncology.org]

We will discuss the etiology of SDI. Method and Result : Case 1 was a 6-month-old boy with history of bilious vomiting. L... [researchmap.jp]

Includes all-new chapters on cytology, immunohistochemistry, flow cytometry, molecular biology, and epidemiology and biostatistics. [books.google.de]

Sertoli–Leydig cell tumor group Epidemiology Sertoli-Leydig cell tumors are uncommon benign tumors, accounting for less than 0.5% of all ovarian tumors. [emedicine.medscape.com]

Epidemiology: Most common GCT in females. Prognosis usually good. Microscopic Features: Fried egg appearance (clear cytoplasm, central nucleus). [librepathology.org]

Epidemiology The frequency of sex cord-stromal tumours is similar throughout the world. There does not appear to a racial predisposition, in contrast to epithelial ovarian cancers. [atlasgeneticsoncology.org]

Furuya M (2012) Ovarian cancer stroma: pathophysiology and the roles in cancer development. Cancers (Basel) 4: 701-724. Roth LM, Talerman A (2006) Recent advances in the pathology and classification of ovarian germ cell tumors. [omicsonline.org]

Birth control pills can help prevent new cysts. Rarely, ovarian cysts can become cancerous. This risk increases as you get older. A health problem that involves ovarian cysts is polycystic ovary syndrome (PCOS). [icdlist.com]

Preventive Services Task Force Reaffirmation Recommendation Statement. USPSTF [On-line information]. Available online at http://www.uspreventiveservicestaskforce.org/uspstf12/ovarian/ovarartaddend.htm. [labtestsonline.it]