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Hilar Cell Tumor of the Ovary

Ovarian Hilar Cell Tumor


Presentation

  • A bound-in CD-ROM contains all the images from the book, downloadable to PowerPoint presentations.[books.google.de]
  • Seite 106 - Ib but with tumor on the surface of one or both ovaries; or with capsule ruptured; or with ascites present containing malignant cells or with positive peritoneal washings.[books.google.de]
  • Case Presentation We present the case of a 22-year old lactating woman who presented with four months of amenorrhea associated with signs of virilization.[jmedicalcasereports.biomedcentral.com]
  • Top Abstract Introduction Case Presentation Discussion References[turkjpath.org]
  • The cut surfaces are typically yellow or orange if large amounts of lipid are present, red to brown if the cells are lipid-poor or dark brown to black if large quantities of cytoplasmic lipochrome pigment are present.[ijpmonline.org]
Virilization
  • Pre-operative retrograde venous catheterization and sampling were used to localize this virilizing tumor.[ncbi.nlm.nih.gov]
  • Synopsis virilization (virilizing ovarian Leydig cell tumor) hyperandrogenism Cushing syndrome ( 18463044 ) Variants bilateral ovarian Leydig cell tumor See also Leydig cell tumor References Virilizing ovarian Leydig cell tumor in a woman with subclinical[humpath.com]
  • Discussion In a case of rapid-onset hirsutism, virilization, and menstrual irregularity, neoplastic etiology should always be kept in mind. Therefore, comprehensive workup is required.[edmcasereports.com]
  • It is usually benign and unilateral and causes hyperandrogenism and virilization.[omicsonline.org]
  • Virilization secondary to an ovarian Leydig cell tumor. Management. The patient underwent a left salpingo-oophorectomy that confirmed the diagnosis of a unilateral Leydig cell tumor.[nature.com]
Virilization
  • Pre-operative retrograde venous catheterization and sampling were used to localize this virilizing tumor.[ncbi.nlm.nih.gov]
  • Synopsis virilization (virilizing ovarian Leydig cell tumor) hyperandrogenism Cushing syndrome ( 18463044 ) Variants bilateral ovarian Leydig cell tumor See also Leydig cell tumor References Virilizing ovarian Leydig cell tumor in a woman with subclinical[humpath.com]
  • Discussion In a case of rapid-onset hirsutism, virilization, and menstrual irregularity, neoplastic etiology should always be kept in mind. Therefore, comprehensive workup is required.[edmcasereports.com]
  • It is usually benign and unilateral and causes hyperandrogenism and virilization.[omicsonline.org]
  • Virilization secondary to an ovarian Leydig cell tumor. Management. The patient underwent a left salpingo-oophorectomy that confirmed the diagnosis of a unilateral Leydig cell tumor.[nature.com]
Pathologist
  • More than 90 preeminent surgical pathologists offer expert advice on the diagnostic evaluation of every type of specimen from every anatomic site. The Fourth Edition contains 3,494 full-color photographs, of which over 1,100 are new.[books.google.de]
  • It is an essential reference for all pathologists, and an important review aid for GYN residents preparing for their Boards.[books.google.de]
  • Clement, Chapter 40 in Histology for Pathologists , 2nd edition, edited by S. S. Sternberg, Lippincott-Raven Publishers 1997 The Ovary by R. H. Young, P. B. Clement & R. E.[path.upmc.edu]
Lymphedema
  • 岡山 武谷千晶 婦人科癌患者における術前の栄養状態と術後リンパ浮腫に関する検討 第1回日本リンパ浮腫学会総会 2017.3 東京 その他 武谷千晶,萬来めぐみ,髙橋怜奈,小宮山慎一,久布白兼行 婦人科がん術後のリンパ浮腫における当院の取り組み方 第1回東邦大学医療センター大橋病院医学会 2016.7 東京 小宮山慎一 Feasibility study on the effectiveness of Goreisan-based Kampo therapy for lower abdominal lymphedema[lab.toho-u.ac.jp]
Hirsutism
  • To describe provocative testing and alternative imaging strategies used to localize an androgen-producing tumor in a 58-year-old woman with severe hirsutism. Case report. Clinical Research Center.[ncbi.nlm.nih.gov]
  • Discussion In a case of rapid-onset hirsutism, virilization, and menstrual irregularity, neoplastic etiology should always be kept in mind. Therefore, comprehensive workup is required.[edmcasereports.com]
  • Following total abdominal hysterectomy and bilateral salpingo-oophorectomy, the patient had regression of the hirsutism, and the plasma testosterone dropped to normal level. 1997 S.[karger.com]
  • Hirsutism and virilisation. In Harrison’s Principles pf Internal Medicine. 17th edition.[ijrcog.org]
  • PMID: 9286731 Hilus cell pathology and hirsutism. McLellan AR, Mowat A, Cordiner J, Beastall GH, Wallace AM, Connell JM, Davies DL. Clin Endocrinol (Oxf). 1990 Feb;32(2):203-12.PMID: 2112066[humpath.com]
Hirsutism
  • To describe provocative testing and alternative imaging strategies used to localize an androgen-producing tumor in a 58-year-old woman with severe hirsutism. Case report. Clinical Research Center.[ncbi.nlm.nih.gov]
  • Discussion In a case of rapid-onset hirsutism, virilization, and menstrual irregularity, neoplastic etiology should always be kept in mind. Therefore, comprehensive workup is required.[edmcasereports.com]
  • Following total abdominal hysterectomy and bilateral salpingo-oophorectomy, the patient had regression of the hirsutism, and the plasma testosterone dropped to normal level. 1997 S.[karger.com]
  • Hirsutism and virilisation. In Harrison’s Principles pf Internal Medicine. 17th edition.[ijrcog.org]
  • PMID: 9286731 Hilus cell pathology and hirsutism. McLellan AR, Mowat A, Cordiner J, Beastall GH, Wallace AM, Connell JM, Davies DL. Clin Endocrinol (Oxf). 1990 Feb;32(2):203-12.PMID: 2112066[humpath.com]
Adnexal Mass
  • Página 406 - Goldstein SR, Subramanyam B, Snyder JR et al: The postmenopausal cystic adnexal mass, the potential role of ultrasound in conservative management. Obstet Gynaecol 73:8, 1989. ‎ Página 46 - Kelly, SJ (1977).[books.google.es]
  • Treating adnexal masses. Operative laparoscopy vs. laparotomy. J. Reprod. Med. 42, 551–558 (1997). 25. Medeiros, L.R, Fachel, J. M., Garry, R., Stein A. T. & Furness S. Laparoscopy versus laparotomy for benign ovarian tumours.[nature.com]
Salpingitis
  • No other gross abnormality was detected including the salpinges, ovaries, omentum and lymph nodes. Both salpinges were sampled completely by cutting them into two along the long axis. No omental and lymh node involvement was detected.[turkjpath.org]

Workup

  • Therefore, comprehensive workup is required. Serum testosterone and DHEA-S assays are the first tests used for the evaluation of either an adrenal or ovarian source of pathology for the hyperandrogenism.[edmcasereports.com]
Ovarian Mass
  • Management of ovarian masses. AAGL 1990 survey. J. Reprod. Med. 37, 599–602 (1992). 27. Fanfani, F. et al. A prospective randomized study of laparoscopy and minilaparotomy in the management of benign adnexal masses. Hum.[nature.com]
  • According to Outwater et al. the ovarian masses are isoechogenic (82%) or hypoechogenic (18%) and ascites is an infrequent finding (23%). Only a minority of SCT (14%) are calcified on image studies.[omicsonline.org]
  • Female adnexal tumor of probable wolffian origin arises primarily in the broad ligament but may present as an ovarian mass. The architecture varies from cystic, to a slitlike glandular or a sievelike pattern.[emedicine.medscape.com]

Treatment

  • The primary treatment is surgical extirpation of the primary lesion, and there are no reports of effective treatment with radiation or chemotherapy [ 10 ].[jmedicalcasereports.biomedcentral.com]
  • Treatment [ edit ] The usual treatment is surgery. The surgery usually is a fertility-sparing unilateral salpingo-oophorectomy.[en.wikipedia.org]
  • The primary treatment is surgical extirpation of the primary lesion and there are no reports of effective treatment with radiation or chemotherapy.[ijpmonline.org]
  • Discussion: Surgical treatment is mandatory and it ranges from unilateral oophorectomy to complete staging surgery. Adjuvant treatment is not usually required. Prognosis is good in most cases.[omicsonline.org]
  • Página 84 - Somatomedin-C in normal puberty and in true precocious puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist. ‎ Página 368 - HJ.[books.google.es]

Prognosis

  • The prognosis is generally good as the tumour tends to grow slowly and usually is benign : 25% are malignant. [ citation needed ] For malignant tumours with undifferentiated histology, prognosis is poor. [7] See also [ edit ] Androgen-dependent syndromes[en.wikipedia.org]
  • Prognosis and predictive factors About 30% of cases are clinically malignant and have an extraovarian spread of tumor at the time of operation.[emedicine.medscape.com]
  • Prognosis is good for most SCT of the ovary, although malignancy has been reported in as high as 28.6- 43 % of cases [ 3, 25 ].[omicsonline.org]
  • […] similar to endocervical glands; Synchronous endometrial carcinoma or hyperplasia in 1/3 rd cases Clear cell 5% Malignant Bilaterality in 12-40% Clear cells resembling clear cell renal carcinoma (mesonephros); hobnail cells; Endometriosis in 25%; worse prognosis[epomedicine.com]
  • Histologic features and prognosis.". Cancer 62 (10): 2212-22. PMID 3179935. URL: . Accessed on: 8 July 2013. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005).[librepathology.org]

Etiology

  • Discussion In a case of rapid-onset hirsutism, virilization, and menstrual irregularity, neoplastic etiology should always be kept in mind. Therefore, comprehensive workup is required.[edmcasereports.com]
  • The neoplasm occurs mainly during the first 3 decades of life. [1] Etiology The etiology of JGCT is unknown.[emedicine.medscape.com]
  • We will discuss the etiology of SDI. Method and Result : Case 1 was a 6-month-old boy with history of bilious vomiting. L...[researchmap.jp]

Epidemiology

  • Includes all-new chapters on cytology, immunohistochemistry, flow cytometry, molecular biology, and epidemiology and biostatistics.[books.google.de]
  • Sertoli–Leydig cell tumor group Epidemiology Sertoli-Leydig cell tumors are uncommon benign tumors, accounting for less than 0.5% of all ovarian tumors.[emedicine.medscape.com]
  • Epidemiology: Most common GCT in females. Prognosis usually good. Microscopic Features: Fried egg appearance (clear cytoplasm, central nucleus).[librepathology.org]
Sex distribution
Age distribution

Pathophysiology

  • Furuya M (2012) Ovarian cancer stroma: pathophysiology and the roles in cancer development. Cancers (Basel) 4: 701-724. Roth LM, Talerman A (2006) Recent advances in the pathology and classification of ovarian germ cell tumors.[omicsonline.org]

Prevention

  • Preventive Services Task Force Reaffirmation Recommendation Statement. USPSTF [On-line information].Available online at October 2012.[labtestsonline.it]
  • Birth control pills can help prevent new cysts. Rarely, ovarian cysts can become cancerous. This risk increases as you get older. A health problem that involves ovarian cysts is polycystic ovary syndrome (PCOS).[icdlist.com]

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