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Histamine H1 Antagonist

Antihistaminics H1


  • Abstract The present studies demonstrate that histamine induces the secretion of IL-6, IL-8 and GM-CSF from human conjunctival epithelial cells in a dose- and time-dependent manner.[ncbi.nlm.nih.gov]
  • Experimental findings and present results show that histamine H1 antagonists have proconvulsant effects, especially in the developmental period.[ncbi.nlm.nih.gov]
  • A multidisciplinary team of leading authorities presents the latest on sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric[books.google.com]
  • […] therapy, monoclonal antibodies, and drug interference with signal transduction pathway therapeutics The book offers concise and informative A-Z drug facts in an encyclopedia format and contains brief descriptions of conditions, diseases, and disorders presented[books.google.com]
  • No significant difference was found in time from fever detection to seizure onset or seizure duration between patients who received a first-generation antihistamine and those who received a second-generation antihistamine.[dovepress.com]
  • DB01114 Chlorphenamine For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.[drugbank.ca]
  • Description -------------------------------------------------------------------------------- This medicine is used to treat symptoms of hay fever such as runny nose, watery eyes and sneezing.[pharmacycode.com]
  • DB00342 Terfenadine For the treatment of allergic rhinitis, hay fever, and allergic skin disorders. DB00637 Astemizole Astemizole was indicated for use in the relieving allergy symptoms, particularly rhinitis and conjunctivitis.[drugbank.ca]
  • Antihistamines are used to relieve the symptoms of allergic reactions, especially hay fever and other allergic disorders of the nasal passages. Some antihistamines have an antinauseant action that is useful in the relief of motion sickness .[medical-dictionary.thefreedictionary.com]
  • […] constipation dry eyes a dry mouth drowsiness or sedation a headache low blood pressure mucus thickening in the airways a rapid heartbeat urinary problems Side effects of second-generation antihistamines may include: abdominal pain coughing drowsiness fatigue[drugs.com]
  • Promethazine (Phenergan) 10-25 mg bid Piperazines Hydroxyzine (Atarax) 10-25 mg tid Piperidines Cyproheptadine (Periactin) 4 mg tid Azatadine (Zadine) 1-2 mg tid Unwanted effects are common with these antihistamines, the commonest being sedation, dizziness fatigue[nutramed.com]
  • […] mild cognitive difficulty, sleep disturbance (somnolence and insomnia), impaired concentration, depression, hallucination, delusion, paranoia, anxiety, agitation, aggressive behavior, mania, emotional labiality, catatonia, melancholia, psychosis, and fatigue[aaaai.org]
  • Promethazine: PO, intramuscular (IM), rectal, or intravenous (V) of 12.5 to 25 mg every 6 hours, as needed Adverse Effects Many anticholinergic effects including central nervous system (CNS) depression, fatigue, paradoxical vomiting, blurred vision, xerostomia[statpearls.com]
  • The most common adverse effects noted for second-generation agents include drowsiness, fatigue, headache, nausea and dry mouth. src: clincancerres.aacrjournals.org First-generation (non-selective, classical) These are the oldest H 1 -antihistaminergic[yourindicatinfo.blogspot.com]
  • Edit Findings to refine your results. 11-beta-hydroxylase deficiency 0/0 21-hydroxylase deficiency 0/0 AA amyloidosis 0/0 Abdominal aortic aneurysm 0/0 Aberrant carotid artery 0/0 Abrin poisoning 0/0 Acalculous cholecystitis 0/0 Acanthamoeba keratitis[visualdx.com]
Allergic Cough
  • They are usually prescribed to patients with allergic cough. Do they have any contraindications or precautions? These medicines have a sedative effect which may cause drowsiness.[futura-sciences.us]
  • While xerostomia can be a mild aggravation for the patient and may not appear to be clinically relevant, chronic xerostomia can increase the risk for dental caries as well as worsen symptoms of gastroesophageal reflux disease (GERD).[ebmconsult.com]
  • Promethazine: PO, intramuscular (IM), rectal, or intravenous (V) of 12.5 to 25 mg every 6 hours, as needed Adverse Effects Many anticholinergic effects including central nervous system (CNS) depression, fatigue, paradoxical vomiting, blurred vision, xerostomia[statpearls.com]
  • Dry mouth, drowsiness, urine retention in , tachycardia.[medical-dictionary.thefreedictionary.com]
  • In conclusion, exogenous histamine intracerebroventricularly results in sinusoidal tachycardia in broiler chickens and central H1 receptors mediate the stimulatory effects of histamine on heart rate, but H2 receptors had no role in this manner.[ijvr.shirazu.ac.ir]
  • A patient with delirium, seizures or tachycardia has a wide range of diagnoses when initially admitted. When a diagnosis of anticholinergic toxicity is suspected, a healthcare provider should perform a screening test.[statpearls.com]
  • Clinical Therapeutics, 21(2), 281-295. [3] Kuchar, D.L., Walker, B.D., Thorburn, C.W., Ventricular tachycardia following ingestion of a commonly used antihistamine. Med J Aust 2002; 176 (9): 429-430.[healinghistamine.com]
  • […] for: Histamine H1 Antagonist Alone Attenuates d-Tubocurarine-induced Hypotension You will receive an email whenever this article is corrected, updated, or cited in the literature.[anesthesiology.pubs.asahq.org]
  • […] oral region angioedema manifestations same as urticaria but more severe, can includ airway obstruction bronchospasm, thickkened bronchi with increased mucus and eosinophils systemic anaphylaxis lesions urticaria, angioedema, bronchospasm, vasodilation, hypotension[quizlet.com]
  • Intravenous injection of histamine produces hypotension, mediated predominantly by H1-receptors.[ncbi.nlm.nih.gov]
  • Infrequent adverse effects include urinary retention, palpitations, hypotension, headache, hallucination, and psychosis.[yourindicatinfo.blogspot.com]
  • Histamine, acting on H 1 -receptors, produces pruritus , vasodilatation , hypotension , flushing , headache , tachycardia , bronchoconstriction , increase in vascular permeability , potentiation of pain , and more. [2] While H 1 -antihistamines help against[wikidoc.org]
  • However, there is a concern that these agents due to their potentially hypertensive effects, may precipitate adverse cardiovascular effects, such as stroke.[pharmacology2000.com]
Skin Patch
  • patch overlying a plasmacytoma syndrome 0/0 Adhesive capsulitis of the shoulder 0/0 Adiposis dolorosa 0/0 Adrenal crisis 0/0 Adrenal hemorrhage 0/0 Adrenal pseudocyst 0/0 Adrenocortical carcinoma 0/0 Adrenogenital syndrome 0/0 Adrenoleukodystrophy 0[visualdx.com]
  • patches generalized edema of skin, lips, oral region angioedema manifestations same as urticaria but more severe, can includ airway obstruction bronchospasm, thickkened bronchi with increased mucus and eosinophils systemic anaphylaxis lesions urticaria[quizlet.com]
  • […] relevant MeSH terms: Layout table for MeSH terms Migraine Disorders Headache Migraine without Aura Headache Disorders, Primary Headache Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Pain Neurologic Manifestations Signs[clinicaltrials.gov]
  • […] thereby reducing degranulation produced by antigen-IgE interaction suppress chemoattractant-induced activation of white cells adverse effects of mast cell stabilizers very well tolerated, few adverse effects coughing, bronchospasm, laryngeal edema, headache[quizlet.com]
  • [FDA label] Mirtazapine has been used off-label for a variety of conditions including panic disorder, generalized anxiety disorder, dysthymia, tension headaches, hot flushes, post-traumatic stress disorder (PTSD), sleep disorders, substance abuse disorders[drugbank.ca]
  • ., dry mouth and eyes, mydriasis ;, dizziness, tinnitus, urinary retention ;, and tachycardia ; ( mostly with first-generation antihistamines ) Headaches Indications First-generation antihistamines Primarily used as sedative or anti emetic agents (e.g[amboss.com]
  • Side effects of second-generation antihistamines may include: abdominal pain coughing drowsiness fatigue a headache nausea a sore throat.[drugs.com]
  • Some anti-allergic agents act as histamine H1 antagonists and induce seizure discharges in epileptic patients. Of these agents, ketotifen has an especially potent effect.[ncbi.nlm.nih.gov]
  • Ketotifen produced seizures in a 5-year-old boy with secondary generalized epilepsy (SGE) and allergic rhinitis.[ncbi.nlm.nih.gov]
  • […] susceptibility due to antihistamines is provoked in patients with febrile seizures.[dovepress.com]
  • It has been reported that some histamine H1 antagonists induce seizures in epileptic patients.[ncbi.nlm.nih.gov]
  • May also be used to treat depression accompanied by anxiety or agitation.[drugbank.ca]
  • Physicians should use benzodiazepines for agitation, but physostigmine may be more effective (Grade IV and Grade V). [17] [18] A toxicologist should be consulted if physostigmine is needed.[statpearls.com]
  • Cognitive decline, falls, and behaviors such as hallucinations, delirium, and agitated aggressive behaviors may result in affected patients being hospitalized or admitted to long term care facilities.[todaysgeriatricmedicine.com]
  • […] antimuscarinic) and include: Drowsiness and slowed reaction times affecting the performance of skilled tasks Dry mouth, blurring of vision, difficulty passing urine and impotence (antimuscarinic effects) Paradoxical stimulant effect (wakefulness and even agitation[dermnetnz.org]
  • Anxiety and agitation with diffuse, deep, odd body sensations:"...my bones are on fire", "I feel weird all over", "...a deep pricking, crawling sensation...".[nutramed.com]
  • Possible Side Effects -------------------------------------------------------------------------------- Common side effects include: dizzines drowsiness dry mouth This medicine can cause excitement especially in children.[pharmacycode.com]
  • H1 receptor antagonists produce drowsiness because they oppose this action, reducing neuronal excitation [ PMID: 8008209 ].[ebi.ac.uk]
  • Once activated in the cerebral cortex, the H1 receptor can inhibit potassium channels in neuronal cell membranes, depolarizing the neurons and increasing neuronal excitation.[news-medical.net]
  • Spring has sprung, and Stan is excited! He grabs his ball cap and bat and heads outside. Within minutes, Stan begins sneezing. Then his nose starts to drip. Sadly, he heads back inside.[study.com]
  • ADRs - H1 - antgonists • Frequent but mild – inter-individual difference to different drugs – Sedation (Paradoxical Excitation in children), diminished alertness, loss to concentrate, dizziness, motor incordination, tendency to fall asleep – commonest[slideshare.net]
  • Benadryl has been used as a sedative infants and children, although the occasional child will become restless or hyperactive after taking it.[nutramed.com]
  • […] intractable hiccups; for the treatment of severe behavioral problems in children (1 to 12 years of age) marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive[drugbank.ca]
  • These ligands are useful pharmacological tools and are currently being assessed for their clinical potential in allergy, inflammatory disorders, attention deficit hyperactivity disorder, Alzheimer's disease and obesity.[sigmaaldrich.com]


  • treatment of bipolar I disorder.[drugbank.ca]
  • To stay abreast of these rapidly emerging drugs and novel avenues of treatment constant vigilance is required.[books.google.com]
  • In clinical trials, astemizole 10 mg daily was comparable to or better than chlorpheniramine for treatment of chronic rhinitis. Both terfenadine and astemizole were effective for treatment of chronic urticaria.[ncbi.nlm.nih.gov]
  • Plasma noradrenaline and dopamine levels were not affected by treatment with d-chlorpheniramine. These findings indicate that histamine H1 receptors blockade produced convulsions and increased epileptic discharges on EEG.[ncbi.nlm.nih.gov]
  • Methods: Thirty-two allergic conjunctivitis patients were randomized to combined-treatment (n 15) or single-treatment groups (n 17). The improvement of subjective symptoms as well as objective findings were evaluated.[karger.com]


  • Despite this, recent studies have revealed not only a role for H4 receptors in the etiology of itch, the hallmark symptom of ocular allergy, but also identified the H4R as a new target to treat inflammation.[iovs.arvojournals.org]
  • Etiology, classification, and treatment of urticaria. Cutis. 2007 Jan. 79(1):41-9. [Medline]. Bains SN, Hsieh FH. Current approaches to the diagnosis and treatment of systemic mastocytosis.[medscape.com]
  • Given recent reports suggesting a possible role for histamine H 2 or H 4 receptors in the etiology of ocular allergy, we examined the binding properties of alcaftadine at all histamine receptor types.[dovepress.com]
  • If there is any question of the etiology of the poisoning, please call the United States Poison Control network at 1-800-222-1222.[statpearls.com]


  • Nature 2011 The biogenic amine histamine is an important pharmacological mediator involved in pathophysiological processes such as allergies… (More) Gaetano Di Chiara, Assunta Impérato Proceedings of the National Academy of Sciences… 1988 The effect of[semanticscholar.org]
  • […] our findings suggest a pronounced centrally mediated action of naltrexone on histamine induced pruritus . a Department of Dermatology, University Erlangen-Nürnberg, Hartmannstr. 14, 91052 Erlangen, Germany b Institute of Physiology and Experimental Pathophysiology[journals.lww.com]
  • It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[genecards.org]
  • Histamine plays an important role in a variety of pathophysiological conditions. In allergic conditions, histamine is released from basophils and mast cells and is responsible for symptoms of allergic conditions of the skin and airways.[ebi.ac.uk]
  • Pharmacological Properties Histamine is a biogenic amine that is widely distributed in the body and is involved in a number of physiological and pathophysiological functions (Hill et al. 1997 ; Parsons and Ganellin 2006 ).[link.springer.com]


  • Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity.[mesh.kib.ki.se]
  • The antihistamines are divided into histamine 1 (H 1 ) and histamine 2 (H 2 ) blockers, depending on the responses to histamine they prevent.[medical-dictionary.thefreedictionary.com]
  • DB06766 Alcaftadine For the prevention of itching associated with allergic conjunctivitis.[drugbank.ca]
  • We conclude that the release of histamine makes a major contribution to alcoholic beverage-induced bronchoconstriction in Japanese asthmatic patients, and that histamine H1 antagonists may be effective in preventing alcoholic beverage-induced bronchoconstriction[erj.ersjournals.com]

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