This allergy presents itself in a variety of ways such as a rash and anaphylaxis depending on your inherent sensitivity to it. [dnafit.com]

The term “histamine intolerance” was coined by following the concept presented by lactose intolerance. [news.doccheck.com]

H3 receptors are present on cells of the central and peripheral nervous systems where histamine acts as a neurotransmitter. [histamine-sensitivity.com]

Within 26 months, 394 children presented with chronic abdominal … View Full Text Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. [adc.bmj.com]

If you have histamine intolerance, you must avoid many foods: Histamine is present in a lot of products from eggs and cheese to meat and fish. If you don’t want to give up eating fish, here’s how to enjoy your meal without regret. [food.r-biopharm.com]

• Fatigue

  Side effects to the intolerance are widespread and include: Severe itching Hives Swelling of facial and oral tissues and the throat Increased heart rate Runny nose Chest pain Anxiety Conjunctivitis Migraine and fatigue Loss of concentration, dizziness [dnafit.com]

  Headaches/migraines Vertigo Accelerated heart rate Anxiety Nausea/Vomiting Abnormal Menstrual Cycle Hives Fatigue Itching Throat or face swelling Dietary Management of Histamine Intolerance Foods high in histamine: Fermented Foods such as kombucha, kefir [physiologicnyc.com]

  Many people turn to a wholefoods diet in a bid to manage a variety of health concerns such as irritable bowel syndrome (IBS), chronic sinusitis, anxiety, headaches or fatigue. [fxmedicine.com.au]

  Common symptoms of histamine intolerance Severe fatigue after eating Reddening of the skin Breathing difficulties up to and including bronchial asthma Stomach complaints, diarrhea, loose stools Headaches Mild nausea Cardiac arrhythmias Menstrual disorders [1090.ihrlabor.at]

  This substance clogs up the vital channels of the body, disrupting digestion and ultimately giving rise to everything from fatigue to disease. [greenmedinfo.com]

• Nasal Congestion

  Possible symptoms include: Nasal congestion; sneezing; itchy nose Pain in stomach; nausea Indigestion; heartburn Rashes; hives; itchiness; eczema Racing heart; heart palpitations Itchy eyes; tearing Irregular menstrual cycles; menstrual pain; cramping [integrative-medicine.ca]

  congestion, runny nose and seasonal allergies Conjunctivitis Headaches and migraines Nausea and vomiting Reflux, indigestion, diarrhoea and heartburn Fatigue, confusion and irritability Abnormal menstrual cycle Another reason why histamine intolerance [superpharmacy.com.au]

  congestion and runny nose Conjunctivitis (irritated, watery, reddened eyes) Some types of headaches that differ from those of migraine Fatigue, confusion, irritability Very occasionally loss of consciousness usually lasting for only one or two seconds [greenmedinfo.com]

• Postnasal Drip

  Beneficial as the immunological effects of released histamine can be, the released histamine may cause itching, wheals, bronchoconstriction, and postnasal drip (runny nose) in certain individuals. [accessscience.com]

• Vomiting

  The clinical evidence for histamine intolerance is based on chronic headache, diarrhoea, vomiting, flush, urticaria, asthma-like symptoms, rhinitis and others. [ncbi.nlm.nih.gov]

  In fact, histamine intolerance can be responsible for conditions as diverse as seasickness, headaches and migraine, tachycardia, gastric disorders, diarrhea, intolerance to contrast media, parodontosis, period pains, nausea and vomiting in pregnancy, [bookdepository.com]

  The following are mentioned as typical symptoms: Sudden skin redness (flush symptoms) Itching and redness on the body Digestive complaints such as nausea, vomiting, diarrhoea, abdominal pains Drop in blood pressure, dizziness, palpitations In women: menstrual [aha.ch]

• Diarrhea

  Effects can range from common digestive system problems including abdominal pain and spasms, diarrhea, constipation, and flatulence, to headaches, to skin rash and eczema - all due to the body's inability to thoroughly digest food caused by the lack of [histame.com]

  In fact, histamine intolerance can be responsible for conditions as diverse as seasickness, headaches and migraine, tachycardia, gastric disorders, diarrhea, intolerance to contrast media, parodontosis, period pains, nausea and vomiting in pregnancy, [bookdepository.com]

  The ingestion of histamine-rich food or of alcohol or drugs that release histamine or block DAO may provoke diarrhea, headache, rhinoconjunctival symptoms, asthma, hypotension, arrhythmia, urticaria, pruritus, flushing, and other conditions in patients [ncbi.nlm.nih.gov]

  Common symptoms of histamine intolerance Severe fatigue after eating Reddening of the skin Breathing difficulties up to and including bronchial asthma Stomach complaints, diarrhea, loose stools Headaches Mild nausea Cardiac arrhythmias Menstrual disorders [1090.ihrlabor.at]

• Constipation

  Effects can range from common digestive system problems including abdominal pain and spasms, diarrhea, constipation, and flatulence, to headaches, to skin rash and eczema - all due to the body's inability to thoroughly digest food caused by the lack of [histame.com]

  Symptoms can include but not limited to anyone of the following: depression, anxiety gut issues (irritable bowel syndrome, inflammatory bowel disease, constipation, diarrhoea) migraines, headaches fluid retention behavioural problems skin conditions bloating [naturalhealthmedicine.com.au]

  […] the head and chest irritable bowel syndrome or IBS congested, runny, or itchy nose red, itchy, or watery eyes sneezing shortness of breath hives or red, raised, itchy, burning bumps very itchy skin unexplained anxiety stomach cramps or pain chronic constipation [medicalnewstoday.com]

• Flatulence

  Details Headache, tachycardia, abdominal pain, flatulence, rash and itching may be signs of histamine intolerance. Histamine is responsible for the body’s defense against unwanted substances. [selfdiagnostics.com]

  Effects can range from common digestive system problems including abdominal pain and spasms, diarrhea, constipation, and flatulence, to headaches, to skin rash and eczema - all due to the body's inability to thoroughly digest food caused by the lack of [histame.com]

  These include stomach pain, bloating, gas/flatulence, diarrhoea, irritable bowel syndrome (IBS), rashes, hives (urticaria), recurrent mouth ulcers or headaches. [allergy.org.au]

  […] body.[3] Symptoms[edit] Possible symptoms after ingestion of histamine-rich food include[4]: Skin rash, hives, eczema, itching Headache, flushing, migraine, dizziness Narrowed or runny nose, difficulty breathing, bronchial asthma, sore throat Bloating (flatulence [en.wikipedia.org]

  Typical symptoms of histamine intolerance are: - redness, itching and swelling on the skin - stomach and intestinal cramps, flatulence, diarrhea - runny nose, cough, asthma, difficulty swallowing - headache and dizziness— rapid heartbeat, increased blood [cerascreen.ie]

• Flushing

  The clinical evidence for histamine intolerance is based on chronic headache, diarrhoea, vomiting, flush, urticaria, asthma-like symptoms, rhinitis and others. [ncbi.nlm.nih.gov]

  We offer the following parameters: Quantitative histamine determination Detection of histamine-forming microorganisms Determination of diaminooxidase (DAO) activity Characteristic symptoms of a histamine intolerance are: flushing, nausea, diarrhoea, migraine [mikrooek.de]

  The histamine buildup is what gives you a headache and leaves you feeling flushed, itchy and miserable. [yourlongevityblueprint.com]

  In the SPC, the clauses “can cause asthma attacks” or “may lead to flush reactions” are well hidden. It’s a contentious matter that many drugs which are used by asthmatics inhibit DAO and other enzymes. [news.doccheck.com]

  […] activity of intestinal diamine oxidase (DAO), histamine-rich foods (eg, aged cheese, cured meat or sausages, fish) cause above-normal serum histamine levels. 3 These elevated histamine levels cause various histamine receptor–mediated symptoms such as flush [adc.bmj.com]

• Urticaria

  The clinical evidence for histamine intolerance is based on chronic headache, diarrhoea, vomiting, flush, urticaria, asthma-like symptoms, rhinitis and others. [ncbi.nlm.nih.gov]

  […] intestinal diamine oxidase (DAO), histamine-rich foods (eg, aged cheese, cured meat or sausages, fish) cause above-normal serum histamine levels. 3 These elevated histamine levels cause various histamine receptor–mediated symptoms such as flush, headache or urticaria [adc.bmj.com]

  Histamine is an important mediator of allergic diseases such as hay fever and bronchial asthma, food allergies, urticaria, and drug hypersensitivity. Knowledge of histamine as a cause of numerous non-allergic symptoms and signs is, however, limited. [bookdepository.com]

  The ingestion of histamine-rich food4 or alcohol4,5 may provoke heterogeneous symptoms and signs such as diarrhea, headache,5 rhinoconjunctivitis, asthma, hypotension,4,6,7 arrhythmia, urticaria, pruritus, and flushing.8 Additionally, several drugs have [journals.sagepub.com]

  Patients with chronic idiopathic hives/urticaria and GI symptoms have reduced DAO activity [ 89, 90 ]. [selfhacked.com]

• Sweating

  The skin and sweat glands There are two different types of sweat gland in the skin on the human body. These are: Apocrine sweat glands. Eccrine (or merocrine) sweat glands. [patient.info]

  The second is more systemic and can cause a wide range of symptoms, including hives, flushing, low pain tolerance, sweating, excess mucous production and seasonal allergies. It may result cause hyperactivity, compulsiveness and depression. [houseofhealth.co.nz]

  These areas are a result of local inflammation of the sweat glands. [medicinenet.com]

  Hidradenitis suppurativa is a chronic inflammatory skin disease involving the hair follicles and sweat glands. Also known as acne inversa, this condition usually begins with the appearance of pimple-like bumps on the skin. [my.clevelandclinic.org]

  Contributory factors include the following: Hormones may be involved in the control of apocrine sweat glands and might play a part in the disease. [britishskinfoundation.org.uk]

• Pruritus

  The patients with pruritus had elevated histamine (20.7 nmol/l), compared with the patients without pruritus (4.2) and normal subjects (2.1). [selfhacked.com]

  The ingestion of histamine-rich food or of alcohol or drugs that release histamine or block DAO may provoke diarrhea, headache, rhinoconjunctival symptoms, asthma, hypotension, arrhythmia, urticaria, pruritus, flushing, and other conditions in patients [ncbi.nlm.nih.gov]

  This makes it difficult to differentiate between histamine excess and allergy. diarrhea headache rhinoconjunctival symptoms asthma hypotention arrhythmia urticaria pruritus flushing Foods high in histamine include fermented products such as wine, dry [naturalhealthmedicine.com.au]

  Common symptoms of both conditions include poor digestion, food sensitivities, chemical/environmental sensitivities, pruritus, brain fog, urticaria, hypotension, tachycardia, anxiety, depression, and chronic fatigue. [botanicalmedicine.org]

  Janice Joneja's 2010 paper : Pruritus (itching especially of the skin, eyes, ears, and nose) Urticaria (hives) Tissue swelling (angioedema) especially of facial and oral tissues and sometimes the throat, the latter causing the feeling of "throat tightening [greenmedinfo.com]

• Headache

  One slice of yeasted bread or a glass of white wine and the next day the nausea and headache are back. The hardest thing about HIT is getting a diagnosis. [telegraph.co.uk]

  Details Headache, tachycardia, abdominal pain, flatulence, rash and itching may be signs of histamine intolerance. Histamine is responsible for the body’s defense against unwanted substances. [selfdiagnostics.com]

  The clinical evidence for histamine intolerance is based on chronic headache, diarrhoea, vomiting, flush, urticaria, asthma-like symptoms, rhinitis and others. [ncbi.nlm.nih.gov]

  […] the following parameters: Quantitative histamine determination Detection of histamine-forming microorganisms Determination of diaminooxidase (DAO) activity Characteristic symptoms of a histamine intolerance are: flushing, nausea, diarrhoea, migraine headache [mikrooek.de]

• Dizziness

  Side effects to the intolerance are widespread and include: Severe itching Hives Swelling of facial and oral tissues and the throat Increased heart rate Runny nose Chest pain Anxiety Conjunctivitis Migraine and fatigue Loss of concentration, dizziness [dnafit.com]

  The following are mentioned as typical symptoms: Sudden skin redness (flush symptoms) Itching and redness on the body Digestive complaints such as nausea, vomiting, diarrhoea, abdominal pains Drop in blood pressure, dizziness, palpitations In women: menstrual [aha.ch]

  […] itchy nose red, itchy, or watery eyes sneezing shortness of breath hives or red, raised, itchy, burning bumps very itchy skin unexplained anxiety stomach cramps or pain chronic constipation nausea and vomiting gas or bloating unexplained exhaustion dizziness [medicalnewstoday.com]

See Workup for more detail. [emedicine.medscape.com]

• Serotonin Increased

  It decreases anxiety, increases serotonin, increases dopamine, and is useful for the treatment of OCD [ 52, 53 ]. [selfhacked.com]

• Vitamin C Increased

  Nutrient supplementation with some of the most important being:[4,15-17] quercetin (antihistamine and anti-inflammatory properties) vitamin B6 (increases DAO activity) vitamin C (increases histamine metabolism and breakdown) vitamin E (may decrease mast [fxmedicine.com.au]

Aside from dietary changes, there is no set treatment for people with histamine intolerance. But most people with the condition benefit from a few different medical treatments, depending on their symptoms or the cause of the condition. [medicalnewstoday.com]

Finally he also deals with the issue of treatments for DAO deficiency and the intolerance to histamine. [dr-healthcare.com]

What is the long-term outlook (prognosis)? The prognosis is very variable. Not everyone progresses from stage 1 to stage 3. For many affected people, hidradenitis suppurativa is a painful and debilitating condition. [patient.info]

No single treatment has shown overwhelmingly positive outcomes. [60] Spontaneous resolution is rare. [7] Specific factors appear to influence the prognosis. Larger excisions may offer a better outcome. [emedicine.medscape.com]

Prognosis of migraine and tension-type headache: a population-based follow-up study. Neurology. 2005;65(4):580–585. doi: 10.1212/01.wnl.0000172918.74999.8a. [PubMed] [CrossRef] [Google Scholar] 5. [ncbi.nlm.nih.gov]

Evidence pertinent to the etiology of HS and its association with other autoimmune conditions implies a possible denominator in the disease etiopathogenesis. [ncbi.nlm.nih.gov]

Etiology of Hidradenitis Suppurativa The exact etiology of hidradenitis suppurativa remains obscure. [emedicine.medscape.com]

Sattler J, Hafner D, Klotter HJ, Lorenz W, Wagner PK: Food-induced histaminosis as an epidemiological problem: plasma histamine elevation and haemodynamic alterations after oral histamine administration and blockade of diamine oxidase (DAO). [aerzteblatt.de]

Sattler, J, Häfner, D, Klotter, HJ. (1988) Food-induced histaminosis as an epidemiological problem: plasma histamine elevation and haemodynamic alterations after oral histamine administration and blockade of diamine oxidase (DAO). [journals.sagepub.com]

Epidemiology of insomnia: a longitudinal study in a UK population. Sleep. 2007;30(3):274–280. [PubMed] [Google Scholar] 20. Kessler RC, Berglund PA, Coulouvrat C, et al. [ncbi.nlm.nih.gov]

Food-induced histaminosis as an epidemiological problem: plasma histamine elevation and haemodynamic alterations after oral histamine administration and blockade of diamine oxidase (DAO). [cerascreen.co.uk]

Author information 1 Comenius University in Bratislava, Jessenius Faculty of Medicine, Department of Pathophysiology, Mala Hora, 036 01 Martin, Slovakia. 2 Comenius University in Bratislava, Jessenius Faculty of Medicine, Department of Pathophysiology [dr-healthcare.com]

HIT is more widely accepted in Europe as a true condition and was recognized in 2012 by the German Society for Allergology and Clinical Immunology as a true disease for which the pathophysiology has yet to be determined. [theceliacmd.com]

Pathophysiology of hidradenitis suppurativa: An update. J Am Acad Dermatol 2015;73:S8–11. [PubMed] [Google Scholar] [7] Jemec GBE, Heidenheim M, Nielsen NH. The prevalence of hidradenitis suppurativa and its potential precursor lesions. [ncbi.nlm.nih.gov]

ANTIHISTAMINE. cetirizine Zyrtec antihistamine, H1 receptor cetirizine- pseudoephedrine Zyrtec-D antihistamine, H1 receptor-decongestant desloratadine Clarinex antihistamine, H1 receptor fexofenadine Allegra antihistamine, H1 receptor ... 9 Portable Pathophysiology [educalingo.com]

Pathophysiological basis for unstable angina pectoris is unstable atherosclerosis plaque complicated with endothelial damage, activation of platelets and spasm (reversible ischemia) [33]. [hindawi.com]

Therefore, the same amount of histamine will be circulating in the body as before taking the antihistamine; it is simply prevented from exerting its effects. [histamine-sensitivity.com]

Antihistamine drugs exert their effects by blocking the combination of histamine with these receptors or by halting the release of histamine, thereby preventing the allergic reaction. [accessscience.com]

HIT is a pathological process, in which the enzymatic activity of histamine-degrading enzymes is decreased or inhibited and they are insufficient to inactivate histamine from food and to prevent its passage to blood-stream. [dr-healthcare.com]

Antihistamines prevent this inflammatory response. Histamine causes your blood vessels to swell, or dilate, so that your white blood cells can quickly find and attack the infection or problem. [amymyersmd.com]

Preventing food allergy in children Allergy prevention in children is an active area of research. [betterhealth.vic.gov.au]