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Histamine Intolerance

Histaminosis


Presentation

  • This allergy presents itself in a variety of ways such as a rash and anaphylaxis depending on your inherent sensitivity to it.[dnafit.com]
  • The term “histamine intolerance” was coined by following the concept presented by lactose intolerance.[news.doccheck.com]
  • H3 receptors are present on cells of the central and peripheral nervous systems where histamine acts as a neurotransmitter.[histamine-sensitivity.com]
  • Within 26 months, 394 children presented with chronic abdominal … View Full Text Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service.[adc.bmj.com]
  • Histamine is present in many deeply flavoursome things. Bread, cheese and wine, for starters. Also vinegar, bacon, any kind of smoked or canned fish, anchovies, shellfish and Marmite. And – sniff – chocolate.[telegraph.co.uk]
Fatigue
  • Side effects to the intolerance are widespread and include: Severe itching Hives Swelling of facial and oral tissues and the throat Increased heart rate Runny nose Chest pain Anxiety Conjunctivitis Migraine and fatigue Loss of concentration, dizziness[dnafit.com]
  • Headaches/migraines Vertigo Accelerated heart rate Anxiety Nausea/Vomiting Abnormal Menstrual Cycle Hives Fatigue Itching Throat or face swelling Dietary Management of Histamine Intolerance Foods high in histamine: Fermented Foods such as kombucha, kefir[physiologicnyc.com]
  • This substance clogs up the vital channels of the body, disrupting digestion and ultimately giving rise to everything from fatigue to disease.[greenmedinfo.com]
  • Because histamine also influences neurotransmitters, DAO deficient or histamine intolerant people may also experience: brain fog bloating wheezing eczema fatigue, anxiety and irritability hormone imbalances low blood pressure low sex drive migraines nausea[umbrelluxdao.com]
  • […] pressure (hypertension), tachycardia, cardiac arrhythmias, low blood pressure (hypotension) Menstrual disorders (dysmenorrhea), cystitis, urethritis and mucosal irritation of female genitalia Water retention (edema), bone marrow edema (BME), joint pain Fatigue[en.wikipedia.org]
Nasal Congestion
  • congestion and runny nose Conjunctivitis (irritated, watery, reddened eyes) Some types of headaches that differ from those of migraine Fatigue, confusion, irritability Very occasionally loss of consciousness usually lasting for only one or two seconds[greenmedinfo.com]
  • The following are some of the most common signs and symptoms of histamine intolerance ( 2, 7 ) : Itching, redness, hives and/or swelling of the lips, tongue, or skin Sneezing and nasal congestion Asthma Low blood pressure Heart arrhythmia Diarrhea Headache[functionalnutritionanswers.com]
  • This may be why they can trigger flushing, migraines and nasal congestion in some people. Salicylates are natural aspirin like compounds that are present in a wide variety of herbs, spices as well as fruit and vegetables.[allergy.org.au]
Vomiting
  • The clinical evidence for histamine intolerance is based on chronic headache, diarrhoea, vomiting, flush, urticaria, asthma-like symptoms, rhinitis and others.[ncbi.nlm.nih.gov]
  • The reaction can cause symptoms like breathing problems, throat tightness, hoarseness, coughing, vomiting, abdominal pain, hives, swelling, or a drop in blood pressure.[kidshealth.org]
  • […] irritable bowel syndrome or IBS congested, runny, or itchy nose red, itchy, or watery eyes sneezing shortness of breath hives or red, raised, itchy, burning bumps very itchy skin unexplained anxiety stomach cramps or pain chronic constipation nausea and vomiting[medicalnewstoday.com]
Diarrhea
  • Effects can range from common digestive system problems including abdominal pain and spasms, diarrhea, constipation, and flatulence, to headaches, to skin rash and eczema - all due to the body's inability to thoroughly digest food caused by the lack of[histame.com]
  • Because histamine circulates in the bloodstream and can be found in nearly every human tissue, one person with overload might suffer from intractable headaches, while another could have chronic diarrhea.[experiencelife.com]
  • Symptoms of food intolerance can include nausea, gas, cramps, abdominal pain, diarrhea, irritability, nervousness, or headaches. A food allergy happens when the body's immune system, which normally fights infections, sees the food as an invader.[kidshealth.org]
Constipation
  • Effects can range from common digestive system problems including abdominal pain and spasms, diarrhea, constipation, and flatulence, to headaches, to skin rash and eczema - all due to the body's inability to thoroughly digest food caused by the lack of[histame.com]
  • […] the head and chest irritable bowel syndrome or IBS congested, runny, or itchy nose red, itchy, or watery eyes sneezing shortness of breath hives or red, raised, itchy, burning bumps very itchy skin unexplained anxiety stomach cramps or pain chronic constipation[medicalnewstoday.com]
Flatulence
  • Details Headache, tachycardia, abdominal pain, flatulence, rash and itching may be signs of histamine intolerance. Histamine is responsible for the body’s defense against unwanted substances.[selfdiagnostics.com]
  • Effects can range from common digestive system problems including abdominal pain and spasms, diarrhea, constipation, and flatulence, to headaches, to skin rash and eczema - all due to the body's inability to thoroughly digest food caused by the lack of[histame.com]
  • These include stomach pain, bloating, gas/flatulence, diarrhoea, irritable bowel syndrome (IBS), rashes, hives (urticaria), recurrent mouth ulcers or headaches.[allergy.org.au]
  • […] body. [2] Symptoms [ edit ] Possible symptoms after ingestion of histamine-rich food are: Skin rash, hives, eczema, itching Headache, flushing, migraine, dizziness narrowed or runny nose, difficulty breathing, bronchial asthma, sore throat Bloating (flatulence[en.wikipedia.org]
  • Symptoms The symptoms of lactose intolerance are: Diarrhoea Bloating Flatulence (wind) Abdominal pain or discomfort Infantile colic And less commonly, it can cause constipation and nausea.[allergyuk.org]
Chronic Abdominal Pain
  • In adults, measuring low DAO levels ( 1 Chronic abdominal pain is a common problem in paediatric gastroenterology. In children, there is no study that addresses the question if HIT can be identified as the cause for chronic abdominal pain.[adc.bmj.com]
Flushing
  • The clinical evidence for histamine intolerance is based on chronic headache, diarrhoea, vomiting, flush, urticaria, asthma-like symptoms, rhinitis and others.[ncbi.nlm.nih.gov]
  • We offer the following parameters: Quantitative histamine determination Detection of histamine-forming microorganisms Determination of diaminooxidase (DAO) activity Characteristic symptoms of a histamine intolerance are: flushing, nausea, diarrhoea, migraine[mikrooek.de]
  • […] activity of intestinal diamine oxidase (DAO), histamine-rich foods (eg, aged cheese, cured meat or sausages, fish) cause above-normal serum histamine levels. 3 These elevated histamine levels cause various histamine receptor–mediated symptoms such as flush[adc.bmj.com]
  • In the SPC, the clauses “can cause asthma attacks” or “may lead to flush reactions” are well hidden. It’s a contentious matter that many drugs which are used by asthmatics inhibit DAO and other enzymes.[news.doccheck.com]
  • People with chronic stress and/or inflammation have the MC4R receptor activated, which then leads to flushing, weight loss, lower blood pressure, and increased pain [ 72 ]. My guess is that both histamine and MC4R cause flushing symptoms.[selfhacked.com]
Urticaria
  • The clinical evidence for histamine intolerance is based on chronic headache, diarrhoea, vomiting, flush, urticaria, asthma-like symptoms, rhinitis and others.[ncbi.nlm.nih.gov]
  • […] intestinal diamine oxidase (DAO), histamine-rich foods (eg, aged cheese, cured meat or sausages, fish) cause above-normal serum histamine levels. 3 These elevated histamine levels cause various histamine receptor–mediated symptoms such as flush, headache or urticaria[adc.bmj.com]
  • Zuberbier, T, Aberer, W, Asero, R. ( 2014 ) The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: The 2013 revision and update. Allergy 69: 868 – 887.[journals.sagepub.com]
  • Wedi B, Kapp A (2005) Chronic urticaria. G Ital Dermatol Venereol 140:435–443 Google Scholar 22. Wedi B, Kapp A (2005) Chronic urticaria: assessment of current treatment. Exp Rev Clin Immunol 1:459–473 CrossRef Google Scholar 23.[doi.org]
  • Patients with chronic idiopathic hives/urticaria and GI symptoms have reduced DAO activity [ 89, 90 ].[selfhacked.com]
Pruritus
  • The patients with pruritus had elevated histamine (20.7 nmol/l), compared with the patients without pruritus (4.2) and normal subjects (2.1).[selfhacked.com]
  • Janice Joneja's 2010 paper : Pruritus (itching especially of the skin, eyes, ears, and nose) Urticaria (hives) Tissue swelling (angioedema) especially of facial and oral tissues and sometimes the throat, the latter causing the feeling of "throat tightening[greenmedinfo.com]
  • The ingestion of histamine-rich food 4 or alcohol 4, 5 may provoke heterogeneous symptoms and signs such as diarrhea, headache, 5 rhinoconjunctivitis, asthma, hypotension, 4, 6, 7 arrhythmia, urticaria, pruritus, and flushing. 8 Additionally, several[journals.sagepub.com]
Headache
  • One slice of yeasted bread or a glass of white wine and the next day the nausea and headache are back. The hardest thing about HIT is getting a diagnosis.[telegraph.co.uk]
  • Details Headache, tachycardia, abdominal pain, flatulence, rash and itching may be signs of histamine intolerance. Histamine is responsible for the body’s defense against unwanted substances.[selfdiagnostics.com]
  • The clinical evidence for histamine intolerance is based on chronic headache, diarrhoea, vomiting, flush, urticaria, asthma-like symptoms, rhinitis and others.[ncbi.nlm.nih.gov]
  • […] the following parameters: Quantitative histamine determination Detection of histamine-forming microorganisms Determination of diaminooxidase (DAO) activity Characteristic symptoms of a histamine intolerance are: flushing, nausea, diarrhoea, migraine headache[mikrooek.de]
  • […] of intestinal diamine oxidase (DAO), histamine-rich foods (eg, aged cheese, cured meat or sausages, fish) cause above-normal serum histamine levels. 3 These elevated histamine levels cause various histamine receptor–mediated symptoms such as flush, headache[adc.bmj.com]
Dizziness
  • Side effects to the intolerance are widespread and include: Severe itching Hives Swelling of facial and oral tissues and the throat Increased heart rate Runny nose Chest pain Anxiety Conjunctivitis Migraine and fatigue Loss of concentration, dizziness[dnafit.com]
  • […] itchy nose red, itchy, or watery eyes sneezing shortness of breath hives or red, raised, itchy, burning bumps very itchy skin unexplained anxiety stomach cramps or pain chronic constipation nausea and vomiting gas or bloating unexplained exhaustion dizziness[medicalnewstoday.com]

Treatment

  • Aside from dietary changes, there is no set treatment for people with histamine intolerance. But most people with the condition benefit from a few different medical treatments, depending on their symptoms or the cause of the condition.[medicalnewstoday.com]
  • Finally he also deals with the issue of treatments for DAO deficiency and the intolerance to histamine.[dr-healthcare.com]

Epidemiology

  • Sattler J, Hafner D, Klotter HJ, Lorenz W, Wagner PK: Food-induced histaminosis as an epidemiological problem: plasma histamine elevation and haemodynamic alterations after oral histamine administration and blockade of diamine oxidase (DAO).[aerzteblatt.de]
  • Sattler, J, Häfner, D, Klotter, HJ. ( 1988 ) Food-induced histaminosis as an epidemiological problem: plasma histamine elevation and haemodynamic alterations after oral histamine administration and blockade of diamine oxidase (DAO).[journals.sagepub.com]
Sex distribution
Age distribution

Pathophysiology

  • They are important in cell–cell communications and a breadth of physiological and pathophysiological responses, notably antigen presentation and host defenses.[doi.org]

Prevention

  • Therefore, the same amount of histamine will be circulating in the body as before taking the antihistamine; it is simply prevented from exerting its effects.[histamine-sensitivity.com]
  • Antihistamine drugs exert their effects by blocking the combination of histamine with these receptors or by halting the release of histamine, thereby preventing the allergic reaction.[accessscience.com]
  • Preventing food allergy in children Allergy prevention in children is an active area of research.[betterhealth.vic.gov.au]
  • Its stocked with the powerful enzyme diamine oxidase (DAO) which breaks down and helps eliminate histamine to maintain your biochemical balance (and prevent uncomfortable reactions).[umbrelluxdao.com]
  • An intact gut lining prevents foods from “leaking” into the bloodstream and provoking an allergic reaction. Try a four-week elimination diet.[experiencelife.com]

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