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Histiocytoma


Presentation

  • Symptoms include dysphagia, dyspnoea and when the mass is located in the tongue, difficulty to speak may be present. CT may be requested if involvement of bone is suspected. MRI studies are present regarding soft tissue BFH [ 10 ].[ncbi.nlm.nih.gov]
  • The tumors typically grow for a long time before presenting any symptoms. The first thing one may notice is a painless lump in the area where the cancer is growing.[nicklauschildrens.org]
  • Entry status i Reviewed (UniProtKB/Swiss-Prot) Annotation program Chordata Protein Annotation Program Disclaimer Any medical or genetic information present in this entry is provided for research, educational and informational purposes only.[uniprot.org]
  • ., Browne, R.M. (1995) Malignant fibrous histiocytoma presenting as perioral abscess.[scindeks.ceon.rs]
Sepsis
  • Up-regulated upon sepsis (PubMed: 26599367 ). Up-regulated by glucose (PubMed: 29168081 ).[uniprot.org]
Dysphagia
  • Symptoms include dysphagia, dyspnoea and when the mass is located in the tongue, difficulty to speak may be present. CT may be requested if involvement of bone is suspected. MRI studies are present regarding soft tissue BFH [ 10 ].[ncbi.nlm.nih.gov]
Ulcer
  • Buccal mass with ulceration. Oral Surg Oral Med Oral Path. 1997; 5 :527–530. doi: 10.1016/S1079-2104(97)90115-3. [ PubMed ] [ CrossRef ] [ Google Scholar ] 10.[ncbi.nlm.nih.gov]
Suggestibility
  • The molecular basis for the relationship between EFH and benign fibrous histiocytoma has remained largely unknown, with some authors suggesting that EFH represents an entity that is biologically distinct from benign fibrous histiocytoma.[journals.lww.com]
  • The clinical appearance of the lesion suggested the possibility of a neoplasm of soft tissues.[ncbi.nlm.nih.gov]
Aggressive Behavior
  • The clinical diagnosis of oral BFH is made by a gradually enlarging growth, that is well-circumscribed and does not show aggressive behavior or damage overlying mucosa.[ncbi.nlm.nih.gov]
Irritability
  • Chronic irritation, continuous trauma and spontaneous development have been reported for those located within the oral cavity.[ncbi.nlm.nih.gov]

Treatment

  • Radical excision with wide margins was the treatment of choice. Two challenges posed in this treatment were avoiding any damage to mental nerves on both side and maintaining esthetics in the chin region.[ncbi.nlm.nih.gov]
  • Surgery to remove the tumor is the primary treatment for MFH whenever possible. Chemotherapy and radiation therapy are also often needed in order to kill cancer that has spread beyond the tumor and keep it from coming back.[nicklauschildrens.org]
  • It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.[uniprot.org]
  • ., Hoffman, H. (2003) Locoregional treatment for adult soft tissue sarcomas of the head and neck: An institutional review.[scindeks.ceon.rs]

Prognosis

  • The prognosis of oral BFH is very good. Metastases have not been reported. Local recurrence is present when the excision is incomplete.[ncbi.nlm.nih.gov]

Etiology

  • The etiology of oral BFH is obscure. Chronic irritation, continuous trauma and spontaneous development have been reported for those located within the oral cavity.[ncbi.nlm.nih.gov]

Prevention

  • To prevent this, overlying skin was sutured to the underlying bone and resulted in good post surgical outcome. The etiology of oral BFH is obscure.[ncbi.nlm.nih.gov]

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