We present a 37-year-old female patient diagnosed with unilateral hyperhidrosis coincident with Holmes-Adie syndrome because of this unusual presentation. [ncbi.nlm.nih.gov]

Ophthalmologic examination confirmed Holmes-Adie syndrome (HAS), and peripheral distal polyneuropathy, orthostatic hypotension and leg hyperhidrosis were detected on further workup. [ncbi.nlm.nih.gov]

“Their deep tendon reflexes were also tested clinically and a full autonomic and neurological workup was performed to look for an underlying cause for their Harlequin syndrome.” [eyeworld.org]

Can be dangerous if a manifestation Horner's syndrome (e.g. carotid dissection) or from damage to the third nerve (e.g. aneurysmal expansion) Consider further workup such as imaging if anisocoria is suspected to be from a pathologic process Relative Afferent [stanfordmedicine25.stanford.edu]

Given that malignancy is a prominent feature of recently diagnosed preganglionic Horner syndrome, patients may avoid an unnecessary extensive workup for carcinoma if the lesion can be shown to be old or long-standing. [emedicine.medscape.com]

Thoracic sympathectomy, which severs the involved sympathetic nerve, is the definitive treatment for excessive sweating. [ninds.nih.gov]

The usual treatment of a standardised Adie syndrome is to prescribe reading glasses to correct for impairment of the eye(s).[1] Pilocarpine drops may be administered as a treatment as well as a diagnostic measure, and should be applied three times daily [eyecare-information-service.org.uk]

Treatments of Adie’s Syndrome The usual treatment of a standardised Adie syndrome is to prescribe reading glasses to correct for impairment of the eye(s). [whereincity.com]

Five such patients are reported on who also had a troublesome chronic dry cough, which was of unknown aetiology and was resistant to a range of treatments. The cough may be related to involvement of afferent or efferent pathways in the vagus. [ncbi.nlm.nih.gov]

Although bronchodilator treatment improved the dyspnoea it did not prevent coughing. She had been hypertensive and noted that treatment with an angiotensin converting enzyme inhibitor exacerbated her cough and the drug was withdrawn. [jnnp.bmj.com]

This has a number of implications, including those relating to aetiology and prognosis. The authors recommend regular clinical and laboratory follow-up, especially of cardiovascular autonomic function, in patients with HAS. [ncbi.nlm.nih.gov]

Prognosis Holmes-Adie syndrome is not life-threatening or disabling. The loss of deep tendon reflexes is permanent. Some symptoms of the disorder may progress. [ninds.nih.gov]

Pilocarpine drops may be administered as a treatment as well as a diagnostic measure, and should be applied three times daily.[1] Thoracic sympathectomy is the definitive treatment of diaphoresis, if the condition is not treatable by drug therapy.[1] Prognosis [eyecare-information-service.org.uk]

[…] tonic pupils: Holmes Adie syndrome or generalized neuropathy Adie syndrome - GARD Center Diagram of the Eye Eye Disease Simulations Adie Syndrome Holmes-Adie syndrome – definition Adie's syndrome Alternative eponyms Adie syndrome - Symptoms, Diagnosis, Prognosis [weheartvision.com]

[…] correct for impairment of the eye(s). [1] Pilocarpine drops may be administered as a treatment as well as a diagnostic measure. [1] Thoracic sympathectomy is the definitive treatment of diaphoresis, if the condition is not treatable by drug therapy. [1] Prognosis [en.wikipedia.org]

The HAS can be either idiopathic or associated with neuropathy of various etiology (autoimmune, paraneoplastic and infectious). In our patient, the pupillotonia was the first and early symptom of hitherto unrecognized HIV neuropathy. [ncbi.nlm.nih.gov]

A syndrome of unknown etiology and pathology characterized by tonic pupillary reactions with tendon reflexes possibly absent or diminished. [medical-dictionary.thefreedictionary.com]

The book describes the varied etiology of the disease, but emphasizes clinical protocols and step-by-step procedures for diagnosis and treatment planning. [books.google.com]

The etiology is still unknown. Bibliography J. Ware: Observations relative to the near and distant sight of different persons. Philosophical Transactions of the Royal Society of London, 1813: 31-50. [whonamedit.com]

[…] treatable by drug therapy. [1] Prognosis [ edit ] Adie's syndrome is not life-threatening or disabling. [1] As such, there is no mortality rate relating to the condition; however, loss of deep tendon reflexes is permanent and may progress over time. [1] Epidemiology [en.wikipedia.org]

Th e epidemiology of Sjogren’s syndrome. Clin Epidemiol 2014;6:247-55. Gabriel SE, Michaud K. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res Th er 2009;11:229. [scopublicaciones.socoftal.com]

Epidemiology Frequency United States Anisocoria is common, although no overall prevalence statistics are available. The incidence and prevalence data for anisocoria depend on the specific pathophysiology and population. [emedicine.medscape.com]

Abstract The pathophysiological mechanisms underlying benign areflexia were studied in six patients with Holmes-Adie syndrome. No impairment of sensory conduction velocity of sural nerve was found. [ncbi.nlm.nih.gov]

Disponible en ligne depuis le mercredi 20 septembre 2017 Doi : 10.1016/j.neucli.2017.08.001 Received : 20 June 2017 ; accepted : 25 August 2017 Areflexia in Holmes-Adie syndrome: A sign in search of its pathophysiology Aréflexie dans le syndrome de Holmes-Adie [em-consulte.com]

Bilateral tonic pupil and polyneuropathy in Sjögren's syndrome: a common pathophysiological mechanism? Eur Neurol, 1991; 31: 114–116. [link.springer.com]

[…] loss of deep tendon reflexes, and abnormalities of sweating. [1] Other signs may include hyperopia due to accommodative paresis, photophobia and difficulty reading. [3] Some individual with Adie syndrome may also have cardiovascular abnormalities. [4] Pathophysiology [en.wikipedia.org]

We can hope that Holmes-Adie Syndrome can be prevented and treated better in the days ahead. [weheartvision.com]

Prevention of hip fracture in elderly people with use of a hip protector. ‏ [books.google.com]

Much of this research focuses on finding better ways to prevent, treat, and ultimately cure disorders, such as HAS. Select this link to view a list of studies currently seeking patients. [web.archive.org]

Much of this research focuses on finding better ways to prevent, treat, and ultimately cure disorders, such as HAS. Information from the National Library of Medicine’s MedlinePlus Autonomic Nervous System Disorders Eye Diseases [ninds.nih.gov]