Semilobar holoprosencephaly The basic structure of the cerebral lobes are present but are fused most commonly anteriorly and at the thalami. [radiopaedia.org]

• Median Cleft Lip

  Most commonly associated with facial abnormalities such as cyclopia, ethmocephaly, cebocephaly, and median cleft lip. For more details see the article on alobar holoprosencephaly. [radiopaedia.org]

Treatment and prognosis The prognosis is dependent on the type of HPE with almost all alobar and semilobar forms incompatible with extrauterine life. There may be recurrence risk for ~6% with non-chromosomal sporadic HPE. [radiopaedia.org]

Treatment and prognosis The prognosis is dependent on the type of HPE with almost all alobar and semilobar forms incompatible with extrauterine life. There may be recurrence risk for ~6% with non-chromosomal sporadic HPE. [radiopaedia.org]