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Human Herpesvirus 3

Chickenpox Virus


Presentation

  • (A) Phylogenetic tree of the gene region presenting ORFs 14 to 17. (B) Phylogenetic tree of the gene region presenting ORFs 18 to 21. (C) Phylogenetic tree of the gene region presenting ORFs 22 to 26.[doi.org]
  • Five of seven VZV genotypes were reliably discriminated using only four single nucleotide polymorphisms (SNP) present in ORF22, and the E1 and E2 genotypes were resolved using SNP located in ORF21, ORF22 or ORF50.[ncbi.nlm.nih.gov]
  • […] with severe headache and hemiplegia See Clinical Presentation for more detail.[emedicine.medscape.com]

Workup

  • […] acyclovir-resistant VZV, detections of mutations in thymidine kinase can be determined by PCR and sequence analysis MRI may be useful if myelitis or encephalitis is suspected Lumbar puncture may be helpful if signs suggest myelitis or encephalitis See Workup[emedicine.medscape.com]
  • Fever of unknown origin was defined as fever 100 o F on two occasions during any 48 hr period for which an etiology could not be determined despite 3 days of appropriate diagnostic workup ( 19 ).[journals.lww.com]

Treatment

  • Topical acyclovir is intended for treatment of minor mucocutaneous HSV infections and plays no role in treatment of VZV. Herpes sores heal after 3-4 days but often recur. Treatment relieves pain and discomfort but cannot prevent recurrence.[lianavargas.com]
  • Screening of CSF for VZV by PCR is recommended for all patients with encephalitis and for those with viral meningitis of unclear origin in order to better target antiviral treatment.[ncbi.nlm.nih.gov]
  • FIRST AID/TREATMENT: Varicella is a mild and self-limited illness in healthy children; treatment with antiviral agents is not recommended.[canada.ca]

Prognosis

  • The four patients with encephalitis had a less favorable prognosis: one patient recovered without residual neurological sequelae; two had a chronic neuropsychological handicap, speech difficulties, facial nerve palsy, and focal seizures; one patient died[ncbi.nlm.nih.gov]
  • Prognosis HHV-6 infections are mainly uncomplicated and have a self-limited course. They are usually asymptomatic. Even when HHV-6 leads to roseola, it is a mild illness in children who are immunocompetent.[emedicine.medscape.com]
  • What Is the Prognosis for Shingles? What Are Possible Shingles Complications? Many cases of shingles go away by themselves, with or without treatment. The rash and pain should be gone in two to three weeks.[emedicinehealth.com]
  • VZV may exacerbate the condition of cancer patients and worsen prognosis.[infectagentscancer.biomedcentral.com]

Etiology

  • Year introduced: 1994 PubMed search builder options Subheadings: analysis anatomy and histology chemistry classification complications cytology drug effects enzymology etiology genetics growth and development immunology isolation and purification metabolism[ncbi.nlm.nih.gov]
  • Expansions in this Fifth Edition comprise (1) new data on viral etiology, genetics and cell markers of oral cancer, and premalignant lesions, (2) diagnosis, staging, imaging, and nutrition, (3) genomics and molecular progression, (4) control of malignant[books.google.it]
  • Central nervous system complications of unknown etiology after liver transplantation may be related to HHV-6 infection.[journals.lww.com]
  • Michael VanElzakker, a researcher affiliated with the Tufts University PTSD neuroimaging laboratory as well as the Massachusetts General Hospital Psychiatric Neuroscience division, has published a novel hypothesis on the possible etiology of Chronic Fatigue[hhv-6foundation.org]

Epidemiology

  • EPIDEMIOLOGY : Varicella-zoster infections occur worldwide. Varicella/chickenpox is more common in temperate climates than in tropical countries.[canada.ca]
  • (Zoster) - local mainfestation following reactivation of varicella present in latent form in sensory ganglia; inflammatory reaction of the posterior nerve roots and ganglia, accompanied by crops of vesicles over skin supplied by the affected nerves EPIDEMIOLOGY[msdsonline.com]
  • Varicella seroprevalence and molecular epidemiology of varicella-zoster virus in Argentina, 2002. J. Clin. Microbiol. 42 : 5698 -5704. Faga, B., W. Maury, D. A. Bruckner, and C. Grose. 2001.[doi.org]
  • Practically all molecular epidemiological data on global VZV strains distribution obtained with targeted sequencing of selected regions.[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • Synonym Subfamily Pathophysiology HHV-1 Herpes simplex virus-1 (HSV-1) (Alpha) Oral and/or genital herpes (predominantly orofacial) HHV-2 Herpes simplex virus-2 (HSV-2) Oral and/or.[lianavargas.com]
  • Useful For Suggests clinical disorders or settings where the test may be helpful As an adjunct in the rapid diagnosis of human herpesvirus-6 infection in plasma specimens Clinical Information Discusses physiology, pathophysiology, and general clinical[mayomedicallaboratories.com]
  • Pathophysiology HHV-6 belongs to the Betaherpesvirinae subfamily and to the Roseolovirus genus.[emedicine.medscape.com]

Prevention

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