The patient presented to the emergency department soon thereafter with worsening eruption, fever, rigors, facial edema, and lymphadenopathy. Methylprednisolone was initiated. [ncbi.nlm.nih.gov]

• Movement Disorder

  We report two previously healthy young boys with human herpesvirus 6-associated encephalitis who developed a progressive, and ultimately fatal, encephalopathy with refractory movement disorder concurrent with acquisition of acute human herpesvirus 6 infection [ncbi.nlm.nih.gov]

• Hypothermia

  He was hospitalized for pylexia and status epilepticus, diagnosed with acute encephalopathy, and treated with intensive supportive care including mechanical ventilation, support for hypothermia, and control of the intracranial pressure, that caused severe [ncbi.nlm.nih.gov]

• Constitutional Symptom

  Lymphadenopathy, haematological abnormalities and constitutional symptoms are among the non-specific manifestations seen in drug rash with eosinophilia and systemic symptoms (DRESS), an uncommon but potentially fatal cutaneous adverse drug reaction. [ncbi.nlm.nih.gov]

• Urticaria

  Reactivation of latent herpesviridae has not been studied systematically in chronic idiopathic/spontaneous urticaria (CIU). [ncbi.nlm.nih.gov]

• Facial Edema

  Drug-induced hypersensitivity syndrome (DIHS) is characterized by high fever, facial edema, diffuse maculopapular eruption, and multiorgan involvement. [ncbi.nlm.nih.gov]

• Febrile Seizures

  Serum TIMP-1 levels were significantly higher in infants with febrile seizures than in infants without febrile seizures. Serum MMP-9/TIMP-1 ratios were significantly lower in infants with febrile seizures than in infants without febrile seizures. [ncbi.nlm.nih.gov]

  HHV-6 Infection in Febrile Seizure Patients and Controls The HHV-6 status could be determined in all 17 patients with complex febrile seizures but in only 18 of the 28 patients with simple febrile seizures. [pediatrics.aappublications.org]

• Cranial Neuropathy

  Neurologic examination revealed cranial neuropathies, cerebellar dysfunction, and extremity weakness. Magnetic resonance imaging abnormalities located in the cerebellum, basal ganglia/thalamus, and cerebral hemispheres were detected in 2 patients. [ncbi.nlm.nih.gov]

This article describes the clinical presentation, diagnostic workup, and neurologic outcome of 3 immunocompetent pediatric patients diagnosed with human herpesvirus 6 (HHV6) rhombencephalitis. [ncbi.nlm.nih.gov]

In emergency department, patient underwent septic workup, including lumbar puncture (adhesive bandage), with normal cerebrospinal fluid analysis results. [emedicine.medscape.com]

The height of the fever, as well as the spectrum of accompanying clinical signs not usually associated with roseola, such as otitis and diarrhea, resulted in a varied, often time-consuming, and expensive workup in the emergency department. [nejm.org]

Anti-HHV-6 treatment improved the patient's vision, but immune restoration seems to remain essential for long-term recovery. [ncbi.nlm.nih.gov]

Despite the poor prognosis, no validated treatments or preventative measures have been established. Establishment of preventative strategies represents an important challenge. [ncbi.nlm.nih.gov]

Considering that the prognosis of this type of epileptic encephalopathy is devastating, elucidation of the mechanisms responsible for the development of epileptic encephalopathy and development of a new strategy for its management are urgently needed. [jstage.jst.go.jp]

HHV-6A has not been etiologically linked to any human disease, but such an association will probably be found soon. [doi.org]

The etiological diagnosis is possible only by examining the blood and cerebrospinal fluid, when the patient shows no skin rash. [ncbi.nlm.nih.gov]

The two subtypes share certain biological properties and a high level of sequence homology, but differ dramatically in their epidemiology. [ncbi.nlm.nih.gov]

Paolo Lusso, HHV-6 and HIV-1 Infection, Human Herpesvirus-6, Second Edition - General Virology, Epidemiology and Clinical Pathology, 10.1016/S0168-7069(06)12021-2, (263-277), (2006). [doi.org]

Little is known about the epidemiology or clinical implications of HHV-6A. The clinical manifestations, diagnosis, and treatment of HHV-6 infection in adults will be presented here. [uptodate.com]

SUMMARY: Understanding the pathophysiology of HHV-6B encephalitis remains incomplete, especially regarding young children. Clinical trials of antiviral therapy are warranted for treatment and prevention of HHV-6B encephalitis after transplantation. [ncbi.nlm.nih.gov]

There are still numerous pending questions about HHV-6 which should stimulate future research works on the pathophysiology, diagnosis, and therapy of this remarkable human virus. Copyright 2015, American Society for Microbiology. [cmr.asm.org]

Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology. Significant investments in therapeutic ... [annualreviews.org]

Useful For Suggests clinical disorders or settings where the test may be helpful As an adjunct in the rapid diagnosis of human herpesvirus-6 infection in cerebrospinal fluid specimens Clinical Information Discusses physiology, pathophysiology, and general [mayocliniclabs.com]

Despite the poor prognosis, no validated treatments or preventative measures have been established. Establishment of preventative strategies represents an important challenge. [ncbi.nlm.nih.gov]

Reeves, Centers for Disease Control and Prevention, Mail Stop A-15, 1600 Clifton Rd., Atlanta, GA 30333 ( [email protected] ). Search for other works by this author on: William C. [doi.org]