The clinical manifestations, diagnosis, and treatment of HHV-6 infection in adults will be presented here. [uptodate.com]

HHV-6 variant B was present in peripheral blood mononuclear cells of 5/32 (15%) patients, but persisted with a latent infection. [ncbi.nlm.nih.gov]

• Hodgkin Lymphoma

  lymphoma, Burkitt lymphoma, lymphoproliferative syndromes*, oral hairy leukoplakia* Cytomegalovirus Human herpesvirus 5 CMV mononucleosis, hepatitis, congenital cytomegalic inclusion disease, hepatitis*, retinitis*, pneumonia*, colitis* Human herpesvirus [merckmanuals.com]

  Virol. 1992:1649-1660(1992) [ PubMed ] [ Europe PMC ] [ Abstract ] "Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin's lymphoma and bone marrow transplant patients." [uniprot.org]

• Sepsis

  Because blood tests are often unreliable, your healthcare provider may diagnose HHV-6 based on symptoms alone, ruling out other likely causes such as mononucleosis, meningitis, cytomegalovirus (CMV), rubella, or sepsis. [verywellhealth.com]

  The reasons for hospitalization were suspected sepsis and toxicity (65 percent), diarrhea and dehydration (15 percent), lower respiratory symptoms (10 percent), and seizures (10 percent). [nejm.org]

• Suggestibility

  Previous research has suggested that human herpesvirus-6 (HHV-6) may integrate into host cell chromosomes and be vertically transmitted in the germ line, but the evidence--primarily fluorescence in situ hybridization (FISH)--is indirect. [ncbi.nlm.nih.gov]

• Encephalopathy

  HHV-6 encephalopathy was more frequent in patients with HLA-B*40:06 (p = 0.027). [ncbi.nlm.nih.gov]

  […] loss (HHV-6 encephalopathy, five; HSE, two), coma (HHV-6 encephalopathy, four; HSE, two), hypopnea (HHV-6 encephalopathy, three; HSE, one), and convulsion (HHV-6 encephalopathy, three; HSE, five). [doi.org]

• Febrile Seizures

  Serum TIMP-1 levels were significantly higher in infants with febrile seizures than in infants without febrile seizures. Serum MMP-9/TIMP-1 ratios were significantly lower in infants with febrile seizures than in infants without febrile seizures. [ncbi.nlm.nih.gov]

  HHV-6 Infection in Febrile Seizure Patients and Controls The HHV-6 status could be determined in all 17 patients with complex febrile seizures but in only 18 of the 28 patients with simple febrile seizures. [pediatrics.aappublications.org]

  HHV-6 and the CNS Febrile seizures. Primary HHV-6 infection has been associated with febrile seizures in infants and young children [4]. [academic.oup.com]

• Amnesia

  Although treatment with anticonvulsants may ameliorate the amnesia in some cases, our experience shows that some patients suffer persistent and occasionally progressive deficits. [n.neurology.org]

  The patient displayed symptoms of confusion, amnesia, and lethargy. Diagnosis was made via polymerase chain reaction analysis of cerebrospinal fluid. Electroencephalogram and magnetic resonance imaging of the brain were unremarkable. [ncbi.nlm.nih.gov]

  On PTD 32, the patient was admitted with acute mental status changes and new onset of severe amnesia, both anterograde and retrograde. [ajnr.org]

  […] in transplant patients with HHV-6 encephalitis More about foscarnet, ganciclovir and cidovofir HHV-6 & Immune Suppression Chromosomally Integrated HHV-6 (ciHHV-6) CIHHV-6 Testing 10 Surprising Facts about CIHHV-6 Conditions Associated Conditions A-H Amnesia [hhv-6foundation.org]

• Stroke

  Short Communication CD46 on glial cells can function as a receptor for viral glycoprotein‐mediated cell–cell fusion † Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland Department [doi.org]

  Stroke 1997 ; 28 : 1082 –85 ↵ Tokunaga Y, Kira R, Takemoto M, et al. Diagnostic usefulness of diffusion-weighted magnetic resonance imaging in influenza-associated acute encephalopathy or encephalitis. [ajnr.org]

  […] potential roles for the adipokines, adiponectin, and leptin; neuroendocrine responses; and HIV‐associated renal disease. 17, 18 Bacterial Infections Chronic bacterial periodontal disease is also linked to hypertension and cardiovascular disease, especially stroke [ahajournals.org]

• Neurologic Manifestation

  HHV-6 is a commensal inhabitant of brains; various neurologic manifestations, including convulsions and encephalitis, can occur during primary HHV-6 infection or in immunocompromised patients. [doi.org]

  He is particularly interested in neurologic manifestations of infectious diseases and in bone infections. [wwwnc.cdc.gov]

This article describes the clinical presentation, diagnostic workup, and neurologic outcome of 3 immunocompetent pediatric patients diagnosed with human herpesvirus 6 (HHV6) rhombencephalitis. [ncbi.nlm.nih.gov]

In emergency department, patient underwent septic workup, including lumbar puncture (adhesive bandage), with normal cerebrospinal fluid analysis results. [emedicine.medscape.com]

The height of the fever, as well as the spectrum of accompanying clinical signs not usually associated with roseola, such as otitis and diarrhea, resulted in a varied, often time-consuming, and expensive workup in the emergency department. [nejm.org]

• Pseudomonas

  […] phage PB1, Pseudomonas phage SN, Pseudomonas phage 14-1, Pseudomonas phage LMA2, Pseudomonas phage LBL3, Pseudomonas phage F8, and Burkholderia phage BcepF1 in the new genus PB1likevirus, family Myoviridae, order Caudovirales 2009.001c,eB create a new [doi.org]

  Three patients died: one from sepsis caused by Pseudomonas aeruginosa, 1 another from interstitial pneumonitis due to respiratory syncytial virus (RSV), and the last from liver failure due to graft-versus-host disease. [ajnr.org]

  Pseudomonas aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-L-Homoserine-Lactone Induces HLA-G Expression in Human Immune Cells. Infect Immun 83, 3918–3925 (2015). 32. Gobin, S. J., Biesta, P., de Steenwinkel, J. [nature.com]

• Candida

  Among other infections EBV was seen in 19.6% of the cases and, less frequently, HSV, Chlamydia, Campylobacter, coxsackie, CMV, Yersinia or Candida. In 46% of the patients there were evident signs of immune deficiency. [doi.org]

  In the absence of positive bacterial/fungal culture tests or positive serological/blood tests for Aspergillus antigen, Candida albicans antigen, Mycoplasma antibody, β-D-glucan, and CMV-pp65 antigen, the patient received empiric antibiotic treatments, [dovepress.com]

• HLA-A2

  Given both the prevalence of the HLA-A2 allele in whites and the fact that it is an immunodominant allele for CMV epitopes, 22, 23 we initially focused on HLA-A2+ donors and analyzed CTL lines generated from 5 donors, 3 of whom were HLA-A2 homozygous [bloodjournal.org]

The clinical manifestations, diagnosis, and treatment of HHV-6 infection in adults will be presented here. [uptodate.com]

Testing List of Genes & Proteins Lab Protocols Pictorial Atlas of HHV-6 HHV-6 Antivirals Researcher FAQ Newsletter Clinicians HHV-6A/B Testing HHV-6 Treatment HHV-6 Antivirals Immune Stimulants Alternative Treatments Antiviral use in transplant patients [hhv-6foundation.org]

Anti-HHV-6 treatment improved the patient's vision, but immune restoration seems to remain essential for long-term recovery. [ncbi.nlm.nih.gov]

Despite the poor prognosis, no validated treatments or preventative measures have been established. Establishment of preventative strategies represents an important challenge. [ncbi.nlm.nih.gov]

Considering that the prognosis of this type of epileptic encephalopathy is devastating, elucidation of the mechanisms responsible for the development of epileptic encephalopathy and development of a new strategy for its management are urgently needed. [jstage.jst.go.jp]

HHV-6A has not been etiologically linked to any human disease, but such an association will probably be found soon. [doi.org]

Little is known about the epidemiology or clinical implications of HHV-6A. The clinical manifestations, diagnosis, and treatment of HHV-6 infection in adults will be presented here. [uptodate.com]

The two subtypes share certain biological properties and a high level of sequence homology, but differ dramatically in their epidemiology. [ncbi.nlm.nih.gov]

These viruses cause ubiquitous human infection and have important differences in epidemiology and pathogenesis. [research.fhcrc.org]

Data Extraction: Data on the virology, detection, epidemiology, clinical features, and treatment of human herpesvirus-6 infection were manually abstracted from the indicated sources and summarized. [annals.org]

SUMMARY: Understanding the pathophysiology of HHV-6B encephalitis remains incomplete, especially regarding young children. Clinical trials of antiviral therapy are warranted for treatment and prevention of HHV-6B encephalitis after transplantation. [ncbi.nlm.nih.gov]

There are still numerous pending questions about HHV-6 which should stimulate future research works on the pathophysiology, diagnosis, and therapy of this remarkable human virus. Copyright © 2015, American Society for Microbiology. [cmr.asm.org]

Useful For Suggests clinical disorders or settings where the test may be helpful As an adjunct in the rapid diagnosis of human herpesvirus-6 infection in plasma specimens Clinical Information Discusses physiology, pathophysiology, and general clinical [mayomedicallaboratories.com]

Useful For Suggests clinical disorders or settings where the test may be helpful As an adjunct in the rapid diagnosis of human herpesvirus-6 infection in cerebrospinal fluid specimens Clinical Information Discusses physiology, pathophysiology, and general [mayocliniclabs.com]

Despite the poor prognosis, no validated treatments or preventative measures have been established. Establishment of preventative strategies represents an important challenge. [ncbi.nlm.nih.gov]

Reeves, Centers for Disease Control and Prevention, Mail Stop A-15, 1600 Clifton Rd., Atlanta, GA 30333 ( [email protected] ). Search for other works by this author on: William C. [doi.org]