The patient presented to the emergency department soon thereafter with worsening eruption, fever, rigors, facial edema, and lymphadenopathy. Methylprednisolone was initiated. [ncbi.nlm.nih.gov]

• Hypothermia

  He was hospitalized for pylexia and status epilepticus, diagnosed with acute encephalopathy, and treated with intensive supportive care including mechanical ventilation, support for hypothermia, and control of the intracranial pressure, that caused severe [ncbi.nlm.nih.gov]

• Long Arm

  Although CIHHV-6 may be located on several chromosomes and not always linked to the short- or long-arms sites, the insertion of the viral genome has invariably been found in the proximity of telomeres. [doi.org]

• Facial Edema

  Drug-induced hypersensitivity syndrome (DIHS) is characterized by high fever, facial edema, diffuse maculopapular eruption, and multiorgan involvement. [ncbi.nlm.nih.gov]

• Febrile Seizures

  Serum TIMP-1 levels were significantly higher in infants with febrile seizures than in infants without febrile seizures. Serum MMP-9/TIMP-1 ratios were significantly lower in infants with febrile seizures than in infants without febrile seizures. [ncbi.nlm.nih.gov]

  HHV-6 Infection in Febrile Seizure Patients and Controls The HHV-6 status could be determined in all 17 patients with complex febrile seizures but in only 18 of the 28 patients with simple febrile seizures. [pediatrics.aappublications.org]

• Deja Vu

  Common symptoms of epilepsy include: Uncontrollable jerking movements Temporary confusion Staring off into space for a short time Fear and anxiety A sense of deja vu Loss of consciousness Loss of awareness Encephalitis HHV-6 is also linked to encephalitis [verywellhealth.com]

• Cranial Neuropathy

  Neurologic examination revealed cranial neuropathies, cerebellar dysfunction, and extremity weakness. Magnetic resonance imaging abnormalities located in the cerebellum, basal ganglia/thalamus, and cerebral hemispheres were detected in 2 patients. [ncbi.nlm.nih.gov]

This article describes the clinical presentation, diagnostic workup, and neurologic outcome of 3 immunocompetent pediatric patients diagnosed with human herpesvirus 6 (HHV6) rhombencephalitis. [ncbi.nlm.nih.gov]

In emergency department, patient underwent septic workup, including lumbar puncture (adhesive bandage), with normal cerebrospinal fluid analysis results. [emedicine.medscape.com]

The height of the fever, as well as the spectrum of accompanying clinical signs not usually associated with roseola, such as otitis and diarrhea, resulted in a varied, often time-consuming, and expensive workup in the emergency department. [nejm.org]

Testing List of Genes & Proteins Lab Protocols Pictorial Atlas of HHV-6 HHV-6 Antivirals Researcher FAQ Newsletter Clinicians HHV-6A/B Testing HHV-6 Treatment HHV-6 Antivirals Immune Stimulants Alternative Treatments Antiviral use in transplant patients [hhv-6foundation.org]

Treatment At this point, we don't have a well-established treatment regimen for active HHV-6 infection. Because symptoms can vary widely from one person to another, healthcare providers generally tailor the treatment to the individual case. [verywellhealth.com]

Ongoing controversies regarding etiology, diagnosis, treatment [cancertherapyadvisor.com]

To date, the prevalence, species distribution, and treatment responses of ciHHV-6 are unknown for cardiac patients. [ncbi.nlm.nih.gov]

Despite the poor prognosis, no validated treatments or preventative measures have been established. Establishment of preventative strategies represents an important challenge. [ncbi.nlm.nih.gov]

Considering that the prognosis of this type of epileptic encephalopathy is devastating, elucidation of the mechanisms responsible for the development of epileptic encephalopathy and development of a new strategy for its management are urgently needed. [jstage.jst.go.jp]

HHV-6A has not been etiologically linked to any human disease, but such an association will probably be found soon. [doi.org]

The etiological diagnosis is possible only by examining the blood and cerebrospinal fluid, when the patient shows no skin rash. [ncbi.nlm.nih.gov]

The two subtypes share certain biological properties and a high level of sequence homology, but differ dramatically in their epidemiology. [ncbi.nlm.nih.gov]

Little is known about the epidemiology or clinical implications of HHV-6A. The clinical manifestations, diagnosis, and treatment of HHV-6 infection in adults will be presented here. [uptodate.com]

Paolo Lusso, HHV-6 and HIV-1 Infection, Human Herpesvirus-6, Second Edition - General Virology, Epidemiology and Clinical Pathology, 10.1016/S0168-7069(06)12021-2, (263-277), (2006). [doi.org]

Data Extraction: Data on the virology, detection, epidemiology, clinical features, and treatment of human herpesvirus-6 infection were manually abstracted from the indicated sources and summarized. [annals.org]

SUMMARY: Understanding the pathophysiology of HHV-6B encephalitis remains incomplete, especially regarding young children. Clinical trials of antiviral therapy are warranted for treatment and prevention of HHV-6B encephalitis after transplantation. [ncbi.nlm.nih.gov]

There are still numerous pending questions about HHV-6 which should stimulate future research works on the pathophysiology, diagnosis, and therapy of this remarkable human virus. Copyright © 2015, American Society for Microbiology. [cmr.asm.org]

Vertical transmission of HHV-6 in children of parents who have chromosomally integrated HHV-6 viral DNA occurs in 1%-2% of births. [9, 10, 7] The development of latent HHV-6 infection is a critical part of the pathophysiology. [emedicine.medscape.com]

Useful For Suggests clinical disorders or settings where the test may be helpful As an adjunct in the rapid diagnosis of human herpesvirus-6 infection in plasma specimens Clinical Information Discusses physiology, pathophysiology, and general clinical [mayomedicallaboratories.com]

Despite the poor prognosis, no validated treatments or preventative measures have been established. Establishment of preventative strategies represents an important challenge. [ncbi.nlm.nih.gov]

Reeves, Centers for Disease Control and Prevention, Mail Stop A-15, 1600 Clifton Rd., Atlanta, GA 30333 ( [email protected] ). Search for other works by this author on: William C. [doi.org]