The clinical manifestations, diagnosis, and treatment of HHV-6 infection in adults will be presented here. [uptodate.com]

HHV-6 variant B was present in peripheral blood mononuclear cells of 5/32 (15%) patients, but persisted with a latent infection. [ncbi.nlm.nih.gov]

• Asymptomatic

  Reference Range: Although the reference range is typically "negative" for this assay, this assay may detect viremia in asymptomatic individuals. [mayomedicallaboratories.com]

  However, antiviral therapy was administered to 5 asymptomatic patients mistaken to have HHV-6 infection because of their very high HHV-6 DNA levels, 3 who developed symptomatic cytomegalovirus disease, and 1 with graft-versus-host disease that was mistaken [ncbi.nlm.nih.gov]

• Infectious Mononucleosis

  Our findings support the hypothesis that individuals who suffered from infectious mononucleosis, a marker of late infection with the Epstein-Barr virus, have an increased risk of multiple sclerosis. [doi.org]

  When the students developed infectious mononucleosis, an assessment was made as to the severity of their infectious mononucleosis independently by 2 physicians using the severity of mononucleosis scale. [prohealth.com]

  We here report the case of a 22-year-old immunocompetent male who presented with acute bilateral ARN and fourth nerve palsy, following HHV6 infection of the CNS and EBV infectious mononucleosis. [ncbi.nlm.nih.gov]

  mononucleosis in children, also interstitial pneumonia, encephalitis, meningitis, hepatitis and aplastic anemia in immunodeficient patients. [vidia.cz]

  Pullen HWright NMurdoch JM Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis. Lancet. 1967;21176- 1178 Google Scholar Crossref 9. Patel BM Skin rash with infectious mononucleosis and ampicillin. [jamanetwork.com]

• Generalized Lymphadenopathy

  Symptoms included high fever, headaches, myalgias, arthralgias, upper respiratory tract infection, and generalized lymphadenopathy. [nature.com]

  Clinical signs observed during primary SIV infection included fever, nasal discharge, generalized lymphadenopathy and splenomegaly; the fever was generally higher and of longer duration in animals coinfected with SIV and HHV-6A. [doi.org]

• Skin Rash

  We report the case of a previously healthy woman who presented with a skin rash, mild upper respiratory symptoms, and abdominal pain and succumbed to fulminant hepatic failure attributed to infection with HHV-6B. [ncbi.nlm.nih.gov]

  Patel BM Skin rash with infectious mononucleosis and ampicillin. Pediatrics. 1967;40910- 911 Google Scholar 10. Salahuddin SZAblashi DVMarkham PD et al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. [jamanetwork.com]

• Skin Disease

  HHV-7 has been reported in some cases of inflammatory skin diseases, such as psoriasis, and in some forms of Kaposi’s sarcoma.4 HHV-6 and -7 are much like other herpesviruses in their ability to establish latent infection. [pathnostics.com]

  Nowadays the number of diseases associated with HHV-6 infection is increasing. HHV-6 may play a pathogenic role in neurologic disorders such as epilepsy, multiple sclerosis as well as skin diseases [11–13]. [bmcpsychiatry.biomedcentral.com]

  Pityriasis rosea--a virus-induced skin disease? An update. Arch Virol. 2000. 145 (8):1509-20. [QxMD MEDLINE Link]. Challoner PB, Smith KT, Parker JD, MacLeod DL, Coulter SN, et al. [emedicine.medscape.com]

• Febrile Seizures

  Serum TIMP-1 levels were significantly higher in infants with febrile seizures than in infants without febrile seizures. Serum MMP-9/TIMP-1 ratios were significantly lower in infants with febrile seizures than in infants without febrile seizures. [ncbi.nlm.nih.gov]

  HHV-6 Infection in Febrile Seizure Patients and Controls The HHV-6 status could be determined in all 17 patients with complex febrile seizures but in only 18 of the 28 patients with simple febrile seizures. [pediatrics.aappublications.org]

  HHV-6 and the CNS Febrile seizures. Primary HHV-6 infection has been associated with febrile seizures in infants and young children [4]. [academic.oup.com]

• Convulsions

  HHV-7 has not been shown to cause a specific disease but is associated with febrile convulsions and has been implicated as a cause of encephalitis. [ncbi.nlm.nih.gov]

  Results PATIENT POPULATION AND SAMPLES Forty eight children were entered into the study: 29 with febrile convulsions, 12 with febrile episodes without convulsions (41 cases in total), and seven controls. [adc.bmj.com]

  HHV-6 is a commensal inhabitant of brains; various neurologic manifestations, including convulsions and encephalitis, can occur during primary HHV-6 infection or in immunocompromised patients. [doi.org]

• Dysphasia

  Suspect in fever, fits, headaches, odd behaviour, dysphasia, hemiparesis, or coma or subacute brain stem encephalitis, meningitis, or myelitis. See also separate Herpes Simplex Encephalitis article. Diagnosis Rising antibody titres in 1° infection. [patient.info]

This article describes the clinical presentation, diagnostic workup, and neurologic outcome of 3 immunocompetent pediatric patients diagnosed with human herpesvirus 6 (HHV6) rhombencephalitis. [ncbi.nlm.nih.gov]

In emergency department, patient underwent septic workup, including lumbar puncture (adhesive bandage), with normal cerebrospinal fluid analysis results. [emedicine.medscape.com]

The height of the fever, as well as the spectrum of accompanying clinical signs not usually associated with roseola, such as otitis and diarrhea, resulted in a varied, often time-consuming, and expensive workup in the emergency department. [nejm.org]

• Leukopenia

  Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia. Case Rep Pediatr. 2016;2016:2483183. [PMC free article: PMC5131235] [PubMed: 27980872] 14. Yavarian J, Gavvami N, Mamishi S. [ncbi.nlm.nih.gov]

  Infection is often asymptomatic [ 10 ], but reactivations can result in fever, rash, thrombocytopenia, leukopenia, pneumonia, hepatitis, pancreatitis, colitis, encephalitis, meningoencephalitis, even prolonged bone marrow suppression [ 4 ]. [virologyj.biomedcentral.com]

  Leukopenia was observed only in patient 32, who had HHV-6–positive hepatitis, and was absent in patients with HHV-6–negative hepatitis. [doi.org]

  ADJU NCTIVE THERAPY Supportive therapy in the form of packed red blood cell transfusions (for anemia) and colony stimulating factors (for leukopenia) may be employed in patients with HHV-6 associated bone marrow suppression. [antimicrobe.org]

  Concomitant febrile episodes and other nonspecific symptoms, such as leukopenia and thrombocytopenia, have often been observed ( 164 ). [cmr.asm.org]

The clinical manifestations, diagnosis, and treatment of HHV-6 infection in adults will be presented here. [uptodate.com]

Testing List of Genes & Proteins Lab Protocols Pictorial Atlas of HHV-6 HHV-6 Antivirals Researcher FAQ Newsletter Clinicians HHV-6A/B Testing HHV-6 Treatment HHV-6 Antivirals Immune Stimulants Alternative Treatments Antiviral use in transplant patients [hhv-6foundation.org]

Anti-HHV-6 treatment improved the patient's vision, but immune restoration seems to remain essential for long-term recovery. [ncbi.nlm.nih.gov]

Despite the poor prognosis, no validated treatments or preventative measures have been established. Establishment of preventative strategies represents an important challenge. [ncbi.nlm.nih.gov]

Considering that the prognosis of this type of epileptic encephalopathy is devastating, elucidation of the mechanisms responsible for the development of epileptic encephalopathy and development of a new strategy for its management are urgently needed. [jstage.jst.go.jp]

HHV-6A has not been etiologically linked to any human disease, but such an association will probably be found soon. [doi.org]

Little is known about the epidemiology or clinical implications of HHV-6A. The clinical manifestations, diagnosis, and treatment of HHV-6 infection in adults will be presented here. [uptodate.com]

The two subtypes share certain biological properties and a high level of sequence homology, but differ dramatically in their epidemiology. [ncbi.nlm.nih.gov]

These viruses cause ubiquitous human infection and have important differences in epidemiology and pathogenesis. [research.fhcrc.org]

Data Extraction: Data on the virology, detection, epidemiology, clinical features, and treatment of human herpesvirus-6 infection were manually abstracted from the indicated sources and summarized. [annals.org]

SUMMARY: Understanding the pathophysiology of HHV-6B encephalitis remains incomplete, especially regarding young children. Clinical trials of antiviral therapy are warranted for treatment and prevention of HHV-6B encephalitis after transplantation. [ncbi.nlm.nih.gov]

There are still numerous pending questions about HHV-6 which should stimulate future research works on the pathophysiology, diagnosis, and therapy of this remarkable human virus. Copyright © 2015, American Society for Microbiology. [cmr.asm.org]

Useful For Suggests clinical disorders or settings where the test may be helpful As an adjunct in the rapid diagnosis of human herpesvirus-6 infection in plasma specimens Clinical Information Discusses physiology, pathophysiology, and general clinical [mayomedicallaboratories.com]

Despite the poor prognosis, no validated treatments or preventative measures have been established. Establishment of preventative strategies represents an important challenge. [ncbi.nlm.nih.gov]

Reeves, Centers for Disease Control and Prevention, Mail Stop A-15, 1600 Clifton Rd., Atlanta, GA 30333 ( wcr1@cdc.gov ). Search for other works by this author on: William C. [doi.org]