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Human Herpesvirus 8

Hhv 8


Presentation

  • These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients.[doi.org]
  • Extracavitary PEL presenting as distinctive multiple lymphomatous polyposis as manifested in the case has not been described previously.[ncbi.nlm.nih.gov]
  • We describe the case of a liver transplant recipient who presented with an acute febrile illness 1 year after transplantation with a rapidly fatal outcome.[ncbi.nlm.nih.gov]
  • Two additional frameshifts in noncoding regions (bp 47,862 and 49,338) are also present compared with the KS5 sequence. Several repeat regions are present in the LUR (Fig. 1 ).[doi.org]
  • The present case report suggests that rapamycin may not protect HHV-8-infected renal transplant recipients from occurrence of PEL or progression of pre-existing PEL.[ncbi.nlm.nih.gov]
Collapse
  • Histologic examination of an enlarged lymph node heavily infected with HHV-8 revealed an atypical lymphoproliferative disorder characterized by paracortical hyperplasia and collapsed primary and secondary follicles.[ncbi.nlm.nih.gov]
Plethora
  • HHV-8 is unusual in its possession of a plethora of "accessory" genes and encoded proteins in addition to the core, conserved herpesvirus and gammaherpesvirus genes that are necessary for basic biological functions of these viruses.[ncbi.nlm.nih.gov]
Splenectomy
  • Thirteen months following the initial splenectomy, metastatic lesions were found in the patient's liver and bone marrow. The proliferating cells were positive for factor VIII-associated antigen and CD34.[ncbi.nlm.nih.gov]
Aspiration
  • We suspected human herpesvirus-8 (HHV-8)-associated multicentric Castleman's disease (MCD) based on the results of a physical examination and laboratory investigations, including bone marrow aspiration.[ncbi.nlm.nih.gov]
  • Coverslips were washed three times with 1 PBS, and all liquid at the edges of the coverslips was removed by aspiration.[doi.org]
  • ., 14 and lymphomas 4, 7, and 8 were reported by Walts et al. 15 Lymphomas 1, 2, and 3 are the three AIDS-related lymphomas found to be positive for KSHV by Chang et al. 5 Heparin-treated peripheral blood, samples of effusion and bone marrow aspirate,[doi.org]
Parotid Mass
  • We report a case of a left parotid mass as an early sign of Kaposi's sarcoma-associated human herpesvirus 8 (HHV-8) infection in a 57-year-old patient.[ncbi.nlm.nih.gov]
Polyneuropathy
  • We report a case of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome in a 55-year-old African American woman in which human herpesvirus-8 (HHV-8) was demonstrated within rare lymphocytes in a Castleman[ncbi.nlm.nih.gov]
Penile Lesion
  • RESULTS: HPV DNA was detected in 31/31 penile lesions. HPV DNA was also detected in 18/31 (58%) female genital brushings and 17/31 (54%) female oral brushings.[ncbi.nlm.nih.gov]

Workup

Right Pleural Effusion
  • Chest radiography and computed tomography showed right pleural effusion. Cytologic analysis of the pleural effusion revealed a high grade lymphoma with round nuclei, prominent nucleoli and abundant cytoplasm.[ncbi.nlm.nih.gov]
Liver Biopsy
  • The patient was serologically positive for HHV-8, and HHV-8 was detected in the liver biopsy tissue both by polymerase chain reaction and by immunohistochemistry for HHV-8-encoded latency-associated nuclear antigen.[ncbi.nlm.nih.gov]

Treatment

  • KS may result from HHV-8 infection in patients undergoing immunosuppressive treatment for rheumatic diseases and this is the first case of IKS occurring in undifferentiated arthritis.[ncbi.nlm.nih.gov]
  • Cisplatin treatment decreased the expression of HHV8 latent genes and activated p53 at serine 15 in PEL cells.[ncbi.nlm.nih.gov]
  • To the best of our knowledge, this is the first report of PEL-like lymphoma following tyrosine kinase inhibitor treatment for CML.[ncbi.nlm.nih.gov]
  • RESULTS: Patients were all immunocompromised by previous treatments, which consisted of steroids and/or immunosuppressive agents, and received RTX for insufficient response, disease progression, or transplant rejection.[ncbi.nlm.nih.gov]
  • In addition, resveratrol treatment increased ROS generation but did not lead to HHV8 reactivation.[ncbi.nlm.nih.gov]

Prognosis

  • The patients' characteristics, clinical presentation, pathogenesis, morphologic-immunophenotypic features, clinical management, and prognosis were studied.[ncbi.nlm.nih.gov]
  • Posttransplant primary effusion lymphoma is exceedingly rare and carries a very poor prognosis. Individualized treatment strategies are necessary given the scant body of published literature with guidance based solely on case reports.[ncbi.nlm.nih.gov]
  • The problems related to the diagnosis, the management strategy of such a rare condition and the prognosis are also discussed.[ncbi.nlm.nih.gov]
  • To elucidate the factors associated with a good prognosis, this study analyzed the clinical parameters of four patients treated in the department and 109 patients reported in case reports.[ncbi.nlm.nih.gov]
  • Human herpesvirus 8 (HHV8)-associated lymphomas are uncommon, mainly affect men infected with the human immunodeficiency virus (HIV), and usually have a poor prognosis.[ncbi.nlm.nih.gov]

Etiology

  • Although a viral etiology has been postulated, a definitive viral agent has not been identified. Recent reports have suggested that human herpesvirus 8 (HHV 8) or Epstein-Barr virus (EBV) may play an etiologic role.[ncbi.nlm.nih.gov]
  • Author information 1 Department of Medical Laboratory Sciences and Biotechnology, Fooyin-University, Kaohsiung, Taiwan, ROC. yfwang@mail.fy.edu.tw Abstract Human herpesvirus 8 (HHV8) is the etiologic agent for primary effusion lymphoma (PEL).[ncbi.nlm.nih.gov]
  • Abstract Kaposi sarcoma herpesvirus/human herpesvirus-8 (KSHV/HHV-8) is etiologically related to the development of several human diseases, including Kaposi sarcoma, primary effusion lymphoma (PEL)/extra-cavitary (EC) PEL, multicentric Castleman disease[ncbi.nlm.nih.gov]
  • Human herpesvirus 8 (HHV-8 or Kaposi's sarcoma herpesvirus) is a gamma herpesvirus that is most likely the etiologic agent of both Kaposi's sarcoma and primary effusion lymphoma (PEL), a rare HIV-associated lymphoma.[ncbi.nlm.nih.gov]
  • Abstract Cherry angiomas (CAs) are common vascular benign skin tumors, characterized by abnormal angiogenesis, whose etiology is still unclear and poorly studied.[ncbi.nlm.nih.gov]

Epidemiology

  • The epidemiology of KSHV in this area is obscure either. The present review summarizes the current knowledge pertaining to the epidemiology of KSHV across Asian countries.[ncbi.nlm.nih.gov]
  • MeSH terms Adult Antibodies, Viral/immunology* Cameroon/epidemiology Enzyme-Linked Immunosorbent Assay Female HIV Infections/epidemiology* HIV Infections/immunology* HIV-1/immunology* HIV-1/isolation & purification Herpesviridae Infections/epidemiology[ncbi.nlm.nih.gov]
  • However, limited information on epidemiologic patterns of HHV8 and HSV2 among MSM is available in mainland China.[ncbi.nlm.nih.gov]
  • A cross-sectional study of 286 ESRD patients and 281 matched subjects without kidney disease was conducted at the First People's Hospital of Huzhou, Zhejiang province to explore the epidemiologic features of HHV8 among ESRD patients in China.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Patricia Jeannin takes part to the diagnostic of flu […] Laboratory Oncogenic Virus Epidemiology and Pathophysiology Antoine Gessain Permanent Researcher Antoine Gessain Oncogenic Virus Epidemiology and Pathophysiology Pr Antoine Gessain is a medical[research.pasteur.fr]
  • HHV-8 is involved in the pathophysiological features of multicentric Castleman's disease (MCD) and primary effusion lymphoma (PEL), both rare B-cell lymphoproliferative diseases.[ncbi.nlm.nih.gov]
  • The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. Br J Haematol . 2005 Apr. 129(1):3-17. [Medline] . Barker R, Kazmi F, Stebbing J, Ngan S, Chinn R, Nelson M, et al.[medscape.com]
  • […] the generation of RTA, it in turn activates synthesis of a stereotypic cascade of secondary and tertiary viral proteins that ultimately make components of the virus capsid and also the DNA synthesis enzymes required to replicate the virus genome. [17] Pathophysiology[en.wikipedia.org]

Prevention

  • MicroRNAs (miRNAs) are small, noncoding regulatory RNA molecules that bind to 3' untranslated regions (UTRs) of mRNAs to either prevent their translation or induce their degradation.[ncbi.nlm.nih.gov]
  • Siltuximab binds to human IL-6 with high affinity and specificity, thereby preventing it from binding to IL-6 receptors, and neutralizing IL-6 bioactivity.[ncbi.nlm.nih.gov]
  • Future systematic collection of data to inform KSHV prevention strategies in Asia is urgently needed. J. Med. Virol. 89:563-570, 2017. 2016 Wiley Periodicals, Inc.[ncbi.nlm.nih.gov]
  • Rapid diagnosis prevents unnecessary examinations and leads to specific, rapid treatment. Therapy is complex, combining antiretroviral therapy and chemotherapy. [Indexed for MEDLINE] Free full text[ncbi.nlm.nih.gov]
  • It is important to implement programs for preventing herpes virus infection among MSM, particularly high-risk groups such as money buys. And protected sexual intercourse should be propagated. J. Med.[ncbi.nlm.nih.gov]

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