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Human Papillomavirus

Human Papilloma Virus


Presentation

  • The presented report is the first documented case of confirmed HPV-associated oropharyngeal squamous cell carcinoma metastasizing to the cavernous sinus, and the only HPV confirmed head and neck cancer case to present with metastasis to the cavernous[ncbi.nlm.nih.gov]
  • In this pregnant adolescent, HPV infection was present in both the cervix and the mouth, but the HPV subtypes infecting these two areas were different.[ncbi.nlm.nih.gov]
  • Hypergranulosis and koilocytosis were also present. Immunohistochemical studies indicated p16 and p53 immunoexpression in the areas with cellular atypia and koilocytosis.[ncbi.nlm.nih.gov]
  • CASE PRESENTATION: We report a rare case of a 67-year-old Japanese man with synchronous triple urogenital cancer including bladder small cell carcinoma, prostatic ductal adenocarcinoma, and penile squamous cell carcinoma, who presented with a history[ncbi.nlm.nih.gov]
  • Here, we present a life-threatening case of ocular and bulbar MG symptoms after HPV vaccination and a brief literature review.[ncbi.nlm.nih.gov]
Hemophilia A
  • Among the eight patients, seven acquired HIV from transfusion (three associated with hemophilia) and one acquired HIV through vertical transmission; this patient also had received a transfusion before sampling.[ncbi.nlm.nih.gov]
  • X-linked recessive disorders: Be Wise Fool’s GOLD Heeds Silly HOpe Bruton’s agammaglobulinemia Wiskott-Aldrich syndrome Fabry’s disease G6PD deficiency Ocular albinism Lesch-Nyhan Syndrome Duchenne’s (and Becker’s) muscular dystrophy Hunter’s Syndrome Hemophilia[ajethno.com]
Turkish
  • This report is the first step for the investigation of involvement of HLA types in the pathogenesis of Turkish patients with FEH.[ncbi.nlm.nih.gov]
  • Polat Dursun, Süheyla S Senger, Hande Arslan, Esra Kuşçu and Ali Ayhan , Human papillomavirus (HPV) prevalence and types among Turkish women at a gynecology outpatient unit , BMC Infectious Diseases , 10.1186/1471-2334-9-191 , 9 , 1 , (2009) .[dx.doi.org]
Severe Abdominal Pain
  • A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil ).[ncbi.nlm.nih.gov]
Neck Mass
  • A 62-year-old non-smoking male presented to the head and neck oncology clinic with a five-month history of enlarging right neck mass causing neck pain, dysphagia, and dysphonia.[ncbi.nlm.nih.gov]
Dysarthria
  • A 23-year-old woman presented with binocular diplopia, ptosis, dysarthria, and dysphagia, which occurred on the 3rd day after the second HPV vaccine administration. She was diagnosed with MG based on history, clinical features, and test results.[ncbi.nlm.nih.gov]

Workup

  • Further workup revealed a p16-positive right tonsillar primary with ipsilateral nodal disease and was classified as T2N2bM1. The patient underwent whole brain irradiation and definitive chemoradiation with curative intent.[ncbi.nlm.nih.gov]
  • […] condylomata demonstrates acanthosis Bowenoid papulosis: Psoriasiform hyperplasia and hyperkeratosis of the epidermis, with increased mitotic figures at all epidermal levels and keratinocytes displaying enlarged pleomorphic and hyperchromic nuclei See Workup[emedicine.medscape.com]
Mycoplasma Hominis
  • In addition, the parasite's endosymbiont Mycoplasma hominis (M.h.) cannot be detected in the Pap test.[ncbi.nlm.nih.gov]

Treatment

  • HPVinfo.ca Provides public education on HPV, including information on prevention, and treatment.[curlie.org]
  • Treatment of HPV-associated vaginitis and cervicitis was also evaluated.[ncbi.nlm.nih.gov]
  • Some treatments for anogenital warts, such as cryotherapy (freezing the warts), are done in a clinic or doctor's office while other treatments, such as prescription creams, can be used at home. Repeat treatments are often necessary.[web.archive.org]
  • After only 1 month of treatment, the gynecologic cytology report tested negative for human papillomavirus.[ncbi.nlm.nih.gov]

Prognosis

  • In patients without PIK3CA alteration, TP53 nonfunctional mutations are associated with poor prognosis.[ncbi.nlm.nih.gov]
  • BACKGROUND/AIM: The aim of this study was to assess the functions of the necroptosis process on the prognosis of high-risk human papillomavirus (HR-HPV)-related cervical cancer.[ncbi.nlm.nih.gov]
  • However, in a prospective, population-based, observational study, the association between HPV status and prognosis strengthened after adjustment for potential confounders. 9 Indeed, tumor HPV status was as important to patient prognosis as tumor stage[doi.org]
  • Given the excellent treatment response and prognosis of HPV-positive disease in general, these patients may be appropriate for definitive treatment approaches. 2014 Wiley Periodicals, Inc.[ncbi.nlm.nih.gov]

Etiology

  • CONCLUSION: A high prevalence of HPV16 suggested that HPV16 has an etiological effect on the progress of EC.[ncbi.nlm.nih.gov]
  • We investigated, retrospectively, an etiologic role for HPVs in a large series of patients with HNSCC.[ncbi.nlm.nih.gov]
  • HPV is also the etiological factor of laryngeal papillomas in both children and adults. However, a considerable amount of research demonstrates that 1-7% of the larynx papillomas in adults undergo transformation into squamous cell carcinoma.[ncbi.nlm.nih.gov]
  • A number of epidemiologic studies have suggested that HPV and Chlamydia trachomatis (CT) play a synergistic role in the etiology of cervical intraepithelial neoplasia and subsequent cervical cancer.[ncbi.nlm.nih.gov]
  • Her symptoms improved significantly with immunomodulatory therapy and re-occurred after immunomodulatory therapy was stopped, suggesting an autoimmune etiology of POTS after vaccination.[ncbi.nlm.nih.gov]

Epidemiology

  • Article Navigation Departments of Laboratory Medicine, Stomatology, and Epidemiology and Biostatistics, University of California, San Francisco Reprints or correspondence: Dr.[doi.org]
  • Such difficulty could be overcome by inferring sexual mixing parameters from HPV epidemiologic data.[ncbi.nlm.nih.gov]
  • The proposed nomenclature system facilitates the comparison of variants across epidemiological studies.[ncbi.nlm.nih.gov]
  • In this article, we review the epidemiology of HPV infection. In addition to estimates of disease frequency, we highlight risk factors for HPV infection, including the number of lifetime sex partners, which is the most salient risk factor.[ncbi.nlm.nih.gov]
  • Phylogenetic and Epidemiologic Classification of HPV Types.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • […] general Nuclear antigen Detection methods include PCR, in-situ hybridization, immunohistochemistry Can also detect via E6/E7 protein, p16 or ProExc (see below) Note: must understand what HPV subtypes / components the particular detection method targets Pathophysiology[pathologyoutlines.com]
  • […] million people are infected with HPV in the United States Lifetime incidence is greater than 50% Highest rate of infection in adolescents and young adults Average age of presentation in children is between 2.8 - 5.6 years ( Pediatr Rev 2011;32:115 ) Pathophysiology[pathologyoutlines.com]
  • This risk window was based on the underlying pathophysiology and clinical manifestation of the autoimmune disorders studied, including their insidious onset; 29 the risk window used in studies of autoimmune disorders following use of other vaccines (Appendix[cmaj.ca]
  • Pathophysiology Cells of the basal layer of the epidermis are invaded by human papillomavirus (HPV). These penetrate through skin and cause mucosal microabrasions.[emedicine.medscape.com]
  • Pathophysiology: HPV is a group of double-stranded DNA viruses. The genome encodes 6 early open reading frames (E1, E2, E4, E5, E6, E7) and 2 late open reading frames (L1, L2).[csh.org.tw]

Prevention

  • An ideal strategy would combine a preventive and therapeutic vaccine. Another prevention strategy that is being explored is topical microbicides.[cancer.gov]
  • Although these cancers are less frequent than cancer of the cervix, their association with HPV make them potentially preventable using similar primary prevention strategies as those for cervical cancer.[web.archive.org]
  • HPVinfo.ca Provides public education on HPV, including information on prevention, and treatment.[curlie.org]
  • Cervical precancers can be detected through screening, and treatment can prevent progression to cancer; HPV vaccination can prevent infection with HPV types that cause cancer at cervical and other sites (3).[ncbi.nlm.nih.gov]

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