Hypergranulosis and koilocytosis were also present. Immunohistochemical studies indicated p16 and p53 immunoexpression in the areas with cellular atypia and koilocytosis. [ncbi.nlm.nih.gov]

When the body isn’t able to fight off HPV, symptoms can present as genital warts. [healthline.com]

Presented in part: 22nd International Papillomavirus Conference, Vancouver, 30 April–6 May 2005 (abstract P-323). [doi.org]

• Pain

  There may be chronic pain, itching, or there may be a lump. Throat cancer might cause a sore throat, ear pain that doesn’t go away, constant coughing, pain or trouble swallowing or breathing, weight loss, or a lump or mass in your neck. [plannedparenthood.org]

  Signs and symptoms of oropharyngeal cancer include: Persistent sore throat, hoarseness, or coughing Persistent ear pain Pain while chewing or swallowing Weight loss A lump in the neck Difficulty opening the mouth fully Change in voice According to the [everydayhealth.com]

  Mild to moderate side effects can include: pain or swelling at the injection site slight fever headache fatigue muscle pain joint pain fainting nausea vomiting pain in the abdomen diarrhea If you get the vaccine and have any of these side effects or other [healthline.com]

  In addition to the distressing medical aspects of HPV infection, sometimes including lengthy and painful treatments, symptom recurrence, a lack of a definitive cure, and its potential for malignant transformation, HPV also results in significant emotional [ncbi.nlm.nih.gov]

  There are usually no symptoms, but some people may notice: bleeding after sex pain during sex abnormal period, vaginal bleeding or discharge pain in the pelvis. [health.gov.au]

• Falling

  Infection with the hpv-16 strain often precedes certain forms of the disease, researchers say Issue 27 Summer/Fall 2016 Experts have long suspected that infection with the human papillomavirus (HPV) in the mouth and throat might be a contributing cause [nyp.org]

  Gillison says this is probably due to falling consumption of tobacco and alcohol, which are also linked to the cancers. [newscientist.com]

  Falls after fainting may sometimes cause serious injuries, such as head injuries. These can largely be prevented by keeping the person seated for up to 15 minutes after vaccination. [cancer.gov]

  The most commonly prescribed medicines fall into these four categories: reverse transcriptase inhibitors (RTIs) protease inhibitors entry or fusion inhibitors integrase inhibitors Combination therapy, with multiple drug types, is commonly used. [healthline.com]

  Given that the global burden still falls heavily on African and Asian countries where vaccination and screening programmes are lacking, there is still a need to for more countries to introduce the HPV vaccine. [web.archive.org]

• Weakness

  If you have a weak immune system or HIV, ask your doctor about checking for anal and penile cancers. If your partner is new, condoms may lower your chances of getting HPV or developing HPV-related diseases. [web.archive.org]

  There is thus no evidence for homologous immunity against any of the HPV types that we studied, suggesting that intratype competition is weak or absent. [pnas.org]

  Certain men are more likely to develop HPV-related cancers: Men with weak immune systems (including those with HIV) who get infected with HPV are more likely to develop HPV-related health problems. [cdc.gov]

• Fever

  […] syphilis Tetanus Toxic shock syndrome (other than streptococcal) Trichinosis Tuberculosis Tularemia Typhoid fever Vancomycin intermediate Staphylococcus aureus (VISA) Vancomycin resistant Staphylococcus aureus (VRSA) Vibrio infections Yellow fever The [nlm.nih.gov]

  […] syphilis Tetanus Toxic shock syndrome (other than streptococcal) Trichinosis Tuberculosis Tularemia Typhoid fever Vancomycin intermediate Staphylococcus aureus (VRSA) Vancomycin resistant Staphylococcus aureus (VRSA) Vibriosis Yellow fever The county [web.archive.org]

  A77 viral disease other/nos (ICPC-2 Rubric) Description Hierarchies Relations PubMed / Doc'CISMeF viral disease other/nos autre maladie virale; maladie virale non classée ailleurs maladie virale autre ou nca adenovirus; Coxsackie diseases; dengue fever [hetop.eu]

  You do not need to delay getting the vaccine if you are sick with a minor cold or have a minor fever. Where can I get the vaccine? In most provinces, boys and girls can get the vaccine as part of a program at school. [caringforkids.cps.ca]

  Allergy, Stuffy Nose, Itchy Eyes, Dry Cough Acceptable as long as you feel well, have no fever, and have no problems breathing through your mouth. A donor with an acute infection should not donate. [redcrossblood.org]

• Swelling

  The most commonly reported adverse reactions were injection site pain, swelling, redness, and headaches. Gardasil 9 is manufactured by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., based in Whitehouse Station, New Jersey. [web.archive.org]

  Mild to moderate side effects can include: pain or swelling at the injection site slight fever headache fatigue muscle pain joint pain fainting nausea vomiting pain in the abdomen diarrhea If you get the vaccine and have any of these side effects or other [healthline.com]

• Pertussis

  Examples are rubeola (measles) and pertussis (whooping cough). Report of total number of cases. Examples are chickenpox and influenza. Cancer. Cancer cases are reported to the state Cancer Registry. [nlm.nih.gov]

  Since almost every state requires Tdap (tetanus, diphtheria, and acellular pertussis vaccine) for middle school entry, parents can use this visit to the doctor to get the first HPV and quadrivalent meningococcal conjugate vaccines for their preteen at [cdc.gov]

• Nausea

  Mild to moderate side effects can include: pain or swelling at the injection site slight fever headache fatigue muscle pain joint pain fainting nausea vomiting pain in the abdomen diarrhea If you get the vaccine and have any of these side effects or other [healthline.com]

  The most common systemic adverse events for Gardasil compared to saline placebo were fever (13.0% vs. 11.2%) and nausea (6.7% vs. 6.6%). [web.archive.org]

  Common side effects of HPV vaccine include: Pain, redness, or swelling in the arm where the shot was given Fever Headache or feeling tired Nausea Muscle or joint pain Brief fainting spells and related symptoms (such as jerking movements) can happen after [cdc.gov]

• Skin Lesion

  In contrast, analyses of skin lesions suggest that beta HPV types may be involved only at early stage of skin carcinogenesis. [ncbi.nlm.nih.gov]

  Methods Using the hyperkeratotic skin lesion polymerase chain reaction/multiplex genotyping assay, each swab sample was used to genotype for 23 cutaneous wart‐associated HPV types. [doi.org]

  Plantar warts – These tend to be flatter lesions that sometimes can be indrawn into the skin. They are found on the soles of the feet. Sometimes they may turn black and painful before spontaneously disappearing. [myvmc.com]

  Smallpox vaccination – close contact with someone who has had the vaccine in the last eight weeks and you have since developed skin lesions or symptoms. Wait 8 weeks (56 days) from the date of the first skin lesion or sore. [redcrossblood.org]

• Erythema

  […] autre maladie virale; maladie virale non classée ailleurs maladie virale autre ou nca adenovirus; Coxsackie diseases; dengue fever; Ross River fever adénovirus; maladie à coxsackie; dengue; fièvre de la Ross River infections other viral exanthem A76; erythema [hetop.eu]

  The most common vaccination site toxicities observed for Gardasil compared to aluminum-containing placebo and saline placebo were pain (83.9% vs. 75.4% and 48.6%), swelling (25.4% vs. 15.8% and 7.3%), and erythema (24.6% vs. 18.4% and 12.1%). [web.archive.org]

  In clinical trials, the most common side effects were injection site pain, swelling, and erythema. [ncbi.nlm.nih.gov]

  Swelling and erythema were the next most common reactions in the vaccine and placebo groups. [cdc.gov]

• Headache

  The most commonly reported adverse reactions were injection site pain, swelling, redness, and headaches. Gardasil 9 is manufactured by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., based in Whitehouse Station, New Jersey. [web.archive.org]

  Mild to moderate side effects can include: pain or swelling at the injection site slight fever headache fatigue muscle pain joint pain fainting nausea vomiting pain in the abdomen diarrhea If you get the vaccine and have any of these side effects or other [healthline.com]

  Common side effects of HPV vaccine include: Pain, redness, or swelling in the arm where the shot was given Fever Headache or feeling tired Nausea Muscle or joint pain Brief fainting spells and related symptoms (such as jerking movements) can happen after [cdc.gov]

• Genital Lesions

  Efficacy of Quadrivalent Vaccine Efficacy against External Genital Lesions in the Per-Protocol Population. [nejm.org]

  METHODS: 14 men and eight women with genital warts had cytobrush samples taken from genital lesions, finger tips, and tips of finger nails. Samples were examined for the presence of HPV DNA by the polymerase chain reaction. [doi.org]

  HPV-related external genital lesions (EGLs) consist of two categories: condyloma (genital warts) and penile intraepithelial neoplasia (PIN). [grantome.com]

  An infection is considered subclinical when there is no evidence of genital lesions or squamous intraepithelial lesions (SILs). [clinicaladvisor.com]

  Low-risk types (especially HPV -6 and HPV -11 ) can cause benign anogenital warts ( condylomata acuminata ) and papillomatous nodules in other genital (e.g., squamous intraepithelial lesions of the cervix ) or non-genital (e.g., oral warts, respiratory [amboss.com]

For women with minor abnormalities on their Pap test, doctors use the HPV test to determine if they have a high-risk HPV infection and need further workup such as a colposcopy. [healthywomen.org]

[…] condylomata demonstrates acanthosis Bowenoid papulosis: Psoriasiform hyperplasia and hyperkeratosis of the epidermis, with increased mitotic figures at all epidermal levels and keratinocytes displaying enlarged pleomorphic and hyperchromic nuclei See Workup [emedicine.com]

• Human Papillomavirus

  These results suggest that genital human papillomavirus is not sexually transmitted in all cases and that it may be acquired by modes other than sexual contact. [doi.org]

  High-risk human papillomavirus infection usually is seen at one anatomic site in an individual. [ncbi.nlm.nih.gov]

  What is Human Papillomavirus (HPV) Statistics on Human Papillomavirus (HPV) Risk Factors for Human Papillomavirus (HPV) Progression of Human Papillomavirus (HPV) Symptoms of Human Papillomavirus (HPV) Clinical Examination of Human Papillomavirus (HPV) [myvmc.com]

  […] determinants of human papillomavirus genital infection in men, Br J Cancer, vol. 86 (pg. 705 - 11 ) 14 Lack of detection of human papillomavirus DNA in male urine samples, Genitourin Med, vol. 69 (pg. 276 - 9 ) 15 Detection of human papillomavirus DNA [dx.doi.org]

Note: Pregnant women, or women trying to conceive, should consult closely with their doctor before starting treatment. HPV treatments can affect pregnancy, so doctors may want to delay treatment until after childbirth. [web.archive.org]

Treatment There is no ‘perfect’ treatment for HPV infection and not everyone requires treatment. The decision to treat genital warts should be made after discussion with your doctor about the advantages and disadvantages. [sahealth.sa.gov.au]

Genital warts can disappear on their own or with treatment, but a person may still have the virus in their body. Many people want to get treatment to make the visible warts go away. [smartsexresource.com]

Early treatment prevents up to 80% of cervical cancers in these countries. [who.int]

This is a more accurate way to describe the prognosis for patients with a particular type and stage of cancer. Five-year rates are used to produce a standard way to discuss prognosis, or outlook for survival. [web.archive.org]

However, in a prospective, population-based, observational study, the association between HPV status and prognosis strengthened after adjustment for potential confounders. 9 Indeed, tumor HPV status was as important to patient prognosis as tumor stage [doi.org]

Prognosis Prevention Education about possible risk factors and effective preventive measures, such as: HPV vaccinatio n : All boys and girls should be vaccinated at 11–12 years of age. [amboss.com]

The recognition that HPV-positive tumours are aetiologically distinct and have a better prognosis than HPV-negative tumours has led to the suggestion that treatment for each type could differ. [nccid.ca]

[Indexed for MEDLINE] Free full text Publication type, MeSH terms, Substances, Grant support Publication type Case Reports MeSH terms Adult Biomarkers, Tumor/analysis Carcinoma, Squamous Cell/chemistry Carcinoma, Squamous Cell/etiology* Carcinoma, Squamous [ncbi.nlm.nih.gov]

The potential etiologic role of human papillomavirus (HPV) in oropharyngeal cancer is supported by a growing body of evidence. [web.archive.org]

A multifactorial etiology of the disease is likely with the microbiota of the vagina playing a role. [jcvi.org]

Article Navigation Departments of Laboratory Medicine, Stomatology, and Epidemiology and Biostatistics, University of California, San Francisco Reprints or correspondence: Dr. [doi.org]

Epidemiologic studies provide useful information regarding the magnitude of STD risk reduction associated with condom use. Extensive literature review confirms that the best epidemiologic studies of condom effectiveness address HIV infection. [cdc.gov]

[…] years: Human papillomavirus (HPV) and cytology cotesting every 5 years (preferred) or cytology alone every 3 years (acceptable) Over 65 years: no screening recommended if adequate prior screening has been negative and high risk factors are not present Pathophysiology [pathologyoutlines.com]

This risk window was based on the underlying pathophysiology and clinical manifestation of the autoimmune disorders studied, including their insidious onset; 29 the risk window used in studies of autoimmune disorders following use of other vaccines (Appendix [cmaj.ca]

Human papillomavirus infection: Epidemiology and pathophysiology. Gynecol Oncol. 2007; 107 :S2–S5. [ PubMed ] [ Google Scholar ] 4. Weinstock H, Berman S, Cates W. [ncbi.nlm.nih.gov]

Pathophysiology [ edit ] Common warts have a characteristic appearance under the microscope. [en.wikipedia.org]

HPV is essential in the pathophysiology of pre-malignance cervical abnormalities and cervical cancer, conditions that are highly prevalent among women in all the world. Women with SLE present even higher risk of development HPV diseases. [ped-rheum.biomedcentral.com]

Looking for a Less Expensive and More Comprehensive Approach to HPV Prevention To help bring down the cost of HPV prevention, researchers are working on finding a different way to attack it. [cancer.org]

An ideal strategy would combine a preventive and therapeutic vaccine. Another prevention strategy that is being explored is topical microbicides. [cancer.gov]

Primary prevention Secondary prevention Tertiary prevention Girls 9-14 years HPV vaccination Women 30 years old or older All women as needed Girls and boys, as appropriate Health information and warnings about tobacco use Sex education tailored to age [who.int]