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Human Parvovirus B19


Presentation

  • Subsequently, evidence of HPV-B19 infection at the time of clinical presentation was ascertained.[ncbi.nlm.nih.gov]
  • Its other clinical presentations include arthralgia, arthritis, transient aplastic crisis, chronic anemia, congenital anemia, and hydrops fetalis.[ncbi.nlm.nih.gov]
  • The patient, a 27-year-old Filipino woman, presented with an erythemato-papular-purpuric eruption localized to the lower limbs.[ncbi.nlm.nih.gov]
  • Our case is unusual due to the presence of a cutaneous rash mimicking leukocytoclastic vasculitis at presentation, moderate leukopenia with thrombocytopenia and the presence of a broad array of autoantibodies.[ncbi.nlm.nih.gov]
  • We present a case of anaemia in HIV positive patient who did not respond to change of drug therapy and nutritional supplements. Bone marrow biopsy suggested parvo virus infection.[ncbi.nlm.nih.gov]
Leg Edema
  • A 39-year-old woman visited our hospital because of low-grade fever, diarrhea, bilateral leg edema, and numbness in the right arm, one and a half months after her daughter developed EI.[ncbi.nlm.nih.gov]
Intravenous Administration
  • Although intravenous administration of Ig (IVIg) reduced serum B19 DNA, the aplastic status of her bone marrow did not improve. Both aplastic anemia and persistent B19 viremia were successfully treated by BMT from an HLA-identical sibling donor.[ncbi.nlm.nih.gov]
Abdominal Pain
  • General symptoms and signs included fever, hypotension, nausea, vomiting, abdominal pain, inguinal lymphadenopathy and polyarthralgia. Laboratory examinations showed leukocytosis, increase in total serum IgA, proteinuria and haematuria.[ncbi.nlm.nih.gov]
  • Two days before, her 6 year old son had been admitted to a clinic with a 1-day history of fever, headache, abdominal pain and vomiting.[ncbi.nlm.nih.gov]
Oral Ulcers
  • Four weeks later, she had high fever, polyarthritis, and oral ulcers, additionally diagnosed with SLE, and subsequently, 15 mg of prednisone was started.[ncbi.nlm.nih.gov]
Microscopic Hematuria
  • When she was 29 years old the first biopsy, performed because of microscopic hematuria and mild proteinuria, showed endocapillary and mesangial proliferative glomerulonephritis in light microscopy as well as deposits of immunoglobulins (Igs) and complement[ncbi.nlm.nih.gov]
Ataxia
  • To the best of the authors' knowledge, this may be the first report of human parvovirus B19 encephalitis complicated by severe ataxia in childhood.[ncbi.nlm.nih.gov]
  • Parvovirus B19 associated acute cerebellar ataxia might occur due to transient vascular reaction in the cerebellum during infection.[ncbi.nlm.nih.gov]
  • The DDR signaling is mainly mediated by the ATR (ataxia telangiectasia-mutated and Rad3-related) pathway, which promotes replication of the viral genome; however, the exact mechanisms employed by B19V to take advantage of the DDR for virus replication[ncbi.nlm.nih.gov]
Dysarthria
  • […] with acute encephalitis by parvovirus B19, documented by polymerase chain reaction performed on cerebrospinal fluid, who was treated with intravenous immunoglobulins and dexamethasone and who developed a cerebellar syndrome with ataxia, dysmetria, and dysarthria[ncbi.nlm.nih.gov]
Dysmetria
  • […] child affected with acute encephalitis by parvovirus B19, documented by polymerase chain reaction performed on cerebrospinal fluid, who was treated with intravenous immunoglobulins and dexamethasone and who developed a cerebellar syndrome with ataxia, dysmetria[ncbi.nlm.nih.gov]
Cerebellar Ataxia
  • Parvovirus B19 associated acute cerebellar ataxia might occur due to transient vascular reaction in the cerebellum during infection.[ncbi.nlm.nih.gov]

Workup

Liver Biopsy
  • One patient was a 56-year-old female with severe hepatitis, with antimitochondrial antibody seropositivity and submassive necrosis at liver biopsy, who responded to corticosteroid therapy.[ncbi.nlm.nih.gov]

Treatment

  • CONCLUSION: Pure red cell aplasia induced by HPV B19 infection is a disease with a favourable prognosis after symptomatic and supportive treatment.[ncbi.nlm.nih.gov]
  • The serum test for anti-erythropoietin antibodies also became negative after the treatment.[ncbi.nlm.nih.gov]
  • However, renal transplant recipients are not routinely tested for parvovirus B19 infection, since there is scanty data or consensus on screening for B19 infection, as well as for treatment or preventive management of transplanted patients.[ncbi.nlm.nih.gov]
  • Accordingly, more significantly increased claudin-1 and decreased occludin are detected in A549 cells by treatment with TNF-α or both dosages of HBoV-VP1u than that of the control.[ncbi.nlm.nih.gov]
  • Blood HPV-B19 PCR results were negative from 35 to 159 days after treatment. Four patients showed side effects of IVIG treatment: acute reversible renal failure (n 2) and pulmonary edema (n 2).[ncbi.nlm.nih.gov]

Prognosis

  • CONCLUSION: Pure red cell aplasia induced by HPV B19 infection is a disease with a favourable prognosis after symptomatic and supportive treatment.[ncbi.nlm.nih.gov]
  • Ischemia/complications Myocardial Ischemia/diagnosis Myocardial Ischemia/immunology* Parvoviridae Infections/blood Parvoviridae Infections/complications Parvoviridae Infections/diagnosis Parvoviridae Infections/immunology* Parvovirus B19, Human/immunology* Prognosis[ncbi.nlm.nih.gov]

Etiology

  • Our patient's case may provide a clue to the etiology of ANCA-associated vasculitis or lupus nephritis.[ncbi.nlm.nih.gov]
  • The etiology of transient erythroblastopenia of childhood (TEC) remains unknown, although an association with viral infections has been proposed.[ncbi.nlm.nih.gov]
  • After stabilization of the patient, finding the etiology of the seizure is of paramount importance. A careful history and physical examination may allow a diagnosis without need for further evaluation.[ncbi.nlm.nih.gov]
  • In conclusion, B19 should be included in differential diagnosis of encephalitic syndromes of unknown etiology in all age groups. Diagnosis should rely on investigation of anti-B19 IgM antibodies and detection of B19 DNA in serum or CSF.[ncbi.nlm.nih.gov]
  • Abstract Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown etiology that impacts various organs including liver. Recently, human parvovirus B19 (B19) is recognized to exacerbate SLE.[ncbi.nlm.nih.gov]

Epidemiology

  • To confirm these outcomes, goal-targeted studies are recommended to exactly identify epidemiological scenarios and explore potential pathogenic mechanisms of these complications.[ncbi.nlm.nih.gov]
  • Moreover, the epidemiological and ecological relationships between human parvovirus B19, man and environment have aroused increasing interest in this virus.[ncbi.nlm.nih.gov]
  • To understand the epidemiology of B19V infection in the greater metropolitan area of Hangzhou, East China, we performed surveys of IgM and IgG antibodies against B19V and quantification of B19V DNA, by using enzyme-linked immunosorbent assay and quantitative[ncbi.nlm.nih.gov]
  • Only few studies have been carried out on distribution and molecular epidemiology of B19 in Iran. We aimed to determine the frequency and genotype of B19 among Iranian patients infected with HIV.[ncbi.nlm.nih.gov]
  • Epidemiological studies done on Niterói population showed that B19 infection occurs periodically in late spring and summer.[scielo.br]
Sex distribution
Age distribution

Pathophysiology

  • Though AITD can be associated with acute EVB19 infection, it is not clear whether EVB19 could have a pathogenetic role in autoimmune thyroid diseases pathophysiology.[ncbi.nlm.nih.gov]
  • Pathophysiological mechanisms involved include lysophosphatidylcholine producing phospholipase A2 (PLA2) activity of the B19V capsid protein VP1. Most recently, VP1 and lysophosphatidylcholine have been shown to inhibit Na( )/K( ) ATPase.[ncbi.nlm.nih.gov]

Prevention

  • During BMT, use of high-titer IVIg for B19 might prevent B19-associated organ failure.[ncbi.nlm.nih.gov]
  • However, renal transplant recipients are not routinely tested for parvovirus B19 infection, since there is scanty data or consensus on screening for B19 infection, as well as for treatment or preventive management of transplanted patients.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: Day-care employees are at an increased risk of B19V infection, which warrants preventive measures. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to .[ncbi.nlm.nih.gov]
  • Public awareness, enlightenment, and screening for the virus should be encouraged to prevent fetal complications during pregnancy.[ncbi.nlm.nih.gov]
  • The impact of this infection on the patient's survival or long-term morbidity is not known. 22 No specific strategies have proved useful in preventing parvovirus B19 infection. 20 The relatively low incidence of this infection and the adverse effects[revistanefrologia.com]

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