Sinus bradycardia is a characteristic presentation of the vasovagal response; examples of other presentations include arrest or atrioventricular block. [ncbi.nlm.nih.gov]

• Fatigue

  […] prescribing of these drugs for use in patients for whom alternative treatment options are inadequate Cases of adrenal insufficiency reported with opioid use, more often following greater than one month of use; symptoms may include nausea, vomiting, anorexia, fatigue [reference.medscape.com]

  Like most prescription narcotics, hydrocodone cessation can spark withdrawal symptoms, which may include: Muscle aches Runny nose Sweating Chills Goosebumps Vomiting Diarrhea Anxiety Headaches Mood swings Depression Fatigue Drug cravings Symptoms last [americanaddictioncenters.org]

  The most common side effects are constipation, nausea, drowsiness, fatigue, headache, dizziness, dry mouth, vomiting and itching. [cbsnews.com]

  The most common side effects reported in company trials included constipation, nausea, drowsiness, fatigue, dizziness, dry mouth, vomiting and itching. [nydailynews.com]

• Unconsciousness

  This is when an unconscious or semi-conscious user who is lying on their back vomits into their mouth and unknowingly suffocates. [psychonautwiki.org]

  A cuffed endotracheal tube should be inserted before gastric lavage of the unconscious patient and, when necessary, to provide assisted respiration. Meticulous attention should be given to maintaining adequate pulmonary ventilation. [rxlist.com]

  The DEA notes that a doctor from New York, one of the States that has already scheduled HCPs as schedule II controlled substances under State law, asserted in his comment that up-scheduling “has reduced unconscious (or conscience-less) prescribing without [federalregister.gov]

• Developmental Delay

  Fatal opioid toxicity occurred in a developmentally delayed child aged 5 years 9 months who was inadvertently administered high doses of hydrocodone for a respiratory tract infection. [ncbi.nlm.nih.gov]

  Lauwers, Gideon Koren Abstract Fatal opioid toxicity occurred in a developmentally delayed child aged 5 years 9 months who was inadvertently administered high doses of hydrocodone for a respiratory tract infection. [doi.org]

• Nausea

  The patient's pain and nausea were quantified using a 100-mm visual analog scale (VAS) at baseline prior to drug administration and following doses of hydrocodone, oxycodone, or ondansetron. [ncbi.nlm.nih.gov]

  […] of the skin or eyes); or low cortisol levels -- nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness. [northshore.org]

  If you have nausea, you may take this drug with food, although doing so may decrease its effectiveness. [psyweb.com]

• Vomiting

  Subjects were included if they had self-reported pain or nausea and were excluded if they were unable to speak English, were less than 18 years of age, had liver or renal failure, or carried diagnoses of chronic pain or cyclic vomiting. [ncbi.nlm.nih.gov]

  Hydrocodone can also cause nausea and vomiting; a significant number of deaths attributed to opioid overdose are caused by aspiration of vomit by an unconscious victim. [psychonautwiki.org]

  The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. [northshore.org]

• Suicidal Ideation

  ideation caused by withdrawal symptoms and untreated pain. [doi.org]

• Cloudy Urine

  Check with your doctor immediately if any of the following side effects occur: Less common Bladder pain bloating or swelling of the face, arms, hands, lower legs, or feet bloody or cloudy urine body aches or pain chills cough depression difficult or labored [drugs.com]

• Bladder Pain

  Check with your doctor immediately if any of the following side effects occur: Less common Bladder pain bloating or swelling of the face, arms, hands, lower legs, or feet bloody or cloudy urine body aches or pain chills cough depression difficult or labored [drugs.com]

• Stupor

  Toxicity Symptoms of overdose include respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, dizziness, ringing in [druglib.com]

  Signs And Symptoms Hydrocodone Serious overdose with hydrocodone is characterized by respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis ), extreme somnolence progressing to stupor or coma, skeletal [rxlist.com]

  […] elimination Not Available Half life 1.25-3 hours Clearance Not Available Toxicity Symptoms of overdose include respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence progressing to stupor [drugbank.ca]

• Poor Coordination

  coordination puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue restlessness shivering talking or acting with excitement you cannot control trembling or shaking twitching vomiting Get emergency help immediately if any of the [drugs.com]

One patient receiving hydrocodone ER 30 mg twice daily experienced a severe AE of neurosensory deafness that was considered treatment related. Mean WPI and API remained steady throughout open-label treatment. [ncbi.nlm.nih.gov]

“The DEA finds that the scientific, medical, and epidemiological data are robust and support rescheduling HCPs into schedule II of the CSA (Controlled Substances Act). [nationalpainreport.com]

Access is intended to spur hypothesis generation and testing, cross-cohort analysis of risk factors and outcomes, development of new signal processing tools, and to enhance training in clinical analysis, signal processing, epidemiological analysis, and [incosact.org]

Our findings are consistent with previous epidemiologic and ethnographic studies that suggest that oxycodone is favored over hydrocodone. [doi.org]

CDC Wide-Ranging Online Data for Epidemiologic Research (WONDER). Available at . Accessed June 30, 2011. CDC. Unintentional and undetermined poisoning deaths-11 states, 1990-2001. MMWR 2004;53:233-8. Florida Department of Law Enforcement. [imic.or.jp]

Useful For Suggests clinical disorders or settings where the test may be helpful Detection and quantification of hydrocodone, norhydrocodone, and hydromorphone in urine Clinical Information Discusses physiology, pathophysiology, and general clinical aspects [mayomedicallaboratories.com]

Ballas, Pathophysiology and principles of management of the many faces of the acute vaso‐occlusive crisis in patients with sickle cell disease, European Journal of Haematology, 95, 2, (113-123), (2014). [doi.org]

This will prevent some patients from monthly doctor’s visits to obtain refills. [rehabs.com]

Coadministration of clarithromycin (a potent cytochrome P450 3A4 inhibitor) for an ear infection and valproic acid for seizures since birth further prevented drug elimination from the body. [ncbi.nlm.nih.gov]

However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. [mayoclinic.org]