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Hydrocortisone

Compound F


Presentation

  • When this occurs in pregnant patients during the peripartum period, the usually expected physiological changes may not be present.[ncbi.nlm.nih.gov]
  • Primary adrenal insufficiency is relatively rare in children and, if unrecognized, may present with cardiovascular collapse, making it a potentially life-threatening entity.[ncbi.nlm.nih.gov]
  • Presently, a controversial debate is ongoing regarding whether reduced cortisol secretion in post-traumatic stress disorder promotes an automatic retrieval of trauma-associated memories.[ncbi.nlm.nih.gov]
  • Association of prolonged neonatal cholestasis with hypoglycemia, small penis and congenital hypothalamo-hypopituitary derangement is presented.[ncbi.nlm.nih.gov]
  • This case is presented to draw the attention of clinicians to the occasional hazard of intravenous corticosteroid preparations, specially hydrocortisone.[ncbi.nlm.nih.gov]
Intravenous Administration
  • The patient recovered after reanimation techniques and intravenous administration of atropine, epinephrine and plasma expanders. Although allergic reactions to corticosteroids appear to be rare there are a few case reports in the literature.[ncbi.nlm.nih.gov]
  • Two patients with asthma developed an anaphylactic reaction after the intravenous administration of hydrocortisone. In both cases, the reaction included the rapid development of airflow obstruction.[ncbi.nlm.nih.gov]
  • Our objective was to analyze the inflammatory activity of plasma and carotid plaque MMP-8 and MMP-9 after intravenous administration of hydrocortisone.[ncbi.nlm.nih.gov]
Language Delays
  • The primary outcome at follow-up was a composite of death, cognitive or language delay, cerebral palsy, severe hearing loss, or bilateral blindness at a corrected age of 18-22 months.[ncbi.nlm.nih.gov]

Treatment

  • Analysis of variance found a significant difference between treatment groups (F2,89 3.6, p 0.03), with both cream treatments having significantly better pain reduction than the control, no cream treatment (hydrocortisone vs. no cream, p 0.04; placebo[ncbi.nlm.nih.gov]
  • Smoother cortisol profiles and more sustained cortisol exposure were achieved during treatment with Plenadren, which was the preferred treatment in most patients.[ncbi.nlm.nih.gov]
  • What's more, amelioration of hemodynamic variables was observed after hydrocortisone treatment. No significant association between hydrocortisone treatment and innate immune cell phagocytic function was observed.[ncbi.nlm.nih.gov]
  • HBP was shown to have a good efficacy in the treatment of various oozing and lichenified eczematous skin diseases including atopic dermatitis (AD) and in the treatment of psoriasis vulgaris.[ncbi.nlm.nih.gov]
  • The use of equivalent doses of modified release hydrocortisone preparation should be avoided in patients on mitotane treatment. 2017 John Wiley & Sons Ltd.[ncbi.nlm.nih.gov]

Etiology

  • The etiology of hypotension in the newborn may vary, but the very low birth weight and extremely low birth weight preterm infants are less likely to respond to conventional cardiovascular support when they develop hypotension.[ncbi.nlm.nih.gov]
  • Episodic variation in plasma corticosteroids in subjects with Cushing’s syndrome of differing etiology. J. Clin. Endocrinol. Metab. 36 : 906, 1973. PubMed CrossRef Google Scholar 9. Boyar R.M., Witkin M., Carruth A., Ramsey J.[doi.org]

Epidemiology

  • Intensive Care Unit, Centre Hospitalier Universitaire Rennes, France. 10 Neonatal Intensive Care Unit, Centre Hospitalier de Saint-Denis, France. 11 Neonatal Intensive Care Unit, Centre Hospitalier Universitaire Grenoble, France. 12 Unit of Clinical Epidemiology[ncbi.nlm.nih.gov]
  • Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001 ;29: 1303 - 1310 2. Moreno R, Afonso S, Fevereiro T. Incidence of sepsis in hospitalized patients.[nejm.org]
  • Nonlinearity in the epidemiology of complex health and disease processes. Theor Med Bioeth 1998 ;19: 591 – 607. Google Scholar Crossref Medline 134. Galea, S, Riddle, M, Kaplan, GA, Causal thinking and complex system approaches in epidemiology.[doi.org]
  • Department of Epidemiology and Public Health University College London London UK 2. Unilever Research Colworth Bedford UK 3. Wolfson Institute for Biomedical Research University College London London UK[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • OBJECTIVE: Increased cardiovascular and cerebrovascular morbidity and mortality in hypopituitary subjects may be linked to inappropriate glucocorticoid exposure; however, the pathophysiology remains unclear.[ncbi.nlm.nih.gov]
  • The hypothalamic- pituitary- adrenal axis in PTSD: Pathophysiology and treatment interventions Prog. Neuropsychopharmacol. Biol. Psychiatry 89, (2019) . 3. Quinkler, M., and Stewart, P.M. Hypertension and the cortisol- cortisone shuttle J. Clin.[caymanchem.com]
  • In: Zanchetti A, Mancia G (eds) Handbook of hypertension—pathophysiology of hypertension.[doi.org]
  • Cornelius, The Role of Sex Differences in Inflammation and Autoimmune Diseases, Sex Differences in Cardiovascular Physiology and Pathophysiology, 10.1016/B978-0-12-813197-8.00013-0, (205-217), (2019).[doi.org]

Prevention

  • Overexpression of parkin provides protection against cellular stresses and prevents dopamine cell loss in several PD animal models.[ncbi.nlm.nih.gov]
  • These key benefits may help patients by preventing septic shock.[ncbi.nlm.nih.gov]
  • The prevention of adverse drug reactions to antivenom serum poses a formidable challenge in the management of snakebite.[ncbi.nlm.nih.gov]
  • Oral therapy with glucocorticoids and mineralcorticoids is administered to prevent adrenal crisis and to control hyperandrogenism.[ncbi.nlm.nih.gov]
  • BACKGROUND: To determine whether the application of 1% hydrocortisone cream during radiation therapy can prevent the occurrence of moist desquamation.[ncbi.nlm.nih.gov]

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