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Hyoscyamus Niger Poisoning

Black Henbane Poisoning


Presentation

  • […] information on all major drugs of the time, including opium, cocaine, heroin, cannabis, peyote, fly agaric, henbane, datura, alcohol, kava, betel, coffee, tea, cocoa, and tobacco • A book credited with starting an era of ethnobotany that continues to the present[books.google.com]
  • Patients may present to the emergency department with a psychotic picture [ 3 ].[panafrican-med-journal.com]
  • Activated charcoal can bind tropane alkaloids and may be administered if patients present within 1-2 hours of ingestion and bowel sounds are present.[calpoison.org]
  • YEAR : 2002 CITATION : Vet Hum Toxicol, 44(1), 31-32 [English] FDA #: F25498 ABSTRACT : We present a retrospective analysis of plant and mushroom ingestions reported to the Toxicologic Information Center at the Catholic University of Chile.[accessdata.fda.gov]
Fever
  • الصفحة 31 - ... and inflammation, especially of the throat and has been known to cure ague (burning fever). Boiling the inner bark in vinegar produces a useful external wash for lice and for skin problems such as scabies and scabs.[books.google.com]
  • FEVER AND CHILL Fever and chill Night In bed Periodic, recurring; every fourth day Continued fever in brain (cerebral) dazed from fever in complete daze Stages of chill, heat and sweat; chill followed by heat more ...[abchomeopathy.com]
  • Fever : Its fevers are low forms of fever, the continued fever and the typhoid. Modalities:- Worse : - At night, During menses, Mental activity, Jealousy, unhappy love, When lying down Better Stooping.[planethomeopathy.com]
  • Important Characteristic Features Fever (typhoid): Hyoscyamus is very useful in typhoid fever. In the early stage of the disease, the delirium and later, symptoms of cerebral paralysis may call for Hyoscyamus.[homeopathicmedicine.info]
  • Now let me speak of the fevers of Hyoscyamus. I have already given you the symptoms which would indicate the drug in typhoid fever. We have to see how we may apply it in the treatment of fevers with skin symptoms, as scarlatina.[vithoulkas.com]
Hyperthermia
  • […] due to hyperthermia) and repetitive picking behavior.[calpoison.org]
  • Acute poisoning Stage of early stimulation: Euphoria, excitement, mydriasis, increased HR, BP, RR Stage of advanced stimulation: Vomiting, muscle twitching, dyspnoea, hyperthermia, hallucinations, convulsions Stage of depression: Paralysis of muscles,[slideshare.net]
Pathologist
  • The work is very well referenced, and provides critical information for law enforcement, forensic pathologists, and others, that could be dealing with the criminal poisoner." John H.[books.google.com]
Enuresis
  • Urinary: urination involuntary, suppressed, labour; bladder paralysed, enuresis. Male: impotence. Female: lochia suppressed; pain, inflammation ovary, right.[qjure.com]
Respiratory Disorders
  • Extracts from the seeds can be used to dilate the bronchi of individuals with respiratory disorders or to relax overactive urinary bladders (Gilani et al. 2008).[sites.evergreen.edu]
Nausea
  • […] alternate, simple, toothed; flowers axillary, tubular, 5-parted, greenish yellow or yellowish with purple veins; fruit a capsule Family: Solanaceae Origin: Europe Poison Part: All parts Poison Delivery Mode: Ingestion Symptoms: Salivation, headache, nausea[plants.ces.ncsu.edu]
  • Stomach: belching empty, bitter; nausea, with vertigo; vomiting, with convulsions; haematemesis; violent cramps, vomiting; burning; epigastrium tender, irritating food; hiccough, night; toxic gastritis.[qjure.com]
  • Severity of symptoms can range from headache and nausea to convulsions and death.[medical-dictionary.thefreedictionary.com]
  • This type of poisoning, which can take place even after ingesting a small amount of plant or seed matter, can have symptoms such as increased salivation, headache, nausea, convulsions, hallucinations, stupor, coma and death.[worldseedsupply.com]
  • Nausea, with vertigo. Vomiting, with convulsions; hæmatemesis; violent cramps, relieved by vomiting; burning in stomach; epigastrium tender. After irritating food . Abdomen.-- Colic, as if abdomen would burst. Distention.[homeoint.org]
Abdominal Pain
  • Ingesting just four to eight of the seeds can kill a human, but not before he or she suffers through a host of unpleasant symptoms, including but not limited to nausea, seizures, diarrhea, purging and abdominal pain.[mnn.com]
  • Most symptomatic patients develop nausea, vomiting, diarrhea and abdominal pain, beginning 2-24 hours after ingestion and lasting up to several days.[calpoison.org]
  • Manifestations of acute poisoning include abdominal pain, nausea, vomiting, and collapse.[medical-dictionary.thefreedictionary.com]
Food Poisoning
  • See also food poisoning. Patient discussion about poisoning Q. How Do You Treat Food Poisoning? I've been suffering from food poisoning for the last two days, is there a way to treat it? Is there specific food I should avoid? A.[medical-dictionary.thefreedictionary.com]
  • Jimson weed food poisoning. An epidemic at Usangi rural government hospital. Trop Geogr Med. 1991 Jan-Apr. 43(1-2):85-90. [Medline]. Schultes RE, Hoffmann A. Holy flower of the North Star: Datura.[emedicine.medscape.com]
Flatulence
  • Properly selected according to this depression or the contrary, and in doses to meet each condition, it is extremely useful in spasmodic dysmenorrhea, flatulent colic, gastrodynia, spasmodic bowel disorders, painful hemorrhoids, spasmodic cystic pain,[henriettes-herb.com]
  • Uncommonly great development of flatulence after a very moderate supper ; and frequent, but difficult, discharge of flatus (aft. 14 h.). Flatulent distension of the abdomen, which is painful to the touch. [COSTA, 1. c.][homoeopathie-online.com]
Dyspepsia
  • […] alum ammonia antimony antispasmodic aromatic astringent bark barytes bitter boiling water bruised camphor carbonate chiefly cinnamon colour Comp Compound copper decoction demulcent diaphoretic digest dissolve distilled water diuretic doses of gr dried dyspepsia[books.google.com]
Tachycardia
  • Acute poisoning Euphoria Temporal & spatial disorientation with intensification of sensation & increased clarity of perception Hallucinations, sedation, dysphoria Acute toxic psychosis Tachycardia, palpitations, hypotension Stimulation of appetite 12.[slideshare.net]
  • Symptoms like mydriasis, tachycardia, arrhythmia, agitation, convulsion and coma can appear. Diagnosis is made by clinical symptomatology and history.[ncbi.nlm.nih.gov]
  • Nicotiana spp (tobacco) ingestion, inhalation or transdermal exposure is possible nicotinic syndrome: GI symptoms, sweating, tachycardia, hypotension, tremor, seizures Psychotropic alkaloids, e.g.[lifeinthefastlane.com]
  • Dry mouth, tachycardia, decreased bowel sounds and agitation are all characteristic of both syndromes.[calpoison.org]
  • Overdosage (which is close to the therapeutic dose) causes dry mouth, dysphagia, pupil dilation, tachycardia, restlessness, hallucinations, delirium and coma. Children have been poisoned by eating the seeds.[purplesage.org.uk]
Hypotension
  • Acute poisoning Euphoria Temporal & spatial disorientation with intensification of sensation & increased clarity of perception Hallucinations, sedation, dysphoria Acute toxic psychosis Tachycardia, palpitations, hypotension Stimulation of appetite 12.[slideshare.net]
  • Nicotiana spp (tobacco) ingestion, inhalation or transdermal exposure is possible nicotinic syndrome: GI symptoms, sweating, tachycardia, hypotension, tremor, seizures Psychotropic alkaloids, e.g.[lifeinthefastlane.com]
  • The peripheral effects that are common to anticholinergic agents include mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension [[panafrican-med-journal.com]
  • Hypotension generally responds to isotonic fluid administration. Agitation, psychosis, or seizures are treated with benzodiazepines such as diazepam or lorazepam. Cooling via evaporative methods is generally sufficient if hyperthermia is present.[calpoison.org]
Quickening
  • They produce the same dryness of the throat, flushing of the face, dilatation of the pupils, quickening of the respiratory and heart action, illusions, hallucinations and delirium.[henriettes-herb.com]
Blurred Vision
  • [Case Reports] VL Vnitr Lek 2000; 46(11):808-10 Stefánek J, Dufincová J, … Holmes S The authors describe the case of a 27-year-old man who was examined on account of vertigo and blurred vision.[unboundmedicine.com]
  • Blurred vision and photophobia may be due to mydraisis and paralysis of accomodation. Seizures, paralysis, respiratory depression, and coma may ensue in severe cases.[calpoison.org]
  • Symptoms of Henbane poisoning include a dry mouth, thirst, difficulty in swallowing and speaking, warm flushed skin, dilated pupils, blurred vision and photophobia, vomiting, urinary retention, tachycardia, pyrexia, drowsiness, slurred speech, hyperreflexia[jeremybartlett.co.uk]
  • Causes dry mouth, thirst, difficulty in swallowing and speaking, warm flushed skin, dilated pupils, blurred vision and photophobia, vomiting, urinary retention, tachycardia, pyrexia, drowsiness, slurred speech, hyperreflexia, auditory, visual or tactile[thepoisongarden.co.uk]
Blurred Vision
  • [Case Reports] VL Vnitr Lek 2000; 46(11):808-10 Stefánek J, Dufincová J, … Holmes S The authors describe the case of a 27-year-old man who was examined on account of vertigo and blurred vision.[unboundmedicine.com]
  • Blurred vision and photophobia may be due to mydraisis and paralysis of accomodation. Seizures, paralysis, respiratory depression, and coma may ensue in severe cases.[calpoison.org]
  • Symptoms of Henbane poisoning include a dry mouth, thirst, difficulty in swallowing and speaking, warm flushed skin, dilated pupils, blurred vision and photophobia, vomiting, urinary retention, tachycardia, pyrexia, drowsiness, slurred speech, hyperreflexia[jeremybartlett.co.uk]
  • Causes dry mouth, thirst, difficulty in swallowing and speaking, warm flushed skin, dilated pupils, blurred vision and photophobia, vomiting, urinary retention, tachycardia, pyrexia, drowsiness, slurred speech, hyperreflexia, auditory, visual or tactile[thepoisongarden.co.uk]
Diplopia
  • Eyes: open, staring; downcast, dull, fixed; pupils dilated, sparkling, fixed; strabismus; spasmodic closing of lids; vision double, diplopia, objects have coloured borders.[qjure.com]
  • Diplopia. Objects have colored borders. Mouth.-- Tongue dry, red, cracked, stiff and immovable, protruded with difficulty; speech impaired. Foams at mouth. Teeth covered with sordes. Lower jaw drops. Throat.-- Stinging dryness. Constriction.[homeoint.org]
  • EYES Eyes Pupils dilated, sparkling, fixed Eyes open, but does not pay attention; downcast and dull, fixed Strabismus Spasmodic closing of lids Diplopia Objects have colored borders.[abchomeopathy.com]
Flushing
  • His examination was significant for dry mucus membranes and his skin was warm and flushed. On neurologic exam, he was awake, but was confused, agitated and answering “I am Batman” to all questions.[calpoison.org]
  • They produce the same dryness of the throat, flushing of the face, dilatation of the pupils, quickening of the respiratory and heart action, illusions, hallucinations and delirium.[henriettes-herb.com]
  • Face: Flushed and dark red, bloated and excited face, dryness of the mouth. Dry tongue loaded with a brownish coating. Throat: Constriction of throat with inability to swallow, especially fluids and liquids.[homeopathicmedicine.info]
  • Symptoms of Henbane poisoning include a dry mouth, thirst, difficulty in swallowing and speaking, warm flushed skin, dilated pupils, blurred vision and photophobia, vomiting, urinary retention, tachycardia, pyrexia, drowsiness, slurred speech, hyperreflexia[jeremybartlett.co.uk]
  • Causes dry mouth, thirst, difficulty in swallowing and speaking, warm flushed skin, dilated pupils, blurred vision and photophobia, vomiting, urinary retention, tachycardia, pyrexia, drowsiness, slurred speech, hyperreflexia, auditory, visual or tactile[thepoisongarden.co.uk]
Confusion
  • In the objective case-history there was mild confusion, in the physical examination broad… New Search Next[unboundmedicine.com]
  • Cases of deadly nightshade intoxication may also be confused with post-traumatic brain damage, and acute psychosis.[panafrican-med-journal.com]
  • Confusion, sopor, deep stupor, stupefaction, coma vigil, convulsions, wants to escape, run away. Sad, sobbing, cries, in sleep, in children, suicidal. Nervous agitation; tremulous, weak, restless, twitching of tendons.[qjure.com]
  • .-- Feels light and confused. Vertigo as if intoxicated. Brain feels loose, fluctuating. Inflammation of brain, with unconsciousness; head is shaken to and fro. Eyes.-- Pupils dilated, sparkling, fixed.[homeoint.org]
  • HEAD Head Feels light and confused Brain feels loose, fluctuating Inflammation of brain, with unconsciousness; head is shaken to and fro. Headache Pain, headache; in forehead more ...[abchomeopathy.com]
Headache
  • […] stems; leaves alternate, simple, toothed; flowers axillary, tubular, 5-parted, greenish yellow or yellowish with purple veins; fruit a capsule Family: Solanaceae Origin: Europe Poison Part: All parts Poison Delivery Mode: Ingestion Symptoms: Salivation, headache[plants.ces.ncsu.edu]
  • Hence its value in nervous headache, the headache of debility, the vague pains of so-called chronic rheumatism, idiopathic neuralgia, visceral pain, urethral pain, and that of herpes zoster.[henriettes-herb.com]
  • Head: headache pulsating; light; brain feels loose, fluctuating; encephalitis, inflammation of brain, coma, head shaken; apoplexy.[qjure.com]
  • This type of poisoning, which can take place even after ingesting a small amount of plant or seed matter, can have symptoms such as increased salivation, headache, nausea, convulsions, hallucinations, stupor, coma and death.[worldseedsupply.com]
  • Headache Pain, headache; in forehead more ... EYES Eyes Pupils dilated, sparkling, fixed Eyes open, but does not pay attention; downcast and dull, fixed Strabismus Spasmodic closing of lids Diplopia Objects have colored borders.[abchomeopathy.com]
Stupor
  • As the mania advances he seems to lie in a sort of stupor and yet it is not a real stupor, because the slightest noise rouses him into all these forms of violent mania. Every little impression causes excitement of the sensorium.[vithoulkas.com]
  • -When spoken to answers properly but stupor and delirium return immediately. -Delirium-attempts to run away. Restless, jumps out of bed, wants to escape. -talks of business, complaints of imaginary wrongs.[cure4incurables.com]
  • Confusion, sopor, deep stupor, stupefaction, coma vigil, convulsions, wants to escape, run away. Sad, sobbing, cries, in sleep, in children, suicidal. Nervous agitation; tremulous, weak, restless, twitching of tendons.[qjure.com]
  • This type of poisoning, which can take place even after ingesting a small amount of plant or seed matter, can have symptoms such as increased salivation, headache, nausea, convulsions, hallucinations, stupor, coma and death.[worldseedsupply.com]
  • Low, muttering speech; constant carphologia, deep stupor . Head.-- Feels light and confused. Vertigo as if intoxicated. Brain feels loose, fluctuating. Inflammation of brain, with unconsciousness; head is shaken to and fro.[homeoint.org]
Agitated Delirium
  • Central effects are dose-dependent and agent-dependent [ 5 ], Patients with central anti-cholinergic syndrome may present with ataxia, disorientation, short-term memory loss, confusion, hallucinations, psychosis, agitated delirium, seizures, coma, respiratory[panafrican-med-journal.com]
Night Terrors
  • —Nervous irritability, with unrest and insomnia; dilated pupils and flushed face, accompanied by debility; fright and restlessness in sleep; night terrors; loquaciousness; garrulousness; destructiveness; busy muttering delirium, or singing, talkativeness[henriettes-herb.com]

Treatment

  • Although it is commonly self-limited and can be corrected with close observation and supportive treatments, it should be kept in mind that the prolongation of QT interval can accompany the symptoms of poisoning with this plant (Tab. 1, Fig. 3, Ref. 19[unboundmedicine.com]
  • Its sedative and antispasmodic effect makes it a valuable treatment for the symptoms of Parkinson's disease, relieving tremor and rigidity during the early stages of the disease.[naturalmedicinalherbs.net]
  • […] for toothaches --- to treat nervous ailments --- treatment for rheumatism --- treatment for stomach pain --- treatment for whooping cough Availability Of Hyoscyamus niger Depending on where you live, you might find henbane for sale either with a prescription[a1b2c3.com]
  • The plant is used internally in the treatment of asthma, whooping cough, motion sickness, Meniere's syndrome, tremor in senility or paralysis and as a pre-operative medication.[montana.plant-life.org]

Prognosis

Etiology

  • Therefore, in case of excitability and confusion, as well as somnolence or coma of uncertain etiology, an anticholinergic syndrome caused by ingestion of atropine-containing plants or psychoactive drugs should be included in the differential diagnosis[panafrican-med-journal.com]

Epidemiology

  • Epidemiology Frequency United States Incidence is sporadic, with clusters of poisoning cases, mostly among adolescents using plants for their hallucinogenic effects.[emedicine.medscape.com]
  • Epidemiology The 2004 annual report of the American Association of Poison Control Centers listed 1058 cases of exposure to anticholinergic plants, 456 of these being intentional.[calpoison.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Tropane alkaloids competitively inhibit postsynaptic muscarinic acetylcholine receptors producing the classic anticholinergic syndrome.[calpoison.org]
  • Pathophysiology Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning.[emedicine.medscape.com]

Prevention

  • The author of this important and timely work explores the theoretical bases for understanding homicidal poisoning, the nature of poisons used in homicidal cases, the characteristics of poisoners and their victims, and techniques for detection and prevention[books.google.com]
  • Wear gloves and protective clothing when handling the plants to prevent rashes. Cultural Control Good vegetative cover considerably reduces the chance of infestation.[nwcb.wa.gov]
  • Despite its low incidence, public and medical community education is essential to prevent and manage these intoxications efficiently.[accessdata.fda.gov]
  • It is as if some diabolical force took possession of the brain and prevented its functions. It causes a perfect picture of mania of a quarrelsome and obscene character . Inclined to be unseemly and immodest in acts, gestures and expressions.[homeoint.org]
  • Prevention Most accidental poisonings are preventable. The number of deaths of children from poisoning has declined from about 450 per year in the 1960s to about 50 each year in the 1990s.[medical-dictionary.thefreedictionary.com]

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