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Hyperandrogenism
Hyperandrogenization

Presentation

All patients with PCOS presented clinical and biochemical evidence of hiperandrogenism with oligoovulation and/or ultrasonographic appearance of polycystic ovaries. [journals.viamedica.pl]

If no criteria of malignancy are present, we should assess if borderline malignancy criteria are applicable. [sciencerepository.org]

Non-classic congenital adrenal hyperplasia (NCAH), caused by several mutations in CYP21A2 (6p21.3) gene, is the most common differential diagnosis for girls presented with symptoms of PCOS. [abstracts.eurospe.org]

The highest concentrations are present in the preoptic area of the hypothalamus. [emedicine.medscape.com]

Our longitudinal study in healthy non-obese, non-hyperandrogenic adolescents between 2 and 4 years postmenarche showed that PCOM is present in 33% of girls at 2, 3 and 4 years postmenarche ( Figure 1, with permission) (43). [scielo.br]

Entire Body System

  • Weight Gain

    Signs of Cushing's syndrome include muscle weakness, easy bruising, weight gain, male-pattern hair growth ( hirsutism ), colored stretch marks, and an excessively reddish complexion in the face. [23] Cushing's syndrome has been shown to cause androgen [en.wikipedia.org]

    Weight gain during adolescence carries a higher risk for early puberty, obesity and estrogen-dependent disease later in life, including polycystic ovary syndrome and breast cancer (62). [scielo.br]

Skin

  • Alopecia

    Androgenetic alopecia - Current Status. lndian J Dermatol 2005; 50(4):179-190. [revista.asocolderma.org.co]

    Alopecia is very uncommon in the pediatric popu-lation. A recent retrospective series of 438 pediatric patients (boys and girls) demonstrated that androgenetic alopecia (AGA) is the cause of alopecia in 13% of children and 42% of adolescents. [scielo.br]

    Hyperandrogenism can lead to any or all of the following: Seborrhoea (oily skin) Acne Hidradenitis suppurativa Hirsutism Female pattern balding ( alopecia ) Male pattern balding in females Irregular menstruation Masculine appearance with increased muscle [dermnetnz.org]

    The more prominent signs of hyperandrogenism are hirsutism (unwanted growth of hair especially in the abdominal region and places on the back), acne after adolescence, deepening of voice, and alopecia (balding). [10] Hyperandrogenism has also been seen [en.wikipedia.org]

    A prospective study of the prevalence of clearcut endocrine disorders and polycystic ovaries in 350 patients presenting with hirsutism or androgenic alopecia. [accessmedicina.mhmedical.com]

  • Acne Vulgaris

    Am J Med 111:607, 2001 [PubMed: 11755503] Leyden J, Thiboutot DM, Shalita AR, et al.: Comparison of tazarotene and minocycline maintenance therapies in acne vulgaris: a multicenter, double-blind, randomized, parallel-group study. [accessmedicina.mhmedical.com]

    Sebum production from the PSU is also increased by androgens. [21] Acne vulgaris can be aggravated or initiated by increased androgen levels as the excess sebum production and the shedding of hyperkeratinized epithelium may occlude the hair follicle. [emedicine.medscape.com]

Workup

Biochemical workup showed high levels of dehydroepiandrosterone (DHEA) [above 1000mcg/dl] together with high levels of testosterone [1.7ng/ml]. [sciencerepository.org]

Treatment

In most cases the tumors display no symptoms and require no treatment. [en.wikipedia.org]

Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2008 Apr. 93(4):1105-20. [Medline]. The evaluation and treatment of androgen excess. [emedicine.medscape.com]

The drugs involved in the treatment, the mechanism of action and the collateral effects are analyzed. [scielo.conicyt.cl]

Hum Reprod 19:41, 2004 Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group: Consensus on infertility treatment related to polycystic ovary syndrome. [accessmedicina.mhmedical.com]

Adrenalectomy is the standard of treatment, and laparoscopy should be performed when there is no evidence of malignancy [2, 7]. [sciencerepository.org]

Prognosis

Benign OAN has a relatively good prognosis after surgery, but malignant OAN have a survival rate of only 35-50% depending on the invasion rate Borderlin OAN prognosis is uncertain [3, 5]. [sciencerepository.org]

Etiology

Finally, the ovary etiology of hyperandrogenism was confirmed. This case report is an example of difficulties in recognition the etiology of hyperandrogenism. [wwww.unboundmedicine.com]

Finally, the ovary etiology of hyperandrogenism was confirmed. This case report is an example of difficulties in recognition the etiology of hyperandrogenism. Read this article (multiple options) Comments Related Papers [read.qxmd.com]

Hirsutism: implications, etiology, and management. [accessmedicina.mhmedical.com]

Hirsutism: implications, etiology, and management. Am J Obstet Gynecol. 1981;140(7):815-30. [ Links ] 17. Welt CK, Arason G, Gudmundsson JA, Adams J, Palsdottir H, Gudlaugsdottir G, et al. [scielo.br]

Epidemiology

Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society. [accessmedicina.mhmedical.com]

In premenopausal women, polycystic ovary syndrome was the primary cause of severe DHEAS excess. [24] Epidemiology Frequency United States The prevalence of androgen excess is 8%. [emedicine.medscape.com]

Pathophysiology

Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common endocrinopathy with distinct pathophysiologic features. Am J Obstet Gynecol. 1983 Sep 1. 147(1):90-101. [Medline]. Legro RS. [emedicine.medscape.com]

Polycystic ovarian morphology with regular ovulatory cycles: insights into the pathophysiology of polycystic ovarian syndrome. J Clin Endocrinol Metab. 2004;89(9):4343-50. [ Links ] 52. Pigny P, Jonard S, Robert Y, Dewailly D. [scielo.br]

Am J Obstet Gynecol 194: 1266, 2006 [PubMed: 16647909] Barbieri RL, Ryan KJ: Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common endocrinopathy with distinct pathophysiologic features. [accessmedicina.mhmedical.com]

Prevention

[…] able to find a sufficient method of prevention. [33] However, there are a few things that can help avoid long-term medical issues related to hyperandrogenism like PCOS. [en.wikipedia.org]

Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393, 2002 [PubMed: 11832527] Krowchuk DP: Managing adolescent acne: a guide for pediatricians. [accessmedicina.mhmedical.com]

A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA. 1995 Feb 1. 273(5):402-7. [Medline]. Clark AM, Thornley B, Tomlinson L, Galletley C, Norman RJ. [emedicine.medscape.com]

She was subsequently prevented from competing while she underwent gender testing and was subjected to intense media scrutiny. [ibanet.org]

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