Weight gain during adolescence carries a higher risk for early puberty, obesity and estrogen-dependent disease later in life, including polycystic ovary syndrome and breast cancer (62). [scielo.br]

Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome. [emedicine.medscape.com]

Hyperandrogenism can lead to any or all of the following: Seborrhoea (oily skin) Acne Hidradenitis suppurativa Hirsutism Female pattern balding ( alopecia ) Male pattern balding in females Irregular menstruation Masculine appearance with increased muscle [dermnetnz.org]

Alopecia is very uncommon in the pediatric popu-lation. A recent retrospective series of 438 pediatric patients (boys and girls) demonstrated that androgenetic alopecia (AGA) is the cause of alopecia in 13% of children and 42% of adolescents. [scielo.br]

Prevalence of polycystic ovaries in women with androgenic alopecia. Eur J Endocrinol. 2003 Nov. 149(5):439-42. [Medline]. Kahana M, Grossman E, Feinstein A, Ronnen M, Cohen M, Millet MS. Skin tags: a cutaneous marker for diabetes mellitus. [emedicine.medscape.com]

Sebum production from the PSU is also increased by androgens. [21] Acne vulgaris can be aggravated or initiated by increased androgen levels as the excess sebum production and the shedding of hyperkeratinized epithelium may occlude the hair follicle. [emedicine.medscape.com]