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Hyperextensible Joints


Presentation

  • A man with a history of hyperextensible joints and aortic insufficiency presents for a genetic screening. He is discovered to have a homozygous defect in the gene that encodes the glycoprotein fibrillin.[mdlexicon.com]
  • Quick summary: hyperextensible finger joint is a relatively common condition that is present in a small minority of the general population; the condition is especially frequently present in joints hypermobility syndrome, trisomy 21 & fragile-x syndrome[handresearch.com]
  • Structured chapter template presents information in a consistent format. ICD-9 codes in all disease chapters assist in diagnostic coding. Fast Fact Guide to Patient Assessment on the inside covers puts vital facts at your fingertips.[books.google.de]
  • We demonstrate that fetuses with a paternal-origin deletion of 14q involving the 14q32.2 imprinted region may prenatally present the upd(14)mat-like phenotype such as hypotonia, scoliosis, arthrogryposis and hyperextensible joints.[ncbi.nlm.nih.gov]
  • This GAG is highly expressed in synovial fluid, cartilage, and skin, leading to progressive joint manifestations. 1,2 MPS IX can present at varying ages with chronic joint pain unresponsive to anti-inflammatory medication. 1,2 Observed presentation Symptoms[mpsreference.eu]
Multiple Congenital Anomalies
  • A 2 ½-year-old girl with multiple congenital anomalies and a de novo 5.6-Mb deletion on chromosome 13q12.11-13q12.13 is reported.[wa.multiples.us]
Physician
  • There are many physicians who do not have a desk computer or do not History feel at ease in using one.[books.google.de]
  • Questions physicians should ask patients to detect benign joint hypermobility syndrome. (Reproduced with permission from Hakim AJ, Cherkas LF, Grahame R, Spector TD, MacGregor AJ.[jaoa.org]
  • Australian Family Physician . 39(8), 575-577. (full text) Brown , A. & Cadogan, M. (2006). Rupture of the Ulnar Collateral Ligament. Emergency Medicine Emergency and Acute Medicine: Diagnosis and Management. Hodder Arnold: New York.[lifeinthefastlane.com]
  • Dr Alan Hakim MA FRCP Consultant Rheumatologist and Physician, Medical Advisor , HMSA (V.2) Written June 2013, Adapted from Hakim & Sahota 2006. Revised March 2018. Date of review March 2020.[hypermobility.org]
Camping
  • Prevent and Treat Pregnancy Stretch Marks (Without Coconut Oil) This salve is designed to keep skin supple so that it can accommodate a growing belly, but also to sooth any skin irritation that accompanies pregnancy. 5 Benefits of a Mini Detox Foot Soak – Camp[pinterest.fr]
Pediatric Disorder
  • All new reorganization —a real time saver for the busy trainee or clinician More consistent presentation for greater accessibility New entries on pediatric disorders to help treat your young patients The newest anti-rheumatic drugs , including celecoxib[books.google.de]
Saddle Nose
  • The patient had several typical findings of the Noonan syndrome: short stature (150 cm), exophtalmus, hypertelorism, strabismus, ptosis, webbed neck, low-set ears, saddle nose, sternal deformity, and variations in the size of cervical vertebrae.[jamanetwork.com]
Chest Pain
  • —A 55-year old woman visited our clinic several times because of rhythm disturbances and chest pains. She had been catheterized because of obstructive hypertrophic cardiomyopathy.[jamanetwork.com]
Hyperextensible Joints
  • A man with a history of hyperextensible joints and aortic insufficiency presents for a genetic screening. He is discovered to have a homozygous defect in the gene that encodes the glycoprotein fibrillin.[mdlexicon.com]
  • Hyperextensible Joints Icd 10 Hyperextensible Joints Icd 10 Search Results For Hyperextensible Joints Icd 10 A50.51 Clutton's joints B90.2 Sequelae of tuberculosis of bones and joints M18.0 Bilateral primary osteoarthritis of first carpometacarpal joints[codelay.com]
  • Hyperextensible Joints (hypermobility syndrome or hyperlaxity) are terms used to describe joints that stretch father than normal joints. This disorder can affect a single joint or many joints throughout the body.[coastalhealthcarenj.net]
  • We demonstrate that fetuses with a paternal-origin deletion of 14q involving the 14q32.2 imprinted region may prenatally present the upd(14)mat-like phenotype such as hypotonia, scoliosis, arthrogryposis and hyperextensible joints.[ncbi.nlm.nih.gov]
  • joints & skin; blue sclerae; bilateral epicanthal folds; velvet textured skin; cigarettepaper-like scar; similarly aff. brother; father & pat. side of family have strong history for distal tubular acidosis Passage Frozen 7 Split Ratio 1:3 Temperature[coriell.org]
Hyperlaxity
  • Hyperextensible Joints (hypermobility syndrome or hyperlaxity) are terms used to describe joints that stretch father than normal joints. This disorder can affect a single joint or many joints throughout the body.[coastalhealthcarenj.net]
  • Hypermobility Synonyms hyperlaxity, benign joints hypermobility syndrome (BJHS), hypermobility syndrome (HMS)[en.wikipedia.org]
  • Having joint hypermobility may also be called: having joint laxity, or hyperlaxity being double-jointed having loose joints having hypermobility syndrome Most commonly, hypermobile joints appear without any underlying health conditions.[healthline.com]
  • There may be skin hyperlaxity, easy bruising, abnormal scarring (often described as ‘atrophic’, ‘papyraceous’ or ‘keloid’ scarring), and the onset of stretch marks at an early age at multiple sites.[hypermobility.org]
  • Definitions of hypermobility, hyperlaxity, hyperextensibility The words "hypermobility", "hyperlaxity" and "hyperextensibility" are used interchangeably by some authors[ 17 ] and have not been clearly defined.[ped-rheum.biomedcentral.com]
Arthralgia
  • […] for longer than 3 months in 4 or more joints Minor Criteria A Beighton score of 1, 2 or 3/9 (0, 1, 2 or 3 if aged 50 ) Arthralgia ( 3 months) in one to three joints or back pain ( 3 months), spondylosis, spondylolysis/spondylolisthesis.[shoulderdoc.co.uk]
  • […] for longer than 3 months in four or more joints Minor criteria Beighton score of 1, 2 or 3 Arthralgia ( 3 months) in one to three joints, back pain ( 3 months), or spondylosis/spondylolysis/spondylolisthesis Dislocation or subluxation in more than one[skillsforaction.com]
  • Arthralgia for 3 months in 4 joints Minor Criteria: 1. Beighton score of 1–3 2. Arthralgia in 1–3 joints 3. History of joint dislocation 4. Soft tissue lesions 3 5. Marfan-like habitus 6. Skin striae, hyperextensibility or scarring 7.[ped-rheum.biomedcentral.com]
  • Joint pain (arthralgia) in 1-3 joints for over three months. Back pain for over three months. A back condition seen in teenagers (spondylosis/spondylolysis/spondylolisthesis). More than three 'inflammation' conditions (for example, tendonitis).[patient.info]
Foot Pain
  • These problems can cause foot pain, and impact the child's gait and balance. Getting early medical care and treatment can improve the health of a child with Down syndrome.[orthoinfo.aaos.org]
Strabismus
  • Strube OUP USA , 27.09.2012 - 1386 Seiten For over the past ten years Pediatric Ophthalmology and Strabismus has become the leading textbook in the specialty of pediatric ophthalmology and strabismus.[books.google.de]
  • With the help of 2500 images and illustrations, this book covers topics such as glaucoma, ocular oncology, nystagmus, refractive surgery, strabismus and lasers in ophthalmology.[books.google.de]
  • The patient had several typical findings of the Noonan syndrome: short stature (150 cm), exophtalmus, hypertelorism, strabismus, ptosis, webbed neck, low-set ears, saddle nose, sternal deformity, and variations in the size of cervical vertebrae.[jamanetwork.com]
  • Refractive errors of various degrees up to 93% and strabismus ranging from 30% to 40% have been reported (Storm et al. 1987).[intellectualdisability.info]
Blepharoptosis
  • Features: Head And Neck Microcephaly Triangular Facies Temporal And Frontal Bossing Ears Large Posteriorly Rotated Ears With Prominent Helices Eyes Hypertelorism Blepharoptosis Downslanting Palpebral Fissures Nystagmus Retinal Lesions Epicanthal Folds[neo-genetics.com]
Low Set Ears
  • The patient had several typical findings of the Noonan syndrome: short stature (150 cm), exophtalmus, hypertelorism, strabismus, ptosis, webbed neck, low-set ears, saddle nose, sternal deformity, and variations in the size of cervical vertebrae.[jamanetwork.com]
  • set ears, overlapping fingers, short nails [28] High forehead, short nose, anteverted nares, downturned corners of the mouth, tapering fingers, clinodactyly [18] High forehead, bitemporal narrowing, almond shaped palpebral fissures, short philtrum, downturned[kundoc.com]
Hypertelorism
  • The patient had several typical findings of the Noonan syndrome: short stature (150 cm), exophtalmus, hypertelorism, strabismus, ptosis, webbed neck, low-set ears, saddle nose, sternal deformity, and variations in the size of cervical vertebrae.[jamanetwork.com]
  • Features: Head And Neck Microcephaly Triangular Facies Temporal And Frontal Bossing Ears Large Posteriorly Rotated Ears With Prominent Helices Eyes Hypertelorism Blepharoptosis Downslanting Palpebral Fissures Nystagmus Retinal Lesions Epicanthal Folds[neo-genetics.com]
  • This is a recently described autosomal dominant syndrome characterised by arterial tortuosity, hypertelorism and bifid uvula or cleft palate. It is caused by mutations in the transforming growth factor beta receptor genes (TGFBR1 and 2).[ped-rheum.biomedcentral.com]
Confusion
  • Most likely diagnostic options for hyperextensible finger joints - not to be confused with double-jointed thumbs (ranked by 'weight' for the general population): - ASSOCIATED MEDICAL CONDITIONS: • joints hypermobility syndrome • trisomy 21 ( Down syndrome[handresearch.com]
  • (Note: Readers should not be confused by the similarity of these two names. “Beighton” is the correct spelling of the name of the score, and “Brighton,” the correct spelling of the name of the criteria.)[jaoa.org]
  • Additionally, urticaria does not cross the blood-brain barrier that draws water from the capillaries of the confusion related to premature signaling of the. Keightley ml, chen jk, ptito a. Examining the skin over the a knee dislocation.[smj.org.sa]
  • Some suggest that these types are so similar that they are better classified as one type rather than 2. 1997 classification A relatively simple classification was proposed in 1997 in an attempt to eliminate the confusion associated with the earlier classification[emedicine.medscape.com]
  • They exclude children with a diagnosed HDCT from the diagnosis of (benign) joint hypermobility syndrome, and this approach is confusing for clinicians.[ped-rheum.biomedcentral.com]
Irritability
  • […] recipe for an incredible natural face cleanser that… Homemade Salve to Prevent and Treat Pregnancy Stretch Marks (Without Coconut Oil) This salve is designed to keep skin supple so that it can accommodate a growing belly, but also to sooth any skin irritation[pinterest.fr]
  • Stimulants may not be helpful for children under the age of five as they may cause increased irritability. Hagerman et al. (1995) did a survey of clonidine use among 35 children with FXS.[intellectualdisability.info]
  • Tofts et al 2009 Disorders and symptoms commonly associated with JHS Gastrointestinal manifestations include such as chronic constipation, gastro-esophageal reflux, chronic abdominal pain and irritable bowel syndrome Symptoms related to autonomic dysfunction[skillsforaction.com]
Nystagmus
  • With the help of 2500 images and illustrations, this book covers topics such as glaucoma, ocular oncology, nystagmus, refractive surgery, strabismus and lasers in ophthalmology.[books.google.de]
  • Features: Head And Neck Microcephaly Triangular Facies Temporal And Frontal Bossing Ears Large Posteriorly Rotated Ears With Prominent Helices Eyes Hypertelorism Blepharoptosis Downslanting Palpebral Fissures Nystagmus Retinal Lesions Epicanthal Folds[neo-genetics.com]

Treatment

  • This quick-consult covers the full scope of rheumatologic diagnosis and treatment... A wide range of diagnostic tests —including ANA, DNA, RF, ANCA and CCP antibody tests—show you what test to order and how to interpret the results.[books.google.de]
  • Each section is dedicated to a specific area of the eye and covers basic techniques, investigative modules and treatment methods.[books.google.de]
  • Symptoms Muscle fatigue Joint instability Extreme flexibility Early onset osteoarthritis Pain Temperomandibular joint syndrome Nerve compression disorders Treatment Physical therapy Analgesics Anti-inflammatory drugs Steroid injections Bracing[coastalhealthcarenj.net]
  • Surgical Treatment If the child's musculoskeletal problems do not respond to nonsurgical treatments such as bracing, orthotics, and physical therapy, your doctor may recommend surgery. Spinal fusion.[orthoinfo.aaos.org]

Prognosis

  • Treatment Prognosis References: [10] [13] [14] [15] [3] [#8376}[amboss.com]
  • What is the prognosis of someone with an Ehlers-Danlos Syndrome? The prognosis depends on the type of Ehlers-Danlos syndrome and the individual.[ehlers-danlos.com]
  • What is the prognosis for those affected by joint hypermobility syndrome? Frequently, there are no long-term consequences of joint hypermobility syndrome. However, hypermobile joints can lead to joint pain .[medicinenet.com]
  • The prognosis for this type is poor, and the patient's life span is shortened. Sudden death can occur after visceral perforation or after the rupture of a large vessel, most commonly an abdominal or splenic vessel.[emedicine.medscape.com]
  • Because of its favourable prognosis by comparison with other more serious HDCTs, the term benign joint hypermobility syndrome is also used.[adc.bmj.com]

Etiology

  • Etiology Marfan syndrome Mutation of fibrillin-1 gene (FBN1) on chromosome 15 defective connective tissue microfibrils defective elastin Autosomal dominant inheritance pattern with variable penetrance Ehlers-Danlos syndrome Various mutations in genes[amboss.com]
  • There is no unifying etiology for nocturnal enuresis in the pediatric population and the disorder is likely to be multifactorial.[wa.multiples.us]

Epidemiology

  • The genetic epidemiology of joint hypermobility: A population study of female twins. Arthritis Rheum . 2004;50:2640–2644.) Figure 1. Questions physicians should ask patients to detect benign joint hypermobility syndrome.[jaoa.org]
  • Epidemiological studies have shown that hypermobility (depending on the criteria used) is seen in up to 10% of individuals in Western populations.[adc.bmj.com]
  • Epidemiology of general joint hypermobility and basis for the proposed criteria for benign joint hypermobility syndrome: review of the literature. J Rheumatol.2007;34:804–809.[skillsforaction.com]
  • View Article PubMed Google Scholar Remvig L, Jensen DV, Ward RC: Epidemiology of general joint hypermobility and basis for the proposed criteria for benign joint hypermobility syndrome: review of the literature. J Rheumatol. 2007, 34: 804-809.[ped-rheum.biomedcentral.com]
  • Epidemiology There are about 100–200 affected births in the UK each year. The population prevalence is estimated at 1 in 4000 males and 1 in 8000 females (Hagerman and Hagerman, 2002). It occurs in all races and ethnic groups.[intellectualdisability.info]
Sex distribution
Age distribution

Pathophysiology

  • Understanding the pathophysiology, systemic manifestations, common causes of morbidity and mortality, and anesthetic implications of these disorders is essential for developing a safe perioperative management strategy.[accessanesthesiology.mhmedical.com]
  • Semantic Scholar extracted view of "Pseudotumor cerebri pathophysiology: the likely role of aldosterone." by Vincenzo Salpietro et al. ...[3h5.alienee.us]

Prevention

  • Here is a recipe for an incredible natural face cleanser that… Homemade Salve to Prevent and Treat Pregnancy Stretch Marks (Without Coconut Oil) This salve is designed to keep skin supple so that it can accommodate a growing belly, but also to sooth any[pinterest.fr]
  • Is it possible to prevent joint hypermobility syndrome? Because joint hypermobility syndrome is inherited, it is not preventable.[medicinenet.com]
  • Primary prevention includes genetic counseling, while tertiary prevention involves regular monitoring for complications.[amboss.com]
  • This complex of structures keeps the knee compartment from widening laterally, prevents dislocation of the lateral surface of the tibial component of the knee to the back, keeps the tibia from rotating, and thus prevents both knee hyperextension and genu[news-medical.net]
  • […] separation of a weight by forming a separation preventing frame, thereby improving the safety.[patentscope.wipo.int]

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