The average number of spontaneous losses for these eight women was 3.3 /- 2.1 (range: 1-8). aPL was present in 100% of cases. ANAs and hypergammaglobulinemia were present in 50% of cases and low C4 in 87.5% of cases. [ncbi.nlm.nih.gov]

• Malaise

  Two patients experienced recurring lymph node enlargement with associated mild malaise over an extended period. [ncbi.nlm.nih.gov]

• Falling

  During HIV infection, the proportion of antiidiotypic IgG in fact remains unaltered or falls, making this an unlikely cause of suppressed humoral immunity to HIV-1. [ncbi.nlm.nih.gov]

• Dry Eyes

  Abstract Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by sicca symptoms, including dry eyes and dry mouth. Cevimeline is used for the treatment of dry mouth in patients with SS. [ncbi.nlm.nih.gov]

• Flexion Contracture

  Flexion contractures of elbows and knees and limitation of abduction at the shoulders developed in a few weeks after onset. [ncbi.nlm.nih.gov]

• Dysautonomia

  We described a 51-year-old woman who had a chronic sensory dominant polyneuropathy and dysautonomia associated with hypergammaglobulinemia. [ncbi.nlm.nih.gov]

• Liver Biopsy

  Liver biopsy showed atypical clonal B-cell lymphoproliferation, small cells with prominent plasmacytic differentiation. Serum protein electrophoresis showed monoclonal gammopathy which was IgA. [ncbi.nlm.nih.gov]

Abstract Rituximab is a monoclonal antibody that depletes B cells and is commonly used for the treatment of autoimmune diseases. [ncbi.nlm.nih.gov]

The etiology of this disease is unknown. We described a 51-year-old woman who had a chronic sensory dominant polyneuropathy and dysautonomia associated with hypergammaglobulinemia. [ncbi.nlm.nih.gov]

Epidemiology Frequency United States In 2003, the US XHIGM registry reported that the minimal incidence rate of XHIGM was approximately 1 in 1,000,000 live births from 1984-1993. [4] This may be an underestimation because not all physicians in the United [emedicine.com]

Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies. Adv Immunol. 2007. 94:275-306. [Medline]. Eijkhout HW, van Der Meer JW, Kallenberg CG, et al. [emedicine.com]

[…] member of the following medical societies: Academy of Medicine of New Jersey, American Academy of Allergy Asthma and Immunology, American Academy of Hospice and Palliative Medicine, American Association of Public Health Physicians, American College of Preventive [emedicine.com]