The average number of spontaneous losses for these eight women was 3.3 +/- 2.1 (range: 1-8). aPL was present in 100% of cases. ANAs and hypergammaglobulinemia were present in 50% of cases and low C4 in 87.5% of cases. [ncbi.nlm.nih.gov]

However this disease has been found to be mostly presented with lymphadenopathy and hypergammaglobulinemia. Case Report: We present a forty-year-old woman with anemia, renal insufficiency and abnormal liver function test. [jmatonline.com]

Azotemia was present in three tigers. Diagnostics and management varied with the presenting signs but included magnetic resonance imaging, radiography, chemotherapy, supportive care, and euthanasia. [bioone.org]

• Hemophilia A

  Hyperglobulinemia as the Cause of Hemophilia-like Disease. Blood. 1953; 8: 1067 Google Scholar Nilsson I.M. Wenckert A. Demonstration of a Heparin-like Anticoagulant in Normal Blood. I. Human Blood. [translationalres.com]

  Arch Dis Child. 1985; 60: 530-536 Shannon BT Roach J Cheek-Luten M Orosz C Ruymann FB Progressive change in lymphocyte distribution and degree of hypergammaglobulinemia with age in children with hemophilia. [mayoclinicproceedings.org]

  […] ulcerative colitis Sarcoidosis Chronic autoimmune pancreatitis Hyperimmunoglobulinemia D and periodic fever syndrome Syndrome of IgG2 subclass deficiency Other Hematologic Conditions Idiopathic thrombocytopenic purpura (ITP) Idiopathic neutropenia Severe hemophilia [statpearls.com]

• Pain

  Abstract The syndrome of sternocostoclavicular hyperostosis with painful bilateral clavicular enlargement and subclavian vein obstruction has been recently described in older adults. [acpjournals.org]

  We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: March 27, 2023 [patientslikeme.com]

  Henoch-Schönlein purpura; hypergammaglobulinemia; hypocomplementemia; streptococcal infection Henoch-Schönlein purpura (HSP) is predominantly a childhood vasculitic disease, mainly manifested as skin purpura, joint pain, abdominal pain and nephritis, [oatext.com]

  Society, Infectious Diseases Society of America, Infectious Diseases Society of New Jersey, Medical Society of New Jersey, Pediatric Infectious Diseases Society, Arab Board of Family Medicine, American Academy of Pain Management, National Association [emedicine.com]

  Eight months earlier, she had profound jaundice without abdominal pain. At that time, she got ursodeoxycholic acid and got better. After 2 months of treatment, the patient was lost to follow-up and never visited again to the hospital. [karger.com]

• Hodgkin Lymphoma

  Additional clinical findings one year later led to the diagnosis of Hodgkin’s lymphoma. The second patient was a 17 year old with multiple physical examination and laboratory criteria consistent with MCTD. [ped-rheum.biomedcentral.com]

  FDA expands approved use of Imbruvica for rare form of non-Hodgkin lymphoma. U.S. Food & Drug Administration. Available at https://wayback.archive-it.org/7993/20170723002608/https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm432123.htm. [emedicine.medscape.com]

  Non-Hodgkin's lymphoma in Job's syndrome: a case report and literature review Leuk. Lymphoma. 2004 45 12 2521 -2525 Lo M.S., Zurakowski D., Son M.B.F., and Sundel R.P. [lymphosign.com]

• Fever of Unknown Origin

  Nevertheless, in children having fever of unknown origin, high gamma globulin levels were shown to be associated with a diagnosis of an autoimmune disease (2). [go.gale.com]

  Nonetheless, in one study of children with prolonged fever of unknown origin, elevated gamma globulin levels were associated with an ultimate diagnosis of autoimmune disease [2]. [ped-rheum.biomedcentral.com]

• Constitutional Symptom

  Diferent from the patient in the report by Trigkidis et al. (3,4) Classic kala-azar, characterized by prolonged fever, constitutional symptoms, hepatosplenomegaly, cytopenias and hypergammaglobulinemia is not always manifested in immunocompromised individuals [thefreedictionary.com]

• Heart Disease

  While IgG levels do not seem to correlate with severity of disease, hypergammaglobulinemia may help distinguish active rheumatic fever from inactive rheumatic heart disease [14]. [ped-rheum.biomedcentral.com]

• Hepatomegaly

  However, he was also found to have extensive lymphadenopathy and hepatomegaly. Further evaluation ultimately revealed Burkitt lymphoma. [ped-rheum.biomedcentral.com]

• Skin Disease

  [Crossref] Tokura Y, Yagi H, Yanaguchi H, Majima Y, Kasuya A, et al. (2014) IgG4-related skin disease. Br J Dermatol 171: 959-967. [oatext.com]

• Renal Injury

  There was no significant difference in the incidence of renal injury between the two groups. The patients with renal injury were characterized by transient proteinuria or microscopic hematuria, and all recovered within 3-4 weeks. [oatext.com]

• Hematuria

  Children with renal injury presented with transient proteinuria or microscopic hematuria in both groups, and all of them recovered in 3-4 weeks. The follow-up time was 2.95±1.04 years. No sequela was found. [oatext.com]

(See Pathophysiology, Presentation, and Workup.) Waldenström macroglobulinemia is not curable, but a number of therapies have shown activity in the disease. [emedicine.medscape.com]

• Liver Biopsy

  CASE REPORT: We present a forty-year-old woman with anemia, renal insufficiency and abnormal liver function test. Liver biopsy showed atypical clonal B-cell lymphoproliferation, small cells with prominent plasmacytic differentiation. [ncbi.nlm.nih.gov]

  Case Report: We present a forty-year-old woman with anemia, renal insufficiency and abnormal liver function test. Liver biopsy showed atypical clonal B-cell lymphoproliferation, small cells with prominent plasmacytic differentiation. [jmatonline.com]

  The patient was planned to do magnetic resonance cholangiopancreatography and liver biopsy afterward. However, 1 week later, she visited the outpatient Gastroenterohepatology clinic. [karger.com]

  Intraobserver and Interobserver Variations in Liver Biopsy Interpretation in Patients with Chronic Hepatitis C. Hepatology 1994, 20, 15–20. [mdpi.com]

Abstract Rituximab is a monoclonal antibody that depletes B cells and is commonly used for the treatment of autoimmune diseases. [ncbi.nlm.nih.gov]

Children with PHG and AML were more likely to be in CR after first induction treatment (OR=6.25, p=0.021), independent of sex, age at diagnosis, white blood cell count, percentage of blasts in the bone marrow, FAB phenotype, and treatment protocol. [link.springer.com]

In contrast, MARS treatment had no effect on the immunoglobulin profile in patients with ALF or ACLF after one treatment cycle. [biochemia-medica.com]

A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med.2002;346:564-9. Dispenzieri A, Katzmann JA, Kyle RA, Larson DR, Melton LJ, 3rd Colby C, et al. [he01.tci-thaijo.org]

The prognosis and survival of the patients with AIH are usually good because they respond well to corticosteroid and immunosuppressant therapy [13]. [karger.com]

This phenomenon does not affect the prognosis. [oatext.com]

Outlook / Prognosis What can I expect if I have polyclonal gammopathy? You may be at an increased risk of infections and anemia if you have polyclonal gammopathy. [my.clevelandclinic.org]

Prognosis Waldenström macroglobulinemia is an indolent disorder, and patients survive for a median of approximately 78 months. [emedicine.medscape.com]

The etiology of this disease is unknown. We described a 51-year-old woman who had a chronic sensory dominant polyneuropathy and dysautonomia associated with hypergammaglobulinemia. [ncbi.nlm.nih.gov]

The Incidence and Etiologic Background of Chronic Biologic False Positive Reactions in Serologic Tests for Syphilis. Ann. Int. Med. 1952; 37: 1156 Google Scholar Mueller J.F. Ratnoff O. Heinle R.W. [translationalres.com]

Etiology The exact etiology of hypergammaglobulinemia (polyclonal gammopathy) is unknown. However, the association between hypergammaglobulinemia (polyclonal gammopathy) and a heterogeneous group of conditions is well established. [statpearls.com]

To the Editor: Autoimmune pancreatitis (AIP) is an infrequently recognized disorder of presumed autoimmune etiology that belongs to the spectrum of immunoglobulin G4 (IgG4)–related diseases.1 In 2006, the Mayo Clinic proposed the diagnostic criteria for [journals.lww.com]

These authors propose that soluble PD-1 ligands have the potential to promote disease progression in Waldenström macroglobulinemia. [9] Etiology No definite etiology exists for Waldenström macroglobulinemia. [emedicine.medscape.com]

MGUS is associated with a rate of progression to multiple myeloma or a related malignant condition of 1 percent per year.2 Research regarding epidemiology of MGUS is limited in Pakistan. [thefreedictionary.com]

Epidemiology Waldenström macroglobulinemia is a relatively rare condition, with the 1500 cases diagnosed per year in the United States accounting for approximately 2% of hematologic malignancies. [emedicine.medscape.com]

Immunodeficiency reviews. 1992; [PubMed PMID: 1554497] [19] Yazdani R,Fekrvand S,Shahkarami S,Azizi G,Moazzami B,Abolhassani H,Aghamohammadi A, The hyper IgM syndromes: Epidemiology, pathogenesis, clinical manifestations, diagnosis and management. [statpearls.com]

Epidemiology Frequency United States In 2003, the US XHIGM registry reported that the minimal incidence rate of XHIGM was approximately 1 in 1,000,000 live births from 1984-1993. [4] This may be an underestimation because not all physicians in the United [emedicine.com]

Br J Haematol. 1995; 91: 345-349 Miller RH Linet MS Van Natta ML McCaffrey LD Humphrey RL Serum protein electrophoresis patterns in chronic lymphocytic leukemia: clinical and epidemiologic correlations. [mayoclinicproceedings.org]

A brief review of the history and various manifestations of sarcoidosis including the pathophysiology of hypercalcaemia in sarcoidosis are presented as well as of polyclonal gammopathy. [casereports.bmj.com]

Although IL-6 is pivotal in the pathophysiology of polyclonal gammopathy in inflammatory conditions, polyclonal gammopathy can also occur without a significant inflammatory process. [statpearls.com]

Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies. Adv Immunol. 2007. 94:275-306. [Medline]. Eijkhout HW, van Der Meer JW, Kallenberg CG, et al. [emedicine.com]

(See Pathophysiology, Presentation, and Workup.) Waldenström macroglobulinemia is not curable, but a number of therapies have shown activity in the disease. [emedicine.medscape.com]

Genetics and pathophysiology of severe congenital neutropenia syndromes unrelated to neutrophil elastase Hematol. Oncol. Clin. [lymphosign.com]

According to the study from Kim et al6 in 2010, the glucocorticoid dosage for inducing remission was 30 to 40 mg/d for 1 to 2 months, and remission maintenance was needed to prevent relapse with a dosage of 5 to 10 mg/d for at least 6 months in patients [journals.lww.com]

[…] member of the following medical societies: Academy of Medicine of New Jersey, American Academy of Allergy Asthma and Immunology, American Academy of Hospice and Palliative Medicine, American Association of Public Health Physicians, American College of Preventive [emedicine.com]