The average number of spontaneous losses for these eight women was 3.3 +/- 2.1 (range: 1-8). aPL was present in 100% of cases. ANAs and hypergammaglobulinemia were present in 50% of cases and low C4 in 87.5% of cases. [ncbi.nlm.nih.gov]

However this disease has been found to be mostly presented with lymphadenopathy and hypergammaglobulinemia. Case Report: We present a forty-year-old woman with anemia, renal insufficiency and abnormal liver function test. [jmatonline.com]

Azotemia was present in three tigers. Diagnostics and management varied with the presenting signs but included magnetic resonance imaging, radiography, chemotherapy, supportive care, and euthanasia. [bioone.org]

• Anemia

  CONCLUSION: The presentation of LPL can mimic multiple myeloma (anemia, renal failure and monoclonal gammopathy). Definite histological and immunological technique should be done to confirm the diagnosis. [ncbi.nlm.nih.gov]

  Conclusion: The presentation of LPL can mimic multiple myeloma (anemia, renal failure and monoclonal gammopathy). Definite histological and immunological technique should be done to confirm the diagnosis. [jmatonline.com]

  […] macrocytosis Blood group deletion syndrome Bone marrow: myeloid dysplasia Congenital hypergammaglobulinemia Decreased erythroid precursor production Extramedullary hematopoiesis Hypercoagulability state Hypergammaglobulinemia Macrocytosis Macrocytosis - no anemia [icd9data.com]

  In female patients with hypergammaglobulinemia, the presence of leukopenia, anemia, and normal CRP was 95% predictive of underlying autoimmune disease. [dash.harvard.edu]

• Chronic Infection

  Hypergammaglobulinemia may occur with chronic infections, including HIV infection. Print Print this term Download Glossary English Version PDF(3.13MB) Spanish Version PDF(3.16MB) [clinicalinfo.hiv.gov]

  We encounter it in chronic infections, liver and autoimmune diseases. In electrophoresis, there is an increase in the fraction of gamma globulins forming a wide, blurred band in the area of γ-globulins. [wikilectures.eu]

  Interestingly, stronger Th1 responses and the absence of IFNγ+ IL-10+ CD4 T cells during chronic infection in infected Aicda-/- mice was not caused by a T cell intrinsic effect of AID, but by changes in the cytokine environment during chronic disease. [hal.archives-ouvertes.fr]

  Chronic infections Hypergammaglobulinemia is described in the setting of chronic infections (Dispenzieri et al. 2001; Lo et al. 2013). Chronic infections can of course be a major presentation of primary immunodeficiency. [lymphosign.com]

  Infection was determined to be the primary associated condition in three patients, two of whom had human immunodeficiency virus infection and one had culture-negative endocarditis. [ncbi.nlm.nih.gov]

• Fatigue

  Summary https://doi.org/10.1093/clinchem/hvaa154 A 30-year-old male was referred to Hematologic Oncology after 6 months of worsening lymphadenopathy and symptoms of fatigue, night sweats, weight loss, and shortness of breath. [aacc.org]

  We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: March 27, 2023 [patientslikeme.com]

  If you’re suffering from hypergammaglobulinemia, some common symptoms could include: increased blood count of gamma globulins deficiencies of certain antibodies inflammation swollen lymph nodes fatigue stiffness If you’re concerned that you might have [healthline.com]

  Reasons for checking IgG levels in these patients varied but included fever, fatigue, and elevated ESR. [ped-rheum.biomedcentral.com]

• Abdominal Pain

  Eight months earlier, she had profound jaundice without abdominal pain. At that time, she got ursodeoxycholic acid and got better. After 2 months of treatment, the patient was lost to follow-up and never visited again to the hospital. [karger.com]

  Henoch-Schönlein purpura; hypergammaglobulinemia; hypocomplementemia; streptococcal infection Henoch-Schönlein purpura (HSP) is predominantly a childhood vasculitic disease, mainly manifested as skin purpura, joint pain, abdominal pain and nephritis, [oatext.com]

  Liver diseases, abdominal pain over the last four weeks, food intake within the last six hours, or pregnancy have been excluded in the control group via anamnesis. [biochemia-medica.com]

• Long Arm

  This gene is located on the long arm of the X chromosome at position 26, denoted Xq26.[3] Normally, CD40 ligand is expressed on activated T cells, and is necessary to induce immunoglobulin class switching from IgM to the other immunoglobulin types. [en.wikipedia.org]

• Short Arm

  arm of chromosome 12. [en.wikipedia.org]

• Lethargy

  Sula Abstract Five adult tigers (Panthera tigris) presented with a range of clinical signs, including paresis (2/5), lameness (2/5), ataxia (3/5), anorexia (5/5), and lethargy (5/5). [bioone.org]

(See Pathophysiology, Presentation, and Workup.) Waldenström macroglobulinemia is not curable, but a number of therapies have shown activity in the disease. [emedicine.medscape.com]

• Hypogammaglobulinemia

  The association of thymoma with hypogammaglobulinemia, Mucocutaneous candidiasis, systemic lupus erythematosus and myasthenia gravis is well known. [ijp.iranpath.org]

  Females with hypogammaglobulinemia and high IgM levels should be tested for gene mutations that affect other forms of HIGM. Age Most patients are diagnosed before age 4 years. [emedicine.com]

  After LT, hypogammaglobulinemia can be detected in about 30% of patients, increasing the risk of infection and adding to overall mortality (11, 12). [biochemia-medica.com]

  Serum free light chains in the differential diagnosis and prognosis of primary and secondary hypogammaglobulinemia. J Allergy Clin Immunol. 2015;135(4):1075-1077.e6. [revistamedicinadelaboratorio.es]

  Hypergammaglobulinemia in predominantly antibody immunodeficiencies Humoral immunodeficiencies are typically associated with hypogammaglobulinemia. [lymphosign.com]

• Lymph Node Hyperplasia

  Arthritis Rheum. 1977; 20: 1388-1395 Steinberg JJ Huang PL Ljubich P Lee-Huang S Anti- erythropoietin antibodies in hyperviscosity syndrome associated with giant lymph node hyperplasia (GLNH; Castleman's disease). [mayoclinicproceedings.org]

Abstract Rituximab is a monoclonal antibody that depletes B cells and is commonly used for the treatment of autoimmune diseases. [ncbi.nlm.nih.gov]

Children with PHG and AML were more likely to be in CR after first induction treatment (OR=6.25, p=0.021), independent of sex, age at diagnosis, white blood cell count, percentage of blasts in the bone marrow, FAB phenotype, and treatment protocol. [link.springer.com]

In contrast, MARS treatment had no effect on the immunoglobulin profile in patients with ALF or ACLF after one treatment cycle. [biochemia-medica.com]

A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med.2002;346:564-9. Dispenzieri A, Katzmann JA, Kyle RA, Larson DR, Melton LJ, 3rd Colby C, et al. [he01.tci-thaijo.org]

The prognosis and survival of the patients with AIH are usually good because they respond well to corticosteroid and immunosuppressant therapy [13]. [karger.com]

This phenomenon does not affect the prognosis. [oatext.com]

Outlook / Prognosis What can I expect if I have polyclonal gammopathy? You may be at an increased risk of infections and anemia if you have polyclonal gammopathy. [my.clevelandclinic.org]

Prognosis Waldenström macroglobulinemia is an indolent disorder, and patients survive for a median of approximately 78 months. [emedicine.medscape.com]

The etiology of this disease is unknown. We described a 51-year-old woman who had a chronic sensory dominant polyneuropathy and dysautonomia associated with hypergammaglobulinemia. [ncbi.nlm.nih.gov]

The Incidence and Etiologic Background of Chronic Biologic False Positive Reactions in Serologic Tests for Syphilis. Ann. Int. Med. 1952; 37: 1156 Google Scholar Mueller J.F. Ratnoff O. Heinle R.W. [translationalres.com]

Etiology The exact etiology of hypergammaglobulinemia (polyclonal gammopathy) is unknown. However, the association between hypergammaglobulinemia (polyclonal gammopathy) and a heterogeneous group of conditions is well established. [statpearls.com]

To the Editor: Autoimmune pancreatitis (AIP) is an infrequently recognized disorder of presumed autoimmune etiology that belongs to the spectrum of immunoglobulin G4 (IgG4)–related diseases.1 In 2006, the Mayo Clinic proposed the diagnostic criteria for [journals.lww.com]

These authors propose that soluble PD-1 ligands have the potential to promote disease progression in Waldenström macroglobulinemia. [9] Etiology No definite etiology exists for Waldenström macroglobulinemia. [emedicine.medscape.com]

MGUS is associated with a rate of progression to multiple myeloma or a related malignant condition of 1 percent per year.2 Research regarding epidemiology of MGUS is limited in Pakistan. [thefreedictionary.com]

Epidemiology Waldenström macroglobulinemia is a relatively rare condition, with the 1500 cases diagnosed per year in the United States accounting for approximately 2% of hematologic malignancies. [emedicine.medscape.com]

Immunodeficiency reviews. 1992; [PubMed PMID: 1554497] [19] Yazdani R,Fekrvand S,Shahkarami S,Azizi G,Moazzami B,Abolhassani H,Aghamohammadi A, The hyper IgM syndromes: Epidemiology, pathogenesis, clinical manifestations, diagnosis and management. [statpearls.com]

Epidemiology Frequency United States In 2003, the US XHIGM registry reported that the minimal incidence rate of XHIGM was approximately 1 in 1,000,000 live births from 1984-1993. [4] This may be an underestimation because not all physicians in the United [emedicine.com]

Br J Haematol. 1995; 91: 345-349 Miller RH Linet MS Van Natta ML McCaffrey LD Humphrey RL Serum protein electrophoresis patterns in chronic lymphocytic leukemia: clinical and epidemiologic correlations. [mayoclinicproceedings.org]

A brief review of the history and various manifestations of sarcoidosis including the pathophysiology of hypercalcaemia in sarcoidosis are presented as well as of polyclonal gammopathy. [casereports.bmj.com]

Although IL-6 is pivotal in the pathophysiology of polyclonal gammopathy in inflammatory conditions, polyclonal gammopathy can also occur without a significant inflammatory process. [statpearls.com]

Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies. Adv Immunol. 2007. 94:275-306. [Medline]. Eijkhout HW, van Der Meer JW, Kallenberg CG, et al. [emedicine.com]

(See Pathophysiology, Presentation, and Workup.) Waldenström macroglobulinemia is not curable, but a number of therapies have shown activity in the disease. [emedicine.medscape.com]

Genetics and pathophysiology of severe congenital neutropenia syndromes unrelated to neutrophil elastase Hematol. Oncol. Clin. [lymphosign.com]

According to the study from Kim et al6 in 2010, the glucocorticoid dosage for inducing remission was 30 to 40 mg/d for 1 to 2 months, and remission maintenance was needed to prevent relapse with a dosage of 5 to 10 mg/d for at least 6 months in patients [journals.lww.com]

[…] member of the following medical societies: Academy of Medicine of New Jersey, American Academy of Allergy Asthma and Immunology, American Academy of Hospice and Palliative Medicine, American Association of Public Health Physicians, American College of Preventive [emedicine.com]