We report two patients presenting with LCV who were found to have multiple myeloma on investigation. Multiple myeloma rarely presents as LCV. [1] However, the diagnosis must be suspected in a patient who does not respond to conventional therapy. [ijdvl.com]

This usually develops several years after the diagnosis of Waldenström macroglobulinaemia has been made, but can be the presenting problem. [dermnetnz.org]

Waldenström hyperglobulinemic purpura Other names Purpura hyperglobulinemica Specialty Dermatology Waldenström hyperglobulinemic purpura is a skin condition that presents with episodic showers of petechiae (small red or purple spots) occurring on all [en.wikipedia.org]

Hematuria is the most common presenting sign, but is found in only 50-60% of cases. One-third of tumors are palpable at the time of diagnosis, and one-third present with abdominal or flank pain. [clinicaladvisor.com]

Peripheral blood eosinophilia and elevated IgE levels are often present. Circulating immune complexes, hypocomplementemia, and hyperglobulinemia have been observed but do not aid in the differential diagnosis. P-ANCA is occasionally present. [rheumaknowledgy.com]

• Easy Bruising

  Lesions of colloid milium may become purpuric after trauma.27 FEMALE EASY-BRUISING SYNDROME The female predominance and the frequent association with phases of the menstrual cycle suggest that the female easy-bruising syndrome (purpura simplex) is due [medtextfree.wordpress.com]

  bruising and spontaneous bleeding from the small vessels. [43] Frequently, the bleeding is mainly in the skin, causing petechiae, ecchymoses or both and in some cases there is bleeding also from the mucous membrane. [43] Vascular defect of hemostasis [ijdr.in]

• Purpura

  Curtz FR: Purpura hyperglobulinaemica, Ugesk. f. læger 108: 340, 1946. Google Scholar 3. Humerfelt S: Purpura with hyperglobulinemia, Nord. med. 34: 1101, 1947. MedlineGoogle Scholar 4. [acpjournals.org]

  8833011 Sjogren's syndrome with paraproteinemia and hyperglobulinemic purpura. [eurekamag.com]

  purpura in HLA identical sisters. ( 6437921 ) Ciriello M.M....Ascari E. 1984 8 SjAPgren,'s syndrome and benign hyperglobulinemic purpura of Waldenstrom. ( 7325506 ) Lu L.W....Katzman B. 1981 9 Hyperglobulinemic purpura in the course of multiple myeloma [malacards.org]

  About a case of hyperglobulinemic purpura] [Article in Italian] V VANNUCCHI et al. Riv Crit Clin Med. 1954. No abstract available Similar articles [Hyperglobulinemic purpura]. WOLOSZCZUK I. WOLOSZCZUK I. Pol Tyg Lek. 1961 May 1;16:681-3. [pubmed.ncbi.nlm.nih.gov]

  […] of Waldenstrom Hyperglobulinemic Purpura Hyperglobulinemic Purpura of Waldenström Waldenstrom Hyperglobulinemic Purpura Hyperglobulinemic Purpura, Waldenstrom Hyperglobulinemic Purpuras Purpura, Waldenstrom Hyperglobulinemic Purpuras, Hyperglobulinemic [decs.bvs.br]

• Petechiae

  Waldenström hyperglobulinemic purpura Other names Purpura hyperglobulinemica Specialty Dermatology Waldenström hyperglobulinemic purpura is a skin condition that presents with episodic showers of petechiae (small red or purple spots) occurring on all [en.wikipedia.org]

  Blood spots under the skin may be either purpura or petechiae. CD36 deficiency may be a cause of post transfusion purpura. People with Henoch's purpura are not affected by joint disease. [diki.pl]

  Discussion HGPW, first described in 1943, involves a combination of recurrent lower-extremity petechiae/purpura, elevated ESR, and polyclonal gammopathy [6]. [hss.edu]

  Rumpel-Leede sign: distal shower of petechiae that occurs immediately after the release of pressure from a tourniquet release. Associated with capillary fragility. [slideplayer.com]

  Thus, it is common for the first signs of petechiae due to thrombocytopenia to appear at the ankles. [medtextfree.wordpress.com]

• Amnesia

  Features 30 all-new topics, including Zika virus, hepatitis E, asthma-COPD overlap syndrome, drug-induced parenchymal lung disease, binge eating disorder, hereditary breast and ovarian cancer syndrome, transient global amnesia, and more. [books.google.com]

(See Pathophysiology, Etiology, and Workup.) [emedicine.medscape.com]

A thorough workup is needed to diagnose the underlying condition. We report two patients presenting with LCV who were found to have multiple myeloma on investigation. [ijdvl.com]

^ a b Waldenstrom Macroglobulinemia~workup at eMedicine ^ a b National Cancer Institute. Waldenström Macroglobulinemia: Questions and Answers. [en.wikipedia.org]

• Hyperglobulinemia

  Bing J: Further investigations of hyperglobulinemia, occurrence and degree of hyperglobulinemia in various diseases. Ratio between hyperglobulinemia, hyperproteinemia and hypoalbuminemia (Formol gel-reaction), Acta med. Scandinav. 103: 547, 1940. [acpjournals.org]

  Wal·den·ström mac·ro·glob·u·lin·e·mi·a (vahld'ĕn-strum), macroglobulinemia occurring in old people, characterized by proliferation of cells resembling lymphocytes or plasma cells in the bone marrow, anemia, increased sedimentation rate, and hyperglobulinemia [medical-dictionary.thefreedictionary.com]

  Presently available evidence suggests that purpura hyperglobulinemia is in the collagen disease group and may be an auto-immune process. Full Text [jamanetwork.com]

1 Mycophenolate mofetil treatment of a patient with hyperglobulinemic purpura. ( 15455483 ) 2004 2 Therapeutic effect of ethamsylate in a case of hyperglobulinemic purpura associated with Sjogren's syndrome. ( 8833011 ) Casas H.A. 1996 3 Benign hyperglobulinemic [malacards.org]

Broaden your knowledge with updated information on serological diagnosis of pemphigus, TNF-I for hidradenitis suppurativa, the use of immunosuppressives for atopic dermatitis, excimer laser for the treatment of vitiligo and much more. [books.google.com]

Herein we describe a case of a severe PSS patient refractory to conventional treatment as well as, with a notable response to bortezomib, a proteasome inhibitor commonly used for the treatment of multiple myeloma. [ard.bmj.com]

The exocrine manifestations, diagnosis, treatment, and prognosis of both sicca and extraglandular manifestations are discussed separately. [uptodate.com]

Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.de]

E-selectin: High concentrations in patient sera correlate with low incidence of metastasis and, consequently, correlate with good prognosis. Expression of elevated E-selectin facilitates metastasis. [clinicaladvisor.com]

The prognosis of SBN is severe; however, some authors have reported prolonged complete remission [ 8, 10 – 12 ]. 4. Conclusion BNS is a rare and potentially treatable complication of WM. [hindawi.com]

English : BL blood CF cerebrospinal fluid CI chemically induced CL classification CO complications CN congenital DI diagnosis DG diagnostic imaging DH diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology EH ethnology ET etiology [decs.bvs.br]

Etiology: This systemic vasculitis is of uncertain etiology. [rheumaknowledgy.com]

Williams Dermatology Service, Veterans Administration Medical Center, and Departments of Dermatology and Pediatrics, University of California School of Medicine, San Francisco Abstract Seborrheic dermatitis is a common skin condition of infancy of unknown etiology [pedsinreview.aappublications.org]

Etiology Cryoglobulinemias are associated with a variety of illnesses (listed below), three most common categories being: infections, autoimmune disorders, and malignancies. [clinicaladvisor.com]

McKee's Pathology of the Skin is the most complete, in-depth resource on dermatopathology, covering etiology, pathogenesis, disease mechanisms, and recent genetic, molecular, and basic science data. Drs. J. [books.google.de]

Allowable Qualifiers English : BL blood CF cerebrospinal fluid CI chemically induced CL classification CO complications CN congenital DI diagnosis DG diagnostic imaging DH diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology [decs.bvs.br]

Epidemiology Waldenström macroglobulinemia is a relatively rare condition, with the 1500 cases diagnosed per year in the United States accounting for approximately 2% of hematologic malignancies. [emedicine.medscape.com]

We review the literature on BNS and discuss its epidemiology, presentation, diagnosis, treatment, and prognosis. 2. Case Presentation A 57-year-old man, heavy smoker, was treated since November 2003 for a WM. [hindawi.com]

Dry eyes or mouth--an epidemiological study in Swedish adults, with special reference to primary Sjogren's syndrome. J Autoimmun 1989; 2:521. 12. Vitali, C, Bombardieri, S, Moutsopoulos, HM, et al. [dry.org]

Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.de]

Pathophysiology of circulating immune complexes. Arthritis Rheum, 1982, 125, 783–787. Google Scholar 13. Clark, R.A., Abraham, G.N., Kyle, R., Vaughan, J.H. Gammaglobulin complexes in rheumatoid arthritis and hypergammaglobulinemic purpura. [link.springer.com]

[…] caused by organisms growing in vessel and vessel walls (usually immunocompromised host) o Vessel-invasive fungus ( Mucor, Aspergillus, Cephalosporium, Rhizopus, etc.) o Ecthyma gangrenosum ( Pseudomonas ) o Disseminated strongyloidiasis · Uncertain pathophysiology [dermaamin.com]

Further such reports will help augment our understanding on the pathophysiology of IgA-VN in WD. Author Details Authors Ratna Acharya1 Xu Zeng2 William L. [dustri.com]

0% Emergent - ED Care Needed - Preventable/Avoidable - 0% Emergent - ED Care Needed - Not Preventable/Avoidable - 0% Primary diagnosis of injury 0% Primary diagnosis of mental health problems 0% Primary diagnosis of substance abuse 0% Primary diagnosis [medicbind.com]

Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets [books.google.com]

[…] diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology EH ethnology ET etiology GE genetics HI history IM immunology ME metabolism MI microbiology MO mortality NU nursing PS parasitology PA pathology PP physiopathology PC prevention [decs.bvs.br]

Overview Hypogammaglobulinemia is a problem with the immune system that prevents it from making enough antibodies called immunoglobulins. [healthline.com]