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Hypergonadotropic Hypogonadism-Cataract Syndrome

Lubinsky Syndrome


Presentation

  • She is board certified in Neurology (1997-present) and is a member of the American Academy of Neurology, the American Neurological Association and the Movement Disorder Society.[books.google.com]
  • , mild to severe mental retardation and dysarthria (slow, imprecise speech) are usually present.[ipfs.io]
  • Hormone replacement therapy is needed if hypogonadism is present.[en.wikipedia.org]
  • Hormonal replacement therapy is needed if hypogonadism is present.[marinesco-sjogren.org]
  • CLINICAL PRESENTATION AND INTERVENTION A 25-year-old man with mental retardation presented with multiple skeletal abnormalities, polyuria and polydipsia. He had high glucose concentrations, without ketonuria, and hypergonadotropic hypogonadism.[unboundmedicine.com]
Movement Disorder
  • In addition, he established the Rush Movement Disorder Surgery Program and serves as its Medical Director. His clinical research interests include the development of new medical and surgical therapies for patients with advanced movement disorders.[books.google.com]
  • Hypogonadism has remarkable associations with variable medical disorders; however, it is characterized by a distinctive association with variable neurological disorders: such as epilepsy, ataxia, dysmyelination, nerve muscle disease, movement disorders[springermedizin.de]
  • disorder Trigonobrachycephaly, bulbous bifid nose, micrognathia, and abnormalities of the hands and feet Friedreich ataxia Aicardi-Goutieres syndrome type 5 Corneodermatoosseous syndrome Ankyloblepharon filiforme adnatum cleft palate Renpenning syndrome[checkrare.com]
Pathologist
  • As such, it should be useful to a varied audience, including not only the oral and maxillofacial surgeon but also the oral pathologist, the practitioner of oral medicine, and members of the craniofacial team--the orthodontist, pediatric dentist, speech[books.google.com]
Dentist
  • As such, it should be useful to a varied audience, including not only the oral and maxillofacial surgeon but also the oral pathologist, the practitioner of oral medicine, and members of the craniofacial team--the orthodontist, pediatric dentist, speech[books.google.com]
Inflammation
  • Articles in this issue include: Hereditary Hemochromatosis (HFE and Non-HFE); Iron Refractory Iron Deficiency Anemia (IRIDA); Sideroblastic Anemia; Anemia of Chronic Disease/Inflammation; Pathophysiology of Transfusional Iron Overload; Transfusional Iron[books.google.com]
Skin Lesion
  • Eponym It is named for Gheorghe Marinescu and Torsten Sjögren. [4] See also Skin lesion List of cutaneous conditions References James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.).[ipfs.io]
  • Eponym [ edit ] It is named for Gheorghe Marinescu and Torsten Sjögren . [4] See also [ edit ] Skin lesion List of cutaneous conditions References [ edit ] James, William; Berger, Timothy; Elston, Dirk (2005).[en.wikipedia.org]
  • Keywords Hypogonadotropic hypogonadism; Microphallus; Kallmann syndrome Case Report A 27 year old white male presented to a family medicine clinic with complaint of a changing skin lesion that was a melanoma in situ.[omicsonline.org]
Stroke
  • He then accepted a fellowship at the National Institutes of Health, in the Experimental Therapeutics Branch of the National Institute of Neurological Disorders and Stroke in Bethesda, Maryland under Thomas N. Chase (1992-1994).[books.google.com]
  • Affected individuals can develop acute neurologic events due to stroke-like episodes (summary by Miskinyte et al., 2011 ).For a general phenotypic description and a discussion of genetic heterogeneity of moyamoya disease, see MYMY1 ( OMIM ).[mendelian.co]
  • Affected individuals can develop acute neurologic events due to stroke-like episodes (summary by Miskinyte et al., 2011). For a general phenotypic description and a discussion of genetic heterogeneity of moyamoya disease, see MYMY1 (252350).[ncbi.nlm.nih.gov]
  • PubMed Google Scholar Hopkins SE, Somoza A, Gilbert DL: Rare autosomal dominant POLG1 mutation in a family with metabolic strokes, posterior column spinal degeneration, and multi-endocrine disease.[ojrd.biomedcentral.com]
  • Adenylosuccinase deficiency Torticollis, familial Renal tubular acidosis with deafness Trichothiodystrophy Mucolipidosis type 4 Maturity-onset diabetes of the young Dihydropteridine reductase deficiency Hereditary endotheliopathy, retinopathy, nephropathy, and stroke[checkrare.com]
Cognitive Defect
  • Mild, nonprogresssive cognitive defects and mental retardation are often present. Sensory neuropathy with numbness and tingling develops in the second decade. Mild chorea, upper limb tremor, mild ataxia, and extensor plantar responses may be seen.[disorders.eyes.arizona.edu]
Pendular Nystagmus
  • Strabismus and horizontal pendular nystagmus are common. Visual impairment may be severe. Systemic Features: The neuropathy is primarily motor and usually begins in the lower extremities but is progressive and eventually involves the arms as well.[disorders.eyes.arizona.edu]
Slow Speech
  • On examination, the leading symptoms were difficulties with free walking, slow speech, one-sided cataract, and mild peripheral neuropathy.[thieme-connect.com]
Sexual Dysfunction
  • Discussions on the current methods for the diagnosis and treatment of male hypogonadism, male infertility and male sexual dysfunction follow, with detailed descriptions of types of androgen replacement and the benefits and risks of such treatment.[books.google.com]
  • Osteoporosis, increased risk of testicular cancer secondary to cryptorchidism, sexual dysfunction, and infertility are just a few of the sequelae associated with IHH. When diagnosed early, these co morbidities can be reduced or even eliminated.[omicsonline.org]

Workup

Dyslipidemia
  • Kompoliti’s include the gender differences in Parkinson’s disease and other movement disorders, studies to define the effect of neuroleptics on weight, risk for diabetes and dyslipidemia in patients with Tourette syndrome, and define the current status[books.google.com]
  • Nearly all demonstrate associated dyslipidemia. Other endocrine abnormalities can include hypothyroidism, hypogonadotropic hypogonadism in boys, and polycystic ovaries in girls.[ncbi.nlm.nih.gov]

Treatment

  • Discussions on the current methods for the diagnosis and treatment of male hypogonadism, male infertility and male sexual dysfunction follow, with detailed descriptions of types of androgen replacement and the benefits and risks of such treatment.[books.google.com]
  • Treatment Treatment for MSS is symptomatic and supportive including physical and occupational therapy, speech therapy, and special education. Cataracts must be removed when vision is impaired, generally in the first decade of life.[ipfs.io]
  • Treatment [ edit ] Treatment for MSS is symptomatic and supportive including physical and occupational therapy, speech therapy, and special education. Cataracts must be removed when vision is impaired, generally in the first decade of life.[en.wikipedia.org]
  • It is not clear to what extent combined immunosuppressive treatment can be effective in the treatment of this disease, which typically does not respond to treatment with steroids.[bloodjournal.org]

Prognosis

  • -prognosis? -damage to the Leydig cells impairs testosterone production and/or damages the seminiferous tubules, with resulting oligospermia or azoospermia and elevated LH and FSH, in a setting of low testosterone.[quizlet.com]
  • Prenatal diagnosed 45,X/46,XY or 45,X/46,XX mosaicism have a very different prognosis compared to nonmosaic 45,X. In large studies of prenatally diagnosed 45,X mosaicism with 45,X/46,XY, more than 90% of cases have a normal male phenotype.[clinicaladvisor.com]
  • Parents should talk to their children’s physician and medical team about their child, potential associated symptoms and overall prognosis. 1) Coloboma and other eye abnormalities A coloboma (plural colobomata or colobomas) consists of the partial absence[rarediseases.org]
  • PMID: 6401925 Prognosis França MM, Lerario AM, Funari MFA, Nishi MY, Narcizo AM, de Mello MP, Guerra-Junior G, Maciel-Guerra AT, Mendonça BB Sex Dev 2017;11(3):137-142. Epub 2017 Jun 8 doi: 10.1159/000477193.[ncbi.nlm.nih.gov]
  • The prognosis of hereditary haemochromatosis has improved due to earlier genetic screening.[ojrd.biomedcentral.com]

Etiology

  • Etiology They can be etiologically subcategorised into those with and without typical peripheral nervous system involvement (usually based on nerve conduction studies): with typical peripheral nervous system involvement hypomyelination with congenital[radiopaedia.org]
  • […] which may be 1º, due to a lack of end organ response to FSH or LH produced normally by an intact pituitary gland–hypergonadotropic hypogonadism, or 2º to defective hypothalamic or pituitary hormonal activity–hypogonadotropic hypogonadism Hypogonadism, etiology[medical-dictionary.thefreedictionary.com]
  • Causes [ edit ] There are a multitude of different etiologies of HH.[en.wikipedia.org]
  • The etiology of the condition can be congenital or secondary to other problems.[clinicaladvisor.com]
  • Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.[bioportfolio.com]

Epidemiology

  • […] mellitus Synonym(s): (no synonyms) Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities - Epidemiological[csbg.cnb.csic.es]
  • . : Epidemiological, clinical, paraclinical and molecular study of a cohort of 102 patients affected with autosomal recessive progressive cerebellar ataxia from Alsace, Eastern France: implications for clinical management.[genome.jp]
Sex distribution
Age distribution

Pathophysiology

  • Articles in this issue include: Hereditary Hemochromatosis (HFE and Non-HFE); Iron Refractory Iron Deficiency Anemia (IRIDA); Sideroblastic Anemia; Anemia of Chronic Disease/Inflammation; Pathophysiology of Transfusional Iron Overload; Transfusional Iron[books.google.com]
  • References Seminara S B, Hayes F J, Crowley Jr W F (1998) Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropichypogonadism and Kallmann's syndrome): pathophysiological and genetic considerations.[omicsonline.org]
  • The pathophysiology and genetics of congenital lipoid adrenal hyperplasia. International Congenital Lipoid Adrenal Hyperplasia Consortium. N Engl J Med 1996; 335(25):1870-1878. Nakae J, Tajima T, Sugawara T et al.[endocrine.gr]
  • The postulated genetic locus is described in Pathophysiology, with most notably being mutation of the AIRE gene. Environmental Precipitators of autoimmunity exist, but they continue to be elusive.[emedicine.medscape.com]
  • On the whole, the pathophysiology of endocrine dysfunctions in IEM remains poorly understood.[ojrd.biomedcentral.com]

Prevention

  • Late bacterial and viral infections have been extensively reviewed, and guidelines for preventing and treating these opportunistic infections after SCT are proposed in a document published under the hospice of the Centers for Disease Control and Prevention[bloodjournal.org]
  • If a lactose-restricted diet is provided during the first ten days of life, the severe acute neonatal complications are usually prevented.[ncbi.nlm.nih.gov]
  • It also prevents closure of the potassium channels, inducing a defect in insulin secretion [ 13 – 15 ]. Insulin sensitivity in skeletal muscle is also decreased [ 15 ].[ojrd.biomedcentral.com]

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