Homocysteine auto-oxidizes and reacts with reactive oxygen intermediates, damaging endothelial cells and increasing the risk of thrombus formation. [14] [15] Ectopialentis [ edit ] Homocystinuria is the second most common cause of heritable ectopialentis[en.wikipedia.org]
The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis: a systematic review. Clin. Chem. Lab. Med. 2007; 45 :1621–32. [ PubMed ] [ Google Scholar ] 12.[ncbi.nlm.nih.gov]
It is associated with intellectual disability, osteoporosis, chest deformities, and increased risk of thrombotic episodes.[en.wikipedia.org]
In conclusion, therefore, because of Mendelian randomization generally avoiding confounding, 2, 3 we believe that our data suggest that ICD/VTE causes hyperhomocysteinemia, rather than vice versa. Footnotes Correspondence: Børge G.[bloodjournal.org]
"Serum Homocysteine Levels Are Associated with the Development of (Micro)albuminuria : The Hoorn Study". Arteriosclerosis, Thrombosis, and Vascular Biology. 21 (1): 74–81. doi : 10.1161/01.ATV.21.1.74. PMID 11145936. Jakubowski, H (2006).[en.wikipedia.org]
Cardiovascular risks [ edit ] Elevated homocysteine is a known risk factor for cardiovascular disease as well as thrombosis. [5] It has also been shown to be associated with microalbuminuria which is a strong indicator of the risk of future cardiovascular[en.wikipedia.org]
Mendelian randomisation': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003 ; 32 : 1 -22. Smith GD, Ebrahim S. Mendelian randomisation: prospect, potential, and limitations.[bloodjournal.org]
"Pathophysiological consequences of homocysteine excess". The Journal of Nutrition. 136 (6 Suppl): 1741S–1749S. doi : 10.1093/jn/136.6.1741S. PMID 16702349. McVeigh, Catherine; Passmore, Peter (September 2006).[en.wikipedia.org]
[…] endothelial nitric oxide synthase, as increased endothelial lipid peroxidation and oxidation of the redox-sensitve dye 2,7-dichlorofluoresceine could only be observed after incubation of endothelial cells with L-, but not with D-homocysteine, and could be prevented[eurekaselect.com]
Lowering Homocysteine in Patients With Ischemic Stroke to Prevent Recurrent Stroke, Myocardial Infarction, and Death: The Vitamin Intervention for Stroke Prevention (VISP) Randomized Controlled Trial. J. Am. Med.[ncbi.nlm.nih.gov]
"Homocysteine-lowering interventions for preventing cardiovascular events". The Cochrane Database of Systematic Reviews. 1 : CD006612. doi : 10.1002/14651858.CD006612.pub4. ISSN 1469-493X. PMC 4164174. PMID 25590290. Cattaneo, Marco (1999).[en.wikipedia.org]