In the present study, treatment of cultured endothelial cells with DL-homocysteine was specifically associated with a selective reduction in cellular binding sites for t-PA. [scienceopen.com]

• Vascular Disease

  This may contribute to endothelial dysfunction observed in hyperhomocysteinemia, and promote atherosclerotic vascular disease. [eurekaselect.com]

  Homocysteine and vascular disease. Lancet. 1999;354:407–413. [PubMed] [Google Scholar] 21. Kang S.S., Wong P.W.K., Malinow M.R. hyperhomocysteinemia as a risk factor for occlusive vascular disease. Annu Rev Nutr. 1996;12:279–298. [ncbi.nlm.nih.gov]

  This mutation in MTHFR may represent an important genetic risk factor in vascular disease. [scienceopen.com]

  Homocysteine and vascular disease. Lancet. 1999 ; 354 : 407 -413. [bloodjournal.org]

• Thrombosis

  "Hyperhomocysteinemia, atherosclerosis and thrombosis". Thrombosis and Haemostasis. 81 (2): 165–76. doi : 10.1055/s-0037-1614438. PMID 10063987. ^ Jager, A.; Kostense, P. J.; Nijpels, G.; Dekker, J. M.; Heine, R. J.; Bouter, L. M.; Donker, A. J. [en.wikipedia.org]

  Add a translation Finnish English Info Finnish -nykyinen tai aiempi valtimotromboosi (esim. aivohalvaus, sydäninfarkti, verkkokalvon English embolism-presence or history of arterial thrombosis (e. g. cerebrovascular accident, myocardial infarction, Last [mymemory.translated.net]

  Coexistence of hereditary homocystinuria and factor V Leiden--effect on thrombosis. N. Engl. J. Med. 1996; 334 :763–8. [ PubMed ] [ Google Scholar ] 36. McCully KS. [ncbi.nlm.nih.gov]

• Osteoporosis

  The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis: a systematic review. Clin. Chem. Lab. Med. 2007; 45 :1621–32. [ PubMed ] [ Google Scholar ] 12. [ncbi.nlm.nih.gov]

  It is associated with intellectual disability, osteoporosis, chest deformities, and increased risk of thrombotic episodes. [en.wikipedia.org]

• Fracture

  "Homocysteine as a Predictive Factor for Hip Fracture in Older Persons". New England Journal of Medicine. 350 (20): 2042–9. doi : 10.1056/NEJMoa032739. [en.wikipedia.org]

  Homocysteine as a predictive factor for hip fracture in older persons. N. Engl. J. Med. 2004; 350 :2042–9. [ PubMed ] [ Google Scholar ] 82. Sawka AM, Ray JG, Yi Q, Josse RG, Lonn E. [ncbi.nlm.nih.gov]

• Stroke

  Lowering Homocysteine in Patients With Ischemic Stroke to Prevent Recurrent Stroke, Myocardial Infarction, and Death: The Vitamin Intervention for Stroke Prevention (VISP) Randomized Controlled Trial. J. Am. Med. [ncbi.nlm.nih.gov]

  […] sometimes recommended prior to measurement of homocysteine levels, but this may not be necessary for diagnostic yield. [22] Treatment [ edit ] Vitamins B6, B9, or B12 supplements, while they lower homocysteine level do not change the risk of heart disease, stroke [en.wikipedia.org]

In conclusion, high-dose 5-MTHF treatment for 3 months ensures marked Hcy lowering to normal values even in subjects with high Hcy levels, and should be the treatment of choice in medium hyperhomocysteinemia. [insights.ovid.com]

"Homocysteine, folate and vitamin B12in neuropsychiatric diseases: Review and treatment recommendations". Expert Review of Neurotherapeutics. 9 (9): 1393–412. doi : 10.1586/ern.09.75. [en.wikipedia.org]

There is increasing evidence that time is necessary to identify the disorder and provide treatment for prevention. [scienceopen.com]

Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment. Am. J. Med. 2005; 118 :1154–9. [ PubMed ] [ Google Scholar ] 41. Lindenbaum J, Rosenberg IH, Wilson PWF, Stabler S, Allen RH. [ncbi.nlm.nih.gov]

`Mendelian randomisation': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003 ; 32 : 1 -22. ↵ Smith GD, Ebrahim S. Mendelian randomisation: prospect, potential, and limitations. [bloodjournal.org]

"Pathophysiological consequences of homocysteine excess". The Journal of Nutrition. 136 (6 Suppl): 1741S–1749S. doi : 10.1093/jn/136.6.1741S. PMID 16702349. ^ McVeigh, Catherine; Passmore, Peter (September 2006). [en.wikipedia.org]

[…] endothelial nitric oxide synthase, as increased endothelial lipid peroxidation and oxidation of the redox-sensitve dye 2,7-dichlorofluoresceine could only be observed after incubation of endothelial cells with L-, but not with D-homocysteine, and could be prevented [eurekaselect.com]

Lowering Homocysteine in Patients With Ischemic Stroke to Prevent Recurrent Stroke, Myocardial Infarction, and Death: The Vitamin Intervention for Stroke Prevention (VISP) Randomized Controlled Trial. J. Am. Med. [ncbi.nlm.nih.gov]

"Homocysteine-lowering interventions for preventing cardiovascular events". The Cochrane Database of Systematic Reviews. 1 : CD006612. doi : 10.1002/14651858.CD006612.pub4. ISSN 1469-493X. PMC 4164174. PMID 25590290. ^ Cattaneo, Marco (1999). [en.wikipedia.org]

There is increasing evidence that time is necessary to identify the disorder and provide treatment for prevention. [scienceopen.com]