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Hyperinsulinemia

Presentation

Altogether, 88.1% of the former vs. 40.0% of the latter group presented at least one of these three markers of internal cation imbalance (P less than 0.001). [jci.org]

Thiazolidinedione drugs increase insulin sensitivity, but their use in the metabolic syndrome is only speculative at present. We recommend they be used only as indicated to treat diabetes mellitus. [ccjm.org]

Caloric restriction, increasing hepatic insulin clearance and maximizing insulin sensitivity are at present the three main strategies available for managing hyperinsulinemia. [repub.eur.nl]

Glucose intolerance that was already present was not statistically significant in the group evaluated. [bjorl.org]

Entire Body System

  • Weight Gain

    Although hyperinsulinemia often has little clear indicator, hyperinsulinemia symptoms may include: Weight gain Cravings for sugar Intense hunger Feeling frequently hungry Difficulty concentrating Feeling anxious or panicky Lacking focus or motivation [diabetes.co.uk]

    […] as follows: Weight gain - A sudden restoration of control over the blood glucose levels among diabetic patients that uses insulin can cause weight gain. [absoluteintegrativehealth.com]

    Symptoms of Insulin Resistance One of the first symptoms to develop is weight gain, particularly around the abdominal area. Further symptoms include: Hunger Difficulty concentrating Lethargy High blood pressure. [news-medical.net]

    Intense sugar cravings Weight gain (or resistant to weight loss techniques) Extreme hunger or thirst Anxiety or feelings of panic Fatigue or lack of motivation Visual problems such as blurred vision or double vision Headaches Trembling or shakiness Concentration [serenityhealthcarecenter.com]

  • Weight Loss

    A Mayo Clinic expert explains Intermittent fasting Kidney disease FAQs Low-glycemic index diet Symptom Checker Type 2 diabetes Unexplained weight loss Biliopancreatic diversion with duodenal switch Roux-en-Y gastric bypass Sleeve gastrectomy Weight Loss [mayoclinic.org]

    Weight loss, physical activity, and treatment of the individual risk factors constitute the main strategies for treatment. [ccjm.org]

    If insulin resistance is causing hyperinsulinemia, weight loss, diet, and exercise are the best ways to improve both conditions. [ro.co]

    This dietary strategy is often used for weight loss, but it’s effective for reversing metabolic syndrome (i.e. “insulin resistance syndrome”) even in the absence of weight loss. Supplementation with inositol may be beneficial for those with IR. [blog.designsforhealth.com]

  • Asymptomatic

    After RM repetition, these patients were again asymptomatic. Finally, patients whose nystagmus and vertigo did not disappear when RM were carried out under the supervision of an otolaryngologist were classified as having persistent BPPV. [bjorl.org]

    Asymptomatic atherosclerosis and insulin resistance. Arterioscler Thromb. 1991;111068- 1076Google ScholarCrossref 54. Suzuki MShinozaki KKanazawa A et al. Insulin resistance as an independent risk factor for carotid wall thickening. [jamanetwork.com]

    Asymptomatic atherosclerosis and insulin resistance. [ahajournals.org]

  • Infertility

    Some women experience infertility or amenorrhea due to polycystic ovarian syndrome (PCOS); men may be dealing with erectile dysfunction or an enlarged prostate gland. [westonaprice.org]

    Fertil Steril 61: 598, 1994 82 Bates GW, Whitworth NS: Effect of body weight reduction of plasma androgens in obese, infertile women. [glowm.com]

Neurologic

  • Headache

    Intense sugar cravings Weight gain (or resistant to weight loss techniques) Extreme hunger or thirst Anxiety or feelings of panic Fatigue or lack of motivation Visual problems such as blurred vision or double vision Headaches Trembling or shakiness Concentration [serenityhealthcarecenter.com]

    In older children, symptoms may include anxiety, hunger, shakiness, sweating, increased appetite, lethargy, nausea, vomiting, lack of concentration, tachycardia, seizures, hypothermia, fainting, headache, and changes in behavior. [news-medical.net]

Workup

Serum

  • Dyslipidemia

    Since hypertension is related to all other conditions of metabolic syndrome it can then be extrapolated that cation transport is ubiquitously associated with obesity, dyslipidemia, and glucose intolerance as well. [definitions.net]

    For now, the goals and methods of treating hypertension and dyslipidemia are the same in people with the metabolic syndrome as in the general population. [ccjm.org]

    It’s often associated with other metabolic disorders such as glucose intolerance and dyslipidemia. This close association between metabolic disorders and hyperinsulinemia suggest that they are linked. [serenityhealthcarecenter.com]

    The relationship between hyperinsulinemia and CVD mortality was largely mediated through obesity, hypertension, and dyslipidemia. [jamanetwork.com]

    These results support the notion that hyperinsulinemia may increase the risk of ischemic heart disease through alterations in metabolic processes other than the related dyslipidemia. [nejm.org]

  • Hypertriglyceridemia

    Review Cleveland Clinic Journal of Medicine December 2002, 69 (12) 985-989; ABSTRACT The cluster of hypertriglyceridemia, hyperinsulinemia, obesity, and hypertension markedly increases the risk of coronary artery disease. [ccjm.org]

    This is the case also for other factors that have physiological links with hyperinsulinemia, such as hypertriglyceridemia, low HDL cholesterol level, and hypertension. [jamanetwork.com]

    The deadly quartet: upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med 1989;149:1514-1520 25. Despres JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C. [nejm.org]

    […] associated with low adiponectin concentrations in obese people, though whether low adiponectin has a causal role in hyperinsulinemia remains to be established.[11] May lead to hypoglycemia or diabetes Increased risk of PCOS Increased synthesis of VLDL (hypertriglyceridemia [en.wikipedia.org]

Treatment

Weight loss, physical activity, and treatment of the individual risk factors constitute the main strategies for treatment. [ccjm.org]

"Hyperinsulinemia Treatments". News-Medical. https://www.news-medical.net/health/Hyperinsulinemia-Treatments.aspx. (accessed December 05, 2022). Harvard Robertson, Sally. 2021. Hyperinsulinemia Treatments. [news-medical.net]

This word is another mouthful and essentially means “caused by medical treatment.” Iatrogenic hyperinsulinemia refers to high levels of insulin in the blood that are the direct result of some kind of medical treatment. [ro.co]

In the rare case of a tumor or nesidioblastosis, surgery or other treatment may be necessary. For the most part, however, treatment typically focuses on diet, exercise and weight loss to reduce insulin resistance. [medicalnewstoday.com]

Adherence to treatment and your body’s response to treatment. People can have mild insulin resistance and hyperinsulinemia that never turn into prediabetes or Type 2 diabetes. [my.clevelandclinic.org]

Prognosis

Outlook / Prognosis What is the prognosis (outlook) for hyperinsulinemia? The prognosis (outlook) of hyperinsulinemia depends on several factors, including: The cause of insulin resistance (which causes hyperinsulinemia). [my.clevelandclinic.org]

Triglyceride glucose index and its combination with the Get with the Guidelines-Heart Failure score in predicting the prognosis in patients with heart failure. Han S, Wang C, Tong F, Li Y, Li Z, Sun Z, Sun Z. Han S, et al. [pubmed.ncbi.nlm.nih.gov]

Etiology

This study and the Parkinson’s study both had very small sample sizes, but they raise interesting questions regarding a possible role for chronic hyperinsulinemia and IR in the etiology of neurodegenerative disorders. [blog.designsforhealth.com]

Hyperinsuline-mia is an important etiological factor in the development of metabolic syndrome, type 2 diabetes, cardiovascular disease, cancer and premature mortality. [repub.eur.nl]

Patients diagnosed with secondary BPPV of undetermined etiology, such as traumatic brain injury, Ménière's disease, vestibular neuronitis, post-operative of ear surgery, and vertebrobasilar insufficiency were also excluded. [bjorl.org]

Hyperinsulinemia is an important etiological factor in the development of metabolic syndrome, type 2 diabetes, cardiovascular disease, cancer and premature mortality. hyperinsulinemia insulin resistance insulin secretion insulin clearance growth hormone [encyclopedia.pub]

As it appears likely that obesity precedes hyperinsulinemia, hyperinsulinemia might be a mediating etiologic phenomenon in the causal chain through which obesity increases the risk of CVD. [jamanetwork.com]

Epidemiology

Insulin and its role in chronic kidney disease Medicine, Biology Pediatric Nephrology 2007 The goal of this review was to provide an update of the literature on insulin pathophysiology in CKD, current understanding of its mechanisms, and epidemiological [semanticscholar.org]

Epidemiology of benign paroxysmal positional vertigo: a population based study. J Neurol Neurosurg Psychiatry, 78 (2007), pp. 710-715 [24] H. Tanimoto, K. Doi, T. Nishikawa, K. Nibu. [bjorl.org]

First, the presence of nonalcoholic fatty liver disease was assessed by ultrasonographic method, not by pathologic method, as it is inappropriate to perform invasive tests in a population-based epidemiological study. 24 Joy D. Thava V.R. Scott B.B. [amjmed.com]

Only 2 prospective epidemiological studies have thus far examined the association between plasma insulin and the risk of cerebrovascular disease. [ahajournals.org]

J Reprod Med 39: 327, 1994 58 Flack J, Sowers J: Epidemiologic and clinical aspects of insulin resistance and hyperinsulinemia. [glowm.com]

Pathophysiology

Insulin and its role in chronic kidney disease Medicine, Biology Pediatric Nephrology 2007 The goal of this review was to provide an update of the literature on insulin pathophysiology in CKD, current understanding of its mechanisms, and epidemiological [semanticscholar.org]

We conclude that insulin resistance and/or hyperinsulinemia (a) are present in the majority of hypertensives, (b) constitute a common pathophysiologic feature of obesity, glucose intolerance, and hypertension, possibly explaining their ubiquitous association [jci.org]

It is important to realize that the actual diagnostic criteria for normal glucose tolerance, impaired glucose tolerance and type 2 diabetes are not defined on the basis of pathophysiological abnormalities [43]. [encyclopedia.pub]

J Clin Endocrinol Metab 50: 113, 1980 20 Barbieri RL, Ryan KJ: Hyperandrogenism, insulin resistance, acanthosis nigricans: A common endocrinopathy with unique pathophysiologic features. [glowm.com]

Pathophysiology The differential diagnosis of hypoglycemia is extensive, and determining the underlying cause is often difficult. An understanding of glucose homeostasis can help narrow the differential diagnosis. [emedicine.medscape.com]

Prevention

This may slow down age‐related physiological decline and prevent age‐related diseases. [repub.eur.nl]

However, at this moment it is unclear which strategy is the best for preventing/managing hyperinsulinemia. [encyclopedia.pub]

Top 3 Takeaway Notes To prevent insulin resistance and hyperinsulinemia, enjoy unprocessed low-carb whole foods. Do not rely solely on the results of a glucose tolerance test. [ditchthecarbs.com]

Dermatologist-approved lesson plans, activities you can use Free to everyone, these materials teach young people about common skin conditions, which can prevent misunderstanding and bullying. [aad.org]

Prevention What are the risk factors for developing hyperinsulinemia? Certain genetic and lifestyle risk factors make it more likely that you’ll develop hyperinsulinemia. [my.clevelandclinic.org]

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