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Hyperinsulinemic Hypoglycaemia
Hyperinsulinemic Hypoglycemia

Presentation

Unusual presentations of a rare entity. Arch Surg, 129 (1994), pp. 329-332 [2.] F. Tse-Ling, N.E. Warner, D. Kumar. Pancreatic nesidioblastosis in adults. Diabetes Care, 12 (1989), pp. 108-114 [3.] M.J. Dunne, C. Kane, R.M. Shepherd, J.A. [elsevier.es]

Endogenous and exogenous insulin can be distinguished by the presence or absence of C-peptide, a by-product of endogenous insulin secretion which is not present in pharmaceutical insulin. [en.wikipedia.org]

Treatment

KEYWORDS: Autoimmune hypoglycaemia; Hyperinsulinemic hypoglycaemia; Insulinoma; Nesidioblastosis; Treatment [ncbi.nlm.nih.gov]

The role of glucagon administration in the diagnosis and treatment of patients with tumor hypoglycemia. Cancer, 82 (1998), pp. 1585-1592 [11.] T.J. Wilkin, A.J. Bone, K.A. Webster. Nesidioblastosis. [elsevier.es]

High dose glucocorticoid is an older treatment used for presumptive transient hyperinsulinism but incurs side effects with prolonged use. Idiopathic hypoglycemia [en.wikipedia.org]

Etiology

This etiology should always be considered in patients with a preoperative presumptive diagnosis of insulinoma. In these cases, partial pancreatectomy is indicated, although the optimal treatment remains to be determined. [elsevier.es]

Pathophysiology

[…] hyperinsulinism (glutamate dehydrogenase gain-of-function mutations) Short chain acyl coenzyme A dehydrogenase deficiency Carbohydrate-deficient glycoprotein syndrome (Jaeken's Disease) Beckwith-Wiedemann syndrome(suspected due to hyperinsulinism but pathophysiology [en.wikipedia.org]

Prevention

Further therapy and prevention depends upon the specific cause. Most hypoglycemia due to excessive insulin occurs in people who take insulin for type 1 diabetes. [en.wikipedia.org]

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