Most cases have been reported in Europe with age of presentation between 35 and 60 years. [pubfacts.com]

Due to its uncharacteristic presentation, it is rarely diagnosed clinically. Here we present one such case in a 50-year-old lady. She presented with a hard mobile lesion over her nose which was excised. The histologic picture is characterized... [connection.ebscohost.com]

We present a case of hyperkeratosis lenticularis perstans (Flegel's disease) in a 71-year-old-woman. [ncbi.nlm.nih.gov]

Presentation on theme: "Hyperkeratosis Lenticularis perstans (Flegel’s Disease)"— Presentation transcript: 1 Hyperkeratosis Lenticularis perstans (Flegel’s Disease) Report of a case 高雄長庚紀念醫院皮膚科 病理科* 黃仁杰 黃柏翰 何宜承 黃昭誠* 2 Chief Complain Multiple asymptomatic [slideplayer.com]

Indian J Dermatol 2013;58:161 Sir, A 22-year-old female patient presented with complains of gradually increasing asymptomatic skin lesions all over body for last 2 years. [e-ijd.org]

• Weight Loss

  He also denied constitutional symptoms such as fever, chills, weight loss, myalgia, or arthralgia. Previous Treatment: The lesions were previously treated with topical triamcinolone 0.1% cream with no clinical improvement. [aocd-grandrounds.org]

• Camping

  Australia: Wanneroo, Samford Valley, Mount Gravatt East, Altona North, Caroline Springs, Bulleen, Kensington, Gladesville, Menai, Bondi Beach, Wellington Point, Mount Lawley, Annerley, Tewantin, Box Hill North, Sunshine North, Yokine, Batemans Bay, Camp [maria-online.com]

• Suggestibility

  A genetic influence in this disorder was suggested by its occurrence in sisters in two families and in a mother and daughter. Immunohistochemical and biochemical studies suggested that there is a disorder of keratinocyte proliferation in the disease. [ncbi.nlm.nih.gov]

  Some authors suggest that exposure to the sun may be involved. [emedicine.medscape.com]

  This familial incidence suggests that hyperkeratosis lenticularis perstans is a genodermatosis with an autosomal dominant mode of transmission. The title of benign familial acrokeratoses is proposed. [jamanetwork.com]

• Sezary Cell

  The inflammatory infiltrate in the HLP lesion was composed of small lymphocytes, which often displayed nuclei with deep infoldings resembling Sezary cells, and larger histiocytic cells, many of which were in close contact with the lymphocytes. [thedoctorsdoctor.com]

  In summary, we describe a case of HLP showing ultrastructurally numerous vesicular bodies in the granular layer and Sezary cell-like lymphocytes and histiocytic cells containing lamellated intracytoplasmic bodies in the dermal infiltrate. [journals.lww.com]

Treatment Options Treatment options are summarized in Table I. Table I. [dermatologyadvisor.com]

Therapeutic options are limited to emollients, topical 5-fluorouracil and retinoids, but none of these treatments is consistently helpful. We report a patient with Flegel's disease who responded to psoralen ultraviolet A treatment. [thedoctorsdoctor.com]

The abnormal formation of cystine-rich protein. ( 7117641 ) Tezuka T. 1982 36 Retinoid acid in the treatment of hyperkeratosis lenticularis perstans Flegel. ( 6175154 ) Lindemayr H....Jurecka W. 1982 37 Treatment of hyperkeratosis lenticularis perstans [malacards.org]

Treatment is difficult and rarely fully effective. [riudg.udg.mx]

After this treatment, the skin problems were completely resolved. Continuous peroral application of total corticosteroid at low doses was prescribed; however, this treatment was denied by the patient. [atlasofscience.org]

Prognosis Except for the possibility that lesions may progress slowly and involve more proximal sites, prognosis for hyperkeratosis lenticularis perstans (Flegel disease) is excellent. No mortality has been reported. [emedicine.medscape.com]

Prognosis - Hyperkeratosis lenticularis perstans Not supplied. Treatment - Hyperkeratosis lenticularis perstans Not supplied. Resources - Hyperkeratosis lenticularis perstans Not supplied. [checkorphan.org]

DIFFERENTIAL DIAGNOSIS KEY DIFFERENTIATING FEATURES PROGNOSIS CHARACTERIZATION TREATMENT CHARACTERIZATION GENERAL 5-FLUOROURACIL Hyperkeratosis lenticularis perstans (Flegel's disease)--lack of response to treatment with tacalcitol and calcipotriol. [thedoctorsdoctor.com]

Prognosis Most forms of hyperkeratosis are local skin problems that have a good prognosis. Actinic keratoses can develop into squamous cell skin cancer. [lymphedemapeople.com]

Prognosis It is unusual for lesions to resolve spontaneously. They may lessen in severity with treatment but tend to persist over time. If the itch/scratch cycle can be completely broken then there is a chance of cure but this is not the norm. [patient.info]

Deficiencies of vitamins A and E, B complex vitamins, and essential fatty acids have all been implicated in the etiology. [medical-dictionary.thefreedictionary.com]

Further analysis of probable spirochetal etiology of Flegel disease will show whether this was just an isolated case, or Borrelia can trigger the immune reaction that will result in HLP manifestations. [atlasofscience.org]

Etiology The etiology of hyperkeratosis lenticularis perstans is unknown. [dermatologyadvisor.com]

McKee's Pathology of the Skin is the most complete, in-depth resource on dermatopathology, covering etiology, pathogenesis, disease mechanisms, and recent genetic, molecular, and basic science data. Drs. J. [books.google.de]

OUTLINE EPIDEMIOLOGY CHARACTERIZATION SYNONYMS Hyperkeratosis lenticularis perstans INCIDENCE/ PREVALENCE May be sporadic or inherited as an autosomal dominant condition AGE SEX GEOGRAPHY EPIDEMIOLOGIC ASSOCIATIONS DISEASE ASSOCIATIONS CHARACTERIZATION [thedoctorsdoctor.com]

Epidemiology Frequency United States No data exist on incidence or prevalence of this disease. [emedicine.medscape.com]

One study found hypoplasia of epidermal sensory nerves in the skin of those with prurigo nodularis, even in areas where pruritus was not a problem. [ 2 ] Epidemiology The condition appears to be relatively common, particularly among patients who have [patient.info]

Pathophysiology There is controversial data regarding absent or aberrant lamellar granules (ie, Odland bodies, membrane associated granules) as seen on electron microscopy in lesional skin contributing to the pathophysiology. [dermatologyadvisor.com]

Pathophysiology No instigating factor has been identified clearly; some investigators have implicated UV light. [emedicine.medscape.com]

Pathophysiology of HLP is unknown, but role of ultraviolet light in induction of lesions, role of cell-mediated cytotoxicity against epidermal cells are some of the mechanisms suggested. [e-ijd.org]

Prevention - Hyperkeratosis lenticularis perstans Not supplied. Diagnosis - Hyperkeratosis lenticularis perstans Not supplied. Prognosis - Hyperkeratosis lenticularis perstans Not supplied. [checkorphan.org]

[…] programme that will continue to lead on and champion the London Healthy Workplace Charter. 5) Run Making Every Contact Count programme, is about building the wider public health workforce, making prevention everybody’s business and equipping people with [healthylondon.org]

The information presented here is not intended to diagnose, treat, cure or prevent any disease. Read disclaimer. [gulfdoctor.net]

Whether you are buying a home or receiving counseling on how to prevent a foreclosure, we stay neutral to allow for all participants to trust the process. [hlp.org]