Symptoma

Hyperkeratosis Lenticularis Perstans

Flegel Disease

We present a case of hyperkeratosis lenticularis perstans (Flegel's disease) in a 71-year-old-woman. [ncbi.nlm.nih.gov]

Due to its uncharacteristic presentation, it is rarely diagnosed clinically. Here we present one such case in a 50-year-old lady. She presented with a hard mobile lesion over her nose which was excised. The histologic picture is characterized... [connection.ebscohost.com]

Most cases have been reported in Europe with age of presentation between 35 and 60 years. [pubfacts.com]

Presentation on theme: "Hyperkeratosis Lenticularis perstans (Flegel’s Disease)"— Presentation transcript: 1 Hyperkeratosis Lenticularis perstans (Flegel’s Disease) Report of a case 高雄長庚紀念醫院皮膚科 病理科* 黃仁杰 黃柏翰 何宜承 黃昭誠* 2 Chief Complain Multiple asymptomatic [slideplayer.com]

  • Jaundice

    Authors: K Langer; E Zonzits; K Konrad Related Documents : 24852853 - Circulating free dna in a screening program for early colorectal cancer detection. 24163743 - Diagnostic bronchoscopy--current and future perspectives. 24426393 - Obstructive jaundice [biomedsearch.com]

  • Koebner Phenomenon

    We report a case of a 25-year-old man, who presented with 1-5 mm multiple asymptomatic hyperkeratotic papules of 15 years duration on both legs and hand along with lichenified plaques with Koebner phenomenon in the axillary folds, anticubital and popliteal [pubfacts.com]

  • Sezary Cell

    The inflammatory infiltrate in the HLP lesion was composed of small lymphocytes, which often displayed nuclei with deep infoldings resembling Sezary cells, and larger histiocytic cells, many of which were in close contact with the lymphocytes. [thedoctorsdoctor.com]

    In summary, we describe a case of HLP showing ultrastructurally numerous vesicular bodies in the granular layer and Sezary cell-like lymphocytes and histiocytic cells containing lamellated intracytoplasmic bodies in the dermal infiltrate. [journals.lww.com]

  • Borrelia Burgdorferi

    The presence of antibodies against Borrelia burgdorferi in patient serum was confirmed by a routine ELISA method and verified by Western blot technique. Skin biopsy and blood specimens were analyzed by PCR and multilocus sequence analysis (MLSA). [ncbi.nlm.nih.gov]

    The spirochete Borrelia burgdorferi is a tick-borne obligate parasite causing Lyme disease. [atlasofscience.org]

    However, in one case report, evidence of Borrelia infection ( Borrelia burgdorferi and Borrelia garinii ) was found using DNA sequencing in fresh tissue and blood from a patient with hyperkeratosis lenticularis perstans, without clinical evidence of Lyme [emedicine.medscape.com]

    […] find publications by category 72 results match your criteria Hyperkeratosis Lenticularis Perstans Flegel Disease Detection of Borrelia burgdorferi sensu stricto and Borrelia garinii DNAs in patient with Hyperkeratosis lenticularis perstans (Flegel disease [pubfacts.com]

    burgdorferi sensu stricto and Borrelia garinii DNAs in patient with Hyperkeratosis lenticularis perstans (Flegel disease). ( 26769152 ) Schwarzova K....Rudenko N. 2016 7 A case of localized, unilateral hyperkeratosis lenticularis perstans on a woman's [malacards.org]

Treatment Options Treatment options are summarized in Table I. Table I. [dermatologyadvisor.com]

Perpetual treatment with oral retinoid was successful. [ncbi.nlm.nih.gov]

Therapeutic options are limited to emollients, topical 5-fluorouracil and retinoids, but none of these treatments is consistently helpful. We report a patient with Flegel's disease who responded to psoralen ultraviolet A treatment. [thedoctorsdoctor.com]

Prognosis Except for the possibility that lesions may progress slowly and involve more proximal sites, prognosis for hyperkeratosis lenticularis perstans (Flegel disease) is excellent. No mortality has been reported. [emedicine.medscape.com]

Prognosis - Hyperkeratosis lenticularis perstans Not supplied. Treatment - Hyperkeratosis lenticularis perstans Not supplied. Resources - Hyperkeratosis lenticularis perstans Not supplied. [checkorphan.org]

DIFFERENTIAL DIAGNOSIS KEY DIFFERENTIATING FEATURES PROGNOSIS CHARACTERIZATION TREATMENT CHARACTERIZATION GENERAL 5-FLUOROURACIL Hyperkeratosis lenticularis perstans (Flegel's disease)--lack of response to treatment with tacalcitol and calcipotriol. [thedoctorsdoctor.com]

Prognosis Most forms of hyperkeratosis are local skin problems that have a good prognosis. Actinic keratoses can develop into squamous cell skin cancer. Source: Harvard Health Publications, Copyright 2007 by President and Fellows of Harvard College. [lymphedemapeople.com]

Prognosis It is unusual for lesions to resolve spontaneously. They may lessen in severity with treatment but tend to persist over time. If the itch/scratch cycle can be completely broken then there is a chance of cure but this is not the norm. [patient.info]

Deficiencies of vitamins A and E, B complex vitamins, and essential fatty acids have all been implicated in the etiology. [medical-dictionary.thefreedictionary.com]

Further analysis of probable spirochetal etiology of Flegel disease will show whether this was just an isolated case, or Borrelia can trigger the immune reaction that will result in HLP manifestations. [atlasofscience.org]

Etiology The etiology of hyperkeratosis lenticularis perstans is unknown. [dermatologyadvisor.com]

McKee's Pathology of the Skin is the most complete, in-depth resource on dermatopathology, covering etiology, pathogenesis, disease mechanisms, and recent genetic, molecular, and basic science data. Drs. J. [books.google.com]

OUTLINE EPIDEMIOLOGY CHARACTERIZATION SYNONYMS Hyperkeratosis lenticularis perstans INCIDENCE/ PREVALENCE May be sporadic or inherited as an autosomal dominant condition AGE SEX GEOGRAPHY EPIDEMIOLOGIC ASSOCIATIONS DISEASE ASSOCIATIONS CHARACTERIZATION [thedoctorsdoctor.com]

Epidemiology Frequency United States No data exist on incidence or prevalence of this disease. [emedicine.medscape.com]

One study found hypoplasia of epidermal sensory nerves in the skin of those with prurigo nodularis, even in areas where pruritus was not a problem. [ 2 ] Epidemiology The condition appears to be relatively common, particularly among patients who have [patient.info]

Pathophysiology There is controversial data regarding absent or aberrant lamellar granules (ie, Odland bodies, membrane associated granules) as seen on electron microscopy in lesional skin contributing to the pathophysiology. [dermatologyadvisor.com]

Pathophysiology No instigating factor has been identified clearly; some investigators have implicated UV light. [emedicine.medscape.com]

Pathophysiology of HLP is unknown, but role of ultraviolet light in induction of lesions, role of cell-mediated cytotoxicity against epidermal cells are some of the mechanisms suggested. [e-ijd.org]

Prevention - Hyperkeratosis lenticularis perstans Not supplied. Diagnosis - Hyperkeratosis lenticularis perstans Not supplied. Prognosis - Hyperkeratosis lenticularis perstans Not supplied. [checkorphan.org]

The information presented here is not intended to diagnose, treat, cure or prevent any disease. Read disclaimer. [gulfdoctor.net]

2011: Relative versus absolute standards for everyday risk in adolescent HIV prevention trials: expanding the debate. The concept of minimal risk has been used to regulate and limit participation by adolescents in clinical trials. [wwe.geoscience.net]

Whether you are buying a home or receiving counseling on how to prevent a foreclosure, we stay neutral to allow for all participants to trust the process. [hlp.org]