The hyperkinetic heart syndrome also referred to as hyperkinetic heart disease or idiopathic hyperkinetic state, is a cardiac disorder of unknown etiology, that leads to increased cardiac output, overactivity and responds positively to the administration of beta-blockers.
The hyperkinetic heart syndrome is an idiopathic cardiac condition that involves heart overactivity and hypercontractility, augmented cardiac output and elevated pulse pressure, without an underlying cardiac pathology  .
It is primarily diagnosed in patients aged 7-48 years and patients are mostly asymptomatic and in good health  . Exercise tolerance is normal, and, due to the absence of symptoms, patients are usually referred for a cardiological evaluation for an auscultated heart murmur. The hyperkinetic heart symptom was first described by R. Gorlin in 1959.
According to the first comprehensive study carried out by Goblin and Brachfeld , the hyperkinetic heart syndrome is difficult to diagnose and constitutes a diagnosis made on the basis of clinical suspicion.
Cardiac auscultation reveals a murmur that can be:
During the physical examination, the patients are found to be normotensive or slightly hypertensive, even though an extreme rise in systolic blood pressure is not expected. A diffuse apical impulse and wide pulse pressure are also detected.
An electrocardiogram usually reveals left ventricular hypertrophy or a right ventricular overload with no apparent cause; a right bundle branch block and a prolonged QT interval may be found to co-exist as well. The cold pressor test is generally expected to be positive, illustrating reduced peripheral resistance. Plain radiographs frequently show an enlarged ventricular shadow.
Right heart catheterization provides a diagnostic clue that greatly aids in the diagnosis of the hyperkinetic heart syndrome: it can detect an increased cardiac output, a finding shared by all patients with the disorder. It can also help to differentiate the hyperkinetic heart syndrome from a ventricular septal defect.
Additional blood tests involving a complete blood count and biochemical markers usually reveal no abnormalities, or the abnormalities that are detected are unrelated to the hyperkinetic heart syndrome.