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2.1
Hypermetabolism
Hypercatabolism

Images

WIKIDATA, Public Domain

Presentation

A 22-month-old toddler presented with involuntary movements, hemiparesis, and behavioral changes. Magnetic resonance imaging showed no abnormality, but positron emission tomography (PET) showed focal hypermetabolism. [ncbi.nlm.nih.gov]

Entire Body System

  • Weight Loss

    SUMMARY: Cancer patients may develop weight loss, cachexia, which can be distressing for both patients and their family. [ncbi.nlm.nih.gov]

    The terms used to describe weight loss (hypermetabolism, cachexia, wasting, catabolism) are often inconsistent. The aim of this review is to define the components of energy expenditure and the terms that describe inappropriate weight loss. [journals.lww.com]

    Hypermetabolism (increased resting energy expenditure (REE)) and loss of body weight occur in MND. We aimed to determine whether hypermetabolism correlates with disease severity and weight loss. [jnnp.bmj.com]

    The symptoms of cachexia are loss of appetite, weight loss, muscle atrophy, and fatigue. While anorexia is strongly linked in cachexia, the role of metabolism in cancer cachexia is unclear. [medicalnewsbulletin.com]

  • Heat Intolerance

    Hyperthyroidism: Patients with hyperthyroidism can have mild to overt symptoms, which include anxiety, emotional lability, weakness, tremor, palpitations, heat intolerance, increased perspiration, and weight loss despite a normal or increased appetite [healthtap.com]

    A dictionary of medical eponyms Related people Lars Ernster Rolf Luft A syndrome characterised by severe hypermetabolism, heat intolerance, profuse perspiration, polyphagia, polydipsia without polyuria, muscular wasting and weakness, absent deep reflexes [whonamedit.com]

Cardiovascular

  • Tachycardia

    Supraphysiologic levels of stress hormones contribute to the long-lasting tachycardia, catabolism, and immune suppression that characterize the hypermetabolic response. [ijburns.com]

    • Elevated heart rate ( tachycardia ). • Irregular heart beat. • Excessive sweating. • Shortness of breath. • Dysautonomia ( is a condition in which autonomic nervous system do not work properly) • Insomnia. • Muscle weakness. • Nervousness. • High [healthcaretip.com]

    […] medical eponyms Related people Lars Ernster Rolf Luft A syndrome characterised by severe hypermetabolism, heat intolerance, profuse perspiration, polyphagia, polydipsia without polyuria, muscular wasting and weakness, absent deep reflexes, and resting tachycardia [whonamedit.com]

    Tachycardia, dysrhythmias, and a sympathetic catecholamine surge occur. The hypermetabolism evokes a massive exothermic response, leading to extreme temperature elevation. [emedicine.medscape.com]

    Sepsis was defined as a blood culture identifying the pathogen during hospitalization or at autopsy, in combination with leucocytosis or leucopenia, hyperthermia or hypothermia, and tachycardia. [ccforum.biomedcentral.com]

Treatment

Hypermetabolism of phenytoin is not frequently recognized as a cause of treatment failure. [ncbi.nlm.nih.gov]

Patients were recruited as they benefit from a routinely evaluation before systemic treatment initiation. We included all cancer patients, any stage, evaluated before systemic treatment initiation including adjuvant chemotherapy. [isrctn.com]

If such treatment is delayed, blindness may be permanent. [web.archive.org]

Prognosis

The presence of hypermetabolism may be a factor related to poorer prognosis. [ncbi.nlm.nih.gov]

In contrast, most studies show a higher rate of infectious complications and poorer prognosis when tumor patients are nourished with PN 14 (Ia), 15 (Ib). [scielo.isciii.es]

Mitsumoto H, Chad DA, Pioro EP: Course and prognosis; in Mitsumoto H, Chad DA, Pioro EP (eds): Amyotrophic Lateral Sclerosis. Philadelphia, Davis, 1998, pp 151–163. [karger.com]

Etiology

METHODS: Resting energy expenditure (REE) was measured using indirect calorimetry in 256 cirrhotic patients with different etiologies and disease severity (165 men, 91 women; median age 49 y, age range 16-73 y; median model for end-stage liver disease [ncbi.nlm.nih.gov]

Bartlett Published 1988 in Acta Neurochirurgica DOI: 10.1007/BF01402895 Both metabolic rate and protein catabolism are known to increase following severe head trauma, but the etiology of this hypermetabolism is unknown. [pdfs.semanticscholar.org]

Abstract: Both metabolic rate and protein catabolism are known to increase following severe head trauma, but the etiology of this hypermetabolism is unknown. [deepblue.lib.umich.edu]

I did some more research tonight into the biology and etiology of hypermetabolism. So let’s start with a basic definition from Wikipedia : Hypermetabolism is the physiological state of increased rate of metabolic activity. [edbites.com]

Epidemiology

Epidemiology The reported frequency of MH in the United States ranges from 1 in 10,000 patients receiving anesthetics to 1 in 50,000; the reported frequency in children is higher. [emedicine.medscape.com]

Pathophysiology

These quantitative and qualitative derangements in skeletal muscle bioenergetics likely contribute to the long-term pathophysiological stress response to burn trauma. [ncbi.nlm.nih.gov]

Specific Aim 1 will test the hypothesis that prolonged inflammation induces significant pathophysiological responses which can be characterized by monitoring dynamic changes in gene expression and metabolic fluxes. [grantome.com]

However, the principal contributor to the increased mortality risk -- inflammation, hypermetabolism, or other pathophysiologic factors -- had not been determined. Dr. [medpagetoday.com]

The resolution of PET scans, however, are limited and inconsistent in detecting the details of cortical alterations.[2] Pathophysiology[edit] During the acute phase, the liver redirects protein synthesis, causing up-regulation of certain proteins and [en.wikipedia.org]

Long-term persistance of the pathophysiologic response to severe burn injury. PLoS One 2011;6:e21245. 15. Jeschke MG, Finnerty CC, Suman OE, Kulp G, Mlcak RP, Herndon DN. [ijburns.com]

Prevention

From a treatment perspective, it is recognized that there is probably no "magic bullet"; that regimens will probably be time dependent and "multiple drug"; and that the best treatment is prevention. [ncbi.nlm.nih.gov]

This circulatory stimulation, after regional 2,4-dinitrophenol infusion, was abolished or was prevented from occurring by splenectomy. 6. [clinsci.org]

Unfortunately, existing nutritional therapies are inadequate for preventing the onset of persistent hypermetabolism, because many of the mechanistic details of this process are poorly understood. [dspace.mit.edu]

Science ‎ Pagina 305 - Silva P (1994) Effects of saline, mannitol, and furosemide to prevent acute decreases in renal function induced by ‎ Pagina 465 - Bennett NT, Schultz GS (1993) Growth factors and wound healing: part II. [books.google.it]

In our study, neither of them was helpful in preventing esophageal stricture. [omicsonline.org]

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