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Hypermetabolism


Presentation

  • Author information 1 Department of Pediatrics, Juntendo Nerima Hospital, Tokyo, Japan. [email protected] Abstract A 22-month-old toddler presented with involuntary movements, hemiparesis, and behavioral changes.[ncbi.nlm.nih.gov]
  • Two patients with unilateral Sydenham's chorea are presented. Computed tomographic and magnetic resonance imaging were normal in both.[ncbi.nlm.nih.gov]
  • We present a case report that appears to contradict this doctrine. The patient had a history of atypical meningioma and was treated with surgical resection and postoperative proton-beam radiation therapy.[ncbi.nlm.nih.gov]
  • Abstract We present a case of diffuse and moderately increased 18F-FDG uptake in the entire left lung on 18F-FDG PET without any morphological parenchymal abnormalities in a patient with recent history of esophageal adenocarcinoma treated by minimal invasive[ncbi.nlm.nih.gov]
  • Abstract A 24-year-old Saudi man presented with progressive lower-back pain for 3 months followed by lower-limb weakness, numbness, and urinary retention.[ncbi.nlm.nih.gov]
Weight Loss
  • SUMMARY: Cancer patients may develop weight loss, cachexia, which can be distressing for both patients and their family.[ncbi.nlm.nih.gov]
  • Weight loss, performance status (PS), C-reactive protein (CRP), albumin, the nutritional risk index, daily energy intake, energy balance (equal to daily energy intakes minus the REE), and survival were recorded.[ncbi.nlm.nih.gov]
  • The terms used to describe weight loss (hypermetabolism, cachexia, wasting, catabolism) are often inconsistent. The aim of this review is to define the components of energy expenditure and the terms that describe inappropriate weight loss.[journals.lww.com]
  • Hypermetabolism in MND patients is associated with a greater functional decline but not a change in RFTs or weight loss.[jnnp.bmj.com]
  • The symptoms of cachexia are loss of appetite, weight loss, muscle atrophy, and fatigue. While anorexia is strongly linked in cachexia, the role of metabolism in cancer cachexia is unclear.[medicalnewsbulletin.com]
Heat Intolerance
  • Hyperthyroidism: Patients with hyperthyroidism can have mild to overt symptoms, which include anxiety , emotional lability, weakness, tremor , palpitations, heat intolerance , increased perspiration , and weight loss despite a normal or increased appetite[healthtap.com]
  • - A dictionary of medical eponyms Related people Lars Ernster Rolf Luft A syndrome characterised by severe hypermetabolism, heat intolerance, profuse perspiration, polyphagia, polydipsia without polyuria, muscular wasting and weakness, absent deep reflexes[whonamedit.com]
Wound Infection
  • Demographics, clinical data, serum hormone levels, serum cytokine expression profiles, organ function, hypermetabolism measures, muscle protein synthesis, incidence of wound infection sepsis, and body composition were obtained throughout the acute hospital[ncbi.nlm.nih.gov]
Tachycardia
  • . • Elevated heart rate ( tachycardia ). • Irregular heart beat. • Excessive sweating. • Shortness of breath. • Dysautonomia ( is a condition in which autonomic nervous system do not work properly) • Insomnia. • Muscle weakness. • Nervousness. • High[healthcaretip.com]
  • […] medical eponyms Related people Lars Ernster Rolf Luft A syndrome characterised by severe hypermetabolism, heat intolerance, profuse perspiration, polyphagia, polydipsia without polyuria, muscular wasting and weakness, absent deep reflexes, and resting tachycardia[whonamedit.com]
  • Tachycardia, dysrhythmias, and a sympathetic catecholamine surge occur. The hypermetabolism evokes a massive exothermic response, leading to extreme temperature elevation.[emedicine.medscape.com]
Blepharospasm
  • We examined the difference in cerebral function alterations between drug-induced blepharospasm patients and essential blepharospasm (EB) patients by using positron emission tomography with (18)F-fluorodeoxyglucose.[ncbi.nlm.nih.gov]
Vertical Gaze Palsy
  • Abstract A 52-year-old man developed vertical gaze palsy, convergence spasm, and convergence-retraction nystagmus due to glioblastoma of the right thalamus. 18F-fluorodeoxyglucose positron emission tomography (PET) inadvertently demonstrated markedly[ncbi.nlm.nih.gov]
Urinary Retention
  • Abstract A 24-year-old Saudi man presented with progressive lower-back pain for 3 months followed by lower-limb weakness, numbness, and urinary retention.[ncbi.nlm.nih.gov]
Ataxia
  • KEYWORDS: Ataxia; Downbeat nystagmus; Paraneoplastic syndrome; Vertigo[ncbi.nlm.nih.gov]
  • Friedreich's ataxia: Manifestation: Local cerebral metabolic activity is increased extensively as the disease progresses.[en.wikipedia.org]
  • Neurological examination could not elucidate any reproducible sign, apart from slight ataxia in the left lower limb with characteristic heel-shin ataxia, with slightly irregular side-to-side errors when placing his heel on the opposite knee and moving[archneur.jamanetwork.com]
Nystagmus
  • KEYWORDS: Ataxia; Downbeat nystagmus; Paraneoplastic syndrome; Vertigo[ncbi.nlm.nih.gov]
  • Abstract A 52-year-old man developed vertical gaze palsy, convergence spasm, and convergence-retraction nystagmus due to glioblastoma of the right thalamus. 18F-fluorodeoxyglucose positron emission tomography (PET) inadvertently demonstrated markedly[ncbi.nlm.nih.gov]
Truncal Ataxia
  • Abstract A 52-year-old man with vertigo and imbalance for two weeks showed spontaneous downbeat (DBN), horizontal gaze-evoked, and positional apogeotropic nystagmus along with severe limb and truncal ataxia.[ncbi.nlm.nih.gov]
Downbeat Nystagmus
  • KEYWORDS: Ataxia; Downbeat nystagmus; Paraneoplastic syndrome; Vertigo[ncbi.nlm.nih.gov]
Limb Weakness
  • Abstract A 24-year-old Saudi man presented with progressive lower-back pain for 3 months followed by lower-limb weakness, numbness, and urinary retention.[ncbi.nlm.nih.gov]

Workup

  • FDG-PET hypermetabolism, however, is rarely seen, and the significance of this finding in the epilepsy workup is not well established.[ncbi.nlm.nih.gov]

Treatment

  • Abstract Hypermetabolism of phenytoin is not frequently recognized as a cause of treatment failure.[ncbi.nlm.nih.gov]
  • Treatments directed at reducing the basal metabolic rate and supplementation of testosterone in hypogonadic male patients may have the potential to improve lean body mass, but more research is needed.[ncbi.nlm.nih.gov]
  • All patients underwent 2 PET scans before treatment (active state) and after treatment (suppressive state) with the botulinum neurotoxin type A.[ncbi.nlm.nih.gov]
  • Despite steroid treatment, the patient's clinical status declined rapidly and he died two months later.[ncbi.nlm.nih.gov]
  • Additionally, this article describes novel insights and delineates treatment options to modulate postburn hypermetabolism with the goal to improve outcomes of burn patients.[ncbi.nlm.nih.gov]

Prognosis

  • The effect of hypermetabolism on prognosis in patients with cirrhosis has not been elucidated.[ncbi.nlm.nih.gov]
  • The presence of hypermetabolism may be a factor related to poorer prognosis.[ncbi.nlm.nih.gov]
  • BACKGROUND: Hypermetabolism has a negative effect on prognosis in patients with liver cirrhosis. Its exact prevalence and associations with clinical data, the nutritional state, and beta-adrenergic activity are unclear.[ncbi.nlm.nih.gov]
  • Mitsumoto H, Chad DA, Pioro EP: Course and prognosis; in Mitsumoto H, Chad DA, Pioro EP (eds): Amyotrophic Lateral Sclerosis. Philadelphia, Davis, 1998, pp 151–163.[karger.com]
  • In contrast, most studies show a higher rate of infectious complications and poorer prognosis when tumor patients are nourished with PN 14 (Ia), 15 (Ib).[scielo.isciii.es]

Etiology

  • METHODS: Resting energy expenditure (REE) was measured using indirect calorimetry in 256 cirrhotic patients with different etiologies and disease severity (165 men, 91 women; median age 49 y, age range 16-73 y; median model for end-stage liver disease[ncbi.nlm.nih.gov]
  • Bartlett Published 1988 in Acta Neurochirurgica DOI: 10.1007/BF01402895 Both metabolic rate and protein catabolism are known to increase following severe head trauma, but the etiology of this hypermetabolism is unknown.[pdfs.semanticscholar.org]
  • Abstract: Both metabolic rate and protein catabolism are known to increase following severe head trauma, but the etiology of this hypermetabolism is unknown.[deepblue.lib.umich.edu]
  • I did some more research tonight into the biology and etiology of hypermetabolism . So let’s start with a basic definition from Wikipedia : Hypermetabolism is the physiological state of increased rate of metabolic activity.[edbites.com]
  • Recognition of the underlying etiology and treatment was possible because of abnormalities uncovered on positron emission tomographic images.[scholars.northwestern.edu]

Epidemiology

  • Epidemiology The reported frequency of MH in the United States ranges from 1 in 10,000 patients receiving anesthetics to 1 in 50,000; the reported frequency in children is higher.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • This finding may reflect a prodromal pathophysiology of epilepsy. Attention should be paid to the diagnosis of CJD while using FDG PET.[ncbi.nlm.nih.gov]
  • The pathophysiologic mechanism of CBS is poorly understood. However, hypermetabolism of the thalamocortical pathway as a result of deafferentation was recently proposed as a possible mechanism.[ncbi.nlm.nih.gov]
  • Increased glucose metabolism on the interictal PET scan and decreased glucose metabolism on an interictal PET scan in the epileptogenic supratentorial zones and the contralateral cerebellar hemisphere are interesting observations for understanding the pathophysiology[ncbi.nlm.nih.gov]
  • These quantitative and qualitative derangements in skeletal muscle bioenergetics likely contribute to the long-term pathophysiological stress response to burn trauma.[ncbi.nlm.nih.gov]
  • Correlation with intracranial EEG usually corroborates the highly epileptogenic pathophysiologic state.[ncbi.nlm.nih.gov]

Prevention

  • From a treatment perspective, it is recognized that there is probably no "magic bullet"; that regimens will probably be time dependent and "multiple drug"; and that the best treatment is prevention.[ncbi.nlm.nih.gov]
  • This circulatory stimulation, after regional 2,4-dinitrophenol infusion, was abolished or was prevented from occurring by splenectomy. 6.[clinsci.org]
  • Unfortunately, existing nutritional therapies are inadequate for preventing the onset of persistent hypermetabolism, because many of the mechanistic details of this process are poorly understood.[dspace.mit.edu]
  • Science ‎ Pagina 305 - Silva P (1994) Effects of saline, mannitol, and furosemide to prevent acute decreases in renal function induced by ‎ Pagina 465 - Bennett NT, Schultz GS (1993) Growth factors and wound healing: part II.[books.google.it]

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