• Fatigue

  We present a case of a 54-year-old woman with fatigue, myalgia, and poor concentration who was found to have hypercalcemia (corrected calcium, 11.2 mg/dL) and elevated parathyroid hormone level (112 pg/mL), laboratory values consistent with primary hyperparathyroidism [ncbi.nlm.nih.gov]

  Patient will present as a 62-year-old female complaining of joint pain, polyuria, polydipsia, and generalized fatigue. The patient reports a history of recurrent kidney stones and depression. [smartypance.com]

  We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: May 13, 2019 [patientslikeme.com]

  When she explained her symptoms, such as low bone density, fatigue and kidney stones, Russell ordered additional tests. “Her symptoms were not consistent with that I would have expected,” he recalls. [hopkinsmedicine.org]

  Symptoms may include: Kidney pain (due to the presence of kidney stones) Diminished bone density that causes bone pain Aches and pains Abdominal pain Nausea Vomiting Fatigue Excessive urination Confusion Muscle weakness The symptoms of hyperparathyroidism [chw.org]

• Anorexia

  The symptoms of hyperparathyroidism are related to hypercalcaemia and include General weakness; lethargy; muscle weakness Polyuria and polydipsia Anorexia, vomiting, abdominal pain and constipation Depression, psychosis and memory loss Bone and joint [diapedia.org]

  Gastrointestinal System Anorexia, constipation and nausea can occur as a result of hyperparathyroidism. Peptic ulcer disease occurs in 15 percent of patients. [aafp.org]

  Anorexia; nausea and vomiting; constipation; abdominal pain; peptic ulcer disease (hypercalcaemia can increase gastric acid secretion); acute pancreatitis. Polyuria, polydipsia, dehydration. Renal colic, haematuria, hypertension. [patient.info]

• Malaise

  Those with more significant hypercalcemia may experience cognitive impairment, constipation, bone and joint pain, excessive urination and thirst, and malaise. [nyulangone.org]

  There can be features of tenderness and malaise. The occurrence and severity of muscle symptoms do not correlate with severity of hypercalcemia. Arthralgias can occur at the medium and large joints. The features may mimic polymyalgia rheumatica. [rheumatologyadvisor.com]

• Constipation

  A Chinese female infant presented with poor feeding, constipation, severe hypotonia, and periodic bradycardia. Biochemistry tests revealed markedly elevated serum levels of Ca and parathyroid hormone (PTH). [ncbi.nlm.nih.gov]

  The range of signs and symptoms include: Muscle weakness Bone and joint aches and pains Kidney stones Excessive urination Feeling thirsty more than normal Constipation Fragile bones that may easily fracture (osteoporosis) Depression Pancreatitis Stomach [ucdenver.edu]

  […] medicines Having had radiation treatment in the head or neck Symptoms Symptoms of the condition can include: Muscle weakness Depression Tiredness Confusion and memory loss Poor memory Nausea and vomiting Pain in the stomach area (abdomen) Hard stools (constipation [fairview.org]

  Common symptoms include: Low energy Thin bones Joint pain Constipation Kidney stones Muscle weakness Excessive urination Primary hyperparathyroidism is caused by benign tumors of the parathyroid glands, overgrowth of the glands, or cancers in the parathyroid [nm.org]

  These may include: Fatigue or lack of energy; sluggishness Bone pain, bone loss, or broken bones Constipation Hypertension (high blood pressure) Poor appetite, sometimes with nausea Kidney stones Depression Mood swings; changes in personality Memory problems [roswellpark.org]

• Nausea

  Nausea, vomiting and hypocalcaemia are commonly experienced by patients treated with cinacalcet. [doi.org]

  Symptoms may include: Kidney pain (due to the presence of kidney stones) Diminished bone density that causes bone pain Aches and pains Abdominal pain Nausea Vomiting Fatigue Excessive urination Confusion Muscle weakness The symptoms of hyperparathyroidism [chw.org]

  While each child may experience symptoms differently, some of the most common include: kidney pain (due to kidney stones ) bone pain aches and pains abdominal pain nausea vomiting chronic fatigue excessive urination confusion muscle weakness The symptoms [childrenshospital.org]

  A person who has mild hyperparathyroidism may have some of the following symptoms: Joint pain Muscle weakness Fatigue Depression Trouble concentrating Loss of appetite More severe cases of hyperparathyroidism may produce these symptoms: Nausea and vomiting [my.clevelandclinic.org]

  Symptoms can include: Bone pain or tenderness Depression and forgetfulness Feeling tired, ill, and weak Fragile bones of the limbs and spine that can break easily Increased amount of urine produced and needing to urinate more often Kidney stones Nausea [nlm.nih.gov]

• Abdominal Pain

  The consciousness disturbance caused by severe hypercalcemia probably masked the typical symptoms associated with pancreatitis because she did not report abdominal pain during the clinical course. [ncbi.nlm.nih.gov]

  Symptoms may include: Kidney pain (due to the presence of kidney stones) Diminished bone density that causes bone pain Aches and pains Abdominal pain Nausea Vomiting Fatigue Excessive urination Confusion Muscle weakness The symptoms of hyperparathyroidism [chw.org]

  While each child may experience symptoms differently, some of the most common include: kidney pain (due to kidney stones ) bone pain aches and pains abdominal pain nausea vomiting chronic fatigue excessive urination confusion muscle weakness The symptoms [childrenshospital.org]

  Hyperparathyroidism Thyroid Joint pain Abdominal pain Fatigue Kidney stones Muscle weakness Excessive urination Gene mutations Adenomas Hyperplasias Carcinomas Excess PTH in response to low blood calcium levels Overview Hyperparathyroidism is a condition [nm.org]

  pain Nausea or vomiting Heartburn Constipation Frequent urination Nighttime urination Kidney stones Fractures Thinning hair Headaches Asymptomatic Hyperparthyroidism Surgical treatment of hyperparthyroidism is recommended for people who do not have symptoms [uwhealth.org]

• Loss of Appetite

  A person who has mild hyperparathyroidism may have some of the following symptoms: Joint pain Muscle weakness Fatigue Depression Trouble concentrating Loss of appetite More severe cases of hyperparathyroidism may produce these symptoms: Nausea and vomiting [my.clevelandclinic.org]

  […] of appetite The health care provider will do a physical exam and ask about symptoms. [nlm.nih.gov]

  Although hyperparathyroidism may not cause any symptoms, some patients might experience: Feeling fatigued and weak Constipation Loss of appetite Joint pain Increased thirst Frequent urination Kidney pain, caused by kidney stones (calcium deposits in the [dartmouth-hitchcock.org]

  Some of the general symptoms that may be associated with hypercalcemia include: Weak muscles and fatigue Depression Nausea Loss of appetite Constipation and abdominal pain Feeling thirsty and frequent urination (polyuria) Lack of concentration If the [news-medical.net]

  There are also other patients who have nonspecific symptoms, such as fatigue, weakness, depression, and loss of appetite. [britannica.com]

• Polydipsia

  Patient will present as a 62-year-old female complaining of joint pain, polyuria, polydipsia, and generalized fatigue. The patient reports a history of recurrent kidney stones and depression. [smartypance.com]

  The symptoms of hyperparathyroidism are related to hypercalcaemia and include General weakness; lethargy; muscle weakness Polyuria and polydipsia Anorexia, vomiting, abdominal pain and constipation Depression, psychosis and memory loss Bone and joint [diapedia.org]

  Cardiovascular disease Left ventricular hypertrophy Arterial hypertension Shortened QT interval Kidney Nephrolithiasis, nephrocalcinosis Polyuria, polydipsia Musculoskeletal system Bone, muscle, and joint pain Pseudogout Osteitis fibrosa cystica ( cyst-like [amboss.com]

  Polyuria, polydipsia, dehydration. Renal colic, haematuria, hypertension. Long-standing hypercalcaemia causes corneal calcification, which is usually asymptomatic. [patient.info]

• Hypertension

  Other factors known to increase AIx are female sex ( 16 ), smoking ( 17 ), and hypertension ( 18 ). [doi.org]

  Two unrelated adult patients were referred for nephrolithiasis, hypertension, hypercalcemia, hypercalciuria, normal 25-OHD levels, and inappropriate PTH levels (22 to 92pg/mL;N: 15-68) suggesting primary hyperparathyroidism, leading to surgery. [ncbi.nlm.nih.gov]

  Hypertension, shortened QT interval on ECG and cardiac arrhythmias (rare). Severe cases may lead to coma and death. [patient.info]

  These may include: Fatigue or lack of energy; sluggishness Bone pain, bone loss, or broken bones Constipation Hypertension (high blood pressure) Poor appetite, sometimes with nausea Kidney stones Depression Mood swings; changes in personality Memory problems [roswellpark.org]

• Osteoporosis

  To present a case of denosumab-induced normocalcemic hyperparathyroidism in a woman with postmenopausal osteoporosis without renal impairment or malabsorption syndrome. [ncbi.nlm.nih.gov]

  J Clin Endocrinol Metab 2000 / 85 (1) / 95-101., Riggs BL, et al, A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J. [4.waisays.com]

  Standard treatments for osteoporosis ( bisphosphonates ) work well to improve bone mineral density in osteoporosis due to primary hyperparathyroidism. In people with normocalcaemic hyperparathyroidism, we don’t yet know what the best treatment is. [yourhormones.info]

  Osteoporosis typically occurs when you have too much calcium in your blood and not enough calcium in your bones for a prolonged period. Osteoporosis puts you at a higher risk for bone fractures. [healthline.com]

  They were diagnosed with hypercalcemia, hypophosphatemia, high PTH concentrations, and osteoporosis. A single parathyroid adenoma was confirmed in each patient by Tc-MIBI scintigram, neck ultrasonography and computed tomographic scanning. [doi.org]

• Osteopenia

  The resultant bone resorption produces cortical thinning (subperiosteal resorption) and osteopenia. [radiopaedia.org]

  Over time, patients with primary hyperparathyroidism are at risk for developing kidney stones, pancreatitis, gastroesophageal reflux disease, peptic ulcer disease, osteopenia, osteoporosis and bone fractures. [froedtert.com]

  Abstract Neonatal severe hyperparathyroidism (NSHPT) is a rare, life-threatening condition that presents with severe hypercalcemia, hyperparathyroidism, and osteopenia in the newborn period. [ncbi.nlm.nih.gov]

  This loss of calcium from the bones can lead to weak, brittle bones (osteopenia and osteoporosis) and bone fractures. When the blood with this high calcium goes through the kidneys, the calcium may be filtered into the urine. [cedars-sinai.edu]

• Arthralgia

  There is arthralgia, fractures, bowing of long bones and often gross deformities of the spine and chest. Bibliography G. Engel: Über einen Fall von cystoider Entartung des ganzen Skelettes. Giessen, F. C. Pietsch, 1864. F. [whonamedit.com]

  Arthralgias can occur at the medium and large joints. The features may mimic polymyalgia rheumatica. Weakness, easy fatigability, and atrophy can occur, particularly at the lower extremities. [rheumatologyadvisor.com]

• Headache

  […] the calcium IS causing the recurrent headaches and removing the bad parathyroid gland will fix the headaches. [parathyroid.com]

  Bone pain Joint pain Difficulty concentrating Difficulty sleeping Memory problems Feeling depressed Feeling anxious Abdominal pain Nausea or vomiting Heartburn Constipation Frequent urination Nighttime urination Kidney stones Fractures Thinning hair Headaches [uwhealth.org]

  […] include: Kidney pain (due to the presence of kidney stones) Diminished bone density that causes bone pain Joint aches and pains Abdominal pain Nausea Vomiting Fatigue Excessive urination Confusion Muscle weakness Fractures Weight loss Diarrhea Depression Headache [chop.edu]

  Symptoms commonly seen with primary hyperparathyroidism include: Constipation Nausea Vomiting Abdominal pain Headache Loss of appetite Thirst Frequent and sometimes painful urination due to kidney stones Lethargy Fatigue Muscle weakness Joint pain Memory [uvahealth.com]

• Memory Impairment

  Patients may have neurocognitive effects such as anxiety, depression or memory impairment or gastrointestinal disturbances such as abdominal pain or constipation. Neuromuscular weakness may ensue. [clinicaladvisor.com]

• Kidney Failure

  Common conditions include: Conditions that make it hard for the body to remove phosphate Kidney failure Not enough calcium in the diet Too much calcium lost in the urine Vitamin D disorders (may occur in children who do not eat a variety of foods, and [nlm.nih.gov]

  Most patients with this form of hyperparathyroidism also have chronic kidney failure. Kidney failure causes an abnormality in calcium regulation due to the body's inability to regulate calcium and phosphorus excretion in the urine. [montefiore.org]

  It's associated with very advanced kidney failure (usually requiring dialysis ). People with tertiary hyperparathyroidism are almost always under the care of kidney specialists. [nhs.uk]

  In chronic kidney failure the problem is more specifically failure to convert vitamin D to its active form in the kidney. The bone disease in secondary hyperparathyroidism caused by kidney failure is termed renal osteodystrophy. [en.wikipedia.org]

  […] with very long-standing kidney failure and dialysis Thyroid and Parathyroid Glands: Posterior (Back) View Copyright Nucleus Medical Media, Inc. [uvahealth.com]

• Polyuria

  Polyuria can occur with renal failure. Cardiac arrhythmias can occur and even coma. [smartypance.com]

  Some of the general symptoms that may be associated with hypercalcemia include: Weak muscles and fatigue Depression Nausea Loss of appetite Constipation and abdominal pain Feeling thirsty and frequent urination (polyuria) Lack of concentration If the [news-medical.net]

  The symptoms of hyperparathyroidism are related to hypercalcaemia and include General weakness; lethargy; muscle weakness Polyuria and polydipsia Anorexia, vomiting, abdominal pain and constipation Depression, psychosis and memory loss Bone and joint [diapedia.org]

  Cardiovascular disease Left ventricular hypertrophy Arterial hypertension Shortened QT interval Kidney Nephrolithiasis, nephrocalcinosis Polyuria, polydipsia Musculoskeletal system Bone, muscle, and joint pain Pseudogout Osteitis fibrosa cystica ( cyst-like [amboss.com]

  Polyuria, polydipsia, dehydration. Renal colic, haematuria, hypertension. Long-standing hypercalcaemia causes corneal calcification, which is usually asymptomatic. [patient.info]

• Nephrolithiasis

  Complications of primary hyperparathyroidism include peptic ulcers, nephrolithiasis, pancreatitis and dehydration. Surgical management is usually indicated. [ncbi.nlm.nih.gov]

  Although reduced in prevalence, nephrolithiasis and nephrocalcinosis remain the most common clinical manifestations of the disorder. [doi.org]

  Evidence of nephrolithiasis or nephrocalcinosis via imaging Reduced bone mineral density ( T-score -2.5 at lumbar spine, total hip, femoral neck, or distal third of the radius, or preexisting asymptomatic vertebral fracture ) The procedure depends on [amboss.com]

  A reduction in the recurrence rate of nephrolithiasis has also been noted 59, 60. [f1000research.com]

Each different form of hyperparathyroidism has its own etiologic factors that are grouped together by type [2]:

• Primary hyperparathyroidism develops when one of the parathyroid glands malfunctions, often due to a parathyroid adenoma. Hyperplasia of the parathyroid glands, malignancy and ectopic parathyroid glands, are other etiologic factors behind this form of the disorder.
• Vitamin D deficiency or chronic kidney disease are the contributing factors behind secondary hyperparathyroidism. 
• The etiology of the third form of the disorder, tertiary hyperparathyroidism, is unknown and the condition is characterized by autonomous hypersecretion of parathyroid hormone probably due to persistent parathyroid stimulation.

When the parathyroid glands become overactive and excessively produce parathyroid hormone PTH, which is responsible for the regulation of phosphate and calcium levels in the body, it leads to hyperparathyroidism [1]. Hyperparathyroidism is divided into three forms, primary hyperparathyroidism, secondary hyperparathyroidism, and tertiary hyperparathyroidism.

It should be noted that there are other reasons for the overproduction of PTH. A person could be suffering from a glandular disorder like hyperthyroidism which leads to hypercalcemia, or there could be low calcium levels in the body due to a vitamin D deficiency or a chronic kidney disease.