Edit concept Question Editor Create issue ticket

Hyperproteinemia

Hyperproteinaemia


Presentation

  • SYMPTOMS OF HIGH PROTEIN IN BLOOD Albumin and globulin are the two main types of serum proteins present in the blood. Vitamins, minerals, lipids and hormones are transported around your body by these proteins.[medifitbiologicals.com]
  • : A Review JAHA 2012 Key learning points: Patients presenting with multiorgan derangement should be screened for amyloidosis.[imreference.com]
  • Abstract Multiple myeloma cases notoriously present bizarre clinical syndromes often diagnosed as arthritis, neuritis, severe anemias, or chronic nephritis, etc., depending on the predominance of various symptoms or findings such as pain, pallor, or urinary[annals.org]
  • Blood Plasma Level low & High / Kidney & Lever disease Presentation for Medical Biology Students VARIATIONS IN PLASMA PROTEIN LEVEL The level of plasma proteins vary independently of one another.[nhealthcare.blogspot.com]
  • In reality, normal plasma/serum is roughly 93% water with 7% solids present (proteins and lipids).[labmedicineblog.com]
Hypersomnia
  • 780.2 Hyperreflexia 796.1 Hypersalivation (see also Ptyalism) 527.7 Hypersarcosinemia 270.8 Hypersecretion Hypersegmentation, hereditary 288.2 Hypersensitive, hypersensitiveness, hypersensitivity - see also Allergy Hypersomatotropism (classic) 253.0 Hypersomnia[icd9data.com]
Lymphadenopathy
  • […] albumin, and creatinine) UA Protein electrophoresis and immunofixation performed on serum and a 24-hour urine collection; Quantitative immunoglobulin measurement (IgG, IgM, IgA); Serum free light-chain testing; and A skeletal survey CT scans to assess lymphadenopathy[imreference.com]
Recurrent Bacterial Infection
  • Bacterial Infections / AL Waldenstrom Macroglobulinemia Diagnosis ( NEJM 2006 ) BM Plasma Cells 10 % AND M protein 3 g / dL AND Clinical Symptoms: Present Fatigue Weight loss Purpura Nephrotic Syndrome CHF Peripheral Neuropahty Orthostatic Hypotension[imreference.com]
Chest Pain
  • Pain, Dyspnea, and a Rash Smoldering (Asymptomatic) Myeloma: Significant M protein and / or significant Plasma Cells in BM with negative CRAB - 3 g /dL M protein, AND/OR 10% BM Plasma Cells; 73% risk of progression to MM at 15 yrs Note: In the absence[imreference.com]
Hypersalivation
  • Hyperproteinemia 273.8 Hyperprothrombinemia 289.89 Hyperpselaphesia 782.0 Hyperpyrexia 780.6 Hyperreactor, vascular 780.2 Hyperreflexia 796.1 Hypersalivation (see also Ptyalism) 527.7 Hypersarcosinemia 270.8 Hypersecretion Hypersegmentation, hereditary[icd9data.com]
Chronic Abscess
Dizziness
  • Symptoms of hyperproteinemia can include: nausea, poor appetite, serious fatigue, digestive issues, inexplicable weight loss, continual fever, dizziness upon standing or sitting, and tingling in the fingers and toes.[reference.com]
  • It is best to consult your doctor immediately, in case you experience regular bouts of: Appetite loss Diarrhea Dizziness Drop in blood pressure Fever Nausea Numbness or a tingling sensation in your fingers or toes Severe fatigue Unexplained weight loss[medifitbiologicals.com]
Polyneuropathy
  • Waldenstrom Macroglobulinemia Diagnosis ( NEJM 2006 ) BM Plasma Cells 10 % AND M protein 3 g / dL AND Clinical Symptoms: Present Fatigue Weight loss Purpura Nephrotic Syndrome CHF Peripheral Neuropahty Orthostatic Hypotension Massive Hepatomegaly POEMS (Polyneuropathy[imreference.com]
  • Purified] is an immune globulin injection that is approved to treat primary humoral immunodeficiency (PI) in patients 2 years of age and older, idiopathic thrombocytopenic purpura (ITP) in adults and children, and chronic inflammatory demyelinating polyneuropathy[gammaked.com]
Hyperreflexia
  • Hyperproteinemia 273.8 Hyperprothrombinemia 289.89 Hyperpselaphesia 782.0 Hyperpyrexia 780.6 Hyperreactor, vascular 780.2 Hyperreflexia 796.1 Hypersalivation (see also Ptyalism) 527.7 Hypersarcosinemia 270.8 Hypersecretion Hypersegmentation, hereditary[icd9data.com]

Workup

Hyponatremia
  • In multivariate analysis, hyperproteinemia at the 6-hr time point predicted hyponatremia (P 0.000), and hyperproteinemia at the 24-hr time point predicted both hyponatremia and increased serum viscosity (P 0.024).[ncbi.nlm.nih.gov]
  • "Ten common pitfalls in the evaluation of patients with hyponatremia". European Journal of Internal Medicine. 29 : 22–5. doi : 10.1016/j.ejim.2015.11.022. PMID 26706473.[en.wikipedia.org]
  • […] the blood and therefore in dilutional hyponatremia, which is true hypertonic hypervolemic hyponatremia.[ehealthstar.com]
  • Hyponatremia can be broadly divided into two fundamental categories: "true hyponatremia" (in which the serum sodium concentration is truly less than normal), or "pseudohyponatremia," in which the serum sodium concentration is actually normal but erroneously[renalfellow.blogspot.com]
  • Salt and water: a simple approach to hyponatremia. CMAJ. 2004 Feb 3. 170(3):365-9. [Medline]. Zarinetchi F, Berl T. Evaluation and management of severe hyponatremia. Adv Intern Med. 1996. 41:251-83. [Medline].[emedicine.medscape.com]
Hyperviscosity
  • How I treat amyloidosis: the importance of accurate diagnosis and amyloid typing Blood 2012 Case Discussion Please read Case 2 of : References: Case 2-2016 Blood 2012 HYPERVISCOSITY SYNDROME DDx: Waldenstrom Macroglobulinemia (Pentameric Structure of[imreference.com]
  • Hyperproteinemia (and paraproteinemia) can result in hyperviscosity syndrome (see lower). Hypoproteinemia: Decrease of the total concentration of serum proteins, particularly albumin.[wikilectures.eu]

Treatment

  • Serum glucose, sodium, protein, viscosity, osmolality, and a calculated osmolar gap were obtained prior to therapy, 6 hr after the initiation of therapy, 24 hr after the conclusion of therapy, and on post-treatment day 10.[ncbi.nlm.nih.gov]
  • In the future, the study results may be used to help doctors detect Alzheimer's disease, before major symptom onset, allowing them to create more effective patient treatment plans.[reference.com]
  • Delayed enhancement is not very specific Nulling is very specific (but absence of it does not rule out Amyloid) Treatment (Many present now) Cardiac Amyloid: AL - type : treatment is similar to MM If good performance status is Updates in Cardiac Amyloidosis[imreference.com]
  • Treatment of the underlying infection may bring the protein level toward the normal range.[livestrong.com]
  • Prompt diagnosis and treatments could help you recover at a faster rate.[diethealthclub.com]

Prognosis

  • While monoclonal gammopathy raises concern over an underlying malignancy or serious condition, polyclonal gammopathy is often viewed as a normal reaction to an underlying condition; however, many of those conditions themselves carry a poor prognosis.[thebigl.co]

Etiology

  • Etiology Infection xxx Drugs Intravenous Immunoglobulin (IVIG) (see Intravenous Immunoglobulin, [[Intravenous Immunoglobulin]]) Other End-Stage Liver Disease (see End-Stage Liver Disease, [[End-Stage Liver Disease]]) Multiple Myeloma (see Multiple Myeloma[mdnxs.com]

Epidemiology

  • ., and the Departments of Medicine and of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio. Address reprint requests to Dr. Butler at the Department of Medicine, University Hospitals of Cleveland, Cleveland, OH 44106.[nejm.org]
  • Epidemiology, pathophysiology, and management of hyponatremic encephalopathy. Am J Med. 1997 Jan. 102(1):67-77. [Medline]. Gross P. Treatment of severe hyponatremia. Kidney Int. 2001 Dec. 60(6):2417-27. [Medline]. Gruskin AB, Sarnaik A.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology and treatment of hyponatraemic encephalopathy: an update. Nephrol Dial Transplant. 2003 Dec. 18(12):2486-91. [Medline]. Ayus JC, Achinger SG, Arieff A.[emedicine.medscape.com]
  • […] clinical disorders or settings where the test may be helpful Diagnosis and treatment of a variety of diseases involving the liver, kidney, or bone marrow, as well as other metabolic or nutritional disorders Clinical Information Discusses physiology, pathophysiology[mayomedicallaboratories.com]
  • Pathophysiology Definition of electrophoresis: This is the migration of charged solutes or particles in a liquid medium under the influence of the electrical field. Analytes of interest are: Proteins. Peptides. Aminoacids. Nucleic acid.[labpedia.net]
  • This pattern can originate from a number of pathophysiologic mechanisms; therefore, determination of its cause can be challenging.[cjasn.asnjournals.org]
  • Was he contemplating the role of angiogenesis in the pathophysiology of the disease? Figure 2 Sarah Newbury, the first reported patient with multiple myeloma. (A) Bone destruction in the sternum.[bloodjournal.org]

Prevention

  • This may prevent your blood from flowing easily and possibly lead to blood clots.[gammaked.com]
  • Many cases of acute nongap acidosis are due to infusion of large quantities of Cl -rich solutions during resuscitation; therefore, recognition of this entity could prevent further diagnostic studies ( 14 , 16 ).[cjasn.asnjournals.org]
  • CoA 還元酵素 HNF hepatocyte nuclear factor HNF1B HNF1B HOMA ホメオスタシスモデルアセスメント HOMA-R HOMA-R指数 HOMA-beta HOMA-ベータ指数 Hashimoto's disease 橋本甲状腺炎 Hashimoto's disease 橋本病 Hashimoto's thyroiditis 橋本甲状腺炎 Hashimoto's thyroiditis 橋本病 HbA1c ヘモグロビンA1c Heart outcomes prevention[jds.or.jp]
  • Some of the most important advances are the advent of bisphosphonates to treat hypercalcemia and to prevent myeloma bone disease, the use of vertebroplasty and kyphoplasty to treat vertebral fractures, and judicious use of prophylactic antibiotics in[bloodjournal.org]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!