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Hypertonic Saline Infusion

IV Infusion of Hypertonic Saline


  • We found that the IR-dynorphin present in human plasma was composed of 6K- and 4K-sized peptides and that no larger than 6K or smaller than 4K dynorphins were present.[ncbi.nlm.nih.gov]
  • In general, vaptans are effective in hyponatremias presenting with concentrated urine and, with the exception of hypovolemic hyponatremia, can be used as their primary treatment.[mds.marshall.edu]
  • He has long been involved in research into subarachnoid hemorrhage (SAH) and has presented an innovative therapeutic principle of “timely and appropriate policy”, with targeting of oxidative stress in early brain injury (early phase), immuno-inflammatory[books.google.com]
  • No difference in u-AQP2, u-ENaC(β), u-cAMP, u-PGE(2), C(H2O), and vasoactive hormones was found between patients and controls at baseline, but during HS the patients had higher FE(Na).[ncbi.nlm.nih.gov]
  • Abstract We examined the response of plasma arginine vasopressin (pAVP) to intravenous 5% hypertonic saline in patients with anorexia nervosa (AN) and bulimia nervosa (BN).[ncbi.nlm.nih.gov]
  • Take blood into chilled Li Heparin tube. 6. Repeat blood sample after 15 min 7. Begin infusion of 5% saline at 0.04 mL/kg/min for 2 hours into non-blood sampling arm 8. Take blood samples at 30 min intervals. 9.[pathology.leedsth.nhs.uk]
  • ., avoiding hyperthermia or hyponatremia). 0 This post is co-authored with Ryan Clouser (@neurocritguy), an intensivist colleague who is board certified in neuro-critical care.[emcrit.org]
  • Abstract We examined the response of plasma arginine vasopressin (pAVP) to intravenous 5% hypertonic saline in patients with anorexia nervosa (AN) and bulimia nervosa (BN).[ncbi.nlm.nih.gov]
  • Intracranial pressure crisis ( 20 mm Hg for 20 minutes or new anisocoria) occurred less frequently in the treatment group (12 versus 56; P 0.048).[ncbi.nlm.nih.gov]
  • We analyzed the frequency of episodes with elevated intracranial pressure (new anisocoria or intracranial pressure 20 mm Hg for 20 mins), inhospital mortality, and the occurrence of adverse effects theoretically associated with hypertonic saline.[journals.lww.com]


Cortisol Increased
  • The plasma cortisol increase during hypertonic saline infusion was greater in normal older subjects than in young subjects (p .03), but a stimulatory effect of hypertonic saline infusion on plasma ACTH was not apparent in either older or young subjects[ncbi.nlm.nih.gov]


  • The beneficial effect of this treatment regimen on edema evolution and outcome has to be demonstrated in a controlled trial.[ncbi.nlm.nih.gov]
  • Monitoring of the changes in serum sodium concentration as a guide to treatment changes is imperative regardless of the initial treatment of severe hyponatremia.[mds.marshall.edu]


  • As it was an observational retrospective study, according to the French legislation (articles L.1121-1 paragraph 1 and R1121-2, Public Health Code), neither informed consent nor approval of the ethics committee was needed to use data for an epidemiologic[ccforum.biomedcentral.com]
Sex distribution
Age distribution


  • The cause and pathophysiological consequences of these abnormalities remain unresolved.[ncbi.nlm.nih.gov]
  • Some details of its physiological and pathophysiological role remain poorly defined. Experimental evidence suggests that the antiporter is involved in the regulation of cell volume.[link.springer.com]
  • He introduced the important concepts of “early brain injury after subarachnoid haemorrhage” and “vascular neural network” (relevant to the pathophysiology of stroke).[books.google.com]
  • Review the pathophysiology of hyponatremia from SIADH 2. Explain how normal saline makes it worse 3.[pharmacyjoe.com]


  • In this setting, desmopressin infusion helps prevent overcorrection of the hyponatremia.[mds.marshall.edu]
  • Qureshi et al suggested limiting continuous Hypertonic Saline Infusion to 24 to 48 hours to prevent this phenomenon.[anesthesiageneral.com]
  • His major research interests include cure and restoration of neurological function after CNS injury, minimally invasive surgery for CNS malignancies, personalized minimally invasive surgery and prevention of complications of cerebrovascular diseases.[books.google.com]
  • In an attempt to prevent severe dehydration, a compensation of the volume loss due to excessive diuresis should be performed.[ccforum.biomedcentral.com]
  • […] over 160mmHg) and HR (pulse below 60) B) Treatment of hyponatraemic seizures C) Treatment of Exercise Induced Hyponatraemia Severe hyponatremia (Na Significantly symptomatic (e.g. encephalopathy or acute pulmonary oedema) D) Renoprotective agent (e.g. prevention[emed.ie]

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