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Hyperuricosuria


Presentation

  • We aimed to outline the clinical presentation and natural history of HU not only in children with hematuria, but also in those with dysuria and/or recurrent abdominal/flank pain and a family history of urolithiasis.[ncbi.nlm.nih.gov]
  • Calculi ( 3 mm in diameter) were present in 8.9% of the patients with a family history of nephrolithiasis and in 9.4% of those with no family history (P 0.85). Microcalculi ([ncbi.nlm.nih.gov]
  • Leading experts from Latin America, Africa, Near and Middle East, Indian Subcontinent, Far East, Oceania and Australia present their expert insights into specific conditions, as well as progress and challenges in the development of the specialty.[books.google.com]
  • We aimed to outline the clinical presentation and natural history of HU not only in children with hematuria, but also in those with dysuria and/or recurrent abdominal/flank pain and a family history of urolithiasis. Study Design.[pediatrics.aappublications.org]
Family History of Gout
  • La Manna and associates emphasize the importance of family history of gout or stones in cases of hyperuricosuria. [29] A child with recurrent oliguria secondary to hyperuricosuria is presented.[sjkdt.org]
  • In the presence of recurrent abdominal/flank pain, hematuria without proteinuria or edema, and urological symptomatology, especially in the presence of a positive family history of gout or stones, a search for crystalluria is in order.[sjkdt.org]
Failure to Thrive
  • The aim of this study was to investigate the relationship of symptomatic non-calculous idiopathic HX, HU and both of them with dysuria, failure to thrive (FTT), recurrent urinary tract infection (UTI), dysmorphic RBCs, and abdominal pain in children.[numonthly.com]
  • Failure to thrive, hyperuricemia and renal insufficiency in early infancy secondary to partial hypoxanthine-guanine phosphoribosyl transferase deficiency. J Pediatr 1984;104(1):94-7. 17. Batch JA, Riek RP, Gordon RB, Burke JR, Emmerson BT.[sjkdt.org]
Self-Mutilation
  • Hereditary disorders of purine metabolism with complete deficiency of hypoxanthine phosphoribosyl transferase (HPRT) result in the Lesch Nyhan syndrome, which consists of hyperuricemia, mental retardation, choreoathetosis, and self mutilation. [2] The[sjkdt.org]
Self Mutilation
  • Hereditary disorders of purine metabolism with complete deficiency of hypoxanthine phosphoribosyl transferase (HPRT) result in the Lesch Nyhan syndrome, which consists of hyperuricemia, mental retardation, choreoathetosis, and self mutilation. [2] The[sjkdt.org]
Penile Pain
  • To our knowledge, the vaginal itching and penile pain were not previously described. Family history was positive for stones and/or gout in 62.5%.[sjkdt.org]

Workup

Microalbuminuria
  • — ICD 9 791.0 MedlinePlus 003591 Microalbuminuria occurs when the kidney leaks small amounts of albumin into the urine, in other words, when there is an abnormally high permeability for albumin in the renal glomerulu … Wikipedia Thin basement membrane[medicine.academic.ru]
Uric Acid Decreased
  • Mean urinary uric acid decreased by over 300 mg/24 h at 3 months after entry and finally decreased to over 400 mg/24 h from baseline at 24 months post entry.[ncbi.nlm.nih.gov]

Treatment

  • The following treatments were utilized: restricted purine diet (13%), allopurinol (4%) and potassium citrate (1%). No specific treatment was given to 82% of the patients. Therapy normalized uricosuria with resolution of hematuria over 6-12 months.[ncbi.nlm.nih.gov]
  • In that period, medicine has experienced a real revolution, characterized by minimally invasive treatments, improvement of the quality of life, and cost-effectiveness in treatment outcomes.[books.google.com]
  • The child responded to treatment with increase in the fluid fluid intake along with the xanthine oxidase inhibitor, allopurinol.[ncbi.nlm.nih.gov]
  • Stone Treatment with Extracorporeal ShockWave 928 Thoracoscopy as an Aid to Safer Intercostal Percutaneous 934 Subject Index 1059 946 حقوق النشر[books.google.com]
  • Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions.[drugs.com]

Prognosis

  • Disease and Nutrient Intake in Italy 749 The Significance of Annual Rhythms for the Excretion of Lithogenic 757 The Effect of Fasting on Urinary Stone Risk 765 Stone Formers in Saudi Arabia 769 Statistics of Stone Analysis in Childhood Urolithiasis 777 Prognosis[books.google.com]
  • Prognosis The prognoses of the familial and genetic forms depend on the primary disease and associated abnormalities. With appropriate diagnosis and treatment, most patients survive with minimal long-term morbidity.[emedicine.com]
  • Prognosis The prognosis is uncertain in the severe form of the disease. Severe gout can lead to renal impairment, if not properly treated. The documents contained in this web site are presented for information purposes only.[orpha.net]

Etiology

  • Abstract This review evaluates the epidemiologic, clinical and experimental evidence for an etiological link between urinary uric acid and the propensity to develop calcium oxalate calculi.[ncbi.nlm.nih.gov]
  • Abstract Since monosodium urate (NaU) may play an important etiologic role in the formation of renal stones containing Ca in patients with hyperuricosuria, the current studies were undertaken to define some of the physiocochemical factors which determine[ncbi.nlm.nih.gov]
  • Etiology Hyperuricosuric calcium nephrolithiasis is characterized by calcium oxalate or calcium phosphate stones in persons with hyperuricosuria.[emedicine.com]
  • For instance, a vascular etiology for initiation of stones has been proposed [ 14 ]. Recent data demonstrating an association of stones with coronary heart disease are also of interest [ 15 ].[ncbi.nlm.nih.gov]

Epidemiology

  • Abstract This review evaluates the epidemiologic, clinical and experimental evidence for an etiological link between urinary uric acid and the propensity to develop calcium oxalate calculi.[ncbi.nlm.nih.gov]
  • The role of hyperuricosuria in promoting calcium stones is controversial with only some but not all epidemiologic studies demonstrating associations between increasing urinary uric acid excretion and calcium stone disease.[ncbi.nlm.nih.gov]
  • […] overactivity, glucose-6-phosphatase synthetase deficiency Myeloproliferative disorders (eg, leukemia, hemolytic anemia, neoplasia) Medications Chemotherapy Low urinary volume may result from any of the following: GI disorders Strenuous exercise/dehydration Epidemiology[emedicine.com]
Sex distribution
Age distribution

Pathophysiology

  • PAK Major progress has been made in the pathophysiologic elucidation and management of nephrolithiasis during the past two decades.[books.google.com]
  • Therefore, an understanding of the pathophysiology of uric acid–related nephrolithiasis is important for a cost-effective treatment approach. In patients with hyperuricosuria, dietary purine restriction is the initial treatment.[emedicine.com]
  • Molecular and Systemic Pathophysiology Uric acid is produced in the liver and intestinal mucosa as the end product of purine nucleotide degradation. Both endogenous and dietary purines contribute significantly to daily uric acid production.[link.springer.com]
  • Brenner/Rector remains the go-to resource for practicing and training nephrologists and internists who wish to master basic science, pathophysiology, and clinical best practices.[books.google.com]

Prevention

  • A randomized, controlled trial of allopurinol in patients with hyperuricosuria and normocalciuria was also effective in preventing recurrent stones.[ncbi.nlm.nih.gov]
  • Despite normal levels of serum creatinine and urea, and normal creatinine clearance in the cystic fibrosis patients, risk of future renal damage seems obvious and preventive measures should be considered.[ncbi.nlm.nih.gov]
  • Furthermore, recognition of this association may prevent unnecessary, and in some cases, invasive diagnostic manoeuvres.[ncbi.nlm.nih.gov]
  • In addition, a newer xanthine oxidoreductase inhibitor, febuxostat, may also be effective in the prevention of calcium stones, as it reduces urinary uric acid excretion.[ncbi.nlm.nih.gov]

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