CASE PRESENTATION: Here we present a case of a 45-year-old Asian Indian woman who presented to us with persistent vomiting the cause of which was iatrogenic hypervitaminosis D. [ncbi.nlm.nih.gov]

Case presentation Here we present a case of a 45-year-old Asian Indian woman who presented to us with persistent vomiting the cause of which was iatrogenic hypervitaminosis D. [jmedicalcasereports.biomedcentral.com]

• Persistent Vomiting

  We present here a classic case of iatrogenic hypervitaminosis D, which presented with persistent vomiting and acute renal failure. [ncbi.nlm.nih.gov]

• Hepatosplenomegaly

  Other symptoms can be quite nonspecific: Scaly seborrhoeic eczema Patchy hair loss Stomatitis Loss of appetite Nausea Vomiting Malaise Hepatosplenomegaly Liver failure Raised intracranial pressure Children can present with craniotabes, irritability, failure [patient.info]

• Fear

  The overzealous use of Vitamin D in India due to the fear of rickets can also lead to Vitamin D intoxication. [14], [15] Metastatic calcification as seen in our case is frequently described in hypercalcemia due to hypervitaminosis of Vitamin D. [ssajm.org]

• Microscopic Hematuria

  Two patients with nephrocalcinosis had high serum creatinine, while three patients had evidence of microscopic hematuria. [academic.oup.com]

• Nocturia

  The patient had had an attack of “flu” five months previously, and since that time he had noted recurring headaches, muscle weakness, bouts of conjunctivitis, and increasing frequency and nocturia. [mdedge.com]

• Cesarean Section

  The past history included low birth weight(birth weight 1750 gr length 45 cm and head circumference 31 cm)with cesarean section delivery because of fetal distress, she had been admitted because of anemia and high level of urea with a diagnose of birth [ijn.mums.ac.ir]

• Slurred Speech

  Three months later she developed confusion, slurred speech, unstable gait, and increased fatigue. She was hospitalized for hypercalcemia and acute kidney injury secondary to hypervitaminosis D. [ncbi.nlm.nih.gov]

• Unstable Gait

  Three months later she developed confusion, slurred speech, unstable gait, and increased fatigue. She was hospitalized for hypercalcemia and acute kidney injury secondary to hypervitaminosis D. [ncbi.nlm.nih.gov]

• Stupor

  A 64-year-old man was hospitalized in 2002 with symptoms of stupor, weakness, and renal colic. The clinical examination indicated borderline hypertension, small masses in the glutei, and polyuria. [ncbi.nlm.nih.gov]

• Meningism

  Baby later developed hydrocephalus as sequelae to meningitis. Magnetic resonance imaging of brain showed periventricular calcification probably a sequelae to hypercalcemia. [ssajm.org]

On further workup, it was found that urinary calcium creatinine ratio was 0.92 (normal 200 nmol/L). Thyroid function test was normal and serum Vitamin A or retinol was 37 μg/dL (normal reference interval 38-106). [ssajm.org]

The diagnosis was established in Patient 3.2 at 18 months of age after the family's workup. Notably, his serum calcium level at that time was within the normal range, and intact parathyroid hormone levels were suppressed. [nejm.org]

• Pulmonary Calcification

  Experimental hypervitaminosis D in rabbits resulting in renal and pulmonary calcifications has been shown be have limited reversibility. Timecourse Clinical signs of toxicity may take weeks to several years to become apparent in rabbits. [vetstream.com]

The treatment improved serum calcium, kidney function, and consciousness. The medical history disclosed recent treatment with exceptionally high doses of slow-release intra-muscular cholecalciferol and the recent excretion of urinary stones. [ncbi.nlm.nih.gov]

A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. [stlukes-stl.com]

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. [lutheranhealthcare.org]

Prognosis Mortality is rare. Once identified, the prognosis is good. The yellow coloration of skin will reverse with time. [patient.info]

Outlook (Prognosis) Recovery is expected. [indiatoday.in]

The prognosis upon adequate treatment is excellent Those with severe signs and symptoms of Hypervitaminosis D may require hospitalization with extended treatment. [dovemed.com]

Outlook (Prognosis) Recovery is expected, but permanent kidney damage can occur. [m.ufhealth.org]

Lapis ISSN 2398-2969 Synonym(s): Vitamin D toxicity Contributor(s): Sarah Pellett, Lesa Thompson Introduction Pathogenesis Etiology Incorrectly formulated diets. Overzealous supplementation with oral or injectable preparations. [vetstream.com]

(Etiology) The body requires a specific amount of vitamin D each day. The liver stores vitamin D, which then gets transported to various parts of the body by a specific carrier protein, termed as the vitamin D-binding protein. [dovemed.com]

Calcifediol is implicated in the etiology of atherosclerosis, especially in non-Caucasians.The levels of the active form of vitamin D, calcitriol, are inversely correlated with coronary calcification. [en.wikipedia.org]

Component analysis of urinary calculi in the etiologic diagnosis of urolithiasis in the child. Arch Pediatr 2000;7:855-65. 7. Hathcock JN, Shao A, Vieth R, Heaney R. Risk assessment for Vitamin D. Am J Clin Nutr 2007;85:6-18. 8. Ozyurek HE. [ssajm.org]

Hypothesis: Etiology of atherosclerosis and osteoporosis: Are imbalances in the calciferol endocrine system implicated? J Am Coll Nutr 1992; 11: 567–583. Google Scholar 9. Davies H. Coronary heart disease. [doi.org]

Recent epidemiologic evidence suggests that there is a narrow range of vitamin D levels in which vascular function is optimized. [ipfs.io]

Epidemiology of nephrolithiasis. J Nephrol 2000;13:45-50. 2. López M, Hoppe B. History, epidemiology and regional diversities of urolithiasis. Pediatr Nephrol 2010;25:49-59. 3. Schwarz RD, Dwyer NT. Pediatric kidney stones: Long-term outcomes. [ssajm.org]

Recent epidemiologic evidence suggests that there is a narrow range of vitamin D levels in which vascular function is optimized. Levels above or below this range increased mortality. [en.wikipedia.org]

Confounding is always a potential explanation for associations reported in observational epidemiologic studies. [doi.org]

Pathophysiology The exact pathophysiology of the soft tissue mineralization in rabbits is unknown. [vetstream.com]

[…] of bone, Color Atlas of Pathophysiology. [academic.oup.com]

Brown, EM 1999 Physiology and pathophysiology of the extracellular calcium-sensing receptor. Am J Med 106 238 253 CrossRef PubMed Google Scholar 26. [doi.org]

Vitamin D has been added to milk in the United States since the 1930s to prevent rickets. We report the unusual occurrence of eight cases of vitamin D intoxication that appear to have been caused by excessive vitamin D fortification of dairy milk. [ncbi.nlm.nih.gov]

To prevent this condition, pay careful attention to the correct vitamin D dose. [indiatoday.in]

Kidney stones Call your provider if: You or your child shows symptoms of hypervitaminosis D and has been taking more vitamin D than the RDA You or your child shows symptoms and has been taking a prescription or over-the-counter form of vitamin D To prevent [nlm.nih.gov]

Discussion : Vitamin D plays an essential role in calcium homeostasis and the development and maintenance of the skeleton, is recommended for the prevention of rickets, optimization of peak bone mass, and prevention of bone loss, In addition, vitamin [ijn.mums.ac.ir]