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Hypervitaminosis E


Presentation

  • None have presented with primarily neurologic or psychiatric involvement.[journals.lww.com]
  • Presenting signs Not reported in rabbits. Signs in humans include diarrhea, flatulence and bloating; this progresses to lethargy and weakness. Acute presentation No rabbit specific information recorded.[vetstream.com]
  • Hypervitaminosis E Vitamin E is present in a great many foods, particularly vegetable oils, unprocessed cereal grains, nuts and seeds. There is no evidence of any adverse effects from consuming vitamin E in food.[patient.info]
  • Because vitamin E can act as an anticoagulant and may increase the risk of bleeding problems, many agencies have set an upper tolerable intake level (UL) for vitamin E at 1,000 mg (1,500 IU) per day. [1] Symptoms and presentation See also Vitamin poisoning[wikidoc.org]
  • Foods 40 Favism x 47 Cyanogenetic Glycosides 58 58 Antivitamins in Foods 98 Natural Cholinesterase Inhibitors in Foods 112 Toxicity of the Vitamins 183 Excesses of Indispensable Amino Acids 221 Toxicity of the Essential Minerals 229 Toxic Substances Present[books.google.com]
Rigor
  • OMICS Group is one of the best international publishers with 700 peer-reviewed journals along with eminent scientists in its Editorial Board and expert reviewers to carry rigorous peer-review process.[omicsonline.org]
Nausea
  • More sustained intake of excess vitamin A leads to increased intracranial pressure (pseudotumour cerebri), dizziness, nausea, headaches, skin irritation, pain in joints and bones, coma, and even death.[patient.info]
  • Symptoms of acute vitamin A toxicity include: drowsiness irritability abdominal pain nausea vomiting increased pressure on the brain Symptoms of chronic vitamin A toxicity include: blurry vision or other vision changes swelling of the bones bone pain[healthline.com]
  • Bulging of the soft spot in an infant's skull ( fontanelle ) Changes in alertness or consciousness Decreased appetite Dizziness Double vision (in young children) Drowsiness Hair changes, such as hair loss and oily hair Headache Irritability Liver damage Nausea[medlineplus.gov]
  • Symptoms include: fatigue loss of appetite weight loss excessive thirst excessive urination dehydration constipation irritability, nervousness ringing in the ear ( tinnitus ) muscle weakness nausea, vomiting dizziness confusion, disorientation high blood[medicalnewstoday.com]
  • Vitamin E Taking too much vitamin E may result in nausea, vomiting, severe fatigue, muscle weakness, high blood pressure, easy bruising and bleeding, double vision and slow wound healing.[livestrong.com]
Failure to Thrive
  • Complications can include: Excessively high calcium level Failure to thrive (in infants) Kidney damage due to high calcium Liver damage Taking too much vitamin A during pregnancy may cause abnormal development in the growing baby.[medlineplus.gov]
  • […] to thrive, decreased appetite and pruritus.[patient.info]
Hepatosplenomegaly
  • Other symptoms can be quite nonspecific: Scaly seborrhoeic eczema Patchy hair loss Stomatitis Loss of appetite Nausea Vomiting Malaise Hepatosplenomegaly Liver failure Raised intracranial pressure Children can present with craniotabes, irritability, failure[patient.info]
Bony Swelling
  • Symptoms often include bone pain and bony swelling due to increased bone resorption and periosteal bone formation, often associated with hypercalcaemia.[patient.info]
Bitot's Spots
  • spots, C: Scurvy, D: Rickets / Osteomalacia Mineral deficiency Zinc deficiency - Iron deficiency - Magnesium deficiency - Chromium deficiency Hyperalimentation Obesity - Vitamin poisoning ( Hypervitaminosis A, Hypervitaminosis D, Hypervitaminosis E )[wikidoc.org]
Polyuria
  • Hypervitaminosis D Vitamin D toxicity can cause nonspecific symptoms such as anorexia, weight loss, polyuria, and heart arrhythmias.[patient.info]
Encephalopathy
  • […] presentation See also Vitamin poisoning References External links Vitamin E Toxicity (www.emedicine.com) v t e Nutritional pathology ( E40-68, 260-269 ) Malnutrition Kwashiorkor - Marasmus - Catabolysis Avitaminosis B vitamins : B1: Beriberi / Wernicke's encephalopathy[wikidoc.org]
  • Bardosi A, Creutzfeld W, DiMauro S, Felgenhauer K, Friede RL, Goebel HH, Kohlschütter A, Mayer G, Rahlf G, Servidei S, Van Lessen G, Wetterling T (1987) Myoneuro-gastrointestinal encephalopathy (MNGIE syndrome) due to partial deficiency of cytochrome-c-oxidase[link.springer.com]
Lethargy
  • Signs in humans include diarrhea, flatulence and bloating; this progresses to lethargy and weakness. Acute presentation No rabbit specific information recorded.[vetstream.com]
  • Features of hypercalcaemia include polyuria, polydypsia, vomiting, anorexia, lethargy, dehydration, constipation, hypertension, tetany and seizures. The traditional description of hypercalcaemia is stones, bones and groans.[patient.info]
Bulging Fontanelle
  • Symptoms include: Headache Abdominal pain Nausea or vomiting Lethargy Visual changes Impaired consciousness Other features suggestive of raised intracranial pressure, such as bulging fontanelle (in an infant), papilloedema and diplopia, may also occur[patient.info]

Workup

  • (See Prognosis, Workup, Treatment, and Medication .) Vitamin A An important fat-soluble vitamin, vitamin A’s basic molecule is a retinol, or vitamin A alcohol.[emedicine.medscape.com]

Treatment

  • Stay at the forefront of your field with updated treatment methods throughout, as well as an increased focus on patients with skin of color.[books.google.com]
  • Some amount of liver, kidney, nervous system damage may be observed, if the treatment is delayed.[dovemed.com]
  • Treatment : none as rare. Prognosis : depends on severity. Presenting signs Not reported in rabbits. Signs in humans include diarrhea, flatulence and bloating; this progresses to lethargy and weakness.[vetstream.com]
  • […] color to the skin Vision changes Vomiting These tests may be done if a high vitamin A level is suspected: Bone x-rays Blood calcium test Cholesterol test Liver function test Blood test to check vitamin A level Blood test to check other vitamin levels Treatment[medlineplus.gov]
  • The references it cited reported instances of reduced treatment adverse effects, but also poorer cancer survival, raising the possibility of tumor protection from the intended oxidative damage by the treatments. [2] Diet [ edit ] Recommendations [ edit[en.wikipedia.org]

Prognosis

  • Prognosis Mortality is rare. Once identified, the prognosis is good. The yellow coloration of skin will reverse with time.[patient.info]
  • The prognosis is excellent, if the condition is recognized early and treated appropriately Individuals with severe conditions of Hypervitaminosis A may require hospitalization with extended treatment.[dovemed.com]
  • Prognosis : depends on severity. Presenting signs Not reported in rabbits. Signs in humans include diarrhea, flatulence and bloating; this progresses to lethargy and weakness. Acute presentation No rabbit specific information recorded.[vetstream.com]
  • Prognosis The prognosis for reversing vitamin toxicity is excellent for most patients. Side effects usually go away as soon as overdoses are stopped.[encyclopedia.com]
  • (See Prognosis, Workup, Treatment, and Medication .) Vitamin A An important fat-soluble vitamin, vitamin A’s basic molecule is a retinol, or vitamin A alcohol.[emedicine.medscape.com]

Etiology

  • (Etiology) The body requires a specific amount of vitamin A each day. The liver stores vitamin A, which gets transported to various parts of the body by a specific protein, termed as retinol-binding protein.[dovemed.com]
  • […] the United States population aged 1 year and older took a multivitamin supplement in a given month. [3] In a 2009 survey, 56% of US consumers said they take vitamins or supplements, with 44% saying they take them daily. [4] (See Pathophysiology and Etiology[emedicine.medscape.com]
  • Vitamin B 6 has been shown in at least two small-scale clinical studies to have a beneficial effect on the syndrome, particularly in cases where no trauma or overuse etiology is known.[allaboutheaven.org]

Epidemiology

  • "Epidemiology, Study Design". StatPearls[Internet]. PMID 29262004. Anglemyer A, Horvath HT, Bero L (2014). "Healthcare outcomes assessed with observational study designs compared with those assessed in randomized trials".[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • […] in 2003–2006 33% of the United States population aged 1 year and older took a multivitamin supplement in a given month. [3] In a 2009 survey, 56% of US consumers said they take vitamins or supplements, with 44% saying they take them daily. [4] (See Pathophysiology[emedicine.medscape.com]

Prevention

  • […] address growing concerns related to patient safety and prevent medication-related errors.[books.google.de]
  • As of March 2018, EFSA has not evaluated any vitamin E and cancer prevention claims.[en.wikipedia.org]
  • Prevention Some types of mushrooms contain vitamin D. Discontinuing or lowering your intake of high-dose vitamin D supplements can prevent hypervitaminosis D.[medicalnewstoday.com]
  • Prevention Toxicity from excess of vitamins A and D and, exceptionally, vitamin E, can occur but it is important not to exaggerate the risk.[patient.info]
  • Prevention Hypervitaminosis A can be prevented by not ingesting more than the Tolerable Upper Level of intake for Vitamin A. This level is for synthetic and natural retinol ester forms of vitamin A. Carotene forms from dietarysources are nottoxic.[flipper.diff.org]

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