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Hypervitaminosis K

Vitamin K Toxicity


Presentation

  • Usually, since the water soluble vitamins (B6, B12, Biotin, Folic Acid, Thiamin, Riboflavin, Niacin, Vitamin C, Pantothenic Acid) are not stored in our body and the extra amounts are excreted as waste, they do not present a high level of risk for our[enotes.com]
  • It is written in a lucid style with the subject being presented as an engaging story growing from elementary information to the most recent advances, and with theoretical discussions being supplemented with illustrations, flowcharts, and tables for easy[books.google.com]
  • The present report is of an adult male with this syndrome and demonstrates several interesting features. CASE REPORT Present Illness: A 25 year old Mexican drug store clerk was first seen by us on March 3, FULL TEXT[annals.org]
  • A careful drug history to uncover possible isotretinoin use is important in patients presenting with manifestations suggestive of vitamin A intoxication.[emedicine.medscape.com]
  • All material presented here is unclassified. C. 2009, 2014, All Rights Reserved[brooksidepress.org]
Sparse Hair
  • Chronic intoxication Anorexia, dry Itchy skin, wt. loss, painful extremities, sparse hair, Hepatosplenomegaly, hypoplastic anemia and Benign I.C. Hypertension. c. Normally, vit.[gradestack.com]

Treatment

  • Conditions, tests and treatments A-Z[rbht.nhs.uk]
  • Oral doses of 2mg are adequate. treatment: 1mg SQ or IM, in conjunction with proper laboratory testing of PT. Hypoprothrombinemia in adults: 2.5-25mg. Amount and route of administration depends on severity of disease.[webapp1.dlib.indiana.edu]
  • Treatment In all cases, treatment of vitamin toxicity requires discontinuing vitamin supplements.[encyclopedia.com]

Prognosis

  • Prognosis Mortality is rare. Once identified, the prognosis is good. The yellow coloration of skin will reverse with time.[patient.info]
  • Prognosis The prognosis for reversing vitamin toxicity is excellent for most patients. Side effects usually go away as soon as overdoses are stopped.[encyclopedia.com]
  • Vitamin A status as a marker of prognosis in cystic fibrosis. Abstract book, 11th International CF Congress, Dublin 1992. Poster MP73. Rayner RJ, Tyrell JC, Hiller EJ, et al .[cfmedicine.com]

Etiology

  • Isotretinoin (Accutane), a drug used for the treatment of severe forms of acne, is closely related to the chemical structure of vitamin A and therefore has similar pharmacologic and toxic attributes (see Pathophysiology and Etiology).[emedicine.medscape.com]

Epidemiology

  • Hygiene and epidemiology : selected chapters. 2. edition. Prague. 2008. ISBN 80-246-0793-X.[wikilectures.eu]
  • Acknowledgements Robert A Adler, MD Chief of Endocrinology and Metabolism, McGuire Veterans Affairs Medical Center; Professor, Departments of Internal Medicine and Epidemiology and Community Health, Virginia Commonwealth University Robert A Adler, MD[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Isotretinoin (Accutane), a drug used for the treatment of severe forms of acne, is closely related to the chemical structure of vitamin A and therefore has similar pharmacologic and toxic attributes (see Pathophysiology and Etiology).[emedicine.medscape.com]
  • It is associated with significant mortality risk and its pathophysiology is usually multifactorial, chiefly reduced renal function and drugs.[clinicaladvisor.com]

Prevention

  • Ailments That Vitamin K Eliminates: Treat life-threatening hemorrhaging Helps prevent osteoporosis Prevents hardening of the arteries Reduces risk of cardiovascular disease Prevent abnormal muscle weakness Side Effects/Pre-Cautions Toxicity risk for vitamin[fitnesshealth101.com]
  • […] has been described in at least 17 infants and young children since Josephs' original article in 1944. 1, 2 Sulzberger and Lazar 3 described similar toxic symptoms which occurred in an adult female who took large amounts of vitamin A in an attempt to prevent[annals.org]
  • Warfarin inhibits vitamin K by preventing its enzymatic reactivation. Pathological manifestations are rare. Hypovitaminosis K can lead to jaundice and anaemia in the neonate.[radiopaedia.org]
  • Eijkman, essence in outer coating of rice prevents illness Correlation between chemicals factors and cures for deficiencies Many discovered during the late 19th, early 20th century As they were discovered were labeled using letters (A, B, C, D, E) until[www2.highlands.edu]
  • In some therapeutic dose of vitamin B complex vitamins exceed the daily allowance for healthy people, these drugs can not be used as a preventive measure.[mymedinform.com]

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