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Hypervitaminosis K

Vitamin K Toxicity


Presentation

  • Usually, since the water soluble vitamins (B6, B12, Biotin, Folic Acid, Thiamin, Riboflavin, Niacin, Vitamin C, Pantothenic Acid) are not stored in our body and the extra amounts are excreted as waste, they do not present a high level of risk for our[enotes.com]
  • The present report is of an adult male with this syndrome and demonstrates several interesting features. CASE REPORT Present Illness: A 25 year old Mexican drug store clerk was first seen by us on March 3, FULL TEXT[annals.org]
  • All material presented here is unclassified. C. 2009, 2014, All Rights Reserved[brooksidepress.org]
  • Hypervitaminosis K is extremely rare but when present may cause thrombophilia or hemolysis 3 .[radiopaedia.org]
  • Hypervitaminosis E Vitamin E is present in a great many foods, particularly vegetable oils, unprocessed cereal grains, nuts and seeds. There is no evidence of any adverse effects from consuming vitamin E in food.[patient.info]
Fatigue
  • It can cause liver damage or destruction of red blood cells, leading to a variety of symptoms including fatigue or jaundice -- yellow discoloration of the eyes and skin.[livestrong.com]
  • […] amount Dryness, cracking lips (due to chronic overdose) Eye irritation Increased sensitivity of the eyes to light Irregular heartbeat Rapid heartbeat Bone pain Joint pain Muscle pain Muscle weakness Confusion, mood changes Convulsions (seizures) Fainting Fatigue[en.wikipedia.org]
  • 15 ug/day ( 70yrs) Toxicity Hypervitaminosis D 5 times the AI is dangerous for infants, 10 times the AI for adults Calcification of soft tissue, growth retardation, excess calcium excretion via the kidneys (kidney stones), headaches, muscle weakness, fatigue[www2.highlands.edu]
  • […] long-term overdose), eye irritation, or increased sensitivity to light (for eyes) Heart and blood Irregular or rapid heartbeat Muscles and joints Bone, joint, or muscle pain, or muscle weakness Nervous system Confusion, convulsions (seizures), fainting, fatigue[pharmacytimes.com]
  • […] acid Overdose of folate and 20 mg of folic acid per day is fraught with violation of the kidneys, damage to the nervous system and the development of pernicious anemia. hypervitaminosis B12 Overdose of vitamin B12 or cyanocobalaminleads to weakness, fatigue[mymedinform.com]
Weight Loss
  • loss (from long-term overdose) [3] Causes [ edit ] With few exceptions, like some vitamins from B-complex, hypervitaminosis usually occurs with the fat-soluble vitamins A and D, which are stored, respectively, in the liver and fatty tissues of the body[en.wikipedia.org]
  • Vitamin K can also adversely interfere with some antibiotics, as well as certain weight-loss drugs, such as olestra.[livestrong.com]
  • Vitamin D Vitamin D toxicity can lead to nonspecific symptoms, such as weight loss, increased urination and abnormal heart rhythms.[healthyeating.sfgate.com]
  • loss Patients should consult with their physician or pharmacist before taking any vitamins.[pharmacytimes.com]
Anorexia
  • Chronic intoxication Anorexia, dry Itchy skin, wt. loss, painful extremities, sparse hair, Hepatosplenomegaly, hypoplastic anemia and Benign I.C. Hypertension. c. Normally, vit.[gradestack.com]
  • […] guidelines for performing special techniques and procedures such as anesthesia, clinical pathology, diagnostic imaging, euthanasia and necropsy, fracture management, soft tissue surgery, and therapeutics Covers specific diseases and conditions such as anorexia[books.google.com]
  • Hypervitaminosis D Vitamin D toxicity can cause nonspecific symptoms such as anorexia, weight loss, polyuria, and heart arrhythmias.[patient.info]
  • […] absorption Mineralization and repair of bone Tubular reabsorption of calcium Insulin and thyroid function, improvement of immune function, reduced risk of autoimmune disease Deficiency: Rickets (sometimes with tetany), osteomalacia Toxicity: Hypercalcemia, anorexia[msdmanuals.com]
  • Deficiency in vitamin B1 causes Beriberi and associated symptoms such as tiredness, muscular weakness disorder of memory and concentration, lassitude and anorexia. Alcoholism decreases absorption of vitamin B1.[swissvitamin.ch]
Vomiting
  • Acute manifestation Headache, vomiting and dizziness, signs of ICT (Pseudotumor cerebri) b. Chronic intoxication Anorexia, dry Itchy skin, wt. loss, painful extremities, sparse hair, Hepatosplenomegaly, hypoplastic anemia and Benign I.C.[gradestack.com]
  • . - extra amounts of vitamin D: extra amount of calcium detected in blood, loss of appetite, nausea, vomiting, slowed mental and physical development. - extra amount of vitamin E: hazardous effects on patients that take warfarin and statins - extra amounts[enotes.com]
  • […] burning skin, or rash Yellow-orange areas of skin Sensitivity to sun (more likely to sunburn) Hair loss (from long-term overdose) Intestinal bleeding (from iron) Appetite loss Constipation (from iron or calcium) Diarrhea, possibly bloody Nausea and vomiting[en.wikipedia.org]
  • Features of hypercalcaemia include polyuria, polydypsia, vomiting, anorexia, lethargy, dehydration, constipation, hypertension, tetany and seizures. The traditional description of hypercalcaemia is stones, bones and groans.[patient.info]
  • Symptoms of hypervitaminosis: thirst, nausea, vomiting, abdominal pain, constipation and diarrhea, polyuria. Overdose of vitamin causes an increase in blood pressure, pain in the back of his head.[mymedinform.com]
Loss of Appetite
  • The extra amounts of each fat soluble vitamin can lead to the following symptoms, such that: - extra amount of vitamin A: headache, loss of appetite, nausea, blurred vision, dizziness, risk of hip fracture, severe birth defects, itchy and dry skin. -[enotes.com]
  • […] of appetite, dry skin and mucous membranes, hemorrhages, coma Acute : gastrointestinal upsets/nausea, headaches, dizziness, muscle contraction Vitamin D Two nutritionally important forms: vitamin D 2 (ergocalciferol) which is found in plants and vitamin[www2.highlands.edu]
  • Acute toxicity causes dry, itchy skin, headache, nausea, loss of appetite and blurred vision.[wikilectures.eu]
  • Other symptoms can be quite nonspecific: Scaly seborrhoeic eczema Patchy hair loss Stomatitis Loss of appetite Nausea Vomiting Malaise Hepatosplenomegaly Liver failure Raised intracranial pressure Children can present with craniotabes, irritability, failure[patient.info]
  • Hypervitaminosis of vitamin D may cause hypercalciuria, loss of appetite, nausea and vomiting and dehydration.[swissvitamin.ch]
Tachycardia
  • Tachycardia, enlargement of the heart, systolic murmurs, pulmonary edema, liver enlargement, and oliguria. Pneumonia and septicemia are commonly confused with this form of beri-beri. aphonic beri-beri : peak prevalence is in 4-6 month-old children.[ufrgs.br]
Cracked Lips
  • lips (due to chronic overdose) Eye irritation Increased sensitivity of the eyes to light Irregular heartbeat Rapid heartbeat Bone pain Joint pain Muscle pain Muscle weakness Confusion, mood changes Convulsions (seizures) Fainting Fatigue Headache Mental[en.wikipedia.org]
  • lips (from long-term overdose), eye irritation, or increased sensitivity to light (for eyes) Heart and blood Irregular or rapid heartbeat Muscles and joints Bone, joint, or muscle pain, or muscle weakness Nervous system Confusion, convulsions (seizures[pharmacytimes.com]
Cheilitis
  • […] dimethylbenzene pteryn flavin mononucleotide ( FMN) / E101a / riboflavin phosphate and flavine adenine dinucleotide ( FAD) (prostethic groups) : transport of 2 hydride ions (H 2 ) in flavoproteins quinone semiquinone / semiquinol quinol photophobia, angular cheilitis[ufrgs.br]
Jaundice
  • It can cause liver damage or destruction of red blood cells, leading to a variety of symptoms including fatigue or jaundice -- yellow discoloration of the eyes and skin.[livestrong.com]
  • Hypovitaminosis K can lead to jaundice and anemia in the neonate. Hypervitaminosis K is extremely rare but when present may cause thrombophilia or hemolysis 3 .[radiopaedia.org]
  • Vitamin K toxicity can lead to jaundice, liver damage and anemia. High intake of supplemental vitamin K can interfere with anticoagulants, like warfarin.[healthyeating.sfgate.com]
  • These doses of VK can also increase risk of jaundice. Hypervitaminosis K, or VK toxicity, is fairly rare as the natural forms of VK, phylloquinone and menaquinone, are non toxic at very high dosage levels. Genes In contrast to... References 1.[link.springer.com]
  • It can cause porphynuria; if a pregnant woman gets this, her baby could be born jaundiced. It can cause a side effect as minor as vomiting, or it may cause thrombosis. {{ oArticle.subtitle }}[fitday.com]
Hepatosplenomegaly
  • Chronic intoxication Anorexia, dry Itchy skin, wt. loss, painful extremities, sparse hair, Hepatosplenomegaly, hypoplastic anemia and Benign I.C. Hypertension. c. Normally, vit.[gradestack.com]
  • Other symptoms can be quite nonspecific: Scaly seborrhoeic eczema Patchy hair loss Stomatitis Loss of appetite Nausea Vomiting Malaise Hepatosplenomegaly Liver failure Raised intracranial pressure Children can present with craniotabes, irritability, failure[patient.info]
  • […] retina) Integrity of epithelia Lysosome stability Glycoprotein synthesis Deficiency: Night blindness, perifollicular hyperkeratosis, xerophthalmia, keratomalacia, increased morbidity and mortality in young children Toxicity: Headache, peeling of skin, hepatosplenomegaly[msdmanuals.com]
Hearing Impairment
  • Excess calcium may lead to overproduction of neurotransmitters in the body causing symptoms like hearing impairment, pricking, pain and numbness in other body parts. The recommended daily dosage limit for Vitamin D is 250 mg or 10,000 IU.[vitaminsestore.com]
Blurred Vision
  • The extra amounts of each fat soluble vitamin can lead to the following symptoms, such that: - extra amount of vitamin A: headache, loss of appetite, nausea, blurred vision, dizziness, risk of hip fracture, severe birth defects, itchy and dry skin. -[enotes.com]
  • Taking high doses of retinol – more than 15,000 micrograms over a short period of time – can lead to nausea, vomiting, headaches, blurred vision and dizziness.[healthyeating.sfgate.com]
  • Side effects that occur in the body when too much vitamin A is consumed include: severe growth retardation hair loss blurred vision the enlargement of the liver and spleen It may also result in bone pain.[fitday.com]
  • vision, augmentation of anti-clotting medications ) Vitamin K Two forms: Vitamin K 1 Phyllaquinones (plant source) and vitamin K 2 menaquinone (fish oils and meats) 80% of dietary vitamin K is absorbed The release of vitamin K from food requires bile[www2.highlands.edu]
  • Acute toxicity causes dry, itchy skin, headache, nausea, loss of appetite and blurred vision.[wikilectures.eu]
Eye Irritation
  • irritation Increased sensitivity of the eyes to light Irregular heartbeat Rapid heartbeat Bone pain Joint pain Muscle pain Muscle weakness Confusion, mood changes Convulsions (seizures) Fainting Fatigue Headache Mental changes Irritability Flushing ([en.wikipedia.org]
  • irritation, or increased sensitivity to light (for eyes) Heart and blood Irregular or rapid heartbeat Muscles and joints Bone, joint, or muscle pain, or muscle weakness Nervous system Confusion, convulsions (seizures), fainting, fatigue, headache, mental[pharmacytimes.com]
Redness of Eye
  • […] tongue; eyes burning & itching; scaly & greasy skin Vitamin B2 (food sources) Milk (most important); enriched grains, meats, poultry, fish, mushrooms, spinach, avocados Coenzyme; partner with B2 and B1 in cell metabolism that produce energy; supplmnt[quizlet.com]
Dry Skin
  • The extra amounts of each fat soluble vitamin can lead to the following symptoms, such that: - extra amount of vitamin A: headache, loss of appetite, nausea, blurred vision, dizziness, risk of hip fracture, severe birth defects, itchy and dry skin. -[enotes.com]
  • Men 900 ug RAE/day, women 700 ug RAE/day Men 3000 IU/day, women 2330 IU/day Toxicity Hypervitaminosis A Caused by excess dosages ( 100 times RDA ) Can be fatal ( 13,000 times RDA ) Chronic : liver damage, hair loss, bone/muscle pain, loss of appetite, dry[www2.highlands.edu]
Alopecia
  • Defiency can cause skin inflammation (dermatitis), hair loss (alopecia), conjunctivitis or neurological symptoms. There are no reported hypervitaminosis of vitamin biotin.[swissvitamin.ch]
  • Prospective trials showed that 100,000 to 200,000 IU of vitamin A twice a year can reduce the overall death rate significantly. autolysis, dizziness, alopecia , skin desquamation, metaplasias 2 large controlled trials of b -carotene for prevention of[ufrgs.br]
Sparse Hair
  • Chronic intoxication Anorexia, dry Itchy skin, wt. loss, painful extremities, sparse hair, Hepatosplenomegaly, hypoplastic anemia and Benign I.C. Hypertension. c. Normally, vit.[gradestack.com]
Erythema
  • ., erythema, hyperpigmentation, and scales around the neck) vitamin B 4 / adenine (no longer considered a vitamin !)[ufrgs.br]
Headache
  • Acute manifestation Headache, vomiting and dizziness, signs of ICT (Pseudotumor cerebri) b. Chronic intoxication Anorexia, dry Itchy skin, wt. loss, painful extremities, sparse hair, Hepatosplenomegaly, hypoplastic anemia and Benign I.C.[gradestack.com]
  • The extra amounts of each fat soluble vitamin can lead to the following symptoms, such that: - extra amount of vitamin A: headache, loss of appetite, nausea, blurred vision, dizziness, risk of hip fracture, severe birth defects, itchy and dry skin. -[enotes.com]
  • Dryness, cracking lips (due to chronic overdose) Eye irritation Increased sensitivity of the eyes to light Irregular heartbeat Rapid heartbeat Bone pain Joint pain Muscle pain Muscle weakness Confusion, mood changes Convulsions (seizures) Fainting Fatigue Headache[en.wikipedia.org]
  • Signs of hypervitaminosis A: lack of appetite, runny nose, headache, nausea, vomiting, drowsiness and weakness unfounded. Chronic excess vitamin A can occurchronic administration of vitamin A, even in moderate doses.[mymedinform.com]
  • More sustained intake of excess vitamin A leads to increased intracranial pressure (pseudotumour cerebri), dizziness, nausea, headaches, skin irritation, pain in joints and bones, coma, and even death.[patient.info]
Insomnia
  • As a sign of hypervitaminosis arises insomnia and anxiety, female menstrual cycle is disrupted, a possible miscarriage.[mymedinform.com]
  • Vitamin B-9 or Folate Even though many women are advised to take folic acid, overdose of the vitamin may cause neurological issues like confusion and insomnia.[vitaminsestore.com]
  • Deficiency in vitamin PP can cause fatigue, nausea and vomiting, insomnia, depression and finally pellagra (sun sensitivity and dementia). Alcoholism can cause deficiency.[swissvitamin.ch]
Lethargy
  • Features of hypercalcaemia include polyuria, polydypsia, vomiting, anorexia, lethargy, dehydration, constipation, hypertension, tetany and seizures. The traditional description of hypercalcaemia is stones, bones and groans.[patient.info]
  • The period of the short-term excitation replaced by lethargy and depression. Chronic intoxication with vitamin D leads toits accumulation in various organs and tissues, kidney damage, lung and blood vessels.[mymedinform.com]
Cloudy Urine
  • urine Frequent urination Increased urine amount Dryness, cracking lips (due to chronic overdose) Eye irritation Increased sensitivity of the eyes to light Irregular heartbeat Rapid heartbeat Bone pain Joint pain Muscle pain Muscle weakness Confusion,[en.wikipedia.org]
  • urine, frequent urination, or increased urine amount Eyes, ears, nose, mouth, and throat Dry, cracking lips (from long-term overdose), eye irritation, or increased sensitivity to light (for eyes) Heart and blood Irregular or rapid heartbeat Muscles and[pharmacytimes.com]
Polyuria
  • Hypervitaminosis D Vitamin D toxicity can cause nonspecific symptoms such as anorexia, weight loss, polyuria, and heart arrhythmias.[patient.info]
  • Symptoms of hypervitaminosis: thirst, nausea, vomiting, abdominal pain, constipation and diarrhea, polyuria. Overdose of vitamin causes an increase in blood pressure, pain in the back of his head.[mymedinform.com]

Treatment

  • Search: name, specialism, conditions, treatments, tests or services Search: name, specialism, conditions, treatments, tests or services Search: name, specialism, conditions, treatments, tests or services Royal Brompton & Harefield NHS Foundation Trust[rbht.nhs.uk]
  • Oral doses of 2mg are adequate. treatment: 1mg SQ or IM, in conjunction with proper laboratory testing of PT. Hypoprothrombinemia in adults: 2.5-25mg. Amount and route of administration depends on severity of disease.[oacapps.med.jhmi.edu]
  • Treatment In all cases, treatment of vitamin toxicity requires discontinuing vitamin supplements.[encyclopedia.com]
  • Role in coagulation therapy The role of vitamin K is often exploited in anticoagulation treatments in patients with increased risk of thrombosis.[wikilectures.eu]

Prognosis

  • Prognosis Mortality is rare. Once identified, the prognosis is good. The yellow coloration of skin will reverse with time.[patient.info]
  • Prognosis The prognosis for reversing vitamin toxicity is excellent for most patients. Side effects usually go away as soon as overdoses are stopped.[encyclopedia.com]
  • Vitamin A status as a marker of prognosis in cystic fibrosis. Abstract book, 11th International CF Congress, Dublin 1992. Poster MP73. Rayner RJ, Tyrell JC, Hiller EJ, et al.[cfmedicine.com]

Epidemiology

  • 6 hypervitaminoses are associated with side effects that usually rapidly subside with supplement reduction or cessation. [ citation needed ] Prevention [ edit ] Do not take more than the normal or recommended amount of multivitamin supplements. [3] Epidemiology[en.wikipedia.org]
  • Hygiene and epidemiology : selected chapters. 2. edition. Prague. 2008. ISBN 80-246-0793-X.[wikilectures.eu]
Sex distribution
Age distribution

Prevention

  • Hypervitaminosis D High-dosage, regular and slow-release vitamin B 3 ; Niacin ; and very high-dosage vitamin B 6 hypervitaminoses are associated with side effects that usually rapidly subside with supplement reduction or cessation. [ citation needed ] Prevention[en.wikipedia.org]
  • […] has been described in at least 17 infants and young children since Josephs' original article in 1944. 1, 2 Sulzberger and Lazar 3 described similar toxic symptoms which occurred in an adult female who took large amounts of vitamin A in an attempt to prevent[annals.org]
  • Warfarin inhibits vitamin K by preventing its enzymatic reactivation. Pathological manifestations are rare. Hypovitaminosis K can lead to jaundice and anemia in the neonate.[radiopaedia.org]
  • You can generally prevent the use of "cookies" if you prohibit the storage of "cookies" in your browser.[vinocibo.it]
  • In some therapeutic dose of vitamin B complex vitamins exceed the daily allowance for healthy people, these drugs can not be used as a preventive measure.[mymedinform.com]

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