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Hypocupremia


Presentation

  • Abstract Clinical similarities between vitamin B(12) and copper deficiencies prompted us to investigate if hypocupremia is present in patients receiving vitamin B(12) supplementation.[ncbi.nlm.nih.gov]
  • In particular, CSF oligoclonal bands (OCBs) are present in the majority of MS patients and can be suggestive of an MS diagnosis. However, OCBs are not specific to MS and may occur in other CNS inflammatory disorders.[n.neurology.org]
  • Case #3 A 53-year-old man presented with anemia, leukopenia and neurological symptoms ( Table 1 ).[haematologica.org]
Anemia
  • Hypocupremia occurred in an adult with sickle cell anemia who received zinc as an antisickling agent for two years. The hypocupremia was associated with microcytosis and relative neutropenia.[ncbi.nlm.nih.gov]
  • TY - JOUR T1 - Copper deficiency in infants; a syndrome characterized by hypocupremia, iron deficiency anemia, and hypoproteinemia.[wwww.unboundmedicine.com]
  • The book mentions need for interventional strategies for the management of nutritional anemia.[books.google.com]
  • We have since observed hypoceruloplasminemia of varying degrees in several other sickle cell anemia patients who were receiving oral zinc therapy. This complication was easily corrected by copper supplementation.[210.46.82.192]
Failure to Thrive
  • Signs and symptoms : Signs and symptoms include failure to thrive, pallor, anemia, muscular hypotonia, short stature, repeated seizures, acne, deep philtrum, wide nasal bridge and early balding.[xpertdox.com]
  • Differential Diagnoses Bone Marrow Failure Diamond Blackfan anemia Fanconi Anemia Kearns-Sayre Syndrome MELAS Syndrome Myelodysplastic Syndrome Neutropenia Nutritional Considerations in Failure to Thrive Shwachman-Diamond Syndrome Author Zora R Rogers[emedicine.staging.medscape.com]
Headache
  • […] nausea, vomiting, constipation, polydipsia, polyuria, renal stones, hypertension Vitamin E Loss of reflexes, gait disturbance (posterior tract-spinocerebellar symptoms), paresis of gaze, eczema, psoriasis, poor wound healing, broken capillaries Fatigue, headache[emedicinehealth.com]
  • Copper toxicity can have unpleasant and potentially fatal side effects, including ( 40, 41 ): Nausea Vomiting (food or blood) Diarrhea Stomach pain Black, “tarry” stools Headaches Difficulty breathing An irregular heartbeat Low blood pressure Coma Yellow[healthline.com]

Workup

  • Extensive workup is necessary to confirm the diagnosis. As for management, the earlier the intervention is initiated, the better prognosis would be for recovery.[ncbi.nlm.nih.gov]

Treatment

  • The early recognition and treatment of the symptoms of hypocupremia is emphasized to avoid these long-term sequelae.[ncbi.nlm.nih.gov]
  • Article Access Statistics Viewed 5321 Printed 133 Emailed 2 PDF Downloaded 190 Comments However an overzealous treatment with zinc over a prolonged period can have its own dangers.[neurologyindia.com]
  • CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes.[resourcerepository.org]
  • Treatment of hypocupremia consists of the prompt reversal of the deficiency with intravenous copper infusion, oral supplementation of copper, or both, depending on the severity of the condition.[aafp.org]

Prognosis

  • […] retardation hypocupremia hypobetalipoproteinemia Home medical testing related to Mental retardation - hypocupremia - hypobetalipoproteinemia: Concentration -- Home Testing ADHD -- Home Testing Mental Health: Home Testing: Home Emotional Stress Tests Prognosis[checkorphan.org]
  • Treatment and prognosis Cocoa is often trialled initially as it contains copper naturally in reasonable amounts and is palatable to the patient 1.[radiopaedia.org]
  • As for management, the earlier the intervention is initiated, the better prognosis would be for recovery. There are several treatment options which should be tailored to every patient with neurologic Wilson disease.[ncbi.nlm.nih.gov]

Etiology

  • It is increasingly evident that a multitude of etiologies can give rise to signal abnormality in the dorsal and lateral columns of the spinal cord, apart from pernicious anemia.[ncbi.nlm.nih.gov]
  • While the actual prevalence of copper deficiency is not known, our series of patients and those reported recently by others suggests that it may be an under-recognized etiology of anemia and neutropenia appearing as MDS.[doi.org]
  • Copper deficiency in sheep inWestern Australia: a preliminary account of the etiology of enzootic ataxia in lambs and an anemia in ewes. Aust Vet J. 1937 ; 13 : 138 – 49. 6. Barlow, RM.[cambridge.org]
  • Resch : An approach to the etiologic mechanisms in cerebral atherosclerosis, 168–173. In: Millikan, C. H., R. G. Siekert , and J. P. Whisnant (Eds). Cerebral vascular diseases. New York-London: Grune & Stratton 1965. Google Scholar Glynn, L.[link.springer.com]

Pathophysiology

  • Useful For Suggests clinical disorders or settings where the test may be helpful Diagnosis of: -Wilson disease -Primary biliary cirrhosis -Primary sclerosing cholangitis Clinical Information Discusses physiology, pathophysiology, and general clinical[mayomedicallaboratories.com]
  • This article presents a case of a patient who developed hypocupremia with associated pancytopenia, myeloneuropathy, and leukoencephalopathy following DS and reviews the literature related to the pathophysiology of copper deficiency and copper replacement[dsfacts.com]
  • Future avenues Advances in the understanding of the pathophysiology of CDM may yield further therapeutic approaches in the future.[doi.org]
  • […] excess iron supplementation causes copper deficiency myelopathy. [2] Another rarer cause of copper deficiency is celiac disease, probably due to malabsorption in the intestines. [2] Still, a large percentage, around 20%, of cases have unknown causes. [2] Pathophysiology[en.wikipedia.org]

Prevention

  • We illustrate the importance of identifying these patients early to prevent irreversible neurological injury. 2012 John Wiley & Sons A/S.[ncbi.nlm.nih.gov]
  • Prevention - Mental retardation hypocupremia hypobetalipoproteinemia Not supplied.[checkorphan.org]
  • ., Read, AP, and Fielding, DW, Apparent prevention of neural tube defects by periconceptional vitamin supplementation, Arch. ‏[books.google.com]
  • We illustrate the importance of identifying these patients early to prevent irreversible neurological injury. Biography : Alemayehu A.[longdom.org]
  • We illustrate the importance of identifying these patients early to prevent irreversible neurological injury. Biography Alemayehu A.[omicsonline.org]

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