Male hypogonadism is characterized by impaired testicular function, which can affect spermatogenesis and/or testosterone synthesis. [dnatesting.uchicago.edu]

Fluoxymesterone An anabolic steroid that has been used in the treatment of male HYPOGONADISM, delayed puberty in males, and in the treatment of breast neoplasms in women. [bioportfolio.com]

Systemic diseases such as malnutrition, depression, nephrotic syndrome and chronic diarrhea were excluded. In all IHH patients, 203 were KS and 151 were nIHH. [ajandrology.com]

In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. [genecards.org]

In around 50-60% of cases, CHH is associated with a variety of non-reproductive abnormalities, most commonly anosmia/hyposmia, which defines Kallmann Syndrome (KS) by its presence. [moh-it.pure.elsevier.com]

(loss of the sense of smell ) including sensorineural deafness, coloboma, bimanual synkinesis, craniofacial abnormalities, and/or renal agenesis. [4] Causes [ edit ] IHH is divided into two syndromes: IHH with olfactory alterations or anosmia, Kallmann [en.wikipedia.org]

Critical clues are anosmia, absence of menstrual periods, family history of delayed puberty and the presence of other malformations (skeletal, renal, cardiac) in close family members. [edmcasereports.com]

In around 50-60% of cases, CHH is associated with a variety of non-reproductive abnormalities, most commonly anosmia/hyposmia, which defines Kallmann Syndrome (KS) by its presence. [moh-it.pure.elsevier.com]

Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. [genecards.org]

[…] serum gonadotropin levels; 3) otherwisenormal pituitary function; 4) normal serum ferritin concentrations;5) normal magnetic resonance imaging (MRI) of the hypothalamic- pituitary region; and 6) a normal sense of smell on olfactometry, andno anosmia/hyposmia [br.123dok.com]

In women referred for primary amenorrhea and with an hormonal profile suggesting HH but without anosmia or hyposmia or identified genetic anomalies, the diagnosis of CHH must therefore only be considered with care, after ruling out underweight, eating [em-consulte.com]

GNRHR1 mutations, present in a compound heterozygous state, whereas their unaffected parents possessed only one inactivating mutation, demonstrating the autosomal recessive transmission in this kindred and excluding X-linked inheritance equivocally suggested [risweb.st-andrews.ac.uk]

One patient had a heterozygous GNRHR mutation associated with a heterozygous PROKR2 mutation, thus suggesting a possible role of synergistic heterozygosity in the pathogenesis of the disorder. [ncbi.nlm.nih.gov]

S4), suggest that in fact these variants did not affect the structure and the function of NK3R. Panel A. [br.123dok.com]

This suggests an existence of several other candidate genes or environmental factors underlying these syndromes. [karger.com]

However, the occurrence of severe genital anomalies, such as hypospadias, likely suggests the presence of a human chorionic gonadotropin deficiency. [synapse.koreamed.org]

CHH is differentiated from primary testicular disease by the demonstration of low/normal gonadotropin levels in the setting of low T levels and impaired sper-matogenesis. [78stepshealth.us]

Finally, hypogonadotropic hypogonadism can be a component of complex syndromes with multiple somatic abnormalities, such as morbid obesity ( Prader-Willi ), cerebellar ataxia (26), cranial nerves palsies and peripheral neuropathy (27), congenital spherocy-tosis [78stepshealth.us]

Finally, hypogonadotropic hypogonadism can be a component of complex syndromes with multiple somatic abnormalities, such as morbid obesity ( Prader-Willi ), cerebellar ataxia (26), cranial nerves palsies and peripheral neuropathy (27), congenital spherocy-tosis [78stepshealth.us]