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Hypopnea Syndrome

OSAHS


Presentation

  • It may be associated with obstructive sleep apnea-Hypopnea syndrome (OSAHS), and when present is seen more often in patients less than 50 years of age.[eurekaselect.com]
  • Eleven percent of patients presented OSAHS, while 40% presented CSAHS.[revespcardiol.org]
  • It discusses the definition, pathophysiology, clinical presentation, complications, polysomnography findings, and treatment of OSAHS.[ncbi.nlm.nih.gov]
  • It looks like inflammation is present locally in the mucosa of OSAHS patients, but also systemically.[physio-pedia.com]
Fatigue
  • More specifically, cytokines and C-reactive protein are elevated in OSAHS patients and those molecules have been found to be linked to sleepiness, fatigue and the development of cardiovascular and metabolic disorders [5].[physio-pedia.com]
Nocturia
  • OSAHS is often overlooked as a cause of nocturia, especially in the presence of coexisting diseases such as diabetes.[eurekaselect.com]
  • […] pressure swings (to -120 mm Hg), and surges of systemic blood pressure of up to 250/150 mm Hg which is associated with arousals and sleep fragmentation, up to 100 times per hour.[ 3, 5 ] Symptoms include excessive daytime somnolence, non-refreshed sleep, nocturia[ncbi.nlm.nih.gov]
Headache
  • Other symptoms may include headaches, irritability, night sweats, attention deficit, memory loss, decreased libido, and depression [7].[physio-pedia.com]
  • Other symptoms of hypopnea may include depression, forgetfulness, mood or behaviour changes, trouble concentrating, loss of energy, nervousness, and morning headaches.[en.wikipedia.org]
  • […] of up to 250/150 mm Hg which is associated with arousals and sleep fragmentation, up to 100 times per hour.[ 3, 5 ] Symptoms include excessive daytime somnolence, non-refreshed sleep, nocturia, loud snoring, apneas and choking during sleep, morning headaches[ncbi.nlm.nih.gov]

Workup

Liver Biopsy
  • Nonalcoholic subjects with apnea and hypopnea during sleep were found to have raised liver enzymes and fibrosis on liver biopsy, independent of body weight.[ 1 ] Perioperative and postoperative Patients with OSAHS may have an increased perioperative risks[ncbi.nlm.nih.gov]

Treatment

  • treatment is accompanied by benefits in terms of mortality.[revespcardiol.org]
  • Treatment options include nocturnal administration of oxygen, continuous positive airway pressure (CPAP), and medications such as theophylline.[academic.oup.com]
  • Our objective was to determine whether severity of disease of OSAHS based on polysomnography (PSG) data (apnea/hypopnea index [AHI]) is a significant factor in predicting successful treatment by UP3.[semanticscholar.org]
  • In this review, we discuss the various pathophysiologic mechanisms, clinical features and treatment options for patients with nocturia and obstructive sleep apnea-Hypopnea Syndrome.[eurekaselect.com]
  • It discusses the definition, pathophysiology, clinical presentation, complications, polysomnography findings, and treatment of OSAHS.[ncbi.nlm.nih.gov]

Prognosis

  • Abstract Favorites PDF Get Content & Permissions Open SDC Predictive value of the Chinese group on the study of severe hepatitis B-acute-on-chronic liver failure score in the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic[journals.lww.com]

Etiology

  • It has been speculated that OSAHS could play a role in the pathogenesis of left ventricular failure in certain patients with heart failure of unknown etiology and that it could be a cause of heart failure.[revespcardiol.org]

Epidemiology

  • This review focuses on the clinical and epidemiological bases, the pathophysiological mechanisms and the therapeutic implications between HF and sleep apnea-hypopnea syndromes.[revespcardiol.org]
  • Epidemiology of obstructive sleep apnoea: A population health perspective. Am J Respir Crit Care Med. 2002; 165 :1217–39. [ PubMed ] [ Google Scholar ] 13. Schellenberg JB, Maislim Schwab RJ.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • In this review, we discuss the various pathophysiologic mechanisms, clinical features and treatment options for patients with nocturia and obstructive sleep apnea-Hypopnea Syndrome.[eurekaselect.com]
  • Pathophysiology OSAHS could compromise left ventricular function through various mechanisms (Figure 1). Figure 1. Pathophysiologic mechanisms initiated by repeated apneas with direct effects on the cardiovascular system.[revespcardiol.org]
  • It discusses the definition, pathophysiology, clinical presentation, complications, polysomnography findings, and treatment of OSAHS.[ncbi.nlm.nih.gov]
  • Finally, when craniofacial anatomical features are obviously causative in the pathophysiology of a specific subject, then a surgery executed by an otorhinolaryngology might be indicated [1].[physio-pedia.com]

Prevention

  • In these circumstances, treatment can still be considered as a preventive measure according to the severity of the disease since the significant cardiovascular adverse side effects attributed to OSAHS.[physio-pedia.com]
  • The sleepiness may result in inability to work efficiently and may damage interpersonal relationship and prevent socializing.[ncbi.nlm.nih.gov]
  • In addition, the abolition of apnea and hypopnea events through application of CPAP prevents recurrent hypoxemia, reduces nocturnal blood pressure and heart rate, and increases the sensitivity of the baroreflex.[revespcardiol.org]

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