Unusual presentation of atrichia with papular lesions. Indian J Dermatol 2015; 60:107. [Figure 1], [Figure 2] [azmj.eg.net]

Cutis. 2017 July;100(1):E12-E14 Practice Points Hereditary hypotrichosis simplex (HHS) is a rare form of hypotrichosis that typically presents in school-aged children as worsening hair loss localized to the scalp. [mdedge.com]

We report two patients, mother and daughter, presenting a Marie Unna's syndrome and belonging to a family in which the disease appeared in seven members in a period of four generations. [moh-it.pure.elsevier.com]

The mutations in the LIPH gene, identified in the present study, include a novel homozygous splice acceptor site mutation (IVS4-1G→C). [medicaljournals.se]

Structural hair defects may be presented with a genetic disorder affecting hair growth or part of a congenital syndrome or may indicate underlying metabolic disorders, or may be associated with other diseases. [e-ijd.org]

• Falling

  If the transplanted follicles kept falling into the subcutaneous fat due to reduced elasticity of the skin, graft survival was severely compromised and the risk of folliculitis, epidermal cyst, etc. increased (Figure 1). [idnps.com]

  This can lead to thinning hair, patches of hair loss, or hair falling out. [medicalnewstoday.com]

  One of the reasons for the hair to fall out is from washing the hair with water that contains chemicals which are used to purify the water. Wash or rinse the hair with chemical free water. [wikihow.com]

  Scalp hair was sparse at birth, but started progressively falling at the age of 3 months. The eyebrows and eyelashes have never grown. [azmj.eg.net]

  Eventually, there was regrowth of coarse, curly hairs, and later the child had progressive hair fall from past 2 years. Natal and perinatal history was normal. His developmental milestones were normal. There were no abnormalities in sweating. [ijtrichology.com]

• Inflammation

  Histopathology revealed a normal epidermis with decreased follicle number and hypoplastic hair follicles and no evidence of inflammation or fibrosis (A and B)(H&E, original magnifications ×40 and ×100). [mdedge.com]

  Rolled hairs appear as irregular coils of hair along with keratin plugs and inflammation. Genetic factor is suspected but not proven. [omicsonline.org]

  People may lose eyebrow hairs as a result of skin inflammation, dry skin, and rubbing or itching the area around the eyebrows. [medicalnewstoday.com]

• Conjunctival Hyperemia

  There were no reports of skin or iris hyperpigmentation or conjunctival hyperemia. “Bimatoprost 0.03% is a safe, well-tolerated and effective treatment for hypotrichosis of the eyebrows in this population,” the researchers concluded. [healio.com]

  Common adverse events included conjunctival hyperemia, eyelid pruritus, blepharal pigmentation, nasopharyngitis, eyelid erythema, and punctate keratitis. [jcadonline.com]

  No skin or iris hyperpigmentation or conjunctival hyperemia occurred. [journals.lww.com]

• Alopecia

  Therefore, our patient’s family was referred to the National Alopecia Areata Foundation website (https://naaf.org/) for resources on discussing alopecia with school-aged children. [mdedge.com]

  In addition, and as in alopecia areata, we offer an immunological theory as an explanation because of the presence of the lymphocytic infiltrate, especially around hair follicles. [azmj.eg.net]

  Heritability: Autosomal recessive inheritance AKA: hypotrichosis caused by mutation in LIPH, woolly hair, autosomal recessive 2, with or without hypotrichosis, hypotrichosis 7, Mari type alopecia universalis congenita, HYPT7, total hypotrichosis, Mari [monarchinitiative.org]

  L65.9 ICD-10-CM Codes Adjacent To L65.9 L63.9 Alopecia areata, unspecified L64 Androgenic alopecia L64.0 Drug-induced androgenic alopecia L64.8 Other androgenic alopecia L64.9 Androgenic alopecia, unspecified L65 Other nonscarring hair loss L65.0 Telogen [icd10data.com]

  Mild cases have hair loss limited to the scalp, while severe cases show generalized alopecia. Hair shaft abnormalities are characteristic, demonstrating regularly-spaced, spindle-shaped swellings. [medicaljournals.se]

• Sparse Hair

  The eyebrows, eyelashes, and other body hair may be sparse as well. [ncbi.nlm.nih.gov]

  There is receding of hair line with increasingly sparse hair on the vertex, parietal and occipital region resembling androgenetic alopecia. [5] Eyebrows, eyelashes, body hair and secondary sexual hair are sparse or absent. [ijtrichology.com]

  Neonatal hair changes should alert clinicians to the need of ophthalmic evaluation. Clinical features of hypotrichosis with macular dystrophy. A, 28 yo female patient with sparse hair that has limited growth. [iovs.arvojournals.org]

  Autosomal recessive hypotrichosis is a condition that affects hair growth. People with this condition have sparse hair (hypotrichosis) on the scalp beginning in infancy. [ghr.nlm.nih.gov]

• Hyperpigmentation

  B, fundus photography of her left eye showing patchy areas of atrophy and hyperpigmentation in the macular area. [iovs.arvojournals.org]

  Iris hyperpigmentation is believed to be an irreversible side effect caused by topical prostaglandin analog stimulation of melanocytes in the iris.[17] In this pooled safety analysis, two cases of iris hyperpigmentation were reported. [jcadonline.com]

  There were no reports of skin or iris hyperpigmentation or conjunctival hyperemia. “Bimatoprost 0.03% is a safe, well-tolerated and effective treatment for hypotrichosis of the eyebrows in this population,” the researchers concluded. [healio.com]

  No skin or iris hyperpigmentation or conjunctival hyperemia occurred. [journals.lww.com]

• Sparse to No Eyebrows

  The scalp hair is sparse to absent, eyebrows and eyelashes are normal or short and sparse, and the body hairs are normal or sparse. [nature.com]

  Affected individuals have sparse hair on the scalp, sparse-to-absent eyebrows and eyelashes, and sparse body hair. Affected male individuals have normal beard hair (1–3). [medicaljournals.se]

  There is receding of hair line with increasingly sparse hair on the vertex, parietal and occipital region resembling androgenetic alopecia. [5] Eyebrows, eyelashes, body hair and secondary sexual hair are sparse or absent. [ijtrichology.com]

• Sparse to No Body Hair

  […] with this more generalized HHS phenotype to chromosome 18; specifically, an Italian family with sparse scalp and body hair but normal eyelashes and eyebrows,4 and 2 Pakistani families with thinning scalp hair and sparse truncal hair.10 A mutation in [mdedge.com]

  The scalp hair is sparse to absent, eyebrows and eyelashes are normal or short and sparse, and the body hairs are normal or sparse. [nature.com]

  […] loss disorder characterized by sparse scalp hair, sparse to absent eyebrows and eyelashes, and sparse axillary and body hair. [journals.plos.org]

• Stroke

  Saundersfoot Medical Centre Skewen Medical Centre South East Wales Cancer Network South West Wales Cancer Network Speech & Language Therapists (Wales) - Autism St Mark's Dee View Surgery St Thomas and West Cross Surgeries St Thomas Surgery (Pembrokeshire) Stroke [wales.nhs.uk]

Both bimatoprost treatment cohorts displayed significant improvements compared with the vehicle cohort after 1 month, which continued during the treatment and post-treatment periods ( P ≤ .035, all comparisons). [healio.com]

Phase 4 Bimatoprost 0.03% ophthalmic solution 11 Bimatoprost for the Treatment of Eyebrow Hypotrichosis Completed NCT01765764 Phase 3 bimatoprost solution;Vehicle to bimatoprost solution 12 Bimatoprost in the Treatment of Eyelash Hypotrichosis Completed [malacards.org]

Management and treatment There is no treatment for hypotrichosis simplex available to date. The documents contained in this web site are presented for information purposes only. [orpha.net]

No new safety signals were observed with treatment for up to 12 months. Treatment-related AEs. [jcadonline.com]

[…] across all treatment groups. [journals.lww.com]

The prognosis of this disorder is extremely poor, as patients die in infancy. Most deaths are due to recurrent infection, acidosis and critical bleeding [ 2 ]. [casereports.in]

Further reading Lipase member H is a novel secreted protein associated with a poor prognosis for breast cancer patients Meizi Cui, Haofan Jin, Xiumin Shi, Ge Qu, Lidi Liu, Xiaobo Ding, Yanbo Wang & Chao Niu Tumor Biology (2014) A splice variant in KRT71 [nature.com]

Hypotrichosis with keratosis pilaris is a very rare inborn skin disorder of unknown etiology. Here we report a rare case of hypotrichosis with keratosis pilaris in a 7-year-old boy. [azmj.eg.net]

Etiology Both autosomal dominant and recessive modes of transmission have been reported for HHS.Autosomal dominant HHS affecting both scalp and body hair has been reported in one Italian and two Pakistani families as due to mutations in the APCDD1 gene [orpha.net]

No clinically meaningful differences in AE rates by etiology of eyelash hypotrichosis were noted. [dovepress.com]

The etiology suggests that there could be poor absorption of other nutrients as well. [omicsonline.org]

Incidence of AEs by etiology. The overall incidence of AEs, regardless of causality, was slightly higher for subjects receiving up to 12 months of bimatoprost 0.03% compared with up to six months of vehicle (47.4% vs 34.3%, respectively; Table 3 ). [jcadonline.com]

Summary Epidemiology Prevalence is unknown but numerous large pedigrees with several affected members have been described. Both men and women are equally affected. [orpha.net]

ABSTRACT:PURPOSE: Silicone cream has been shown to improve the appearance of postope... more Skin Cancer Epidemiology and Sun Protection Behaviors Among Native American.... [jddonline.com]

[…] complex hair and skin phenotype due to two rare genodermatoses: KLICK and autosomal recessive woolly hair/hypotrichosis simplex. 61 Horev L...Zlotogorski A 21275938 2011 40 Corneodesmosomes and corneodesmosin: from the stratum corneum cohesion to the pathophysiology [malacards.org]

Submit Tips While some causes of hair loss can be treated or prevented, this is not always possible. [wikihow.com]

Folliculitis following pubic hair transplantation In order to prevent movement of transplanted hair, I used a spray adhesive (3M) on the transplant sites (Figure 2). [idnps.com]

At fault is a genetic defect that prevents certain receptors on the surface of hair follicle cells from being correctly formed. [belgraviacentre.com]

Subjects with systemic diseases, including all types of alopecia areata, which could prevent hair growth or produce abnormal growth were excluded, along with subjects with substantial permanent eyebrow loss due to overgrooming; any skin pigmentation/depigmentation [journals.lww.com]