Presentation
The present study demonstrated that HIF‑1α was overexpressed in 20 bladder cancer tissues compared with matched paracarcinoma tissues. [ncbi.nlm.nih.gov]
Entire Body System
- Weight Loss
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- Weakness
P4HB overexpression reflected similar results: patients with over-expression of P4HB had a shorter survival time than those with weak-expression (DFS: 48.03 mo vs 29.64 mo, OS: 52.48 mo vs 36.87 mo). [ncbi.nlm.nih.gov]
Sheltered coves with weak winds and currents allow water to stratify, to form a persistent, low-oxygen band rather than to mix and refresh from top to bottom. [dem.ri.gov]
If working in an enclosed space or with an asphyxiant, move to a well-ventilated area if you become light-headed, weak or disoriented. Be sure you understand the dangers of carbon monoxide in the home and workplace. [ilpi.com]
On women with weak connective tissues, cellulite also frequently appears. [clubchf.co.uk]
Clinically there is weakness, imbecility, disinclination to suck, possibly hypothermia. Foals experience a much more violent, convulsive or dummy syndrome. See also neonatal maladjustment syndrome. [medical-dictionary.thefreedictionary.com]
- Unconsciousness
Most people who make a full recovery have only been briefly unconscious. The longer someone is unconscious, the higher the chances of death or brain death and the lower the chances of a meaningful recovery. [my.clevelandclinic.org]
In severe cases of anoxia and hypoxia, from any cause, the patient is often stuperous or comatose (in a state of unconsciousness) for periods ranging from hours to days, weeks, or months. [neuroskills.com]
Most people who make a full recovery were only briefly unconscious. The longer a person is unconscious, the higher the risk for death or brain death, and the lower the chances of recovery. [medlineplus.gov]
- Congestive Heart Failure
Hypoxia may be caused by any of the following: Travel to a high altitude Near drowning or choking Carbon monoxide poisoning Exposure to cold for a long period of time Severe anemia Chronic lung disease, such as emphysema Congestive heart failure What [drugs.com]
Hypoxia may also be caused by conditions such as asthma, bronchitis, chronic obstructive pulmonary disease (COPD), emphysema, pneumonia (bacterial, viral), congestive heart failure, myocardial infarction, pneumothorax, pulmonary edema, pulmonary embolism [news-medical.net]
heart failure Enhancing Healthcare Team Outcomes Hypoxia is low oxygen content at tissue level to meet the metabolic needs of the cells. [ncbi.nlm.nih.gov]
- Malaise
NSAIDs, especially aspirin, have been shown to cause gastrointestinal bleeding particularly in combination with alcohol. 78 Typical side effects of acetazolamide are diuresis, malaise, paresthesias, nausea, and taste disturbances (eg, carbonated beverages [doi.org]
Respiratoric
- Cough
Abstract A 39-year-old man with HIV presented to the emergency department for evaluation of dyspnea accompanied by fever, diffuse chest discomfort, dry cough, and fatigue for past 1 week. [ncbi.nlm.nih.gov]
Coughing to clear your lungs uses even more oxygen and can make symptoms worse. Hypoxia can also result from lung damage due to trauma. [webmd.com]
Immunizations : Getting a regular flu shot and scheduled pneumonia and pertussis (whooping cough) vaccines can help a person prevent infections that could make lung hypoxia and COPD worse. [medicalnewstoday.com]
They include: Headache Shortness of breath Fast heartbeat Coughing Wheezing Confusion Bluish color in skin, fingernails, and lips Get useful, helpful and relevant health + wellness information enews More health news + info [my.clevelandclinic.org]
- Dyspnea
The patient described his dyspnea as exertional progressing over 1 week to rest dyspnea. He was prescribed antiretroviral therapy but was noncompliant. He had no paroxysmal nocturnal dyspnea, orthopnea, rash, oral thrush, or diarrhea. [ncbi.nlm.nih.gov]
Dyspnea Shortness of breath (SOB) is an indication of respiratory distress. Use of accessory muscles Use of neck or intercostal muscles when breathing is an indication of respiratory distress. [opentextbc.ca]
Very sudden onset dyspnea and hypoxia suggest pulmonary embolus (PE) or pneumothorax (mainly in a patient on positive pressure ventilation). Fever, chills, and productive cough (or increased secretions) suggest pneumonia. [merckmanuals.com]
- Tachypnea
The patient had hypoxia and tachypnea from pulmonary edema during acute ischemic stroke, which may have accentuated the ischemic change in cerebral hemodynamic. [ncbi.nlm.nih.gov]
Signs and Symptoms Indications Tachypnea Increased respiration rate is an indication of respiratory distress. Dyspnea Shortness of breath (SOB) is an indication of respiratory distress. [opentextbc.ca]
In chronic hypoxia, an individual may present with dyspnea on exertion, whereas, in acute hypoxia, both dyspnea and tachypnea are observed. [news-medical.net]
Some of them include: Dizziness or fainting (syncope) Shortness of breath (dyspnea) Confusion, lethargy, and/or lack of judgment Headaches Rapid heart rate (tachycardia) Elevated respiratory rate (tachypnea) Euphoria and a sense of well-being Tingling [verywellhealth.com]
- Dyspnea at Rest
High‐Altitude Pulmonary Edema HAPE symptoms are dyspnea at rest and especially when attempting to exercise, bothersome cough, weakness, and chest tightness. [doi.org]
Gastrointestinal
- Diarrhea
He had no paroxysmal nocturnal dyspnea, orthopnea, rash, oral thrush, or diarrhea. His last record CD4+ lymphocyte count and HIV viral load were 43 cells/mm3 and 178,0000 copies/mL, respectively. [ncbi.nlm.nih.gov]
Theophylline may have substantial side effects and drug–drug interactions (eg, with azithromycin, which is often prescribed for self‐treatment of travelers' diarrhea). [doi.org]
Cardiovascular
- Hypertension
Here we present a case of hepatopulmonary syndrome (HPS) where spontaneous resolution of severe hypoxaemia occurred with the development of pulmonary hypertension over several years after the initial diagnosis of HPS. [ncbi.nlm.nih.gov]
[…] to patients with pulmonary hypertension resulting from left heart disease or hypoxemic lung diseases (Groups II or III pulmonary hypertension). [choosingwisely.org]
- Cyanosis
The most common symptom of hypoxia is cyanosis, a bluish cast to the skin, lips and/or fingernails. Cyanosis is harder to observe in dark-skinned people. [ilpi.com]
Late signs of hypoxia include bluish discoloration of the skin and mucous membranes, where vasoconstriction of the peripheral blood vessels or decreased hemoglobin causes cyanosis. Cyanosis is most easily seen around the lips and in the oral mucosa. [opentextbc.ca]
Hypoxia and Hypoxemia Symptoms Cyanosis or Turning Blue Cyanosis is a bluish color of the skin and mucous membranes due to insufficient oxygen in the blood. [medicinenet.com]
- Hypotension
Patients with hypotension during resuscitation were 3 times more likely to die compared with those without hypotension. [jamanetwork.com]
Acute severe hypoxia (FIO2=0.10) was tolerated, but adding CO2 to the inspirate caused pre-syncope symptoms accompanied by hypotension and large reductions in both mean and diastolic middle cerebral artery velocity, while systolic flow velocity was maintained [ncbi.nlm.nih.gov]
However, when a hypotensive stress is superimposed during hypoxia, compensatory mechanisms may fail to maintain arterial pressure. Thus, systemic hypoxia interferes with autonomic cardiovascular adjustments. [ahajournals.org]
Dexamethasone Oral: 2 mg every 6 hours or 4 mg every 12 hours Hyperglycemia and psychiatric alterations Tadalafil Oral: 10 mg every 12 hours Dizziness, headache, and hypotension Sildenafil Oral: 50 mg every 8 hours Dizziness, headache, and hypotension [doi.org]
- Tachycardia
[…] to levels that are detrimental or fatal to aerobic organisms, often caused by eutrophication. hy·pox′ic adj. hypoxia [hīpok′sē·ə] Etymology: Gk, hypo + oxys, sharp, genein, to produce inadequate oxygen tension at the cellular level, characterized by tachycardia [medical-dictionary.thefreedictionary.com]
Severe hypoxia can result in cyanosis and tachycardia, altered mentation and coma, and even death if not corrected quickly. Stridor (noisy breathing) can be heard in cases of upper airway obstruction. [news-medical.net]
The signs include central cyanosis, frothy sputum, and crackles/wheezing in at least one lung field, tachypnea and tachycardia. 21,23 HAPE is most often misdiagnosed or mistreated as pneumonia. [doi.org]
Some of them include: Dizziness or fainting (syncope) Shortness of breath (dyspnea) Confusion, lethargy, and/or lack of judgment Headaches Rapid heart rate (tachycardia) Elevated respiratory rate (tachypnea) Euphoria and a sense of well-being Tingling [verywellhealth.com]
Psychiatrical
- Aggressive Behavior
behavior, euphoria, or hallucinations. [ncbi.nlm.nih.gov]
Neurologic
- Seizure
After extensive examination and consultation with neurology, the patient was diagnosed with hypoxia-induced seizure, but was not felt to have an underlying seizure disorder. [ncbi.nlm.nih.gov]
When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death. In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration. [my.clevelandclinic.org]
Severe cases can result in seizures and brain death. Read on to learn more about brain hypoxia, also known as cerebral hypoxia. Share on Pinterest Brain hypoxia is a medical emergency and severe symptoms can include seizure and coma. [medicalnewstoday.com]
Seizure-curbing medicines or anesthetics may also be part of your treatment. Recovering from brain hypoxia depends largely on how long your brain has gone without oxygen. [healthline.com]
- Confusion
Severe symptoms seen with cerebral hypoxia include: confusion, inability to communicate, coma, and may result in death. [medicinenet.com]
You are irritable, confused, or unusually drowsy. Care Agreement You have the right to help plan your care. Learn about your health condition and how it may be treated. [drugs.com]
- Stroke
Many cases of stroke are due to focal cerebral ischemia and usually involve occlusion of the middle cerebral artery. [news-medical.net]
As the average age in many countries steadily rises, heart infarction, stroke, and cancer become the most common causes of death in the 21st century. [ncbi.nlm.nih.gov]
Heart attack or stroke. Medical conditions such as a heart attack or stroke. Allergic reactions that lead to anaphylactic shock. Severe cases of asthma. Allergies In infants, improper sleep positions or unsafe sleep environments. [spinalcord.com]
Ischaemic stroke is the third leading cause of death in Western countries, behind only heart disease ... [journal.frontiersin.org]
- Headache
Effects of aspirin during exercise on the incidence of high‐altitude headache: a randomized, double‐blind, placebo‐controlled trial. Headache 2001 ; 41 : 542 – 545. 60, et al. [doi.org]
Hypoxemia can cause mild problems such as headaches and shortness of breath. In severe cases, it can interfere with heart and brain function. Hypoxemia that causes low oxygen levels in your body’s tissues is called hypoxia. [my.clevelandclinic.org]
Response of cluster headache attacks to oxygen inhalation. Headache 1981; 21: 1-4. 37. Fogan L. Treatment of cluster headache. A double-blind comparison of oxygen v air inhalation. Arch Neurol 1985; 42: 362-363. 38. Cohen AS, Burns B, Goadsby PJ. [ge-bu.nl]
Symptoms[edit] Cyanosis Headache Increased reaction time Impaired judgment time Euphoria Visual impairment Drowsiness Lightheaded or dizzy sensation Tingling in fingers and toes Numbness Treatment[edit] Oxygen therapy is very beneficial See also[edit] [en.wikipedia.org]
- Dizziness
headache, and hypotension Dexamethasone Oral: 2 mg every 6 hours or 4 mg every 12 hours Hyperglycemia and psychiatric alterations Tadalafil Oral: 10 mg every 12 hours Dizziness, headache, and hypotension Sildenafil Oral: 50 mg every 8 hours Dizziness [doi.org]
Symptoms[edit] Cyanosis Headache Increased reaction time Impaired judgment time Euphoria Visual impairment Drowsiness Lightheaded or dizzy sensation Tingling in fingers and toes Numbness Treatment[edit] Oxygen therapy is very beneficial See also[edit] [en.wikipedia.org]
Hypoxia Hypoxia, or altitude sickness, reduces the amount of oxygen in the brain causing such symptoms as dizziness, shortness of breath, and mental confusion. hypoxia deficiency of oxygen in the body due to (1) low partial pressure of oxygen in the blood [medical-dictionary.thefreedictionary.com]
They also may feel lightheaded or dizzy. Eventually, they will start to lose coordination. They will experience tunnel vision and their judgment would become impaired. Brain cells are particularly vulnerable to a lack of oxygen. [edition.cnn.com]
Workup
A diagnostic workup is initiated. BTs are a congenital hemolytic anemias characterized by deficiency in the production of β-globin chains. [bloodjournal.org]
EEG
- Burst Suppression
suppression pattern characterized by a background with minimum amplitude (0-2 mV) without variability and occasional high voltage bursts (>25 mV) Continuous low voltage pattern characterized by a continuous low voltage background (< 5 mV) Inactive pattern [emedicine.medscape.com]
Serum
- Hemoglobin Increased
Hemoglobin increases the oxygen-carrying capacity of blood by about 40-fold,[19] with the ability of hemoglobin to carry oxygen influenced by the partial pressure of oxygen in the environment, a relationship described in the oxygen–hemoglobin dissociation [en.wikipedia.org]
- Hypocapnia
They are typically associated with periodic breathing owing to alternating respiratory stimulation by hypoxia and subsequent apneas or hypopneas due to inhibition by hyperventilation‐induced hypocapnia. 13 This periodic interruption to breathing results [doi.org]
Arterial blood gas (ABG) Blood gas monitoring is used to assess acid-base status and to avoid hyperoxia and hypoxia as well as hypercapnia and hypocapnia. During the period of shock, capillary blood gases may not be reliable. [emedicine.medscape.com]
Treatment
Abstract Overcoming the chemoresistance of bladder cancer is a pivotal obstacle in clinical treatments. [ncbi.nlm.nih.gov]
Prognosis
CONCLUSION: Overexpression of HIF-1α and P4HB is associated with poor prognosis in patients with GC. Thus, these genes may be potential prognostic biomarker candidates in GC. [ncbi.nlm.nih.gov]
Etiology
Although Hypoxemia may cause of Hypoxia, it is not the only etiology. Reduced Oxygen Delivery Hypoxia can still occur even in contexts of normal blood oxygenation if that blood does not perfuse tissues at a sufficient rate. [pathwaymedicine.org]
Our case report supports the hypothesis that oxygen availability and delivery could play an important role in the regulation of local penile erection-related mechanisms and that low oxygen levels might be considered an etiological cofactor in erectile [ncbi.nlm.nih.gov]
Epidemiology
The aim of this review is (a) to summarize epidemiological data confirming an association of PHI with an increased risk of a range of psychiatric disorders from childhood through adolescence to adulthood, (b) to present immunohistochemical findings on [ncbi.nlm.nih.gov]
Therapeutics, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada. 5Division of Neurosurgery, Department of Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada. 6Centre for Clinical Epidemiology [journals.lww.com]
Inhalt Epidemiology of the Diabetic Foot l 1 Dermatology 61 New Concepts About the Pathogenesis of Atherosclerosis and Thrombosis 79 Urheberrecht 21 weitere Abschnitte werden nicht angezeigt. [books.google.com]
Studies, reviews, and books specifically pertaining to the epidemiology, prevention, and treatment of high‐altitude illnesses in travelers were selected. [doi.org]
Pathophysiology
High altitude environment represents a fine model to study physiological and pathophysiological effects of oxygen availability on sleep-related erections (SREs). [ncbi.nlm.nih.gov]
This new volume discusses the implications of these new findings on the pathophysiology, development, and treatment of hypoxic metabolic acidosis. [books.google.com]
Therefore, hypoxia is associated with various pathophysiological conditions including chronic obstructive pulmonary disease, pulmonary hypertension, congenital heart disease, cerebral ischemia, and cancer. [novusbio.com]
Knowledge of the effects of pharmacologic HIF activation on human physiology and pathophysiology, however, is still limited. [jasn.asnjournals.org]
Prevention
Medications for Prevention Except for acetazolamide, the effectiveness of drugs used for the prevention of altitude illnesses has been demonstrated in only a limited number of trials. [doi.org]