The aim of the present paper is to review present knowledge about the pathophysiology of perinatal hypoxic-ischemic encephalopathy, especially with respect to novel treatment strategies and biomarkers that might enhance early detection of this disorder [ncbi.nlm.nih.gov]

• Trismus

  BACKGROUND AND OBJECTIVES: We describe the use of mandibular nerve block for the management of bilateral trismus associated with hypoxic-ischemic encephalopathy. [ncbi.nlm.nih.gov]

• Normal Hearing

  RESULTS: SEP to median nerve stimulation showed bilateral absence of the N20 component, while the N13 and P14 peaks were preserved; BAEP showed normal I-V interpeak latency and normal hearing threshold. [ncbi.nlm.nih.gov]

All neonates with stroke had a negative thrombophilia workup. Neonates with stroke had a significantly higher incidence of seizures and increased initial platelet counts on univariate analysis. [ncbi.nlm.nih.gov]

Cerebral Palsy Workup: Approach Considerations, Potentially Helpful Laboratory Tests, Cranial Imaging Studies. (2018, October 02). Retrieved from . [hiehelpcenter.org]

Electroencephalography (EEG) - Standard and amplitude-integrated EEG Hearing test - An increased incidence of deafness has been found among infants with hypoxic-ischemic encephalopathy who require assisted ventilation Retinal and ophthalmic examination See Workup [emedicine.medscape.com]

These guidelines did not address evidence needed for diagnosis of seizures, but were confined to suggestions as to which ASDs were to be considered as 1st-, 2nd- and 3rd-line treatments for seizures, and provided a suggested workup for the potential causes [karger.com]

The SBU assessment stated: "[t]here is limited evidence that either visually rated EEG or qEEG helps the diagnostic workup differentiate AD (Alzheimer’s Disease) patients from controls or AD from other dementia disorders." [aetna.com]

• Burst Suppression

  Abstract In the prediction of neurological sequelae after hypoxic-ischemic encephalopathy (HIE) in the newborn, the electroencephalogram (EEG) burst suppression pattern (BS) and subcortical leukomalacia can mean grave neurodevelopmental problems will [ncbi.nlm.nih.gov]

  Electroencephalograph recordings with an isoelectric or burst-suppression pattern had a specificity of 100% in five of six relevant studies. [anesthesiology.pubs.asahq.org]

• Periodic Lateralized Epileptiform Discharges

  It is the purpose of this review to critically consider and organize the literature dealing with the ephemeral electroencephalographic (EEG) pattern periodic lateralized epileptiform discharges (PLEDs). [researchgate.net]

  lateralized epileptiform discharges and saw gray matter lesions only, and metabolic or electrophysiologic etiologies were also implicated in GPDs. 30, 31 These findings suggest a role for the coordination of cortical and subcortical/brain stem structures [ajnr.org]

  In addition to the presence or absence of reactivity and spontaneous fluctuations the EEGs also were specifically assessed for characteristic patterns such as periodic lateralized epileptiform discharges (PLEDs), bilateral PLEDs (BiPLEDs), periodic generalized [academic.oup.com]

• Blood Culture Positive

  • An elevated CRP concentration during the first postnatal week may be regarded as an expected finding in moderate and severe HIE and, in the overwhelming majority of cases, occurs secondary to hepatic hypoxia-ischemia in the absence of blood culture-positive [ncbi.nlm.nih.gov]

Further research is needed to better understand if the long-term impact of the experimental treatments and whether the combinations of experimental treatments can improve outcomes in infants with HIE. [ncbi.nlm.nih.gov]

HIE patients were further divided into two groups: poor prognosis and better prognosis. [ncbi.nlm.nih.gov]

EEG monitoring and MRI are important tools in determining the etiology of encephalopathy and prognosis of the infant. [ncbi.nlm.nih.gov]

When BISi 10, a neurological etiology death dominated independent of cardiac risk group. [researchgate.net]

Etiology and prognosis of alpha coma. Neurology 1988;38:773-7. [ PUBMED ] 5. Kaplan PW, Genoud D, Ho TW, Jallon P. Etiology, neurologic correlations, and prognosis in alpha coma. Clin Neurophysiol 1999;110:205-13. [ PUBMED ] 6. [neurologyindia.com]

KEYWORDS: all epilepsy / seizures; childhood stroke; cohort studies; epilepsy; risk factors in epidemiology [ncbi.nlm.nih.gov]

Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. [cambridge.org]

In comparison, epidemiologic studies have suggested that 70% of causation is related to chronic antenatal factors. [pediatrics.aappublications.org]

Journal of Clinical Epidemiology 2005; 58: 982–990. pmid:16168343 View Article PubMed/NCBI Google Scholar 23. Hellström-Westas L, Rosén I, Svenningsen NW. [journals.plos.org]

The pathophysiology of HIBI encompasses a heterogeneous cascade that culminates in secondary brain injury and neuronal cell death. This begins with primary injury to the brain caused by the immediate cessation of cerebral blood flow following CA. [ncbi.nlm.nih.gov]

Application of this knowledge will allow us to identify strategies for early intervention and prevent the course of damage caused by hypoxic-ischemic injury. [ncbi.nlm.nih.gov]