Edit concept Question Editor Create issue ticket

Ibuprofen


Presentation

  • In some cases the clinical presentation is that of meningoencephalitis with neurologic focal deficits.[ncbi.nlm.nih.gov]
  • Clinically, the patient presented a triad that characterizes "true" HSR (rash, fever, and liver involvement).[ncbi.nlm.nih.gov]
  • An 11-year-old Thai male presented with fever, rash, altered mental status, and hypotension after oral administration of ibuprofen leading to the diagnosis of SLE. Re-dosing with ibuprofen resulted in recurrence of presenting symptoms.[ncbi.nlm.nih.gov]
  • We present a rare case of oesophageal perforation following ingestion of over-the-counter ibuprofen capsules. Case report and literature review of pill oesophagitis.[ncbi.nlm.nih.gov]
  • CASE 1: A 17-year-old girl presented to the emergency department (ED) following an ibuprofen overdose; she was unresponsive with a metabolic acidosis and hypothermic.[ncbi.nlm.nih.gov]
Aphasia
  • CASE SUMMARY: A previously well 51-year-old white man presented with acute confusion and aphasia 7 days after taking a variety of nonprescription medications, including ibuprofen.[ncbi.nlm.nih.gov]

Workup

  • Laboratory workup revealed elevated amylase and lipase levels more than 3 times the normal limits with complete resolution within 15 hours.[ncbi.nlm.nih.gov]
Mediastinal Shift
  • Mediastinal shift post-pneumonectomy distorted the patient's esophageal anatomy and may have caused decreased esophageal motility, which led to prolonged contact of the ibuprofen with the esophagus.[ncbi.nlm.nih.gov]

Treatment

  • For many years, indomethacin has been the drug of choice in the treatment of PDA.[ncbi.nlm.nih.gov]
  • Adverse events were infrequent and mostly mild or moderate across treatment groups. Tolerability was rated as 'very good' or 'excellent' by most patients in both treatment groups.[ncbi.nlm.nih.gov]
  • There was no significant difference in the odds of mortality, necrotizing enterocolitis, or intraventricular hemorrhage with use of placebo or no treatment compared with any of the other treatment modalities.[ncbi.nlm.nih.gov]
  • 1 2 Completed Treatment Osteoarthritis (OA) 1 2 Completed Treatment Pain NOS 6 2 Completed Treatment Pain, Acute 1 2 Completed Treatment Post-Operative Pain 1 2 Completed Treatment Postoperative Dental Pain 1 2 Completed Treatment Postoperative pain[drugbank.ca]
  • BACKGROUND: Ibuprofen is used for the treatment of non-serious pain. This study assessed the efficacy and safety of a new ibuprofen plaster for the treatment of pain associated with acute sports impact injuries/contusions.[ncbi.nlm.nih.gov]

Prognosis

  • Clinicians should be aware that various mediators of allergy can cause coronary spasm and even plaque rupture and thrombus formation, thereby causing a serious impact on the course, prognosis and management of the allergic reaction.[ncbi.nlm.nih.gov]
  • This case illustrates the need for an efficient coordination between hospitals as a key factor for improving the prognosis.[ncbi.nlm.nih.gov]
  • Anti-BP180 autoantibodies as a marker of poor prognosis in bullous pemphigoid: a cohort analysis of 94 elderly patients. Br J Dermatol. May 1997;136(5):694-8. [Medline]. Bernard P, Vaillant L, Labeille B, et al.[web.archive.org]
  • Serum levels of immunoglobulins G1 and G4 targeting the non-collagenous 16A domain of BP180 reflect bullous pemphigoid activity and predict bad prognosis. J Dermatol. 2015 Aug 24. [Medline]. Liu YD, Wang YH, Ye YC, Zhao WL, Li L.[emedicine.medscape.com]
  • However, in the long term, complications are rare and the prognosis of recurrent pericarditis is good ( Brucato 2006a ).[doi.org]

Etiology

  • Therefore, all patients with AP of an unknown etiology should be carefully questioned about the usage of NSAIDs, and all patients with idiopathic AP restarted on their medications should be closely monitored, and the drug must be immediately discontinued[ncbi.nlm.nih.gov]
  • Etiologic factors contributing to the development of these defects are unknown. To investigate this we have reviewed reports of risk factors for each anomaly and report them here.[dx.doi.org]
  • Yuval Nash and Dan Frenkel, The Role of Chronic Inflammation in the Etiology of Parkinson’s Disease, Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease, 10.1007/978-3-319-42139-1_4, (63-74), (2016). Afrah A.K. Ismaiel, Ana M.[doi.org]
  • First documented in 1922, these conditions were originally thought to be infectious. 1 Although their etiology is not fully understood, most cases of SJS and TEN are now attributed to an immunologically mediated response to drug exposure. 2 Over 100 medications[doi.org]

Epidemiology

  • Use of nonsteroidal anti-inflammatory drugs (NSAID) in general, and possibly ibuprofen in particular, has been shown to be related to lower PD risk in previous epidemiologic studies.[ncbi.nlm.nih.gov]
  • T he protective epidemiological effect of these NSAIDs was then attributed to this γ-secretase modulating activity, not their cyclooxygenase inhibition ( Nov 2001 news story ).[alzforum.org]
  • Abstract: Background:In the past 20 years, substantial evidence from laboratory and epidemiologic studies have suggested that anti-inflammatory medications could defer or prevent the occurrence of Alzheimer's disease (AD).[doi.org]
  • 4 , Karl Wegscheider , trial statistician and professor of medical biometry and epidemiology 5 , Eva Hummers-Pradier , senior investigator and professor of primary care 1 1 Department of General Practice, University Medical Center Göttingen, Humboldtallee[bmj.com]
Sex distribution
Age distribution

Pathophysiology

  • Google Scholar 6 : Physiology of penile erection and pathophysiology of erectile dysfunction. In: Campbell-Walsh Urology. Edited by. New York : Elsevier 2007. sect VI, chapt 21.[doi.org]
  • Paracetamol use has also been implicated in asthma development and the increasing incidence of asthma in adults and children in epidemiological, observational and pathophysiological studies (reviewed in McBride 2011 ; Farquhar et al. 2010 ; Eneli et al[doi.org]
  • Nolan, Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease, Neuropharmacology, 10.1016/j.neuropharm.2012.01.028, 62, 7, (2154-2168), (2012). Anna R.[doi.org]
  • Our approach was to exclude postpericardial syndrome due to the different aetiology and pathophysiology than that of acute or recurrent pericarditis.[doi.org]
  • Jaeschke, Acetaminophen, Liver Pathophysiology, 10.1016/B978-0-12-804274-8.00006-0, (101-112), (2017).[doi.org]

Prevention

  • CONCLUSIONS: Based on a limited number of studies ibuprofen seems efficacious for the prevention of HAH and may therefore represent an alternative for preventing HAH with acetazolamide or dexamethasone.[ncbi.nlm.nih.gov]
  • OBJECTIVE: Recent trials have demonstrated the usefulness of ibuprofen in the prevention of acute mountain sickness (AMS), yet the proposed anti-inflammatory mechanism remains unconfirmed. Acetaminophen and ibuprofen were tested for AMS prevention.[ncbi.nlm.nih.gov]
  • PURPOSE: This study aimed to determine whether nonsteroidal anti-inflammatory drug use before exercise prevents increases in bone structure and strength in response to weight-bearing exercise.[ncbi.nlm.nih.gov]
  • ADMA is a cardiotoxic hormone and biomarker of cardiovascular risk whose effects can be prevented by l-arginine.[ncbi.nlm.nih.gov]
  • We discuss pill-induced oesophageal injury and its prevention. Manufacturers, clinicians and patients can all take steps to avoid this potentially life-threatening complication.[ncbi.nlm.nih.gov]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!