Presentation
We report a typical case of a 21-year-old male with recent onset of smoking, who presented with acute febrile hypoxemic respiratory failure. [ncbi.nlm.nih.gov]
Accordingly, the symptoms are most often present for about a month before diagnosis is made. Respiratory signs Dyspnea and cough are always present. The severity of dyspnea is highly variable [ 3 ]. [ojrd.biomedcentral.com]
The radiographic presentation of eosinophilic pneumonia is similar regardless of the etiology and therefore eliciting correct history from the patient is important in determining the underlying possible etiology. [ijcasereportsandimages.com]
The authors report a typical case of a 21-year-old male with recent onset of smoking, who presented with acute febrile hypoxemic respiratory failure. [raredis.org]
Entire Body System
- Hypoxemia
We describe what we believe is an entirely novel case of a 15-year-old boy with idiopathic acute eosinophilic pneumonia and unusual, resistant hypoxemia which necessitated extracorporeal membrane oxygenation. [ncbi.nlm.nih.gov]
Diagnosis is based on an association of characteristic features including acute respiratory failure with fever, bilateral infiltrates on the chest X-ray, severe hypoxemia and bronchoalveolar lavage fluid >25% eosinophils or a predominant eosinophilic [archive.org]
Laboratory studies showed acute respiratory alkalosis with hypoxemia, an elevated A-a gradient, leukocytosis (WBC count - 24.8x10 3 /mm) with neutrophilia (93%) and elevated LDH (265 IU/L). The blood eosinophil count was 2% on day-1. [ijcasereportsandimages.com]
Acute eosinophilic pneumonia (AEP) is an idiopathic, acute, febrile illness characterized by non-productive cough, dyspnea, diffuse pulmonary infiltrates, and hypoxemia with eosinophilic infiltration of the pulmonary parenchyma. [clinicaladvisor.com]
- Congestive Heart Failure
High-resolution chest computed tomography scan revealed patchy ground glass opacity and ill-defined nodules, diffuse interlobar and interlobular septal thickening, and bilateral small amount of pleural effusion, which mimicked congestive heart failure [ncbi.nlm.nih.gov]
In that study, five patients exhibited abnormal TUS findings but normal chest radiographic profiles, and one suffered congestive heart failure. [journals.plos.org]
- Fatigue
Signs and symptoms may include fever, cough, fatigue, difficulty breathing (dyspnea), muscle pain, and chest pain. [rarediseases.info.nih.gov]
The main symptoms of acute eosinophilic pneumonia are cough, shortness of breath, fatigue, muscle aches, night sweats and chest pain worsened by breathing. Exam findings include high fevers and abnormal lung sounds. [apfed.org]
Respiratoric
- Pleural Effusion
High-resolution chest computed tomography scan revealed patchy ground glass opacity and ill-defined nodules, diffuse interlobar and interlobular septal thickening, and bilateral small amount of pleural effusion, which mimicked congestive heart failure [ncbi.nlm.nih.gov]
Bilateral pleural effusion was also noted ( Fig 1B ). [journals.plos.org]
Small pleural effusions occur in two thirds of patients and are frequently bilateral. HRCT is always abnormal with bilateral, random, patchy ground-glass or reticular opacities. Pleural fluid examination shows marked eosinophilia with high pH. [merckmanuals.com]
Chest X-ray showed increased interstitial markings with bilateral pleural effusions (Figure 1A). Computed Tomography (CT) of the chest showed bilateral ground glass opacities and pleural effusions (Figure 1B). [ijcasereportsandimages.com]
- Tachypnea
Signs include tachypnea, fever (often > 38.5 ° C), and bibasilar inspiratory crackles and, occasionally, rhonchi on forced exhalation. Patients with AEP frequently present with acute respiratory failure requiring mechanical ventilation. [merckmanuals.com]
(2) Physical examination: fever (often high), tachypnea, bibasilar inspiratory crackles, occasionally rhonchi。少見Clubbing and signs of cor pulmonale. (3) 可能一開始就hypoxemic respiratory insufficiency, 需要插管。 2. [lonepair000.pixnet.net]
Physical exam findings include hypoxemia, fever, tachypnea, non-productive cough, and bilateral diffuse rales. If pleural effusions are present, there is decreased tactile fremitus and increased dullness to percussion. [clinicaladvisor.com]
Patients present with cough and dyspnea, which is often severe and associated with tachypnea. Chest pain of pleuritic character and fever are frequently observed. [ojrd.biomedcentral.com]
The attending physician chose a regimen based on the presence of respiratory failure defined as a Pa,O2/FI,O2 ratio ≤ 300 and/or tachypnea (respiration rate ˃ 30 breaths min -1 ). [inspiro-bg.com]
Cardiovascular
- Hypertension
[…] mediared by portopulmonary hypertension Post-Treatment of Schistosomiasis: eosinophilic pneumonitis (lung shift, verminous pneumonia, reactionary Loffler-like pneumonitis) due to antigen release following treatment Strongyloides Stercoralis : simple [mdnxs.com]
He had a history of hypertension, hyperlipidemia and was a chronic active smoker. He has been working as a bicycle mechanic but denied significant exposure to metal fumes at his work place. [ijcasereportsandimages.com]
Clinicians should monitor patients for fluid retention and hypertension while on high-dose glucocorticoids. D. Coronary Artery Disease or Peripheral Vascular Disease. [clinicaladvisor.com]
Musculoskeletal
- Myalgia
It is characterized by acute febrile illness (< 3 weeks), dyspnea, nonproductive cough, pleuritic chest pain, malaise and myalgia. [ijcasereportsandimages.com]
Symptoms are nonproductive cough, dyspnea, malaise, myalgias, night sweats, and pleuritic chest pain. Signs include tachypnea, fever (often > 38.5 ° C), and bibasilar inspiratory crackles and, occasionally, rhonchi on forced exhalation. [merckmanuals.com]
症狀包括:乾咳(95%), 喘(92%),與發燒(88%),另外也會有malaise, myalgias, night sweats, chills, and pleuritic chest pain。 (2) Physical examination: fever (often high), tachypnea, bibasilar inspiratory crackles, occasionally rhonchi。 [lonepair000.pixnet.net]
Syndrome (see Eosinophilia-Myalgia Syndrome, [[Eosinophilia-Myalgia Syndrome]]) Physiology : due to contaminated L-tryptophan (see L-Tryptophan, [[L-Tryptophan]]) Toxic Rapeseed Oil Syndrome (see Contaminated Rapeseed Oil, [[Contaminated Rapeseed Oil [mdnxs.com]
The most common symptoms are non-productive cough, dyspnea, and fever though malaise, night sweats, chills, myalgias, and pleuritic chest pain are possible as well. [clinicaladvisor.com]
Workup
X-Ray
- Bilateral Pulmonary Opacities
The imaging findings of acute eosinophilic pneumonia include rapidly progressive bilateral pulmonary opacities largely indistinguishable from the numerous other causes of acute lung injury or ARDS. [swjpcc.com]
Pleura
- Pleural Effusion
High-resolution chest computed tomography scan revealed patchy ground glass opacity and ill-defined nodules, diffuse interlobar and interlobular septal thickening, and bilateral small amount of pleural effusion, which mimicked congestive heart failure [ncbi.nlm.nih.gov]
Bilateral pleural effusion was also noted ( Fig 1B ). [journals.plos.org]
Small pleural effusions occur in two thirds of patients and are frequently bilateral. HRCT is always abnormal with bilateral, random, patchy ground-glass or reticular opacities. Pleural fluid examination shows marked eosinophilia with high pH. [merckmanuals.com]
Chest X-ray showed increased interstitial markings with bilateral pleural effusions (Figure 1A). Computed Tomography (CT) of the chest showed bilateral ground glass opacities and pleural effusions (Figure 1B). [ijcasereportsandimages.com]
Treatment
Clinical condition and chest radiographs improved dramatically after corticosteroid treatment. [ncbi.nlm.nih.gov]
Treatment : How to Treat "idiopathic acute eosinophilic pneumonia"? The common treatment of idiopathic eosinophilic pneumonia is the use of corticosteroids which produces dramatic improvement of the condition. [signssymptoms.org]
Prognosis
Idiopathic acute eosinophilic pneumonia (IAEP) is a rare disease but of clinical importance because of its good prognosis if treated promptly and appropriately. [ncbi.nlm.nih.gov]
Acute eosinophilic pneumonia is very responsive to steroids and the prognosis is excellent. [apfed.org]
Conclusions AEP is associated with a good prognosis when recognized and treated promptly. [mayoclinic.pure.elsevier.com]
Etiology
The radiographic presentation of eosinophilic pneumonia is similar regardless of the etiology and therefore eliciting correct history from the patient is important in determining the underlying possible etiology. [ijcasereportsandimages.com]
The etiology remains unknown and the temporal relationship between IAEP and a history of resent onset of cigarette smoking has been described. [ncbi.nlm.nih.gov]
etiology of eosinophilic pulmonary infiltrates Clonorchis Sinensis (see Clonorchiasis, [[Clonorchiasis]]) Epidemiology : rare etiology of eosinophilic pulmonary infiltrates Dirofilariasis (see Dirofilariasis, [[Dirofilariasis]]) Clinical : eosinophilic [mdnxs.com]
Diseases with this underlying pattern have been further categorized based on primary (or idiopathic) or secondary (or known) etiologies. [link.springer.com]
Epidemiology
case reports of eosinophilic pneumonia Bipolaris Australiensis Epidemiology : case reports of eosinophilic pneumonia Bipolaris Spicera Epidemiology : case reports of eosinophilic pneumonia Brucellosis (see Brucellosis, [[Brucellosis]]) Epidemiology [mdnxs.com]
[…] eosinophilic pneumonia (AEP) is considered a rare disease, but it occurred at an increased rate among a population of soldiers serving in or near Iraq between March 2003 and March 2004, and may be associated with new-onset smoking and/or dust inhalation, an epidemiologic [acronymfinder.com]
Epidemiologic features differ depending on the clinical syndrome and etiology. [emedicine.medscape.com]
Long-term use of prednisone has many side effects, including increased infections, osteoporosis, stomach ulcers, Cushing's syndrome, and changes in appearance. [6] Epidemiology [ edit ] Eosinophilic pneumonia is a rare disease. [en.wikipedia.org]
Chronic eosinophilic pneumonia in Iceland: clinical features, epidemiology and review. Laeknabladid 2007;93:111–6. PubMed Google Scholar 57. Thomeer MJ, Costabel U, Rizzato G, et al. [link.springer.com]
Pathophysiology
Eosinophil Pathophysiology - Bilobar cells containing granules - Granules contain major basic protein, eosinophilic cationic protein, eosinophil-derived neurotoxin, Charcot-Leydin crystal protein - Cytokines that stimulate eosinophil growth, differentiation [quizlet.com]
Pathophysiology [ edit ] Eosinophilic pneumonia can develop in several different ways depending on the underlying cause of the disease. Eosinophils play a central role in defending the body against infection by parasites. [en.wikipedia.org]
All patients exhibit typical clinical features, including acute-onset respiratory distress with high fever, diffuse pulmonary infiltration, and an increased proportion of eosinophils in BAL fluid, but the detailed pathophysiology remains unknown. [journals.plos.org]
Prevention
Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection. [books.google.com]
Treatment with intravenous (IV) steroids or other medications which suppress the immune system may help stop or decrease the inflammation and prevent respiratory failure. [nationaljewish.org]
Appropriate Prophylaxis and Other Measures to Prevent Readmission. None Cottin, V, Cordier, JF. "Eosinophilic Pneumonias". Allergy. vol. 60. 2005. pp. 841-857. [clinicaladvisor.com]
It is thus advisable to recommend measures to prevent corticosteroid-induced osteoporosis from the start of the treatment. [ojrd.biomedcentral.com]