Clinical presentation, examination, imaging, and laboratory testing of two patients with VZV retinitis are presented. An HIV negative patient with history of herpes zoster presented with rapid loss of vision and examination consistent with PORN. [ncbi.nlm.nih.gov]

• Fatigue

  On jan,2012, I suddenly fell ill ,it is just fatigue ,weakness,drowsiness,anepithymia.After one weeks,I developed liver damage and i have very deep Urine‘s color like tea‘s for two weeks. [protocol-online.org]

  Over the previous few months he had experienced progressive fatigue and slurred speech. [omicsonline.org]

  Patient 6: A 62 year-old professor was diagnosed on November 7th, 2010 with coughing, adynamia, fatigue and progressive dyspnea for four months before. [ncbi.nlm.nih.gov]

  Current symptoms are extreme fatigue, dyspnea and loss of hair. A: Thank you for your question. I assume the absence of other details indicates that your patient has been doing well without recurrent infection, fever, weight loss. [aaaai.org]

  These findings, together with his symptoms of fatigue and night sweats, led to a presumptive diagnosis of AIDS. Nevertheless, he did not receive any treatment for the thrombocytopenia. [nejm.org]

• Hodgkin Lymphoma

  lymphoma, myasthenia gravis, protein-losing enteropathy, RA, chronic kidney disease, sarcoidosis, SLE, thermal injury ) Hereditary Aplasia of lymphopoietic stem cells Ataxia-telangiectasia Cartilage-hair hypoplasia syndrome Idiopathic CD4+ T lymphocytopenia [merckmanuals.com]

  Other noninfectious causes of ICL include hematological malignancies like non-Hodgkin lymphoma (large cell lymphoma, mucosa-associated lymphoid tissue lymphoma, Burkitt lymphoma), mycosis fungoides, and the myelodysplastic syndrome. [5] Autoimmune diseases [jcytol.org]

  Cutaneous T-cell non Hodgkin lymphoma in a patient with idiopathic CD4 lymphocytopenia. Indian J Dermatol Venereol Leprol 2013; 79: 831-3. [ Links ] 15. Moreno M, Pierzchalski J, Verea M, Ivanov M, Torchiari F. [scielo.org.ar]

  lymphoma. [14] The etiology of ICL remains unclear. [neurologyindia.com]

• Swelling

  A second HIV negative patient presented with blurred vision and lid swelling and was found to have peripheral VZV retinitis confirmed by PCR. Laboratory workup revealed lymphocytopenia with a CD4 count of 133/mm(3). [ncbi.nlm.nih.gov]

  The itching, burning and swelling of my labia were simply unbearable. I have purchased several over-the-counter treatments, including Monistat cream to subside the symptoms. [es.slideshare.net]

  On local examination, the swelling was firm, mobile and nontender measuring 1 cm × 1 cm in size. [jcytol.org]

  They are round and pink], this accompanied by swelling on dauily basis. It is all so very strange but I want your opinion. I can tell from this website I would not be the only one interested in your answer. [thebody.com]

• Vomiting

  Case Presentation: A 53‐year‐old woman presented with vomiting, severe headache, and neck stiffness. She had no recent sick contacts, travel or tick bites. [shmabstracts.com]

  More recently over a period of days he had experienced flu-like illness with upper respiratory infection, nausea, vomiting and diarrhea with subjective hearing loss. [omicsonline.org]

  He also had nausea with projectile vomiting. There was history of vertigo on movement of head for the past 2-3 months. [ijmm.org]

  A 30-year-old lady resident of Saharanpur, Uttar Pradesh presented to the Medicine Emergency with complaints of fever for 2 months, a headache for 2 months, nausea, and vomiting for 1 month, and altered sensorium for 4 days. [astrocyte.in]

  He had no fever, nausea, vomiting or any other related symptoms. A CT scan showed signs of pneumoperitoneum, parietal thick ening of the small intestines associated with an alteration of the adjacent fat planes, with no clear view of the appendix. [scielo.org.ar]

• Nausea

  More recently over a period of days he had experienced flu-like illness with upper respiratory infection, nausea, vomiting and diarrhea with subjective hearing loss. [omicsonline.org]

  A 30-year-old lady resident of Saharanpur, Uttar Pradesh presented to the Medicine Emergency with complaints of fever for 2 months, a headache for 2 months, nausea, and vomiting for 1 month, and altered sensorium for 4 days. [astrocyte.in]

  He also had nausea with projectile vomiting. There was history of vertigo on movement of head for the past 2-3 months. [ijmm.org]

  He had no fever, nausea, vomiting or any other related symptoms. A CT scan showed signs of pneumoperitoneum, parietal thick ening of the small intestines associated with an alteration of the adjacent fat planes, with no clear view of the appendix. [scielo.org.ar]

• Osteoporosis

  Patient 5: A 74 year-old woman with history of osteoporosis, gastric cancer 30 years before, cigarette smoke exposure, chronic obstructive pulmonary disease with spontaneous pneumothorax 8 months before, was attended by Staphylococcus aureus methicillin [ncbi.nlm.nih.gov]

• Skin Disease

  Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. [ingentaconnect.com]

  Sarcoidosis Viral disease Hemopathy Immunopathology Infection Leukopenia Autoimmune disease Skin disease Connective tissue disease Keyword (es) Diagnóstico Etiología Idiopático Lupus eritematoso sistémico Linfopenia Enfermedad sistémica Sarcoidosis Virosis [pascal-francis.inist.fr]

• Dermatitis

  By definition, it's a syndrome characterized by low CD4 counts (less than 300) that are not caused by HIV or other medical conditions (Sjogrens Syndrome, Sarcoid, Radiation therapy, atopic dermatitis, steroid therapy or lymphoma). [thebody.com]

• Testicular Mass

  Additionally, the patient previously had an orchidectomy because of a testicular mass with a biopsy showing a granulomatous lesion. [go.gale.com]

Laboratory workup revealed lymphocytopenia with a CD4 count of 133/mm(3). VZV necrotizing retinitis classic for PORN can occur in HIV negative patients. [ncbi.nlm.nih.gov]

Laboratory workup revealed lymphocytopenia with a CD4 count of 133/mm(3). CONCLUSIONS: VZV necrotizing retinitis classic for PORN can occur in HIV negative patients. [eye.hms.harvard.edu]

Genetic Analysis Genetic workup via chromosomal microarray revealed a 1–3 kb Xq13.1 duplication covering exons 25–28 of the MED12 gene. [frontiersin.org]

Opportunistic infections in immunocompetent hosts should lead to a prompt workup for this condition. Cytologic diagnosis of cutaneous cryptococcosis in this case led to the identification of this rare entity, in a clinically unsuspected case. 1. [jcytol.org]

Further workup ensued and he was found to have at that time asymptomatic cryptococcal meningitis [ 8 ]. Learning Points/Take Home Message 1. [omicsonline.org]

• Lymphopenia

  It may be discovered that some of the patients diagnosed during infancy with idiopathic T-cell lymphopenia represent the earliest presentation of the idiopathic CD4-cell lymphopenia described in adults. [frontiersin.org]

  A case is reported wherein a severe immunodeficiency syndrome with persistent idiopathic CD4+ lymphopenia developed in a woman suffering from systemic microscopic polyarteritis; no signs of HIV 1/2 or HTLV I/II infection were evident. [ncbi.nlm.nih.gov]

  Lymphocyte subpopulations were obtained for both patients on 2 occasions 6 weeks apart and notable for isolated CD4 lymphopenia. CONCLUSIONS: We present 2 cases of idiopathic CD4 lymphopenia with no identified precipitating etiologies. [eposters.net]

  A mutation in the human Uncoordinated 119 gene impairs TCR signalling and is associated with CD4 lymphopenia. Blood. 2012;119:1399-406. [msjonline.org]

Treatment with itraconazole was given for 12 months. Because of persistent CD4+ T cell counts below 100/microl, prophylactic antibiotic treatment is continued. [ncbi.nlm.nih.gov]

The prognosis is influenced by the accompanying opportunistic infections and may be affected by publication bias of severe cases with unfavorable outcomes. [ncbi.nlm.nih.gov]

Prognosis: The prognosis ultimately depends on the degree and duration of immune suppression and the presence and type of associated infections and comorbidities. [johnfaheymd.com]

The etiology of ICL is unknown. Mechanisms implicated in CD4 reduction may include decreased production, increased destruction, and tissue sequestration. [ncbi.nlm.nih.gov]

No common clinical or epidemiologic characteristics or evidence of HIV infection were found. It is unclear whether ICL is a syndrome of undetermined etiology or an immunologic manifestation of various diseases. [ncbi.nlm.nih.gov]

Holmberg, a longtime past Chief of Epidemiology in the CDC's Division of HIV/AIDS Prevention, shows us how scientific errors and controversies inevitably occur in the absence, ignorance, or dismissal of good data, and the promotion of bad data or analyses [books.google.com]

Epidemiologic, clinical and immunological characteristics of the syndrome were described in 1993 and ICL is now considered a heterogeneous syndrome not caused by an infectious agent. [clinicaltrials.gov]

Few studies have focused on the pathophysiology of ICL. CD4+ T-lymphocyte phenotyping revealed increased CD95 expression that could be responsible for excess apoptosis leading to lymphocytopenia. [clinicaltrials.gov]

Definition / general Marker of T helper cells, important in T cell activation and receptor for HIV ( Wikipedia, OMIM #186940 ) Also called OKT4 At #12p13.31 Pathophysiology Nonpolymorphous glycoprotein belonging to immunoglobulin superfamily ( Cell 1985 [pathologyoutlines.com]

Regarding the pathophysiological mechanism, we could hypothesize that the inflammatory cytokines alteration could leads to a decrease of CD4+ T lymphocytes, which would gener ate a lower cytotoxic T response, necessary to avoid a reactivation of latent [scielo.org.ar]

[…] infection were reported in Delhi by Mukherjee et al. [6] For improving CD4 counts, treatment with interleukin-2 has been suggested. [3] However, in view of the paucity of data, there are no recommendations on how to treat such patients, and due to unclear pathophysiology [astrocyte.in]

It does not appear to be caused by a transmissible agent, such as a virus. [5] It is widely believed that there is more than one cause. [6] [ non-primary source needed ] Pathophysiology [ edit ] The loss of CD4+ T cells appears to be through apoptosis [en.wikipedia.org]

Idiopathic CD4+ lymohocytopenia (ICL) is a syndrome defined by the Centre for Disease Control and Prevention as a CD4+ count <300 cells/uL or <20% of total T cell count on >1 occasion, with no evidence of human immunodeficiency virus (HIV) infection, [ncbi.nlm.nih.gov]

Our understanding, prevention, and treatment of HIV have made remarkable strides in the past two decades, but the way has not been smooth or straight. [books.google.com]

Idiopathic CD4 lymphocytopenia (ICL) was defined by the United States Centers for Disease Control and Prevention (CDC) as a clinical condition in patients with... [acronymattic.com]

She was treated for her cryptococcal meningitis with flucytosine and amphotericin and started on sulfamethoxazole/trimethoprim and azithromycin for primary prevention of opportunistic infections. [shmabstracts.com]