If you missed the meeting or if you would like a refresher, a few of the presentations below. Lung Transplant presentation Palliative Care presentation Pulmonary Fibrosis Foundation presentation Team Members: [academicdepartments.musc.edu]

Normal sinus rhythm was present in all but 2 patients, who had atrial fibrillation. [circ.ahajournals.org]

“target” or “iris” lesions of the skin are characteristic but not present in all cases, and consist of a blister surrounded by erythematous rings. Oral mucosal blisters and ulcers are present in multiple locations and are painful. [dentalcare.com]

Consultant: Volume 53 - Issue 3 - March 2013 PDF: Citation: Consultant. 2013;53(3):194 In January, a 14-year-old girl presented with purple coloration of the distal toes. [consultant360.com]

The early onset of symptoms in the present series is believed to be related to the prevalence of formula feeding from early infancy in New York City at present. [pediatrics.aappublications.org]

• Pain

  Topical and/or systemic corticosteroids will almost always control, but not cure, painful erosions and ulcers of lichen planus. [dentalcare.com]

  He said there was nothing to be done for DISH except to try to stay active to avoid stiffening of the joints and back, and take pain medicine when necessary. He tried 10 or so pain meds without finding anything that worked very well. [connect.mayoclinic.org]

  The first signs often are joint pain or swelling or warm joints. [kidshealth.org]

  Symptoms of sensory neuropathy may include: numbness, tingling, and burning sensation, particularly in hands and feet vague or strange sensations ( paresthesias ) pain, or inability to feel pain, touch, or temperature lack of coordination or loss of reflexes [healthline.com]

  Other common symptoms include transient altered vision, particularly on movement or bending over, intracranial noise (pulse synchronous tinnitus), stiff neck, back and arm pain, pain behind the eye, exercise intolerance, and memory difficulties. [rarediseases.org]

• Inflammation

  Egg-Associated Inflammation We frequently observe severe, chronic inflammation in the visceral cavity associated with degenerating eggs in diagnostic cases. [zebrafish.org]

  Although the diseases vary they all feature areas of inflammation affecting the central nervous system (brain and/or spinal cord). [manchesterneurophysio.co.uk]

  This tenderness, known as enthesitis, accompanies the joint inflammation of arthritis. It most often affects the hips, knees and feet. Enthesitis-related arthritis may also involve inflammation in parts of the body other than the joints. [arthritis.org]

  Some patients may have a single bout of systemic inflammation, then get control of their disease with treatment, and recover and become more stable, and others may still have flares of their disease, despite treatment. [autoinflammatory.org]

  Interstitial Lung Disease is a large group of lung disorders associated with inflammation and scarring of lung tissue. [academicdepartments.musc.edu]

• Fatigue

  The most common symptoms of JIA are joint inflammation, swelling and tenderness of the joints, inability to bend or straighten joints, fatigue and decreased physical activity. [beyondceliac.org]

  The most common symptoms in adults are exertional dyspnea and fatigue due to pulmonary hemorrhage and iron deficiency anemia. [merckmanuals.com]

  Patients may experience slower movement and speech, fatigue, forgetfulness, loss of smell, depression, and sleep disorders. [aapmr.org]

  […] non-productive cough Worsening shortness of breath, particularly worse on exertion (Obstructive sleep apneoa) Other features include finger clubbing fine late inspiratory crackles cyanosis rarely, other constitutional symptoms e.g. flu-like illness, fatigue [dundeemedstudentnotes.wordpress.com]

  Fatigue. Weight loss. Clubbing, a widening and rounding of the tips of the fingers. Swelling of the legs. Cleveland Clinic News & More Cleveland Clinic News & More [my.clevelandclinic.org]

• Asymptomatic

  It appears clinically as asymptomatic, persistent, erythematous, velvety, focal to diffuse mucosal areas. Because these lesions are asymptomatic, the patient is almost never aware of them. [dentalcare.com]

  It may occur in patients who were previously asymptomatic, as well as in patients who had been severely limited prior to death. [circ.ahajournals.org]

• Severe Pain

  […] an x-ray of the knee replacement years later, I had severe pain in my hip joints and my shoulder joints. [connect.mayoclinic.org]

• Vomiting

  Vomiting was a frequent prodromal symptom. Breast feeding for more than two months was shown to delay the onset of diarrhea. [pediatrics.aappublications.org]

  […] muscle weakness or loss of muscle control trouble with balance and coordination muscle twitching, cramping, or spasms difficulty walking or moving limbs Symptoms of autonomic neuropathy may include: dizziness, or fainting sweating abnormalities nausea, vomiting [healthline.com]

  Nosebleeds Bleeding in the mouth and/or in and around the gums Blood in the vomit, urine or stool Bleeding in the head - this is the most dangerous symptom of ITP. [chop.edu]

  Signs & Symptoms The most common symptom is often an unbearably painful or frequent headache, sometimes associated with nausea and vomiting that is not relieved by medication. The headache often awakens the patient from sleep. [rarediseases.org]

  Adverse drug reactions include nausea and vomiting, bone marrow suppression, gastrointestinal distress, diarrhea, alopecia and lethargy. [59] [60] Hemorrhagic cystitis can also occur but is prevented by fluid intake and mesna. [62] A long-term complication [eyewiki.aao.org]

• Nausea

  […] include: muscle weakness or loss of muscle control trouble with balance and coordination muscle twitching, cramping, or spasms difficulty walking or moving limbs Symptoms of autonomic neuropathy may include: dizziness, or fainting sweating abnormalities nausea [healthline.com]

  Signs & Symptoms The most common symptom is often an unbearably painful or frequent headache, sometimes associated with nausea and vomiting that is not relieved by medication. The headache often awakens the patient from sleep. [rarediseases.org]

  Adverse drug reactions include nausea and vomiting, bone marrow suppression, gastrointestinal distress, diarrhea, alopecia and lethargy. [59] [60] Hemorrhagic cystitis can also occur but is prevented by fluid intake and mesna. [62] A long-term complication [eyewiki.aao.org]

• Flatulence

  Symptoms of chronic idiopathic constipation include:- Constipation or difficulty in passing stools Hard and lumpy stools Straining when defecating Feeling of incomplete evacuation after completion Abdominal pain Abdominal discomfort and bloating Excessive flatulence [news-medical.net]

• Arthritis

  […] synonyms for juvenile arthritis juvenile RA juvenile chronic arthritis juvenile idiopathic arthritis demographics juvenile arthritis 6 weeks poly, pauci or systemic exclusion of other forms juvenile arhtritis SLE, reactive, lymes, dermatomyositis, kawasaki [brainscape.com]

  Other forms of Juvenile Idiopathic Arthritis (JIA): The more commonly known forms of Juvenile Idiopathic Arthritis (JIA) are considered to be autoimmune diseases, and SJIA used to be considered to be more of an autoimmune disease too. [autoinflammatory.org]

  After enrolling 50 JIA patients and patients with active knee arthritis, the team collected between 6 mL and 15 mL of synovial fluid from each patient. [thermofisher.com]

  Nearly 300,000 children – from infants to teenagers – in the U.S. have some form of arthritis. Juvenile idiopathic arthritis (JIA) is the most common type of arthritis in children. The term idiopathic means “of unknown origin.” [arthritis.org]

• Oligoarthritis

  Children with oligoarthritis are more likely to get uveitis (chronic eye inflammation) than those with the other subtypes. [arthritis.org]

  The two types of oligoarthritis, persistent and extended, are determined by how many joints are ultimately involved. Polyarticular arthritis, rheumatoid factor negative. [kidshealth.org]

  The ILAR classification of JIA includes the following categories: Systemic-onset JIA Persistent or extended oligoarthritis Rheumatoid factor (RF)–positive polyarthritis RF-negative polyarthritis Psoriatic JIA Enthesitis-related arthritis Undifferentiated [emedicine.medscape.com]

• Paresthesia

  The decreased blood flow can cause sensations of coldness, pain, and paresthesias. The skin changes vary from pallor to cyanosis to erythema. [consultant360.com]

  Symptoms of sensory neuropathy may include: numbness, tingling, and burning sensation, particularly in hands and feet vague or strange sensations ( paresthesias ) pain, or inability to feel pain, touch, or temperature lack of coordination or loss of reflexes [healthline.com]

• Hyperactivity

  In primary Raynaud phenomenon, laboratory results are often normal, and patients lack a family history of the condition. 1 A hyperactive sympathetic system is thought to cause severe vasoconstriction of the distal arteries of the digits and, rarely, the [consultant360.com]

• Lethargy

  Adverse drug reactions include nausea and vomiting, bone marrow suppression, gastrointestinal distress, diarrhea, alopecia and lethargy. [59] [60] Hemorrhagic cystitis can also occur but is prevented by fluid intake and mesna. [62] A long-term complication [eyewiki.aao.org]

[…] resonance imaging Ultrasonography and echocardiography Nuclear imaging Other studies and procedures that may be considered include the following: Dual-energy radiographic absorptiometry (DRA) Arthrocentesis and synovial biopsy Pericardiocentesis See Workup [emedicine.medscape.com]

Clinical Presentation All patients with suspected NSOI require a full ophthalmic assessment/workup. NSOI is typically characterized by the abrupt onset of pain, proptosis and other inflammatory signs such as swelling and erythema. [eyewiki.aao.org]

Children may develop ITP after a viral infection and usually recover fully without treatment. In adults, the disorder is often long term. If you don't have signs of bleeding and your platelet count isn't too low, you may not need any treatment. [mayoclinic.org]

When treatment is necessary, the two most common forms of treatment are: Steroids, which help prevent bleeding by decreasing the rate of platelet destruction. [chop.edu]

When medical treatment fails and vision is at risk, surgical intervention may be necessary. [rarediseases.org]

Some patients may have a single bout of systemic inflammation, then get control of their disease with treatment, and recover and become more stable, and others may still have flares of their disease, despite treatment. [autoinflammatory.org]

Physiotherapy treatment can help people with IIDDs to maximise their physical function and help improve their independence. Treatment may include specific exercises to work in improving strength, balance and mobility. [manchesterneurophysio.co.uk]

[…] arthritis, toxic synovitis hip neoplasia infantile onset multi systemic psychogenic 1+ joints extra articular features 6+ weeks subtype I: classic II: spondylitic III: psoriatic nail and skin manifestation JIA subtype III pauciarticular determinant of prognosis [brainscape.com]

Because of the poor prognosis of IPF, early discussions with the patient and family about advance care planning and end-of-life care are important. [msdmanuals.com]

No significant difference in prognosis between the different groups was found, but prognosis was influenced by traction bronchiectasis and overall fibrosis scores. [err.ersjournals.com]

[…] finger clubbing fine late inspiratory crackles cyanosis rarely, other constitutional symptoms e.g. flu-like illness, fatigue, weight loss; myalgia Investigations CXR Reticular shadowing (normal bronchi but opaque interstitium) CT Ground glass (better prognosis [dundeemedstudentnotes.wordpress.com]

Although there is no known cause of ITP and there is no cure, the prognosis for a child with ITP is very good. Usually, the body stops making the antibodies that are attacking the platelets and the disorder resolves on its own. [chop.edu]

An important example is rheumatoid arthritis where the hypothesis of a bacterial etiology remains viable despite failure of previous methods to identify a causative organism. [ncbi.nlm.nih.gov]

Etiology The etiology is not yet completely understood. Environmental factors may be associated with IPF (cigarette smoking, exposure to silica and livestock). [orpha.net]

Idiopathic Pulmonary Fibrosis is a type of chronic interstitial lung disease of unknown etiology characterized by the scarring of the lungs resulting in decreased lung function. [academicdepartments.musc.edu]

Hinman Etiologic factors in Peyronie's disease Urol Int, 35 (1980), pp. 407-413 [5.] M.K. Willscher, W.F. Cwazka, D.E. [archbronconeumol.org]

A similar histologic pattern uncommonly occurs in cases of interstitial lung diseases of known etiology (see Table: Key Features of Idiopathic Interstitial Pneumonias ). [msdmanuals.com]

Epidemiological studies have proven how diet and other lifestyle factors contribute to disease. Historically their peers shun the doctors that speak out about this, perhaps that is the reason it is taking so long for the truth to emerge. [thechiropractor.sa.com]

Summary Epidemiology IPF is a rare disease that affects approximately 5 million people worldwide. The prevalence is estimated to be slightly higher in men (1/5000) than in women (1/7700). [orpha.net]

Epidemiology In the United Sates as many as 35 million adults may suffer from chronic idiopathic constipation. The numbers may be higher as all patients do not seek medical help. [news-medical.net]

Because IH is a rare disorder affecting so few patients a central register is key to gathering epidemiological data and to notifying patients of a clinical trial of interest. [rarediseases.org]

Ley B, Collard HR: Epidemiology of idiopathic pulmonary fibrosis. Clin Epidemiol 2013;5:483-492. Sonnenberg A: Effects of environment and lifestyle on gastroesophageal reflux disease. Dig Dis 2011;29:229-234. [karger.com]

[…] congenital conditions are idiopathic, and sometimes the word congenital is used synonymously with idiopathic ; but careful usage prefers to reserve the word congenital for conditions to which the literal sense of the word applies (that is, those whose pathophysiology [en.wikipedia.org]

The pathophysiology of IPF is very complex and the mechanism by which statins may affect cellular and/or molecular pathways to reduce disease progression remains to be explained. [thorax.bmj.com]

Pathophysiology The etiology and pathogenesis of NSOI is currently unknown. Both infectious and immune-mediate etiologies have been implicated. [eyewiki.aao.org]

[…] juvenile idiopathic arthritis Enthesitis-related arthritis Undifferentiated: (A) Fits no other category; (B) Fits more than 1 category Inclusion of psoriatic arthritis, inflammatory bowel disease, juvenile ankylosing spondylitis No Yes Etiology and Pathophysiology [emedicine.medscape.com]

When treatment is necessary, the two most common forms of treatment are: Steroids, which help prevent bleeding by decreasing the rate of platelet destruction. [chop.edu]

[…] itch ESR- high CBC- anemia, leukocytosis and thrombocytosis IgM RF - ANA - age of onset compared to pronosis for systemic JIA younger age of onset -- worse prognosis what can occur in child with persistent JIA management of systemic JIA splinting to prevent [brainscape.com]

This study is testing whether low doses of the medicine danazol help prevent telomeres from getting shorter and reduce signs of damage from aplastic anemia or related conditions. [nhlbi.nih.gov]

Even if a patient is on treatment, MAS can develop,and in some cases, patients on medication for SJIA may have sub-clinical lab findings, and less obvious signs of MAS that should be considered serious, and the disease managed to prevent full-blown MAS [autoinflammatory.org]