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Idiopathic Disease

Idiopathic Disorder


  • If you missed the meeting or if you would like a refresher, a few of the presentations below. Lung Transplant presentation Palliative Care presentation Pulmonary Fibrosis Foundation presentation Team Members:[academicdepartments.musc.edu]
  • Normal sinus rhythm was present in all but 2 patients, who had atrial fibrillation.[circ.ahajournals.org]
  • “target” or “iris” lesions of the skin are characteristic but not present in all cases, and consist of a blister surrounded by erythematous rings. Oral mucosal blisters and ulcers are present in multiple locations and are painful.[dentalcare.com]
  • The early onset of symptoms in the present series is believed to be related to the prevalence of formula feeding from early infancy in New York City at present.[pediatrics.aappublications.org]
  • Consultant: Volume 53 - Issue 3 - March 2013 PDF: Citation: Consultant . 2013;53(3):194 In January, a 14-year-old girl presented with purple coloration of the distal toes.[consultant360.com]
Arm Pain
  • Other common symptoms include transient altered vision, particularly on movement or bending over, intracranial noise (pulse synchronous tinnitus), stiff neck, back and arm pain, pain behind the eye, exercise intolerance, and memory difficulties.[rarediseases.org]
Hand Tremor
  • Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect t ... How common is Parkinson disease? Parkinson disease affects more than 1 million people in North America and more than 4 million people worldwide.[hon.ch]
  • The earliest sign of papilledema on a visual field test is known as an enlarged blind spot. Abnormal CSF pressure can also affect the eye muscles controlling eye movements producing double vision, but this is an infrequent event.[rarediseases.org]


  • […] resonance imaging Ultrasonography and echocardiography Nuclear imaging Other studies and procedures that may be considered include the following: Dual-energy radiographic absorptiometry (DRA) Arthrocentesis and synovial biopsy Pericardiocentesis See Workup[emedicine.medscape.com]
  • Clinical Presentation All patients with suspected NSOI require a full ophthalmic assessment/workup. NSOI is typically characterized by the abrupt onset of pain, proptosis and other inflammatory signs such as swelling and erythema.[eyewiki.aao.org]
Left Axis Deviation
  • Although the electrical axis in the frontal plane was usually normal, left axis deviation was noted in 14 patients. Normal sinus rhythm was present in all but 2 patients, who had atrial fibrillation.[circ.ahajournals.org]
  • The team notes that 4 peptides shared a common binding site for HLA-DR1, a cell surface receptor, and 2 peptides shared the same primary amino acid sequence, with the exception of post-translational modifications.[thermofisher.com]


  • Children may develop ITP after a viral infection and usually recover fully without treatment. In adults, the disorder is often long term. If you don't have signs of bleeding and your platelet count isn't too low, you may not need any treatment.[mayoclinic.org]
  • When treatment is necessary, the two most common forms of treatment are: Steroids, which help prevent bleeding by decreasing the rate of platelet destruction.[chop.edu]
  • When medical treatment fails and vision is at risk, surgical intervention may be necessary.[rarediseases.org]
  • Some patients may have a single bout of systemic inflammation, then get control of their disease with treatment, and recover and become more stable, and others may still have flares of their disease, despite treatment.[autoinflammatory.org]
  • Physiotherapy treatment can help people with IIDDs to maximise their physical function and help improve their independence. Treatment may include specific exercises to work in improving strength, balance and mobility.[manchesterneurophysio.co.uk]


  • […] arthritis, toxic synovitis hip neoplasia infantile onset multi systemic psychogenic 1 joints extra articular features 6 weeks subtype I: classic II: spondylitic III: psoriatic nail and skin manifestation JIA subtype III pauciarticular determinant of prognosis[brainscape.com]
  • Because of the poor prognosis of IPF, early discussions with the patient and family about advance care planning and end-of-life care are important.[msdmanuals.com]
  • No significant difference in prognosis between the different groups was found, but prognosis was influenced by traction bronchiectasis and overall fibrosis scores.[err.ersjournals.com]
  • […] finger clubbing fine late inspiratory crackles cyanosis rarely, other constitutional symptoms e.g. flu-like illness, fatigue, weight loss; myalgia Investigations CXR Reticular shadowing (normal bronchi but opaque interstitium) CT Ground glass (better prognosis[dundeemedstudentnotes.wordpress.com]
  • Although there is no known cause of ITP and there is no cure, the prognosis for a child with ITP is very good. Usually, the body stops making the antibodies that are attacking the platelets and the disorder resolves on its own.[chop.edu]


  • An important example is rheumatoid arthritis where the hypothesis of a bacterial etiology remains viable despite failure of previous methods to identify a causative organism.[ncbi.nlm.nih.gov]
  • Idiopathic Pulmonary Fibrosis is a type of chronic interstitial lung disease of unknown etiology characterized by the scarring of the lungs resulting in decreased lung function.[academicdepartments.musc.edu]
  • A similar histologic pattern uncommonly occurs in cases of interstitial lung diseases of known etiology (see Table: Key Features of Idiopathic Interstitial Pneumonias ).[msdmanuals.com]
  • We have encountered several diseases of unknown cause (idiopathic etiology) and a few that are related to non-infectious causes.[zebrafish.org]
  • Etiology The etiology is not yet completely understood. Environmental factors may be associated with IPF (cigarette smoking, exposure to silica and livestock).[orpha.net]


  • Epidemiological studies have proven how diet and other lifestyle factors contribute to disease. Historically their peers shun the doctors that speak out about this, perhaps that is the reason it is taking so long for the truth to emerge.[thechiropractor.sa.com]
  • Summary Epidemiology IPF is a rare disease that affects approximately 5 million people worldwide. The prevalence is estimated to be slightly higher in men (1/5000) than in women (1/7700).[orpha.net]
  • Because IH is a rare disorder affecting so few patients a central register is key to gathering epidemiological data and to notifying patients of a clinical trial of interest.[rarediseases.org]
  • Epidemiology In the United Sates as many as 35 million adults may suffer from chronic idiopathic constipation. The numbers may be higher as all patients do not seek medical help.[news-medical.net]
  • Ley B, Collard HR: Epidemiology of idiopathic pulmonary fibrosis. Clin Epidemiol 2013;5:483-492. Sonnenberg A: Effects of environment and lifestyle on gastroesophageal reflux disease. Dig Dis 2011;29:229-234.[karger.com]
Sex distribution
Age distribution


  • […] congenital conditions are idiopathic, and sometimes the word congenital is used synonymously with idiopathic ; but careful usage prefers to reserve the word congenital for conditions to which the literal sense of the word applies (that is, those whose pathophysiology[en.wikipedia.org]
  • The pathophysiology of IPF is very complex and the mechanism by which statins may affect cellular and/or molecular pathways to reduce disease progression remains to be explained.[thorax.bmj.com]
  • Pathophysiology The etiology and pathogenesis of NSOI is currently unknown. Both infectious and immune-mediate etiologies have been implicated.[eyewiki.aao.org]
  • […] juvenile idiopathic arthritis Enthesitis-related arthritis Undifferentiated: (A) Fits no other category; (B) Fits more than 1 category Inclusion of psoriatic arthritis, inflammatory bowel disease, juvenile ankylosing spondylitis No Yes Etiology and Pathophysiology[emedicine.medscape.com]


  • When treatment is necessary, the two most common forms of treatment are: Steroids, which help prevent bleeding by decreasing the rate of platelet destruction.[chop.edu]
  • Hospital for Sick Children Health A-Z Search a complete list of child health articles expand_more View All Drug A-Z Search a list of articles about medications expand_more View All Learning Hubs Browse a complete list of content groups Healthy Living & Prevention[aboutkidshealth.ca]
  • […] itch ESR- high CBC- anemia, leukocytosis and thrombocytosis IgM RF - ANA - age of onset compared to pronosis for systemic JIA younger age of onset -- worse prognosis what can occur in child with persistent JIA management of systemic JIA splinting to prevent[brainscape.com]
  • Even if a patient is on treatment, MAS can develop,and in some cases, patients on medication for SJIA may have sub-clinical lab findings, and less obvious signs of MAS that should be considered serious, and the disease managed to prevent full-blown MAS[autoinflammatory.org]
  • Other medications, such as a-blockers, angiotensin-receptor blockers, antiplatelet drugs, topical vasodilators, intravenous prostaglandins, and onabotulinumtoxin A injection, can be used depending on the cause. 3 Preventive measures include avoidance[consultant360.com]

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