If you missed the meeting or if you would like a refresher, a few of the presentations below. Lung Transplant presentation Palliative Care presentation Pulmonary Fibrosis Foundation presentation Team Members: [academicdepartments.musc.edu]

Normal sinus rhythm was present in all but 2 patients, who had atrial fibrillation. [circ.ahajournals.org]

“target” or “iris” lesions of the skin are characteristic but not present in all cases, and consist of a blister surrounded by erythematous rings. Oral mucosal blisters and ulcers are present in multiple locations and are painful. [dentalcare.com]

Consultant: Volume 53 - Issue 3 - March 2013 PDF: Citation: Consultant. 2013;53(3):194 In January, a 14-year-old girl presented with purple coloration of the distal toes. [consultant360.com]

The early onset of symptoms in the present series is believed to be related to the prevalence of formula feeding from early infancy in New York City at present. [pediatrics.aappublications.org]

• Asymptomatic

  It appears clinically as asymptomatic, persistent, erythematous, velvety, focal to diffuse mucosal areas. Because these lesions are asymptomatic, the patient is almost never aware of them. [dentalcare.com]

  It may occur in patients who were previously asymptomatic, as well as in patients who had been severely limited prior to death. [circ.ahajournals.org]

• Pathologist

  The agreement amongst pathologists was poor for NSIP (κ=0.32) and fair for UIP (κ=0.49). [err.ersjournals.com]

• Cough

  Symptoms and signs (eg, subacute dyspnea, nonproductive cough, and Velcro crackles) are nonspecific and usually caused by other, more common disorders. [msdmanuals.com]

  Symptoms and Signs Symptoms and signs of idiopathic pulmonary hemosiderosis in children include recurrent episodes of dyspnea and cough, particularly nonproductive cough initially. Hemoptysis occurs later. [merckmanuals.com]

  They are often symptomatic for shortness of breath and a dry cough. The diseases can be difficult to diagnose and vary from patient to patient. [academicdepartments.musc.edu]

  When to get medical advice See your GP if you've struggled with your breathing for a while or have had a cough for more than three weeks. These symptoms aren't normal and shouldn't be ignored. [nhs.uk]

  […] chronic GORD reflux aspiration Smoking is a risk factor Genetic factors are probably important Usually presents in middle age – older (>55 years old) patients Clinical Presentation Insidious onset Dry/non-productive cough Worsening shortness of breath [dundeemedstudentnotes.wordpress.com]

• Dry Cough

  They are often symptomatic for shortness of breath and a dry cough. The diseases can be difficult to diagnose and vary from patient to patient. [academicdepartments.musc.edu]

  IPF initially manifests with symptoms of exercise-induced breathlessness and dry coughing. Auscultation of the lungs reveals early inspiratory crackles, predominantly located in the lower posterior lung zones. [orpha.net]

  Symptoms include: Dry cough. Shortness of breath, especially during or after physical activity. Fatigue. Weight loss. Clubbing, a widening and rounding of the tips of the fingers. Swelling of the legs. [my.clevelandclinic.org]

  A dry cough often develops (a cough with little or no sputum). Finger or toenail clubbing occurs in about half of cases. Clubbing is a painless swelling at the base of the nails. The cause of clubbing is not clear. [patient.info]

  Symptoms can include: shortness of breath a persistent dry cough tiredness loss of appetite and weight loss rounded and swollen fingertips ( clubbed fingers ) Many people ignore their breathlessness at first and blame it on getting old or being out of [nhs.uk]

• Vomiting

  Vomiting was a frequent prodromal symptom. Breast feeding for more than two months was shown to delay the onset of diarrhea. [pediatrics.aappublications.org]

  […] muscle weakness or loss of muscle control trouble with balance and coordination muscle twitching, cramping, or spasms difficulty walking or moving limbs Symptoms of autonomic neuropathy may include: dizziness, or fainting sweating abnormalities nausea, vomiting [healthline.com]

  Nosebleeds Bleeding in the mouth and/or in and around the gums Blood in the vomit, urine or stool Bleeding in the head - this is the most dangerous symptom of ITP. [chop.edu]

  Signs & Symptoms The most common symptom is often an unbearably painful or frequent headache, sometimes associated with nausea and vomiting that is not relieved by medication. The headache often awakens the patient from sleep. [rarediseases.org]

  Adverse drug reactions include nausea and vomiting, bone marrow suppression, gastrointestinal distress, diarrhea, alopecia and lethargy. [59] [60] Hemorrhagic cystitis can also occur but is prevented by fluid intake and mesna. [62] A long-term complication [eyewiki.aao.org]

• Nausea

  […] include: muscle weakness or loss of muscle control trouble with balance and coordination muscle twitching, cramping, or spasms difficulty walking or moving limbs Symptoms of autonomic neuropathy may include: dizziness, or fainting sweating abnormalities nausea [healthline.com]

  Signs & Symptoms The most common symptom is often an unbearably painful or frequent headache, sometimes associated with nausea and vomiting that is not relieved by medication. The headache often awakens the patient from sleep. [rarediseases.org]

  Adverse drug reactions include nausea and vomiting, bone marrow suppression, gastrointestinal distress, diarrhea, alopecia and lethargy. [59] [60] Hemorrhagic cystitis can also occur but is prevented by fluid intake and mesna. [62] A long-term complication [eyewiki.aao.org]

• Failure to Thrive

  Children with idiopathic pulmonary hemosiderosis may present with only failure to thrive and iron deficiency anemia. The most common symptoms in adults are exertional dyspnea and fatigue due to pulmonary hemorrhage and iron deficiency anemia. [merckmanuals.com]

• Fracture

  Basic radiographic changes in JIA include the following: Soft tissue swelling Osteopenia or osteoporosis Joint-space narrowing Bony erosions Intra-articular bony ankylosis Periosteitis Growth disturbances Epiphyseal compression fracture Joint subluxation [emedicine.medscape.com]

• Fear

  الصفحة 2 - Farewell : read, and fear not thine own understanding ; this book will create a clear one in thee ; and when thou hast considered thy purchase, thou wilt call the price of it a charity to thyself, and at the same time, forgive Thy friend, and [books.google.com]

• Tremor

  Often the first symptom of Parkinson disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect t ... [hon.ch]

  Rehab Management: Several medications are available to manage symptoms, such as tremors and stiffness, in the condition’s early stages. [aapmr.org]

  Various tremors, including essential tremor While these are not parkinsonian disorders, you may be diagnosed with one of these conditions if tremor is your only symptom. [parkinsons.org.uk]

  The word essential is sometimes synonymous with idiopathic (as in essential hypertension, essential thrombocythemia, and essential tremor ) and the same is true of primary (as in primary biliary cholangitis, or primary amenorrhea ), with the latter term [en.wikipedia.org]

[…] resonance imaging Ultrasonography and echocardiography Nuclear imaging Other studies and procedures that may be considered include the following: Dual-energy radiographic absorptiometry (DRA) Arthrocentesis and synovial biopsy Pericardiocentesis See Workup [emedicine.medscape.com]

Clinical Presentation All patients with suspected NSOI require a full ophthalmic assessment/workup. NSOI is typically characterized by the abrupt onset of pain, proptosis and other inflammatory signs such as swelling and erythema. [eyewiki.aao.org]

Children may develop ITP after a viral infection and usually recover fully without treatment. In adults, the disorder is often long term. If you don't have signs of bleeding and your platelet count isn't too low, you may not need any treatment. [mayoclinic.org]

When treatment is necessary, the two most common forms of treatment are: Steroids, which help prevent bleeding by decreasing the rate of platelet destruction. [chop.edu]

When medical treatment fails and vision is at risk, surgical intervention may be necessary. [rarediseases.org]

Some patients may have a single bout of systemic inflammation, then get control of their disease with treatment, and recover and become more stable, and others may still have flares of their disease, despite treatment. [autoinflammatory.org]

Physiotherapy treatment can help people with IIDDs to maximise their physical function and help improve their independence. Treatment may include specific exercises to work in improving strength, balance and mobility. [manchesterneurophysio.co.uk]

[…] arthritis, toxic synovitis hip neoplasia infantile onset multi systemic psychogenic 1+ joints extra articular features 6+ weeks subtype I: classic II: spondylitic III: psoriatic nail and skin manifestation JIA subtype III pauciarticular determinant of prognosis [brainscape.com]

Because of the poor prognosis of IPF, early discussions with the patient and family about advance care planning and end-of-life care are important. [msdmanuals.com]

No significant difference in prognosis between the different groups was found, but prognosis was influenced by traction bronchiectasis and overall fibrosis scores. [err.ersjournals.com]

[…] finger clubbing fine late inspiratory crackles cyanosis rarely, other constitutional symptoms e.g. flu-like illness, fatigue, weight loss; myalgia Investigations CXR Reticular shadowing (normal bronchi but opaque interstitium) CT Ground glass (better prognosis [dundeemedstudentnotes.wordpress.com]

Although there is no known cause of ITP and there is no cure, the prognosis for a child with ITP is very good. Usually, the body stops making the antibodies that are attacking the platelets and the disorder resolves on its own. [chop.edu]

An important example is rheumatoid arthritis where the hypothesis of a bacterial etiology remains viable despite failure of previous methods to identify a causative organism. [ncbi.nlm.nih.gov]

Etiology The etiology is not yet completely understood. Environmental factors may be associated with IPF (cigarette smoking, exposure to silica and livestock). [orpha.net]

Idiopathic Pulmonary Fibrosis is a type of chronic interstitial lung disease of unknown etiology characterized by the scarring of the lungs resulting in decreased lung function. [academicdepartments.musc.edu]

Hinman Etiologic factors in Peyronie's disease Urol Int, 35 (1980), pp. 407-413 [5.] M.K. Willscher, W.F. Cwazka, D.E. [archbronconeumol.org]

A similar histologic pattern uncommonly occurs in cases of interstitial lung diseases of known etiology (see Table: Key Features of Idiopathic Interstitial Pneumonias ). [msdmanuals.com]

Epidemiological studies have proven how diet and other lifestyle factors contribute to disease. Historically their peers shun the doctors that speak out about this, perhaps that is the reason it is taking so long for the truth to emerge. [thechiropractor.sa.com]

Summary Epidemiology IPF is a rare disease that affects approximately 5 million people worldwide. The prevalence is estimated to be slightly higher in men (1/5000) than in women (1/7700). [orpha.net]

Epidemiology In the United Sates as many as 35 million adults may suffer from chronic idiopathic constipation. The numbers may be higher as all patients do not seek medical help. [news-medical.net]

Because IH is a rare disorder affecting so few patients a central register is key to gathering epidemiological data and to notifying patients of a clinical trial of interest. [rarediseases.org]

Ley B, Collard HR: Epidemiology of idiopathic pulmonary fibrosis. Clin Epidemiol 2013;5:483-492. Sonnenberg A: Effects of environment and lifestyle on gastroesophageal reflux disease. Dig Dis 2011;29:229-234. [karger.com]

[…] congenital conditions are idiopathic, and sometimes the word congenital is used synonymously with idiopathic ; but careful usage prefers to reserve the word congenital for conditions to which the literal sense of the word applies (that is, those whose pathophysiology [en.wikipedia.org]

The pathophysiology of IPF is very complex and the mechanism by which statins may affect cellular and/or molecular pathways to reduce disease progression remains to be explained. [thorax.bmj.com]

Pathophysiology The etiology and pathogenesis of NSOI is currently unknown. Both infectious and immune-mediate etiologies have been implicated. [eyewiki.aao.org]

[…] juvenile idiopathic arthritis Enthesitis-related arthritis Undifferentiated: (A) Fits no other category; (B) Fits more than 1 category Inclusion of psoriatic arthritis, inflammatory bowel disease, juvenile ankylosing spondylitis No Yes Etiology and Pathophysiology [emedicine.medscape.com]

When treatment is necessary, the two most common forms of treatment are: Steroids, which help prevent bleeding by decreasing the rate of platelet destruction. [chop.edu]

[…] itch ESR- high CBC- anemia, leukocytosis and thrombocytosis IgM RF - ANA - age of onset compared to pronosis for systemic JIA younger age of onset -- worse prognosis what can occur in child with persistent JIA management of systemic JIA splinting to prevent [brainscape.com]

This study is testing whether low doses of the medicine danazol help prevent telomeres from getting shorter and reduce signs of damage from aplastic anemia or related conditions. [nhlbi.nih.gov]

Even if a patient is on treatment, MAS can develop,and in some cases, patients on medication for SJIA may have sub-clinical lab findings, and less obvious signs of MAS that should be considered serious, and the disease managed to prevent full-blown MAS [autoinflammatory.org]