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Idiopathic Hypercalcuria


Presentation

  • May rarely present with features of acute kidney injury or chronic kidney disease.[patient.info]
  • He is Executive Advisory Editor of Bone Research (2013-present).[books.google.com]
  • The latter indicates reduced tubular reabsorption of calcium and is present in hypoparathyroidism and metabolic acidosis; it does not contribute directly to calcium stone disease.[indiana.pure.elsevier.com]
  • IH patients present frequently with gross or microscopic hematuria, abdominal pain and a variety of urinary tract complaints (frequency-dysuria syndrome, enuresis, recurrent tract infection), with-noncalculus manifestation more prevalent than stone disease[eurekaselect.com]
Inflammation
  • […] peritonitis Pain and tenderness Abdominal pain Small renal calculi, nonurologic etiology (gastrointestinal origin) Flank pain (sharp, extreme pain with sudden onset) Urinary calculi, musculoskeletal spasm Flank tenderness Urinary calculi, musculoskeletal inflammation[aafp.org]
Chronic Diarrhea
Polyuria
  • Hypercalcaemia: polyuria and polydipsia, nausea and vomiting. May cause hypertension.[patient.info]
  • These children were checked for polyuria, concentrating defects, and their fluid intake. The renal functions in all patients were checked and if there was any decrease in renal function, they were excluded from the study.[sjkdt.org]
  • The transplant outcome and acute rejectionrates were similar to control subjects.4 To our knowledgethere is only one previous case report from India byRakesh Lodha et al,6 a fourteen year old girl with failureto thrive, polyuria and polydypsia.[japi.org]
  • The young man had polyuria and radiological nephrocalcinosis demonstrated by a concentration defect resistant to pitressin (260 mOsm/l), which seemed to contribute to the existing hypokalaemia (2.5-3.2mEq/l), given the secondary hyperaldosteronism.[revistanefrologia.com]

Workup

Nephrolithiasis
  • Cross sectional studies have suggested a causal association between IH and hematuria, nephrolithiasis and more recently, osteopenia.[siicsalud.com]
  • Effectiveness of thiazide therapy was evaluated by comparing stone recurrence between the pre- and post-treatment period, while the comparison was also made for untreated 56 Ca-nephrolithiasis patients who served as control.[webview.isho.jp]
  • Abstract The most common presentation of nephrolithiasis is idiopathic calcium stones in patients without systemic disease.[nature.com]
  • Randomized clinical trial comparing water therapy plus low-salt diet to water therapy alone in patients affected by idiopathic calcium nephrolithiasis.[clinicaltrials.gov]
  • Risk factors for nephrolithiasis in patients with familial idiopathic hypercalciuria. In: American Journal of Medicine , 2002, vol. 113, n 2, p. 99-103. 193 hits 0 download Update Deposited on : 2015-02-23 Export document Format : Citation style :[archive-ouverte.unige.ch]

Treatment

  • If diagnosed promptly and appropriate treatment is provided, then the outlook is good If the individual responds to various treatment measures, the prognosis is generally better, compared to those who do not respond favorably to treatment Additional and[dovemed.com]
  • Several pharmacological treatments have been described that can decrease the levels of urinary calcium or its index of urinary crystallization.[cochrane.org]
  • […] end oí a nine month treatment.[scielo.conicyt.cl]
  • Our inclusion criteria were no organic disease and discontinuing other treatment for the last four weeks.[sjkdt.org]

Prognosis

  • What is the Prognosis of Idiopathic Hypercalciuria? (Outcomes/Resolutions) The prognosis of Idiopathic Hypercalciuria depends on the severity of the condition.[dovemed.com]
  • Prognosis The prognosis depends mainly on the aetiology of the nephrocalcinosis.[patient.info]

Etiology

  • Treatment options for hypercalciuria depend on the etiology. B ecause most cases are idiopathic, initial therapy involves aggressive hydration.[johnsarm.net]
  • Crystallographic analysis of retrieved calculus remnants can help identify the underlying etiology and may obviate a complete metabolic evaluation.[aafp.org]
  • The etiology of incrusted cystitis with alkaline urine. JAMA, 85 (1925), pp. 1352-1355 [23] J.B. Sumner. Isolation and crystallization of enzyme urease: preliminary paper. J Biol Chem, 69 (1926), pp. 435-441 [24] M. Hammes, J.C. Lieske, S. Pawar, B.[analesdepediatria.org]

Epidemiology

  • […] genetics — Kidney Calculi/*epidemiology — Male — Middle Aged — Multivariate Analysis — Odds Ratio — Prevalence — Probability — Prospective Studies — Risk Factors — Sex Distribution — Statistics, Nonparametric Identifiers DOI: 10.1016/S0002-9343(02)01152[archive-ouverte.unige.ch]
  • Google Scholar Willett WC: Nutritional epidemiology. Modern epidemiology. Edited by: Rothman KJ, Greenland S. 1998, Philadelphia; Lippincott-Raven Publishers, 623-642.[nutritionj.biomedcentral.com]
  • Epidemiology Microscopic nephrocalcinosis is a common incidental finding at post-mortem but macroscopic nephrocalcinosis is uncommon.[patient.info]
  • Iran 2 Department of Students Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, IR Iran 3 Department of Surgery, School of Medicine, Arak University of Medical Sciences, Arak, IR Iran 4 Department of Biostatistics and Epidemiology[numonthly.com]
  • Schneider HJ: Epidemiology of urolithiasis; in Schneider HJ (ed): Urolithiasis. Berlin, Springer, 1985, pp 137–184. Article / Publication Details First-Page Preview[karger.com]
Sex distribution
Age distribution

Pathophysiology

  • Click on "pathophysiology" on the main menu to begin. When you finish that section, return to the menu page and click on "osteopenia". Be sure to try all the nephron segments to see the movies![courses.washington.edu]
  • Furthermore, studies on the pathophysiology of IH distinguish two prominent types of IH: the absorptive, characterized by increased intestinal Ca absorption, and the renal, characterized by decreased tubular Ca reabsorption.[eurekaselect.com]
  • Support for the role of bone in the pathophysiology of hypercalciuria has been corroborated.[journals.lww.com]
  • Brenner/Rector remains the go-to resource for practicing and training nephrologists and internists who wish to master basic science, pathophysiology, and clinical best practices.[books.google.com]
  • […] fasting Ca/creatinine ratio 0.23 0.23 0.36 0.36 urine Ca/creatinine ratio (1g load) 0.77 0.77 0.77 0.77 24h urine calcium (restricted 400mg diet) 5 mmol N ie 5 mmol 5 mmol 5 mmol Pathophysiology hyperabsorption of calcium diet-responsive hypercalciuria[pathology.leedsth.nhs.uk]

Prevention

  • […] the main cause (or causes) of Idiopathic Hypercalciuria is unknown, the preventative measures are generally relate to leading a healthy lifestyle.[dovemed.com]
  • The traditionally recommended low-calcium diet does not appear to prevent further renal stones.[mdedge.com]
  • Objectives: To assess the benefits and harms of pharmacological interventions for preventing complications and decreasing urological symptoms in patients with idiopathic hypercalciuria.[cochrane.org]
  • Generally, the main goal of treatment applied on hypercalciuric children should be to alleviate and finally eliminate the symptoms of the disease, to prevent renal stone formation or recurrence and to permit the acquisition of the optimal bone mass.[eurekaselect.com]
  • Stone Recurrence: Prevention and Treatment After the initial stone episode has resolved, patients should be counseled about prevention of recurrences.[aafp.org]

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