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Idiopathic Interstitial Pneumonia


Presentation

  • All presented with dyspnea as the initial symptom and with ILD as the first manifestation. Elevated CPK was identified in three patients but only two had muscle weakness.[ncbi.nlm.nih.gov]
  • UCTD was considered present when serum autoantibodies were present and symptoms or signs suggested CTD. The relationship between UCTD and NSIP histology was evaluated.[ncbi.nlm.nih.gov]
  • RESULTS: The cohort included 33 patients; most were white women with a mean age at presentation of 55 years. Their pulmonary physiologic impairment was moderate.[ncbi.nlm.nih.gov]
  • Clinicians identified 75% and radiologists identified 48% of these cases before presentation of the histopathologic information.[ncbi.nlm.nih.gov]
Mediastinal Lymphadenopathy
  • Franquet T, Gimenez A, Alegret X et al (1998) Mediastinal lymphadenopathy in cryptogenic fibrosing alveolitis: the effect of steroid therapy on the prevalence of nodal enlargement. Clin Radiol 53:435–438 CrossRef PubMed Google Scholar 37.[link.springer.com]
  • The presence of extensive ground-glass opacities, nodules, upper lobe or mid-zone predominance of findings, and significant hilar or mediastinal lymphadenopathy should question the radiographic diagnosis of IPF.[dx.doi.org]
  • Atypical findings include extensive ground-glass opacities, nodules, upper-lobe or midzone predominance of findings, and significant hilar or mediastinal lymphadenopathy.[archinte.ama-assn.org]
Failure to Thrive
  • Filiz O Seeborg, Mary E Paul, Stuart L Abramson, Debra L Kearney, Scott R Dorfman, Steven M Holland and William T Shearer, A 5-week-old HIV-1–exposed girl with failure to thrive and diffuse nodular pulmonary infiltrates, Journal of Allergy and Clinical[dx.doi.org]
Muscle Weakness
  • Though unlikely to influence the improvement of muscle weakness in AQM patients, the lung diseases associated with AQM may require specific consideration in determining suitable rehabilitation programs and observing patients before and after full recovery[ncbi.nlm.nih.gov]
  • Elevated CPK was identified in three patients but only two had muscle weakness. Pulmonary physiology revealed restriction (forced vital capacity 60% of predicted) and impaired gas transfer (diffusing capacity for carbon monoxide 40% of predicted).[ncbi.nlm.nih.gov]

Workup

  • It is possible that bronchiolocentric interstitial pneumonia represents a form of chronic hypersensitivity pneumonitis for which the inhalational stimulus has not been identified despite our extensive workup for this condition.[nature.com]
Human Herpesvirus 6
  • In all four patients, (1) the conditioning regimen induced total body irradiation, (2) serological reactivation of cytomegalovirus and/or human herpesvirus-6 preceded the onset of IIP, (3) their human leucocyte antigen types were among those suspected[ncbi.nlm.nih.gov]

Treatment

  • Although pulmonary (67)Ga uptake significantly decreased after treatment (P 0.001), there was no correlation between either initial (67)Ga uptake or change in (67)Ga uptake on treatment and 1-y prognosis.[ncbi.nlm.nih.gov]
  • Considering the results of the current study, further investigations into the effects and treatment potential of long-term administration of lecithinized superoxide dismutase may be warranted.[ncbi.nlm.nih.gov]
  • Effective symptom-management requires a multidisciplinary approach that incorporates patient education and self-management to formulate goals of care and treatment plans.[ncbi.nlm.nih.gov]
  • If you have any questions about your treatment, contact your healthcare professional.[ema.europa.eu]
  • Histopathologic classification plays a key role in separating multiple forms of idiopathic interstitial pneumonia into clinically meaningful categories with important differences in natural history, prognosis, and treatment.[ncbi.nlm.nih.gov]

Prognosis

  • In patients with IPF or fibrotic NSIP, pulmonary (67)Ga scintigraphy may be useful for predicting response to therapy and prognosis.[ncbi.nlm.nih.gov]
  • Predicting prognosis in the individual patient is challenging but various clinical and radiologic variables have been identified.[ncbi.nlm.nih.gov]
  • Idiopathic pulmonary fibrosis has a worse response to therapy and prognosis. New insight into the pathophysiology of idiopathic pulmonary fibrosis suggests a distinctly fibroproliferative process, and antifibrotic therapies show promise.[ncbi.nlm.nih.gov]
  • Third, the relationship between serum syndecan-4 levels and prognosis was evaluated.[ncbi.nlm.nih.gov]

Etiology

  • As the name implies, the etiology is unknown. In the more severe forms of IIP, such as idiopathic pulmonary fibrosis and acute interstitial pneumonia, no effective therapies have been identified.[ncbi.nlm.nih.gov]
  • Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10coded.com]
  • Abstract Idiopathic interstitial pneumonias are interstitial lung diseases of unknown etiology which prognosis is usually fatal.[ncbi.nlm.nih.gov]
  • The etiology of an acute exacerbation of idiopathic interstitial pneumonia is unknown. In this study, we tested the hypothesis that an acute exacerbation of idiopathic interstitial pneumonia is induced by respiratory viral infections.[ncbi.nlm.nih.gov]
  • Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. yasuos@med.gunma-u.ac.jp Abstract Idiopathic interstitial pneumonia (IIP) is a progressive fibrosing interstitial pneumonia of unknown etiology[ncbi.nlm.nih.gov]

Epidemiology

  • SETTING: Although the incidence and prevalence of idiopathic interstitial pneumonia (IIP) and idiopathic pulmonary fibrosis (IPF) have been assessed in Western countries, their epidemiology has not been analysed in Asian countries, including the Republic[ncbi.nlm.nih.gov]
  • Jump to: navigation, search Idiopathic Interstitial Pneumonia Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Idiopathic interstitial pneumonia from other Diseases Epidemiology[wikidoc.org]
  • Contents Complications and Discontinuation 339 Oxygen Therapy and Toxicity 345 ProtocolDriven Care in Respiratory Therapy 351 Epidemiology Natural History 357 Prophylaxis 364 Chronic Thromboembolic Pulmonary Hypertension 375 Unusual Forms of Embolism[books.google.com]
  • Idiopathic Interstitial Pneumonia Aka: Idiopathic Pulmonary Fibrosis, Usual Interstitial Pneumonia, Desquamative Interstitial Pneumonia, Respiratory Bronchiolitis, RB-ILD, Acute Interstitial Pneumonia, Hamman-Rich Disease, Nonspecific Interstitial Pneumonia Epidemiology[66.199.228.237]
  • Epidemiology of idiopathic pulmonary fibrosis. Semin Respir Med 1993 ;14: 181 –196. Crossref, Google Scholar 16. Coultas DB, Zumwalt RE, Black WC, Sobonya RE. The epidemiology of interstitial lung disease.[dx.doi.org]
Sex distribution
Age distribution

Pathophysiology

  • New insight into the pathophysiology of idiopathic pulmonary fibrosis suggests a distinctly fibroproliferative process, and antifibrotic therapies show promise.[ncbi.nlm.nih.gov]
  • There are multiple contributing pathophysiological mechanisms, including ventilatory mechanical limitation, impaired gas exchange, pulmonary vascular insufficiency and peripheral muscle dysfunction.[ncbi.nlm.nih.gov]
  • Abstract The term 'idiopathic interstitial pneumonia' (IIP) encompasses a wide variety of diseases with different and often unexplained pathophysiology as well as diverse natural histories.[ncbi.nlm.nih.gov]
  • Reactive oxygen species and their cytotoxic effects on the lung epithelial cells have been reported to participate in the pathophysiology of the disease.[ncbi.nlm.nih.gov]
  • Our findings provide further evidence of the importance of inflammation in the pathophysiology of IIPs.[ncbi.nlm.nih.gov]

Prevention

  • Since IP itself is likely a risk factor for PP, prevention of BPF is important for patients with IP, as it can lead to PP.[ncbi.nlm.nih.gov]
  • Secondary Prevention Future or Investigational Therapies Case Studies Case #1 Idiopathic interstitial pneumonia On the Web Most recent articles Most cited articles Review articles CME Programs Powerpoint slides Images American Roentgen Ray Society Images[wikidoc.org]
  • Prevention of bacterial endocarditis. ‎ Page 303 - American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. ‎[books.google.com]
  • Can interstitial lung disease be prevented? Interstitial lung disease can be prevented only to the extent that its individual causes may be prevented.[medicinenet.com]
  • Now, prevention, quite difficult, no proven therapy as well. Oxygen supplementation to treat hypoxemia. Please understand that you’re giving oxygen even though there might be a decrease in DLCO. Only small percentages respond to steroid therapy.[lecturio.com]

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