The median age at presentation was 36. Fifty-four percent of patients had the nephrotic syndrome at presentation. Half of the patients were treated at some stage with cyclophosphamide or corticosteroids. [ncbi.nlm.nih.gov]

• Pathologist

  Assessment of these factors thus allows the pathologist to make a relevant statement concerning the probable course and prognosis of the disease at the time of the diagnostic biopsy. [ncbi.nlm.nih.gov]

• Suggestibility

  The fact that both brothers had identical HLA antigens suggests a genetic predisposing background. [ncbi.nlm.nih.gov]

• Microscopic Hematuria

  Symptoms and Signs Patients typically present with edema and nephrotic-range proteinuria and occasionally with microscopic hematuria and hypertension. Symptoms and signs of a disorder causing MN (eg, a cancer) may be present initially. [merckmanuals.com]

  Moreover, adults show an increased incidence of atypical clinical features such as hypertension, renal function impairment, non-selective proteinuria and microscopic hematuria 2, 3. [revistanefrologia.com]

  Mild microscopic hematuria may be present in MN (both primary and secondary). A 24 hour urine collection should be obtained to quantify the amount of proteinuria. [renalandurologynews.com]

  Severe hypoproteinemia (albumin 3.5 g/l) in 30 (41.1%), microscopic hematuria in 15 (20.5%), accompanying hypertension in 23 (31.5%), and eGFR 2 at the time of renal biopsy in 26 (35.6%) patients. [spandidos-publications.com]

  The presence of microscopic hematuria is common (30 to 40%), but macroscopic hematuria and red cell casts are rare and suggest a different diagnosis ( 13 ). [cjasn.asnjournals.org]

• Neglect

  For this study biopsies containing less than 10 nonsclerotic glomeruli were neglected. Immunofluorescence microscopy Tissue was snap frozen, sectioned at 5 µ and fixed in 95% alcohol for 10 min. [revistanefrologia.com]

Unlike these cases, our patient's workup did not reveal any underlying etiology for secondary MN. [karger.com]

Secondary causes of MN were excluded after clinical workup including detailed medical history, clinical examination, analysis like lupus antibodies, hepatitis B, C and HIV, and at least chest X-ray and abdominal ultrasound. [scielo.mec.pt]

The two can be distinguished by clinical, laboratory, and histological features (see Presentation and Workup ). [1] Successful treatment of the underlying cause may be curative in secondary forms. [emedicine.medscape.com]

An infectious workup, including blood and urine cultures, was negative and the symptoms resolved with only supportive care. A specific virus was not isolated, but the course was most consistent with a viral process. [bmcnephrol.biomedcentral.com]

The patient underwent extensive serologic workup including monoclonal protein studies, serum complement levels, anti-neutrophil cytoplasmic antibodies, hepatitis B and C and HIV serology, and anti-nuclear antibody, all of which were negative or in the [cjasn.asnjournals.org]

• Creatinine Increased

  The patients (six male, four female, mean age 50 years) were monitored over 9-30 months during which time creatinine clearance reduced from (mean /- SEM) 83 /- 10 to 29 /- 6 ml/min, and plasma creatinine increased from 135 /- 22 to 297 /- 35 mumol/l. [ncbi.nlm.nih.gov]

A significantly greater improvement in urinary protein excretion was, however, observed at all time points in the treatment group. Plasma albumin was also significantly higher in the treatment group at 18 and 24 months. [ncbi.nlm.nih.gov]

Assessment of these factors thus allows the pathologist to make a relevant statement concerning the probable course and prognosis of the disease at the time of the diagnostic biopsy. [ncbi.nlm.nih.gov]

A careful medication history and renal biopsy were essential in identifying the etiology of the acute kidney injury in this patient with a complex renal history. [ncbi.nlm.nih.gov]

Unlike these cases, our patient's workup did not reveal any underlying etiology for secondary MN. [karger.com]

Ongoing controversies regarding etiology, diagnosis, treatment 1. The role of M-type phospholipase A2 receptor and antibodies in pediatric patients with IMN is unknown. 2. [clinicaladvisor.com]

Lancet (1975) [ Pubmed ] Effect of protein A immunoadsorption in nephrotic syndrome of various etiologies. Esnault, V.L., Besnier, D., Testa, A., Coville, P., Simon, P., Subra, J.F., Audrain, M.A. J. Am. Soc. [wikigenes.org]

Epidemiology and clinical outcomes of patients with idiopathic membranous glomerulonephritis at Groote Schuur Hospital over a ten year period. University of Cape Town. Includes bibliographical references [open.uct.ac.za]

Membranous nephropathy in the older adult: epidemiology, diagnosis and management. Drugs Aging. 2007; 24(9): 717-32. [arupconsult.com]

View Article : Google Scholar : PubMed/NCBI 4 Li LS and Liu ZH: Epidemiologic data of renal diseases from a single unit in China: Analysis based on 13,519 renal biopsies. Kidney Int. 66:920–923. 2004. [spandidos-publications.com]

In an epidemiologic biopsy study of patients with HIV and renal disease, Szczech et al. [ 1 ] described HIV-positive patients with MN benefitting primarily from treatments other than HAART. [karger.com]

Detailed epidemiology: The incidence of MN is low in children and it is documented in 1-5% of all kidney biopsies performed in pediatric patients with proteinuria or nephrotic syndrome. [clinicaladvisor.com]

From basic science and pathophysiology to clinical best practices, Brenner & Rector’s The Kidney is your go-to resource for any stage of your career. [books.google.de]

"The finding not only furthers our understanding of the pathophysiological basis of membranous nephropathy, but also allows for the potential identification and monitoring of patients who are positive for anti-THSD7A autoantibodies, by both serologic [medpagetoday.com]

Definition / general Most common cause of nephrotic syndrome in adults (40%); 5% of cases in children Diffuse glomerular wall thickening due to in situ immune complexes (electron dense) in glomerular basement membrane but NOT in mesangium Pathophysiology [pathologyoutlines.com]

[Membranous nephropathy: Diagnosis, new insights in pathophysiology, and therapeutic approach]. Rev Med Interne. 2016 May 25. [Medline]. Tran TH, J Hughes G, Greenfeld C, Pham JT. [emedicine.medscape.com]

Although there have been considerable advances in the management of renal failure by dialysis and transplantation, there has been relatively little progress in its prevention. [books.google.de]

[…] tacrolimus and mycophenolate mofetil tacrolimus 2mg bd adjusted to achieve levels of 5-12ng/L mycophenolate mofetil 500mgs bd adjusted to achieve levels of 1.5-3mg/L Other Names: prograf cellcept Primary Outcome Measures : Efficacy of mycophenolate in preventing [clinicaltrials.gov]

Research is still trying to establish the best treatments to control membranous nephropathy and prevent it from causing kidney failure. [edren.org]

Is chronic lung disease in low birth weight infants preventable? A survey of eight centers. ‎ Página 84 - Tanner JM, Whitehouse RH, Marubini E, Resele LF. The adolescent growth spurt of boys and girls of the Harpenden growth study. ‎ [books.google.es]

The twin aims of treating membranous nephropathy are first to induce a remission of the nephrotic syndrome and second to prevent the development of end-stage kidney failure. [en.wikipedia.org]