Many patients present with café au lait spots, which, in most individuals, are present at birth. [emedicine.medscape.com]

A 35 year old white woman presented in March 2000 to a genitourinary medicine (GUM) clinic with 5 year history of recurrent lesions typical of genital herpes simplex virus (HSV) infection occurring almost every month. [sti.bmj.com]

• Splenomegaly

  Organomegaly manifested mostly as hepatomegaly (82%), lymphadenopathy (65%), or splenomegaly (39%). Endocrinopathy occurred as impotence (78%) or gynecomastia (68%) in men and as amenorrhea (68%) in women. [emedicine.medscape.com]

• Disability

  Recurrent and Disabling Cutaneous Herpes Drugs & Therapeutics for Idiopathic Recurrent and Disabling Cutaneous Herpes Genetic Tests for Idiopathic Recurrent and Disabling Cutaneous Herpes Anatomical Context for Idiopathic Recurrent and Disabling Cutaneous [malacards.org]

  This case demonstrates the importance of early recognition of urticaria associated with HSV infections in order to avoid delay in instituting antiviral treatment in GUM clinics or other settings for this disabling skin condition. [sti.bmj.com]

• Anemia

  Severe anemia (hemoglobin Iron deficiency anemia Iron deficiency anemia can cause changes in the appearance of the nails, tongue, and hair. In iron deficiency, nails become fragile and develop longitudinal ridges. [emedicine.medscape.com]

  PATOLOGIA IMMUNITARIA min. max. fisso 9302 ANEMIA EMOLITICA AUTOIMMUNE / / 41 9303 ARTRITE REUMATOIDE CON CRONICIZZAZIONE DELLE MANIFESTAZIONI / / 50 9312 GAMMAPATIA MONOCLONALE BENIGNA / / 25 9319 LINFOMI LINFOBLASTICI (NON HODGKIN) / / 60 9320 LUPUS [medisoc.it]

• Amyloidosis

  Biopsy samples of tissue with lichen amyloidosis and macular amyloidosis differ from samples of tissue with systemic amyloidosis because of sparing of dermal blood vessels. [emedicine.medscape.com]

• Sepsis

  On one hand, extensive loss of skin integrity causes patients with pyoderma gangrenosum to be more prone to sepsis at the time of chemotherapy-induced neutropenia. On the other hand, immunosuppression with steroids remains an issue. [emedicine.medscape.com]

• Skin Disease

  Skin diseases (eg, cutaneous plasmacytoma or polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes [POEMS] syndrome ) can be observed with clonal plasma cell proliferation. [emedicine.medscape.com]

• Skin Ulcer

  Clinically, patients present with painful, necrotic skin ulcers. [emedicine.medscape.com]

• Hyperkeratosis

  Follicular hyperkeratosis, most prominent on the nose, is considered a sign of paraneoplastic myeloma. Cutaneous plasmacytoma of the skin manifests as nontender, smooth, cutaneous or subcutaneous nodules 1-5 cm in diameter. [emedicine.medscape.com]

• Dysesthesia

  The onset of ulcers is often spontaneous, with prodromal pain or dysesthesias in the area. A history of previous leg ulcers is the strongest predictor of recurrence. [emedicine.medscape.com]

• Hyperprolactinemia

  Other endocrine abnormalities were glucose intolerance, hyperthyroidism, hyperprolactinemia, and adrenal insufficiency. In contrast to multiple myeloma, no anemia, no renal insufficiency, and only rare cases of hypercalcemia are reported. [emedicine.medscape.com]

• Staphylococcus Aureus

  Secondary infections, mostly with Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus species, and Bacteroides species are most common. [emedicine.medscape.com]

Excluding the infection by using cultures is critical before treatment is instituted. Corticosteroids remain the treatment of choice. In patients with underlying hematologic malignancies, topical treatment is generally not effective. [emedicine.medscape.com]

This case demonstrates the importance of early recognition of urticaria associated with HSV infections in order to avoid delay in instituting antiviral treatment in GUM clinics or other settings for this disabling skin condition. [sti.bmj.com]

Given the rarity of these diseases, the treatments outlined in the abstracts are not always evidence based. The information in the abstracts isnot intended to replace existing local, regional or country specific recommendations and guidelines. [orpha.net]

Also, in recent years, effective forms of treatment for several peripheral neuropathies have been introduced, making accurate diagnosis imperative. [accessmedicine.mhmedical.com]

The prognosis for leukemia cutis is related directly to the prognosis for the systemic disease. Therapy is usually directed at the underlying leukemia. [emedicine.medscape.com]

PATOLOGIA NEOPLASTICA min. max. fisso 9322 NEOPLASIE A PROGNOSI FAVOREVOLE CON MODESTA COMPROMISSIONE FUNZIONALE / / 11 9323 NEOPLASIE A PROGNOSI FAVOREVOLE CON GRAVE COMPROMISSIONE FUNZIONALE / / 70 9325 NEOPLASIE A PROGNOSI INFAUSTA O PROBABILMENTE [medisoc.it]

They are organised into groups, and further divided into clinical, etiological or histopathological sub-types. [orpha.net]

Warfarin also has been implicated in the etiology of calciphylaxis in patients with end-stage renal disease. It is a poorly understood disorder associated with high morbidity and mortality (60-80%). [emedicine.medscape.com]

Based on clinical experience and epidemiologic studies, the causes of leg ulceration can be divided into 3 categories: reduction in blood supply to the skin (infarction being the primary cause), local edema, and minor trauma. [emedicine.medscape.com]

The goal of treatment in idiopathic thrombocytopenic purpura is to elevate the platelet count to a level adequate to prevent major bleeding. [emedicine.medscape.com]